We are interested in the brain and how it regulates appetite, blood glucose levels, body weight and energy expenditure. Centres in the brain detect what is happening inside the body, but also in the environment, and then respond to control the amount we eat, the level of glucose in our blood which acts as a fuel, and the amount of fat that we use as an energy store. We wish to understand how the brain senses these different parameters and then interacts with other organs, like the liver, to control them. Our research requires a multidisciplinary approach covering genes, cells, tissues and behaviour. An understanding of these systems may allow them to be manipulated in the future to control metabolic diseases, such as obesity and diabetes.
1982 - 1986 BSc, University of Bath.
1986 - 1990 PhD, University of Cambridge.
1990 - 1991 Wellcome Trust Fellow. INSERM Unit 176, Bordeaux, France.
1991 - 1994 Associate Researcher. Department of Anatomy, University of Cambridge.
1994 - 2000 BBSRC Advanced Fellow. The Babraham Institute, Cambridge.
2000 - 2003 Lecturer. School of Biological Sciences, University of Manchester.
2003 - 2006 Senior Lecturer. Faculty of Life Sciences, University of Manchester.
2006 - 2008 Reader. Faculty of Life Sciences, University of Manchester.
2008 - 2015 Professor of Integrative Biology, University of Manchester.
2015 - present Brackenbury Chair of Physiology, University of Manchester.