Dr Sean Knight

NIHR Clinical Lecturer

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I have been interested in the fundamental questions behind clinical conditions from the beginning of my medical training. I completed a PhD in gene therapy in 2011 whilst at medical school through the MB PhD program at UCL. In my postgraduate training I became fascinated with disorders of the respiratory system and how the immune system can influence pathogenesis and clinical course. I have used NIHR funded posts to develop a core theme of respiratory immunology that I have applied to a broad range of respiratory conditions, most notably lung cancer and the recent COVID-19 pandemic.


Following an intercalated BSc in Immunology, I joined the MB PhD program at UCL in 2008. This led to a PhD in gene therapy, where I worked on how retroviral vectors dysregulate neighbouring gene expression. I also developed a new production system for lentiviral vectors that is scalable, enabling sufficient quantities of vector for widespread application. I graduated from UCL medical school in 2013 and joined the academic foundation program in Cambridge. I started a Respiratory Academic Clinical Fellowship in London in 2015 and relocated to the North West in 2017. I am now an Academic Clinical Lecturer and specialist registrar in Respiratory Medicine

External positions

Honorary Respiratory Registrar, Salford Royal NHS Foundation Trust

8 Aug 20197 Aug 2020

Areas of expertise

Research Networks and Beacons

Biology, Medicine and Health (BMH) Domains

Education / academic qualifications

  • 2013 - Bachelor of Medicine and Bachelor of Surgery University College London (UCL)
  • 2012 - Doctor of Philosophy, Lentiviral Vectors for Gene Therapy, University College London (UCL)
  • 2007 - Bachelor of Science, Immunology and Cell Pathology, University College London (UCL)

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