Dr Rok Krašovec

UKRI Future Leaders Fellow

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Biography

I am an evolutionary biologist at The University of Manchester. I use microbes to investigate fundamental questions about evolutionary mechanisms. My main focus is environmental dependence of mutation rates, and I use that understanding to find novel ways of mitigating the antimicrobial resistance. After gaining a BA and a PhD in biology at The University of Ljubljana, I spent a few years in the Industry. I first came to The University of Manchester in 2011 (Chris Knight lab) to conduct post-doctoral research on microbial mutation rates funded by EPSRC and BBSRC. In 2020 I was awarded the Future Leaders Fellowship to use single-cell technologies to study environmental dependence of de novo mutations in individual bacterial cells.

Keywords

  • mutagenesis, DNA repair, mutation rate plasticity, NUDIX hydrolases, cell heterogeneity, cell-cell interactions, quorum-sensing, antimicrobial resistance, antibiotic persistence, antibiotic heteroresistance, single-molecule fluorescence, single-cell imaging, super-resolution microscopy, fluctuation assay, metabolic fingerprinting, microbial evolution, microbial ecology, evolutionary biology

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