Prof Robert Clarke PhD

Professor

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Overview

Professor of Breast Biology

Publications on Google Scholar: https://scholar.google.co.uk/citations?hl=en&user=h_gpwEwAAAAJ

Director of the Manchester Breast Centre, comprising 39 basic, translational and clinician scientists active in breast cancer research:

http://www.breastcentre.manchester.ac.uk/

Founder Member and Treasurer, European Network for Breast Development and Cancer (ENBDC):

http://www.enbdc.org/

Founder Member, EurOPDX Consortium:

http://europdx.eu/

Editorial Board: Breast Cancer Research and Journal of Mammary Gland Biology and Neoplasia

Latest Publications:

Palafox M, Monserrat L, Bellet M, Villacampa G, Gonzalez-Perez A, Oliveira M, Brasó-Maristany F, Ibrahimi N, Kannan S, Mina L, Herrera-Abreu MT, Ódena A, Sánchez-Guixé M, Capelán M, Azaro A, Bruna A, Rodríguez O, Guzmán M, Grueso J, Viaplana C, Hernández J, Su F, Lin K, Clarke RB, Caldas C, Arribas J, Michiels S, García-Sanz A, Turner NC, Prat A, Nuciforo P, Dienstmann R,  Verma C, Lopez-Bigas N, Scaltriti M, Arnedos M, Saura C, Violeta Serra V (2022) High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer. Nature Communications, 13, 5258, online 7 Sept.

Bartlett TE, Evans I, Jones A, Barrett JE, Haran S, Reisel D, Papaikonomou K, Jones L, Simões BM, Clarke RB, Evans DG, Ghezelayagh TS, Ponandai-Srinivasan, Boggavarapu SNR, Lalitkumar PG, Howell SJ, Risques RA, Rådestad AF, Dubeau L, Gemzell-Danielsson K and Widschwendter M*. (2022) Targeting progesterone reduces epigenetic and genetic cancer surrogates in normal breast tissue, Genome Medicine, 14 (1), 1-18.

Pellegrino B, Herencia A, Llop-Guevara A, Pedretti F, Moles A, Viaplana C, Villacampa G, Guzmán M, Rodríguez O, Grueso J, Jimenez J, Forment JV, O’Connor MJ, Cairo S, Zhou Y, Musolino A, Caldas C, Clarke RB, Nuciforo P, Díez O, Serres X, Peg V, Espinosa M, Macarulla T, Oaknin A, Mateo J, Bellet M, Oliveira M, Saura C, Gutiérrez-Enríquez S, Balmaña J and Serra V (2022) Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification. Cancer Research, 82(8):1646-1657.

Biography

Rob is Professor of Breast Biology and Director of the Manchester Breast Centre, based at the Oglesby Cancer Research Building.  Undergraduate BSc studies were in Biology at the University of Sussex and the Université de Grenoble.  Following two and half years as a Research Assistant with Chris Potten at the Paterson Institute for Cancer Research, Rob studied the control of proliferation in the normal and neoplastic human mammary gland for my PhD at The University of Manchester (1995).  Post-doctoral training was with Dr Liz Anderson in the Clinical Research Department of The Christie, Manchester, and in 2001, Rob returned to The University of Manchester as a Cancer Research Campaign Research Fellow in the Cancer Biology. Rob was appointed as a lecturer and Breast Cancer Campaign Research Fellow from 2006-2011, a Senior Lectureship from 2009 and a Reader in Breast Biology from 2014-2018.

Qualifications

BSc (Hons), PhD

Memberships of committees and professional bodies

Service on committees

Member of the Medical Research Council Clinical Training and Career Development Panel, 2022-2024.

Member of the Swiss National Science Foundation, Division Biology and Medicine Panel, 2022-2024.

Research Networks and Beacons

Biology, Medicine and Health (BMH) Domains

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