Prof Robert Clarke PhD


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Professor of Breast Biology

Publications on Google Scholar:

Director of the Manchester Breast Centre, comprising 33 basic, translational and clinician scientists active in breast cancer research:

Founder Member and Treasurer, European Network for Breast Development and Cancer (ENBDC):

Founder Member, EurOPDX Consortium:

Editorial Board: Breast Cancer Research and Journal of Mammary Gland Biology and Neoplasia

Latest Publications:

Sarmiento-Castro A, Caamaño-Gutiérrez E, Sims AH, James MI, Santiago-Gómez A, Eyre R, Clark C, Brown ME, Brooks MD, Wicha MS, Howell SJ, Clarke RB* and Simões BM* (2020) Increased expression of interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cells, Stem Cell Reports, 15(2):307-316. *Co-corresponding senior authors.

Simões BM, Santiago-Gómez A, Chiodo C, Moreira T, Conole D, Lovell S, Alférez D, Eyre R, Spence K, Sarmiento-Castro A, Kohler B, Morisset L, Lanzino M, Andò S, Marangoni E, Sims AH, Tate E, Howell SJ and Clarke RB (2020) Targeting STAT3 signalling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer. Oncogene, 39(25):4896-4908.

Eyre R, Alférez DG, Santiago-Gómez A, Spence K, McConnell JC, Hart C, Simões BM, Lefley D, Tulotta C, Storer J, Gurney A, Clarke N, Brown MD, Howell SJ, Sims AH, Farnie G, Ottewell PD and Clarke RB (2019) Microenvironmental IL1β promotes metastatic colonisation of breast cancer cells in the bone via activation of Wnt, Nature Communications, 10(1):5016.

Santiago-Gomez A, Kedward T, Simões BM, Dragoni I, NicAmhlaoibh R, Trivier E, Sabin V, Gee JM, Sims AH, Howell SJ and Clarke RB (2019) PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer, Cancer Letters, 458:66-75.


I am Professor of Breast Biology and Director of the Manchester Breast Centre, based at the Oglesby Cancer Research Building.  My undergraduate BSc studies were in Biology at the University of Sussex and the Université de Grenoble.  Following two and half years as a Research Assistant with Chris Potten at the Paterson Institute for Cancer Research, I studied the control of proliferation in the normal and neoplastic human mammary gland for my PhD at The University of Manchester (1995). Subsequently, my post-doctoral training was with Dr Liz Anderson in the Clinical Research Department of The Christie, Manchester, and in 2001, I returned to The University of Manchester as a Group Leader in the Division of Cancer Sciences. I was Lecturer and Cancer Research UK Research Fellow from 2001-2006, a Senior Lecturer and Breast Cancer Now Research Fellow from 2006-2011 and a Reader in Breast Biology from 2014.


BSc (Hons), PhD

Memberships of committees and professional bodies

Service on committees

Chair of the Breast Cancer Now Catalyst Grants Committee (Europe), 2019-

Organising committee for the 12th European Network for Breast Development and Cancer (ENBDC) Workshop, Luzern, Switzerland, May, 2021.

Research Networks and Beacons

Biology, Medicine and Health (BMH) Domains

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