My area of research is complex disease genetics. This applies to conditions where multiple genes interplay with environmental triggers.
I use both genetic and functional approaches to further the understanding of:
(i) The commonest inflammatory arthritis to affect children under 16 years – Juvenile Idiopathic Arthritis.
(ii) Changes that arise with weight variation a. Obesity
b. Bariatric surgery
c. Diabetes (T2DM, T1D, GDM)
(iii) Inflammatory pathologies, especially where variation in steroid sensitivity is a factor (eg SLE).
Rachelle Donn MB ChB PhD
Expertise in: Molecular Genetics and Functional Genomics.
Main Research interests:
1) Genetics of complex diseases (Juvenile Idiopathic Arthritis, Diabetes, Systemic Lupus Erythematosus)
2) Genetic basis of drug response (Steroids)
3) Network analysis of complex genetic diseases
The Healthy City Initiative is a long term, sustainable endeavour to improve the health of Salford residents, principally by educating and monitoring in relation to type 2 diabetes. This has fed forwards into more funding coming to Salford for extended projects related to wider, related public health issues such as the national diabetes prevention programme. I am chair of the streeing group for the Healthy City Initiative and liaise regularly with Diabetes UK in relation to this long term project.