I originally studied undergraduate physics and then medicine. Graduating from The Manchester Medical School 1989, I went on to study clinical academic surgery, emergency medicine and critical care at the Universities of Glasgow and Manchester in the UK, and at the Catholic University of Leuven, Belgium. I returned to Manchester in 1998 as MRC Clinical Training Fellow, completing my PhD supervised by Professor Rod Little at the MRC Trauma Unit in 2002, where I developed non-invasive methods to transduce and study dynamic cardio-respiratory responses to tissue injury and haemorrhage. I was appointed to my current clinical academic post at the University of Manchester in 2003, developing clinical services and academic practice in Critical Care Medicine as Honorary NHS Consultant at Salford Royal NHS Foundation Trust. I have developed and provided leadership for a programme of work, funded largely by the National Institute of Health Research (NIHR), investigating and assessing the diagnostic utility of emerging molecular technologies in the setting of sterile tissue injury and severe infection. Funded by Innovate UK (formerly Technology Strategy Board) I have also led a programme of work developing novel technologies aimed at rapid point-of-care infection/sepsis diagnosis. I am NIHR's National Specialty Lead for Critical Care providing leadership and advice for a range of large-scale pragmatic clinical trials in the UK and I represent NIHR internationally. Appointed recently as Research Professor in The Humanitarian and Conflict Response Institute at The University of Manchester, I also provide strategic interdisciplinary collaborative leadership and translation of acute care research in low income settings.
BSc (Physics) MB ChB (Manchester 1989), FRCS (Edinburgh 1994), PhD (Biomedical Engineering, Faculty of Medicine, Victoria University of Manchester 2002), FRCEM (London, 2002), FFICM (London 2012), FRCA (Hon, London 2019).
Memberships of committees and professional bodies
Member of the national Urgent Public Health Research Advisory Group (COVID-19), NIHR/DHSC/CMOs (March 2020 - present)
NIHR National Specialty Lead for Critical Care, King's College London (2015 - present)
NIHR's international representative, International Forum for Acute Care Trialists, Toronto, Canada (2016 - present)
NIHR's international representative, COMBACTE-NET IMI programme, European Union (2016 - present)
Critical Care Leadership Forum, Research Lead, Faculty of Intensive Care (2015- present)
NIHR Greater Manchester LCRN Critical Care Speciality Group Lead (2011-2016)
NIHR Greater Manchester LCRN Divisional Clinical Lead (2015-19)
Member of National Critical Care Specialty Group Committee (2013- present) Chair from 2015 - present
Member of UK Intensive Care Society Research Committee (2013 - present)
Organising Committee Chair, UK Critical Care Research Forum (2014 - 15)
Director, Greater Manchester Academic Centre for Acute Care and Trauma, Manchester Academic Health Science Centre, Health Innovation Manchester (2013 - present)
Board Member, UK Trauma Audit and Research Network (TARN) (2015- present)
Lead Specialist Member, Diagnostic Advisory Committee, National Institute for Health and Care Excellence (2014 - present)