Mr Paul Humphreys

Research Associate

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Currently working towards a doctorate in the field of Regenerative Medicine; supervised by Professor Sue Kimber and Professor Rob Lucas.

My project involves manipulating TGFß signalling in pluripotent stem cells through the novel technology of optogenetics. Precise control of TGFß signalling will enable us to investigate and enhance differentiation of human pluripotent stem cells (hPSCs) towards chondrocytes; which will be important in the development of cell-based therapies for osteoarthritis. The main aims of the project are as follows:

1. Develop and optimise a TGFß signalling system

2. Demonstrate and titrate light-activated TGFß signalling with an associated downstream response

3. Fine-tune light dosage during hPSC differentiation to enhance chondrogenesis


My research is co-funded by the MRC and EPSRC.


Social responsibility

I regularly contribute to public engagement and outreach activities such as British Science Week, in which myself and other members of the CDT in Regenerative Medicine hosted a stand where we introduced Regenerative Medicine concepts to secondary school students. 

I also contribute to the FBMH Doctoral Academy blog: Research Hive. My role as scientific sub-editor involves highlighting current and novel work being performed at the University of Manchester, particularly by PhD students and early career researchers. 


MRes Tissue Engineering for Regenerative Medicine, Distinction, University of Manchester

Bsc (Hons) Biological Sciences, 1st Class, Lancaster University

Biology, Medicine and Health (BMH) Domains

Education / academic qualifications

  • 2016 - Master of Research, Tissue Engineering for Regenerative Medicine, The University of Manchester (2015 - 2016)
  • 2013 - Bachelor of Science, Biological Sciences, Lancaster University (2010 - 2013)

Related information

Prizes highlights

Prize: Prize (including medals and awards)

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