Michelle obtained her BSc (1st Class Hons) in Molecular Biology in 1992 from the University of Portsmouth. In 1995 she completed her PhD under the supervision of Prof Geoff Kneale within the Biophysics group at Portsmouth and then moved to the University of Cambridge to take up a Postdoctoral research position in Dame Jean Thomas’s laboratory where she investigated the interactions of HMG1 with DNA and Chromatin. in 1998 she obtained an Oppenheimer Fellowship to contiue he work on chromatin structure. In 1999 she took up a lectureship in Chemical Biology at the University of Sheffield where she began her independent research career on the functional analysis the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2 and missense mutations contained within them. In 2004 she was appointed to Lectureship in Medical Genetics in the School of Medicine and Human Health at the University.