Dr Margherita Bertuzzi

Research Fellow

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Overview

I am a postdoctoral research fellow of the Manchester Fungal Infection Group (MFIG, http://www.inflammation-repair.manchester.ac.uk/mfig). I am currently working on a MRC-funded research project titled “Structure-function analysis of a pH-responsive molecular switch required for fungal pathogenicity".

Biography

My PhD and post-doctoral studies focused extensively on fungal pathogenesis, with particular emphasis on the filamentous fungus Aspergillus fumigatus and the mechanisms by which this major fungal pathogen senses and adapts to the mammalian host niche.

During my PhD studies at Imperial College London, I studied A. fumigatus PacC/Rim101 signalling pathway and in particular the putative pH-receptor PalH and the transcription factor PacC, identifying a pH-sensitive switch which governs both virulence and epithelial damage mediated by Aspergillus fumigatus.

My first post-doctoral project focused on developing innovative tools for calcium imaging and measurements using genetically encoded probes, to gain novel insights into calcium signalling in filamentous fungi. The output of this project represents a cohort of A. fumigatus strains expressing different Ca2+ reporters with the first-in-field imaging of real-time pulsatile calcium flux in living hyphae of a pathogenic fungus.

Qualifications

2002-2005: BSc (Hons) Molecular Biology, University of Padua, Italy

2005-2007: MRes Human Health Biology, University of Padua, Italy

2007-2011: MPhil/PhD Molecular Mycology, Imperial College London, UK

Title of thesis: Sensory perception in model and pathogenic fungi: engineering misappropriation of response

Memberships of committees and professional bodies

BSMM, British Society for Medical Mycology (member since 2008)

Biochemical Society (Early career, member since 2009)

Isham, International Society for Human and Animal Mycology (young member since 2012)

ESCMID, European Society of Clinical Microbiology and Infectious Diseases (young scientist member since 2013)

Biology, Medicine and Health (BMH) Domains

Related information

Publications

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