Dr Kathryn McGurk

Honorary Lecturer

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Biography

I am a British Heart Foundation Centre of Research Excellence Fellow and Assistant Supervisor with the Cardiovascular Genomics group at the National Heart and Lung Institute, Imperial College London, UK. With my background in metabolomics and common variant analyses, and my current work in rare variant analyses and large data sets (e.g. phenotyping and imaging), I investigate the role of genetic factors in cardiomyopathy risk by analysing the whole genetics and outcome data of 500,000 volunteers from the UK Biobank, and patient cohorts. I am at the intersection of rare variant analysis with Dr. James Ware and deep imaging data analyses with Prof. Declan O'Regan. I hold an honorary contract with the Royal Brompton and Harefield Hospitals, London.

After my undergraduate degree in Natural Sciences with a 2-year moderatorship in Genetics at Trinity College Dublin, Ireland, I undertook a 4-year Ph.D. in Cardiovascular Sciences, funded by the Medical Research Council, UK, entitled “Heritability and family-based GWAS analyses to discover novel lipidomic biomarkers of Cardiovascular Disease” with Prof. Bernard Keavney and Prof. Anna Nicolaou at the University of Manchester. I was afforded 'time out of programme' research experiences with the University of Cape Town, South Africa under Prof. Bongani Mayosi, and with Stoller Biomarker Discovery Center, Manchester, UK under Prof. Anthony Whetton. I continue to lecture with the University of Manchester in pharmacogenetics as an Honorary Lecturer for the Division of Pharmacy and Optometry.

 

Publications

Genetic and environmental determinants of diastolic heart function. 
Thanaj M., Meikle J., McGurk K., et al., Apr 2022, Nature Cardio. Res.
doi: https://doi.org/10.1038/s44161-022-00048-2

Genetic analyses of circulating PUFA-derived mediators identifies heritable dihydroxyeicosatrienoic acid species.
McGurk K., et al., Apr 2022, Prostaglandins Other Lipid Mediat.
doi: https://doi.org/10.1016/j.prostaglandins.2022.106638

Effect of taurine administration on symptoms, severity, or clinical outcome of dilated cardiomyopathy and heart failure in humans: a systematic review.
McGurk K., et al., Feb 2022, Wellcome Open Res.
doi: https://doi.org/10.12688/wellcomeopenres.17505.2

Correspondence on “ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG)” by Miller et al.
McGurk K., et al., Nov 2021, Genet. Med.
doi: https://doi.org/10.1016/j.gim.2021.10.020

Phenotypic expression and outcomes in individuals with rare genetic variants of hypertrophic cardiomyopathy.
de Marvao A., McGurk K., et al., Sep 2021, JACC.
doi: 10.1016/j.jacc.2021.07.017

Circulating ceramides as biomarkers of cardiovascular disease: evidence from phenotypic and genomic studies.
McGurk K., et al., May 2021, Atherosclerosis
doi: https://doi.org/10.1016/j.atherosclerosis.2021.04.021

Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome.
McGurk, K., et al., March 2021, Human Molecular Genetics.
doi: https://doi.org/10.1093/hmg/ddab002

The genetic architecture of left ventricular non-compaction reveals both substantial overlap with other cardiomyopathies and a distinct aetiology in a subset of cases.  Mazzarotto, F., Hawley, M., Beltrami, M., Beekman, L., de Marvao, A., McGurk, K., et al., Jan 2021, Genomics in Medicine.
doi: https://doi.org/10.1038/s41436-020-01049-x

Heritability of haemodynamics in the ascending aorta.
McGurk, K., et al., Sep 2020, Scientific Reports.
doi: https://doi.org/10.1038/s41598-020-71354-7

The use of missing values in proteomic data-independent acquisition mass spectrometry to enable disease activity discrimination. 
McGurk, K., et al., Apr 2020, Bioinformatics.
doi:10.1093/bioinformatics/btz898

The Open Science of Atrial Fibrillation. 
Keavney, B. & McGurk, K., Jan 2020, Circulation research. 126, p. 210-211
doi: 10.1161/CIRCRESAHA.119.316357

Marked variation in heritability estimates of left ventricular mass depending on modality of measurement. 
Nethononda, R., McGurk, K., et al., Sep 2019, Scientific Reports.
doi: 10.1038/s41598-019-49961-w 

Qualifications

2020: Ph.D. in Cardiovascular Sciences, University of Manchester, UK.

2016: “Design and Analysis of Genetic-Based Association Studies” at the Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

2016: “Introduction to R” at the MRC Biostatistics Unit, Cambridge, UK.

2015: BA. Hons. in Natural Sciences with a Moderatorship in Genetics, Trinity College Dublin, Ireland.

2011: Leaving Certificate, Wesley College Dublin, Ireland. Chemistry (A*) Biology (A).

Areas of expertise

Biology, Medicine and Health (BMH) Domains

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