Honorary Senior Research Fellow
Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health
Jocelyn (Jo) Glazier is a Honorary Senior Research Fellow in the Division of Evolution and Genomic Sciences, University of Manchester. Jo's research investigates diverse aspects of placental nutrient transport function in normal and complicated pregnancies, and more recently she has been investigating the role of the yolk sac in early embryonic nutrient provision.
Her research has focussed on placental development and the regulation of placental function, both in normal pregnancy and in pregnancy complications such as intrauterine growth restriction and pre-eclampsia. In particular, she is interested in the mechanisms underlying placental nutrient transfer capacity and their modes of regulation, and how these might be altered in pregnancy complications leading to altered patterns of fetal development and growth, which may be associated with long term health impacts later on in life. Her studies have focused on the placental transport of amino acids, folate and calcium with a strong interest in one-carbon metabolism and the folate-methionine-homocysteine axis of placental function.
Her research group has also been investigating the impact of maternal intermittent fasting (as a model of fasting during Ramadan) on pregnancy outcomes, and growth and development of the baby. Additionally, more recently, her group has been investigating the effects of maternal immune activation on placental function and the programming of neurodevelopmental diseases such as schizophrenia.
Her broad knowledge and application of various models has provided insights into the integrative physiological framework governing nutrient delivery to the developing embryo, and by defining key mechanistic loci, the aim is to develop novel therapeutic interventions to improve outcome in complicated pregnancies.
Jo has published over 115 peer-reviewed articles, including reviews and book chapters and has served on the International Editorial Board of the journal ‘Placenta’. She is a member of the International Federation of Placental Associations (IFPA), The Physiological Society and the Society for Research into Hydrocephalus and Spina Bifida (SRHSB) and is a member of the Executive Committee of SRHSB.
BSc Biochemistry (Hons), University of Manchester 1980
MSc, University of Manchester 1989
PhD, Univeristy of Manchester 1994
Memberships of committees and professional bodies
International Federation of Placental Associations (IFPA)
European Placenta Group
The Physiological Society
Society for Research into Hydrocephalus and Spina Bifida (SRHSB)