Mitochondria are vitally important organelles within living cells, which are often described as their powerhouses since they generate the primary energy for biological activities. It is no surprise, therefore, mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Alzheimer’s and Parkinson’s diseases). Mitochondria contain about 1500 different proteins, and ~99% of these proteins are synthesized in the cytosol and imported into the organelle for their functions. Consequently, protein folding and protein homeostasis or quality control are essential for mitochondrial function. Our research interests are (1) understanding the function and functional mechanism of mitochondrial proteins; (2) oxidative folding of industrially and pharmaceutically important proteins; and (3) recently extended to the biological applications of graphene oxide.
1997: D.Phil,Oxford Centre for Molecular Sciences, Oxford University
1997 -2000: Postdoctoral Researcher, Biochemistry Department, Imperial College, London
2000 -2001:Postdoctoral Researcher, Department of Medicine, University College of London
2001 -2003:Postdoctoral Researcher, Biochemistry Department, Manchester University
2003 - 2011: The Royal Society University Research Fellow, Faculty of Life Sciences, Manchester University
2011 – Lecturer of Biochemistry, Faculty of Life Sciences, Manchester University