Dr Hui Lu BSc, MSc, DPhil

Lecturer

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Overview

Mitochondria are vitally important organelles within living cells, which are often described as their powerhouses since they generate the primary energy for biological activities. It is no surprise, therefore, mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Alzheimer’s and Parkinson’s diseases). Mitochondria contain about 1500 different proteins, and ~99% of these proteins are synthesized in the cytosol and imported into the organelle for their functions. Consequently, protein folding and protein homeostasis or quality control are essential for mitochondrial function. Our research interests are (1) understanding the function and functional mechanism of mitochondrial proteins; (2) oxidative folding of industrially and pharmaceutically important proteins; and (3) recently extended to the biological applications of graphene oxide.

Biography

1997: D.Phil,Oxford Centre for Molecular Sciences, Oxford University

1997 -2000: Postdoctoral Researcher, Biochemistry Department, Imperial College, London

2000 -2001:Postdoctoral Researcher, Department of Medicine, University College of London

2001 -2003:Postdoctoral Researcher, Biochemistry Department, Manchester University

2003 - 2011: The Royal Society University Research Fellow, Faculty of Life Sciences, Manchester University

2011 – Lecturer of Biochemistry, Faculty of Life Sciences, Manchester University

Qualifications

BSc, MSc, PhD

Keywords

  • Mitochondrial protein biogenesis, Protein folding and function, Thiol-disulphide redox regulation, Mitochondrial protein quality control, graphene

Education / academic qualifications

  • Doctor of Science

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