Dr Hui Lu BSc, MSc, DPhil

Lecturer

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Overview

Mitochondria are vitally important organelles within living cells and are often described as their powerhouses. They generate the primary energy for all biological activities, from ATP generation to cell growth and death (apoptosis). It is no surprise, therefore, mitochondrial dysfunction leads to life threatening diseases, such as cancer, diabetes, stroke, and various neurodegenerative diseases (e.g. Alzheimer’s and Parkinson’s diseases). Structurally, mitochondria have two membranes dividing the organelle into four sub-compartments: outer membrane (OM), intermembrane space (IMS), inner membrane (IM), and matrix. Mitochondria contain about 1500 proteins and ~99% of the proteins are synthesized in the cytosol and post-transnationally imported into the organelle for function. Research in my group focuses on (1) understanding the molecular mechanisms of mitochondrial protein quality control; (2) understanding the mechanisms of key proteins involved in mitochondrial protein import and folding, and their application in enhance oxidative folding of industrial important proteins; as well as (3) exploring graphene assembly and its application in biology.

Biography

1997: D.Phil,Oxford Centre for Molecular Sciences, Oxford University

1997 -2000: Postdoctoral Researcher, Biochemistry Department, Imperial College, London

2000 -2001:Postdoctoral Researcher, Department of Medicine, University College of London

2001 -2003:Postdoctoral Researcher, Biochemistry Department, Manchester University

2003 - 2011: The Royal Society University Research Fellow, Faculty of Life Sciences, Manchester University

2011 – Lecturer of Biochemistry, Faculty of Life Sciences, Manchester University

Qualifications

BSc, MSc, PhD

Keywords

  • Mitochondrial protein biogenesis, Protein folding and function, Thiol-disulphide redox regulation, Mitochondrial protein quality control, graphene

Education / academic qualifications

  • Doctor of Science

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