This portfolio of compositions researches the use of DNA sequences as a system for music composition. The main objective is to identify and create musical expression using sequences of DNA, which carry embedded structure and organisation. An effective model of DNA sonification was implemented through the use of a Parameter Mapping Sonification Interface that can obtain a musical rendering of the genetic material through the replication of different stages of DNA coding. In this way the composer could make compositional decisions a priori in mapping musical parameters (musification), and make use of sonification as a tool in order to successfully generate, organise and develop musical material in a compositional system based on DNA and RNA sequences. This is in contrast to a hard scientific sonification perspective, where unedited outputs are presented as a musical composition. As a result, the portfolio provides an intelligible corpus of music that integrates science, literature, cultural heritage and the social sphere in order to deliver my musical discourse. Nine compositions are presented in the portfolio, each of these explores the use of sonification and musification as a compositional tool to generate and organise musical materials.