This thesis focuses on the research of RTDI policies (research, technology, development and innovation), and the main theme of this thesis is to link the three variables together: RTDI policy-making process---the contents of RTDI policies---the appropriateness of RTDI policies on configuration of the national, the sectoral and the technological innovation systems. We assume the policy-making process of RTDI policies would shape the contents of the RTDI policies. Once the contents of RTDI policies are implemented, the RTDI policies would influence, whether appropriate or inappropriate, on configuration of the three innovation systems. We define the configuration of the three innovation systems as national, sectoral and technological innovation system (NSTIS). We use the Taiwanese biotechnology and related sectoral policies as the empirical examples. Biotechnology in Taiwan configures with three sectors, i.e. pharmaceuticals, agriculture and medical device. Between 2000 and 2008, the Taiwanese government intensively promoted many policies in order to support the development of biotechnology and related sectors. Among the various policies, we choose the National Science and Technology Programs and the regulation policies (in terms of Law of Pharmaceutical Affairs and the Agro-pesticides Management Act) as our two empirical cases and set up the in-depth discussion for the policy-making process of the two policies.On the basis of the empirical cases of Taiwan, we explore the influence of the RTDI policy-making process on the contents of RTDI policies which further shapes the development of the NSTIS.