Epstein-Barr Virus Infection in Adult Renal Transplant Recipients

UoM administered thesis: Unknown

  • Authors:
  • David Morton

Abstract

Aims: To explore the clinical significance of EBV infection in adult renal transplant recipients when detected in the late post-transplant period.Methods: (1) A prospective observational study recruiting 499 stable adult kidney transplant recipients with serial blood sampling for EBV DNAemia and assessment of clinical outcomes and associated factors. (2) A retrospective analysis of PTLD incidence, timing and outcomes in relation to EBV infection. Results: EBV DNAemia in stable kidney transplant recipients is common, found in 46% of recruited individuals screened over 1 year, with persistent DNAemia seen in 10%. DNAemia prevalence increased significantly with time from transplant (p

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Original languageEnglish
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Award date31 Dec 2013