This thesis presents the results of an experimental, numerical and analytical study to develop a design method to calculate punching shear resistance for a new shearhead system between tubular steel column and reinforced concrete flat slab. This shearhead system enables two of the most popular structural systems, i.e. reinforced concrete flat slab floor and steel tubular column, to be used to produce efficient structures of low cost and short construction time. This research investigates slabs without and with a service hole adjacent to the column. The new shearhead system should not only possess sufficient punching shear resistance, but should also be efficient for construction. The main methodology for this project was based on numerical finite element simulations verified by two full scale tests. These two tests were carried out in the University of Manchester's Structural Testing Laboratory. The two specimens had the same slab size, thickness and reinforcement ratio, but differed in the column shape (rectangular or circular), central reinforcement arrangement (continuous or discontinuous), shearhead position in the slab thickness and shearhead fabrication arrangement. Recorded load-deflection and load-strain relationships, crack development and critical perimeter were used for detailed validation of using the commercial finite element software ABAQUS. The validated ABAQUS model was used to conduct a comprehensive parametric study to investigate the effects of a number of design parameters, including the effect of varied column size, shearhead arm length, shearhead arm cross section, shearhead arm angle, amount of flexural reinforcement, slab thickness, shearhead positions and hole positions. The main conclusion from the parametric study was that the shearhead system could be treated as an enlarged column in normal flat slab structure. The parametric study enabled pressure distribution below the shearhead arms to be approximated for checking whether the shearhead arms would be sufficient for the enlarged column assumption to be valid. The parametric study results were also used to determine the effective depth of the flat slab and critical punching shear perimeter of the slab with and without a service hole.Using the enlarged column assumption, the punching shear resistance of all structures used in the parametric study were re-calculated using Eurocode 2 (EC2), British stand 8110 (BS8110) and American Concrete Institute code 318 (ACI 318). Comparison of calculation results using these three design methods indicates that both EC2 and BS8110 predicted very close value which reached very good agreement with the ABAQUS simulation (normally within 10%). Among these three design methods, ACI 318 was the only code that explicitly considered shearhead system. ACI 318 was not able to predict the slab critical perimeter length with good accuracy, however, its prediction of slab punching shear resistance achieved reasonably good agreement with numerical analysis results and were on the safe side. Based on these studies, a design method for calculating punching resistance of the proposed shearhead system between reinforced concrete flat slab and steel tubular column has been developed in this thesis.