A COMPARISON OF ATROPHIC AND HYPERTROPHIC FACIAL PHOTOAGEING

UoM administered thesis: Doctor of Medicine

  • Authors:
  • Jean Ayer

Abstract

Abstract Background: Photoageing is due to the cumulative effects of sun exposure superimposed on chronological cutaneous ageing. Clinically, amongst Fitzpatrick skin types I-IV, it is thought that two main phenotypes of facial photoageing may exist: atrophic smooth telangiectactic skin (AP) and hypertrophic coarse wrinkled skin (HP). AP is more prone to the development of non-melanoma skin cancers (NMSC). Aim: To investigate the morphological and histological differences in photoexposed facial skin and photoprotected buttock skin from prototypic subjects with atrophic skin and hypertrophic phenotypes. Patients and Methods: Subjects with atrophic and hypertrophic skin were pre-selected based on their phenotype from the general population (n=40; n=20, hypertrophic phenotype, 10 males, 10 females; n=20, atrophic phenotype, 10 males, 10 females). All subjects had a 4mm punch biopsy taken from their UV exposed facial skin (cheek) and a 6mm punch biopsy taken from their UV-protected buttock skin. All selected participants were: ex- or non-smokers, had no history of inflammatory skin disease, and aged > 50 years (mean ± SE); [AP (78.7y ±2.02) and HP (74.6y ±2.08)]. Staining for elastic fibres, fibrillin-rich microfibrils (FRMs), collagen VII and Von Willebrand Factor (vWF) as well as morphometric measurements including dermal-epidermal convolution and epidermal thickness were performed. Demographic data and VISIA® photoassessments were additionally compiled. Analysis using ImageJ software and SPSS (Statistics 20; IBM) was performed. Results: We found that AP epidermis was thicker than HP (p0.05). The percentage of dermis occupied by mature elastin fibres was significantly greater in HP than AP (p

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Original languageEnglish
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Award date31 Dec 2016