Prof Tracy HussellPhD

Centre Director (MCCIR)

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Publications

  1. 2019
  2. Accepted/In press

    CD200R1 regulates eosinophilia during pulmonary fungal infection in mice

    Salek-Ardakani, S., Bell, T., Jagger, C., Snelgrove, R. J. & Hussell, T., 14 May 2019, (Accepted/In press) In : European journal of immunology.

    Research output: Contribution to journalArticle

  3. Published

    Endothelin-1 mediates Aspergillus fumigatus induced airway inflammation and remodelling.

    Labram, B., Namvar, S., Hussell, T. & Herrick, S., 2019, In : Clinical and Experimental Allergy.

    Research output: Contribution to journalArticle

  4. Published

    Genome-wide effect of pulmonary airway epithelial cell–specific Bmal1 deletion

    Zhang, Z., Hunter, L., Wu, G., Maidstone, R., Mizoro, Y., Vonslow, R., Fife, M., Hopwood, T., Begley, N., Saer, B., Wang, P., Cunningham, P., Baxter, M., Durrington, H., Blaikley, J. F., Hussell, T., Rattray, M., Hogenesch, J. B., Gibbs, J., Ray, D. W. & 1 othersLoudon, A. S. I., 2019, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. p. fj.201801682R

    Research output: Contribution to journalArticle

  5. Published

    Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases

    Fujino, N., Brand, O., Morgan, D., Fujimori, T., Grabiec, A., Jagger, C., Maciewicz, R., Yamada, M., Itakura, K., Sugiura, H., Ichinose, M. & Hussell, T., 2019, In : Journal of Experimental Medicine.

    Research output: Contribution to journalArticle

  6. Published

    The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

    Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H., Madsen, J., Evans, C. M., Sutherland, T. E., Ivens, A. C., Thornton, D. J., Grencis, R. K., Hussell, T., Cunoosamy, D. M., Cook, P. C. & MacDonald, A. S., 2019, In : Nature Immunology.

    Research output: Contribution to journalArticle

  7. 2018
  8. Accepted/In press

    Innate immune cell suppression and the link with secondary lung bacterial pneumonia

    Morgan, D., Casulli, J., Chew, C., Connolly, E., Lui, S., Brand, O., Rahman, R., Jagger, C. & Hussell, T., 30 Nov 2018, (Accepted/In press) In : Frontiers in Immunology.

    Research output: Contribution to journalArticle

  9. Published

    Mycobacterium tuberculosis Joyrides Alveolar Macrophages into the Pulmonary Interstitium

    Goenka, A., Casulli, J. & Hussell, T., 12 Sep 2018, In : Cell Host and Microbe. 24, 3, p. 331-333 3 p.

    Research output: Contribution to journalArticle

  10. Published

    Representing the process of inflammation as key events in adverse outcome pathways

    Villeneuve, D. L., Landesmann, B., Allavena, P., Ashley, N., Bal-Price, A., Corsini, E., Halappanavar, S., Hussell, T., Laskin, D., Lawrence, T., Nikolic-Paterson, D., Pallardy, M., Paini, A., Pieters, R., Roth, R. & Tschudi-Monnet, F., 1 Jun 2018, In : Toxicological Sciences. 163, 2, p. 346-352 7 p.

    Research output: Contribution to journalEditorial

  11. Published

    Axl and MerTK receptor tyrosine kinases maintain macrophage efferocytic capacity in the presence of viral triggers

    Grabiec, A. M., Goenka, A., Fife, M. E., Fujimori, T. & Hussell, T., May 2018, In : European journal of immunology. 48, 5

    Research output: Contribution to journalArticle

  12. Published

    VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy [version 1; referees: 2 approved]

    Fletcher, H. A., Chatterjee, M., Cooper, A., Hussell, T., Kaye, P. M., Prior, J., Reljic, R., Vermaak, S., Vordermeier, M., Williams, A. & McShane, H., 23 Apr 2018, In : F1000Research. 7, 485.

    Research output: Contribution to journalArticle

  13. Published

    An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

    Patel, D. F., Peiró, T., Shoemark, A., Akthar, S., Walker, S. A., Grabiec, A. M., Jackson, P. L., Hussell, T., Gaggar, A., Xu, X., Trevor, J. L., Li, J., Steele, C., Tavernier, G., Edwin Blalock, J., Niven, R. M., Gregory, L. G., Simpson, A., Lloyd, C. M. & Snelgrove, R. J., 2018, In : Science Translational Medicine. 10, 455, eaaq0693.

    Research output: Contribution to journalArticle

  14. Published

    Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis

    Bell, T. J., Brand, O., Morgan, D., Salek-Ardakani, S., Jagger, C., Fujimori, T., Cholewa, L., Tilakaratna, V., Östling, J., Thomas, M., Day, A., Snelgrove, R. J. & Hussell, T., 2018, In : Matrix Biology.

    Research output: Contribution to journalArticle

  15. Published

    The consequence of matrix dysfunction on lung immunity and the microbiome in COPD

    Hussell, T., Lui, S., Jagger, C., Morgan, D. & Brand, O., 2018, In : European Respiratory Review . 27, 148, p. 180032

    Research output: Contribution to journalArticle

  16. 2017
  17. Published

    Development of a 37-Channel Mass Cytometry (CyTOF) Panel to Predict Treatment Response in Rheumatoid Arthritis

    Mulhearn, B., Viatte, S., Hussell, T. & Barton, A., 6 Jul 2017, In : European Medical Journal Rheumatology.

    Research output: Contribution to journalBook/Film/Article review

  18. E-pub ahead of print

    Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

    Grabiec, A. M., Denny, N., Doherty, J., Happonen, K. E., Hankinson, J., Connolly, E., Fife, M. E., Fujimori, T., Fujino, N., Goenka, A., Holden, S., Gioan-Tavernier, G., Shah, R., Cook, P., MacDonald, A., Niven, R., Dahlbäck, B., Fowler, S., Simpson, A. & Hussell, T., 12 Apr 2017, In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalLetter

  19. Published

    Progress and prospects of early detection in lung cancer

    Knight, S. B., Crosbie, P. A., Balata, H., Chudziak, J., Hussell, T. & Dive, C., 2017, In : Open Biology. 7, 9, 170070.

    Research output: Contribution to journalArticle

  20. 2016
  21. Published

    Immunopathology of lung diseases: introduction for the special issue

    Hussell, T. & Grabiec, A., 1 Jul 2016, In : Seminars in Immunopathology. 38, 4, p. 407-408 2 p.

    Research output: Contribution to journalArticle

  22. Published

    The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

    Grabiec, A. & Hussell, T., Jul 2016, In : Seminars in Immunopathology. 38, 4, p. 409-423 15 p.

    Research output: Contribution to journalArticle

  23. Published

    Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors

    Weiss, G., Lai, C., E Fife, M., M Grabiec, A., Tildy, B., Snelgrove, R. J., Xin, G., M Lloyd, C. & Hussell, T., 2016, In : Mucosal Immunology.

    Research output: Contribution to journalArticle

  24. 2015
  25. Published

    The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

    Fujimori, T., Grabiec, A. M., Kaur, M., Bell, T. J., Fujino, N., Cook, P., Svedberg, F. R., Macdonald, A., Maciewicz, R. A., Singh, D. & Hussell, T., 21 Jan 2015, In : Mucosal Immunology. 8, 5

    Research output: Contribution to journalArticle

  26. Published

    TLR vaccine adjuvants: closing the stable door before novel influenza strains bolt?

    Hussell, T. & Goenka, A., 2015, In : Immunology and cell biology. p. 1-2 2 p.

    Research output: Contribution to journalArticle

  27. 2014
  28. Published

    Influenza Promotes Collagen Deposition via αvβ6 Integrin-mediated Transforming Growth Factor β Activation.

    Jolly, L., Stavrou, A., Vanderstoken, G., Meliopoulos, V. A., Habgood, A., Tatler, A. L., Porte, J., Knox, A., Weinreb, P., Violette, S., Hussell, T., Kolb, M., Stampfli, M. R., Schultz-Cherry, S. & Jenkins, G., 19 Dec 2014, In : The Journal of biological chemistry. 289, 51

    Research output: Contribution to journalArticle

  29. Published

    Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

    Elderfield, R. A., Watson, S. J., Godlee, A., Adamson, W. E., Fernandez-Alonso, M., Blumenkrantz, D., Zambon, M., Openshaw, P., Barclay, W. S., Chaussable, D., Adamson, W. E., Carman, W. F., Thompson, C., Zambon, M. C., Aylin, P., Ashby, D., Barclay, W. S., Brett, S. J., Cookson, W. O., Drumright, L. N. & 34 othersDunning, J., Elderfield, R. A., Garcia-Alvarez, L., Gazzard, B. G., Griffiths, M. J., Habibi, M. S., Hansel, T. T., Herberg, J. A., Holmes, A. H., Hussell, T., Johnston, S. L., Kon, O. M., Levin, M., Moffatt, M. F., Nadel, S., Openshaw, P. J., Warner, J. O., Aston, S. J., Gordon, S. B., Hay, A., McCauley, J., O'Gara, A., Bancherau, J., Hayward, A., Baillie, J. K., Hume, D. A., Simmonds, P., McNamara, P. S., Semple, M. G., Smyth, R. L., Nguyen-Van-Tam, J. S., Ho, L-P., McMichael, A. J. & Kellam, P., Nov 2014, In : Journal of virology. 88, 22

    Research output: Contribution to journalArticle

  30. Published

    An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.

    Gibbs, J., Ince, L., Matthews, L., Mei, J., Bell, T., Yang, N., Saer, B., Begley, N., Poolman, T., Pariollaud, M., Farrow, S., DeMayo, F., Hussell, T., Worthen, G. S., Ray, D. & Loudon, A., Jul 2014, In : Nature Medicine. 20, 8, p. 919-926 7 p.

    Research output: Contribution to journalArticle

  31. Published

    Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

    Van Maele, L., Fougeron, D., Janot, L., Didierlaurent, A., Cayet, D., Tabareau, J., Rumbo, M., Corvo-Chamaillard, S., Boulenouar, S., Jeffs, S., Vande Walle, L., Lamkanfi, M., Lemoine, Y., Erard, F., Hot, D., Hussell, T., Ryffel, B., Benecke, A. G. & Sirard, J-C., May 2014, In : Mucosal Immunology. 7, 3

    Research output: Contribution to journalArticle

  32. Published

    OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

    Gwyer Findlay, E., Danks, L., Madden, J., Cavanagh, M. M., McNamee, K., McCann, F., Snelgrove, R. J., Shaw, S., Feldmann, M., Taylor, P. C., Horwood, N. J. & Hussell, T., 11 Feb 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 6

    Research output: Contribution to journalArticle

  33. Published

    Alveolar macrophages: plasticity in a tissue-specific context.

    Hussell, T. & Bell, T. J., Feb 2014, In : Nature reviews. Immunology. 14, 2

    Research output: Contribution to journalArticle

  34. 2013
  35. Published

    Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice.

    Sanders, R. D., Godlee, A., Fujimori, T., Goulding, J., Xin, G., Salek-Ardakani, S., Snelgrove, R. J., Ma, D., Maze, M. & Hussell, T., Jul 2013, In : Critical Care Medicine. 41, 7

    Research output: Contribution to journalArticle

  36. Published

    Bacterial superinfection following lung inflammatory disorders.

    Habibzay, M., Weiss, G. & Hussell, T., Feb 2013, In : Future microbiology. 8, 2

    Research output: Contribution to journalArticle

  37. 2012
  38. Published

    Epidemiological isolation causing variable mortality in Island populations during the 1918-1920 influenza pandemic

    Shanks, G. D., Hussell, T. & Brundage, J. F., Nov 2012, In : Influenza and Other Respiratory Viruses. 6, 6, p. 417-423 6 p.

    Research output: Contribution to journalArticle

  39. Published

    Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung

    Habibzay, M., Saldana, J. I., Goulding, J., Lloyd, C. M. & Hussell, T., Sep 2012, In : Mucosal Immunology. 5, 5, p. 524-534 10 p.

    Research output: Contribution to journalArticle

  40. Published

    Respiratory viral infections: Knowledge based therapeutics

    Hussell, T., Godlee, A., Salek-Ardakani, S. & Snelgrove, R. J., Aug 2012, In : Current opinion in immunology. 24, 4, p. 438-443 5 p.

    Research output: Contribution to journalArticle

  41. Published

    The microbiology of asthma

    Edwards, M. R., Bartlett, N. W., Hussell, T., Openshaw, P. & Johnston, S. L., Jul 2012, In : Nature Reviews Microbiology. 10, 7, p. 459-471 12 p.

    Research output: Contribution to journalArticle

  42. Published

    IFITM3 restricts the morbidity and mortality associated with influenza

    Hussell, T., Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., Chin, C. R., Feeley, E. M., Sims, J. S., Adams, D. J., Wise, H. M., Kane, L., Goulding, D., Digard, P., Anttila, V., Baillie, J. K., Walsh, T. S., Hume, D. A., Palotie, A. & 10 othersXue, Y., Colonna, V., Tyler-Smith, C., Dunning, J., Gordon, S. B., Smyth, R. L., Openshaw, P. J., Dougan, G., Brass, A. L. & Kellam, P., 26 Apr 2012, In : Nature. 484, 7395, p. 519-523 4 p.

    Research output: Contribution to journalArticle

  43. Published

    OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection

    Snelgrove, R. J., Cornere, M. M., Edwards, L., Dagg, B., Keeble, J., Rodgers, A., Lyonga, D. E., Stewart, G. R., Young, D. B., Walker, B. & Hussell, T., 15 Mar 2012, In : Journal of INfectious Diseases. 205, 6, p. 975-983 8 p.

    Research output: Contribution to journalArticle

  44. Published

    Macrophage-mediated inflammation and disease: a focus on the lung.

    Gwyer Findlay, E. & Hussell, T., 2012, In : Mediators of Inflammation. 2012

    Research output: Contribution to journalArticle

  45. 2011
  46. Published

    Sedation & immunomodulation

    Sanders, R. D., Hussell, T. & Maze, M., Dec 2011, In : Anesthesiology Clinics. 29, 4, p. 687-706 19 p.

    Research output: Contribution to journalArticle

  47. Published

    IL-17 boosts proinflammatory outcome of antiviral response in human cells

    Ryzhakov, G., Lai, C. C. K., Blazek, K., To, K. W., Hussell, T. & Udalova, I., 15 Nov 2011, In : Journal of Immunology. 187, 10, p. 5357-5362 5 p.

    Research output: Contribution to journalArticle

  48. Published

    Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection

    Goulding, J., Godlee, A., Vekaria, S., Hilty, M., Snelgrove, R. & Hussell, T., 1 Oct 2011, In : Journal of INfectious Diseases. 204, 7, p. 1086-1094 8 p.

    Research output: Contribution to journalArticle

  49. Published

    Airway immune homeostasis and implications for influenza-induced inflammation

    Snelgrove, R. J., Godlee, A. & Hussell, T., Jul 2011, In : Trends in Immunology. 32, 7, p. 328-334 6 p.

    Research output: Contribution to journalArticle

  50. Published

    IRF5 promotes inflammatory macrophage polarization and T H1-TH17 responses

    Krausgruber, T., Blazek, K., Smallie, T., Alzabin, S., Lockstone, H., Sahgal, N., Hussell, T., Feldmann, M. & Udalova, I. A., Mar 2011, In : Nature Immunology. 12, 3, p. 231-238 7 p.

    Research output: Contribution to journalArticle

  51. 2010
  52. Published

    A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation

    Snelgrove, R. J., Jackson, P. L., Hardison, M. T., Noerager, B. D., Kinloch, A., Gaggar, A., Shastry, S., Rowe, S. M., Shim, Y. M., Hussell, T. & Blalock, J. E., 1 Oct 2010, In : Science. 330, 6000, p. 90-94 4 p.

    Research output: Contribution to journalArticle

  53. Published

    Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR

    Drexler, S. K., Wales, J., Andreakos, E., Kong, P., Davis, A., Garlanda, C., Mantovani, A., Hussell, T., Feldmann, M. & Foxwell, B. M. J., Jun 2010, In : Scandinavian Journal of Immunology. 71, 6, p. 393-402 9 p.

    Research output: Contribution to journalArticle

  54. Published

    Structured regulation of inflammation during respiratory viral infection

    Hussell, T. & Goulding, J., May 2010, In : The Lancet Infectious Diseases. 10, 5, p. 360-366 6 p.

    Research output: Contribution to journalArticle

  55. Published

    The chemokine MIP1α/CCL3 determines pathology in primary RSV infection by regulating the balance of t cell populations in the murine lung

    Tregoning, J. S., Pribul, P. K., Pennycook, A. M. J., Hussell, T., Wang, B., Lukacs, N., Schwarze, J., Culley, F. J. & Openshaw, P. J. M., 24 Feb 2010, In : PLoS ONE. 5, 2, e9381.

    Research output: Contribution to journalArticle

  56. Published

    Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage toll-like receptor signaling and cytokine production

    Peirce, M. J., Brook, M., Morrice, N., Snelgrove, R., Begum, S., Lanfrancotti, A., Notley, C., Hussell, T., Cope, A. P. & Wait, R., 2010, In : PLoS ONE. 5, 7, e11465.

    Research output: Contribution to journalArticle

  57. 2009
  58. Published

    Sedation & Immunomodulation

    Sanders, R. D., Hussell, T. & Maze, M., Jul 2009, In : Critical Care Clinics. 25, 3, p. 551-570 19 p.

    Research output: Contribution to journalArticle

  59. Published

    Immune homeostasis in the respiratory tract and its impact on heterologous infection

    Wissinger, E., Goulding, J. & Hussell, T., Jun 2009, In : Seminars in Immunology. 21, 3, p. 147-155 8 p.

    Research output: Contribution to journalArticle

  60. Published

    Bacterial complications during pandemic influenza infection

    Hussell, T., Wissinger, E. & Goulding, J., 2009, In : Future microbiology. 4, 3, p. 269-272 3 p.

    Research output: Contribution to journalArticle

  61. Published

    Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

    Janot, L., Sirard, J. C., Secher, T., Noulin, N., Fick, L., Akira, S., Uematsu, S., Didierlaurent, A., Hussell, T., Ryffel, B. & Erard, F., 2009, In : European journal of immunology. 39, 6, p. 1587-1596 9 p.

    Research output: Contribution to journalArticle

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