Prof Tracy HussellPhD

Centre Director (MCCIR)

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Publications

  1. 2019
  2. Accepted/In press

    CD200R1 regulates eosinophilia during pulmonary fungal infection in mice

    Salek-Ardakani, S., Bell, T., Jagger, C., Snelgrove, R. J. & Hussell, T., 14 May 2019, (Accepted/In press) In : European journal of immunology.

    Research output: Contribution to journalArticle

  3. Published

    Endothelin-1 mediates Aspergillus fumigatus induced airway inflammation and remodelling.

    Labram, B., Namvar, S., Hussell, T. & Herrick, S., 2019, In : Clinical and Experimental Allergy.

    Research output: Contribution to journalArticle

  4. Published

    Genome-wide effect of pulmonary airway epithelial cell–specific Bmal1 deletion

    Zhang, Z., Hunter, L., Wu, G., Maidstone, R., Mizoro, Y., Vonslow, R., Fife, M., Hopwood, T., Begley, N., Saer, B., Wang, P., Cunningham, P., Baxter, M., Durrington, H., Blaikley, J. F., Hussell, T., Rattray, M., Hogenesch, J. B., Gibbs, J., Ray, D. W. & 1 othersLoudon, A. S. I., 2019, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. p. fj.201801682R

    Research output: Contribution to journalArticle

  5. Published

    Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases

    Fujino, N., Brand, O., Morgan, D., Fujimori, T., Grabiec, A., Jagger, C., Maciewicz, R., Yamada, M., Itakura, K., Sugiura, H., Ichinose, M. & Hussell, T., 2019, In : Journal of Experimental Medicine.

    Research output: Contribution to journalArticle

  6. Published

    The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

    Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H., Madsen, J., Evans, C. M., Sutherland, T. E., Ivens, A. C., Thornton, D. J., Grencis, R. K., Hussell, T., Cunoosamy, D. M., Cook, P. C. & MacDonald, A. S., 2019, In : Nature Immunology.

    Research output: Contribution to journalArticle

  7. 2018
  8. Accepted/In press

    Innate immune cell suppression and the link with secondary lung bacterial pneumonia

    Morgan, D., Casulli, J., Chew, C., Connolly, E., Lui, S., Brand, O., Rahman, R., Jagger, C. & Hussell, T., 30 Nov 2018, (Accepted/In press) In : Frontiers in Immunology.

    Research output: Contribution to journalArticle

  9. Published

    Mycobacterium tuberculosis Joyrides Alveolar Macrophages into the Pulmonary Interstitium

    Goenka, A., Casulli, J. & Hussell, T., 12 Sep 2018, In : Cell Host and Microbe. 24, 3, p. 331-333 3 p.

    Research output: Contribution to journalArticle

  10. Published

    Representing the process of inflammation as key events in adverse outcome pathways

    Villeneuve, D. L., Landesmann, B., Allavena, P., Ashley, N., Bal-Price, A., Corsini, E., Halappanavar, S., Hussell, T., Laskin, D., Lawrence, T., Nikolic-Paterson, D., Pallardy, M., Paini, A., Pieters, R., Roth, R. & Tschudi-Monnet, F., 1 Jun 2018, In : Toxicological Sciences. 163, 2, p. 346-352 7 p.

    Research output: Contribution to journalEditorial

  11. Published

    Axl and MerTK receptor tyrosine kinases maintain macrophage efferocytic capacity in the presence of viral triggers

    Grabiec, A. M., Goenka, A., Fife, M. E., Fujimori, T. & Hussell, T., May 2018, In : European journal of immunology. 48, 5

    Research output: Contribution to journalArticle

  12. Published

    VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy [version 1; referees: 2 approved]

    Fletcher, H. A., Chatterjee, M., Cooper, A., Hussell, T., Kaye, P. M., Prior, J., Reljic, R., Vermaak, S., Vordermeier, M., Williams, A. & McShane, H., 23 Apr 2018, In : F1000Research. 7, 485.

    Research output: Contribution to journalArticle

  13. Published

    An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

    Patel, D. F., Peiró, T., Shoemark, A., Akthar, S., Walker, S. A., Grabiec, A. M., Jackson, P. L., Hussell, T., Gaggar, A., Xu, X., Trevor, J. L., Li, J., Steele, C., Tavernier, G., Edwin Blalock, J., Niven, R. M., Gregory, L. G., Simpson, A., Lloyd, C. M. & Snelgrove, R. J., 2018, In : Science Translational Medicine. 10, 455, eaaq0693.

    Research output: Contribution to journalArticle

  14. Published

    Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis

    Bell, T. J., Brand, O., Morgan, D., Salek-Ardakani, S., Jagger, C., Fujimori, T., Cholewa, L., Tilakaratna, V., Östling, J., Thomas, M., Day, A., Snelgrove, R. J. & Hussell, T., 2018, In : Matrix Biology.

    Research output: Contribution to journalArticle

  15. Published

    The consequence of matrix dysfunction on lung immunity and the microbiome in COPD

    Hussell, T., Lui, S., Jagger, C., Morgan, D. & Brand, O., 2018, In : European Respiratory Review . 27, 148, p. 180032

    Research output: Contribution to journalArticle

  16. 2017
  17. Published

    Development of a 37-Channel Mass Cytometry (CyTOF) Panel to Predict Treatment Response in Rheumatoid Arthritis

    Mulhearn, B., Viatte, S., Hussell, T. & Barton, A., 6 Jul 2017, In : European Medical Journal Rheumatology.

    Research output: Contribution to journalBook/Film/Article review

  18. E-pub ahead of print

    Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

    Grabiec, A. M., Denny, N., Doherty, J., Happonen, K. E., Hankinson, J., Connolly, E., Fife, M. E., Fujimori, T., Fujino, N., Goenka, A., Holden, S., Gioan-Tavernier, G., Shah, R., Cook, P., MacDonald, A., Niven, R., Dahlbäck, B., Fowler, S., Simpson, A. & Hussell, T., 12 Apr 2017, In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalLetter

  19. Published

    Progress and prospects of early detection in lung cancer

    Knight, S. B., Crosbie, P. A., Balata, H., Chudziak, J., Hussell, T. & Dive, C., 2017, In : Open Biology. 7, 9, 170070.

    Research output: Contribution to journalArticle

  20. 2016
  21. Published

    Immunopathology of lung diseases: introduction for the special issue

    Hussell, T. & Grabiec, A., 1 Jul 2016, In : Seminars in Immunopathology. 38, 4, p. 407-408 2 p.

    Research output: Contribution to journalArticle

  22. Published

    The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

    Grabiec, A. & Hussell, T., Jul 2016, In : Seminars in Immunopathology. 38, 4, p. 409-423 15 p.

    Research output: Contribution to journalArticle

  23. Published

    Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors

    Weiss, G., Lai, C., E Fife, M., M Grabiec, A., Tildy, B., Snelgrove, R. J., Xin, G., M Lloyd, C. & Hussell, T., 2016, In : Mucosal Immunology.

    Research output: Contribution to journalArticle

  24. 2015
  25. Published

    The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

    Fujimori, T., Grabiec, A. M., Kaur, M., Bell, T. J., Fujino, N., Cook, P., Svedberg, F. R., Macdonald, A., Maciewicz, R. A., Singh, D. & Hussell, T., 21 Jan 2015, In : Mucosal Immunology. 8, 5

    Research output: Contribution to journalArticle

  26. Published

    TLR vaccine adjuvants: closing the stable door before novel influenza strains bolt?

    Hussell, T. & Goenka, A., 2015, In : Immunology and cell biology. p. 1-2 2 p.

    Research output: Contribution to journalArticle

  27. 2014
  28. Published

    Influenza Promotes Collagen Deposition via αvβ6 Integrin-mediated Transforming Growth Factor β Activation.

    Jolly, L., Stavrou, A., Vanderstoken, G., Meliopoulos, V. A., Habgood, A., Tatler, A. L., Porte, J., Knox, A., Weinreb, P., Violette, S., Hussell, T., Kolb, M., Stampfli, M. R., Schultz-Cherry, S. & Jenkins, G., 19 Dec 2014, In : The Journal of biological chemistry. 289, 51

    Research output: Contribution to journalArticle

  29. Published

    Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

    Elderfield, R. A., Watson, S. J., Godlee, A., Adamson, W. E., Fernandez-Alonso, M., Blumenkrantz, D., Zambon, M., Openshaw, P., Barclay, W. S., Chaussable, D., Adamson, W. E., Carman, W. F., Thompson, C., Zambon, M. C., Aylin, P., Ashby, D., Barclay, W. S., Brett, S. J., Cookson, W. O., Drumright, L. N. & 34 othersDunning, J., Elderfield, R. A., Garcia-Alvarez, L., Gazzard, B. G., Griffiths, M. J., Habibi, M. S., Hansel, T. T., Herberg, J. A., Holmes, A. H., Hussell, T., Johnston, S. L., Kon, O. M., Levin, M., Moffatt, M. F., Nadel, S., Openshaw, P. J., Warner, J. O., Aston, S. J., Gordon, S. B., Hay, A., McCauley, J., O'Gara, A., Bancherau, J., Hayward, A., Baillie, J. K., Hume, D. A., Simmonds, P., McNamara, P. S., Semple, M. G., Smyth, R. L., Nguyen-Van-Tam, J. S., Ho, L-P., McMichael, A. J. & Kellam, P., Nov 2014, In : Journal of virology. 88, 22

    Research output: Contribution to journalArticle

  30. Published

    An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.

    Gibbs, J., Ince, L., Matthews, L., Mei, J., Bell, T., Yang, N., Saer, B., Begley, N., Poolman, T., Pariollaud, M., Farrow, S., DeMayo, F., Hussell, T., Worthen, G. S., Ray, D. & Loudon, A., Jul 2014, In : Nature Medicine. 20, 8, p. 919-926 7 p.

    Research output: Contribution to journalArticle

  31. Published

    Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

    Van Maele, L., Fougeron, D., Janot, L., Didierlaurent, A., Cayet, D., Tabareau, J., Rumbo, M., Corvo-Chamaillard, S., Boulenouar, S., Jeffs, S., Vande Walle, L., Lamkanfi, M., Lemoine, Y., Erard, F., Hot, D., Hussell, T., Ryffel, B., Benecke, A. G. & Sirard, J-C., May 2014, In : Mucosal Immunology. 7, 3

    Research output: Contribution to journalArticle

  32. Published

    OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

    Gwyer Findlay, E., Danks, L., Madden, J., Cavanagh, M. M., McNamee, K., McCann, F., Snelgrove, R. J., Shaw, S., Feldmann, M., Taylor, P. C., Horwood, N. J. & Hussell, T., 11 Feb 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 6

    Research output: Contribution to journalArticle

  33. Published

    Alveolar macrophages: plasticity in a tissue-specific context.

    Hussell, T. & Bell, T. J., Feb 2014, In : Nature reviews. Immunology. 14, 2

    Research output: Contribution to journalArticle

  34. 2013
  35. Published

    Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice.

    Sanders, R. D., Godlee, A., Fujimori, T., Goulding, J., Xin, G., Salek-Ardakani, S., Snelgrove, R. J., Ma, D., Maze, M. & Hussell, T., Jul 2013, In : Critical Care Medicine. 41, 7

    Research output: Contribution to journalArticle

  36. Published

    Bacterial superinfection following lung inflammatory disorders.

    Habibzay, M., Weiss, G. & Hussell, T., Feb 2013, In : Future microbiology. 8, 2

    Research output: Contribution to journalArticle

  37. 2012
  38. Published

    Epidemiological isolation causing variable mortality in Island populations during the 1918-1920 influenza pandemic

    Shanks, G. D., Hussell, T. & Brundage, J. F., Nov 2012, In : Influenza and Other Respiratory Viruses. 6, 6, p. 417-423 6 p.

    Research output: Contribution to journalArticle

  39. Published

    Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung

    Habibzay, M., Saldana, J. I., Goulding, J., Lloyd, C. M. & Hussell, T., Sep 2012, In : Mucosal Immunology. 5, 5, p. 524-534 10 p.

    Research output: Contribution to journalArticle

  40. Published

    Respiratory viral infections: Knowledge based therapeutics

    Hussell, T., Godlee, A., Salek-Ardakani, S. & Snelgrove, R. J., Aug 2012, In : Current opinion in immunology. 24, 4, p. 438-443 5 p.

    Research output: Contribution to journalArticle

  41. Published

    The microbiology of asthma

    Edwards, M. R., Bartlett, N. W., Hussell, T., Openshaw, P. & Johnston, S. L., Jul 2012, In : Nature Reviews Microbiology. 10, 7, p. 459-471 12 p.

    Research output: Contribution to journalArticle

  42. Published

    IFITM3 restricts the morbidity and mortality associated with influenza

    Hussell, T., Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., Chin, C. R., Feeley, E. M., Sims, J. S., Adams, D. J., Wise, H. M., Kane, L., Goulding, D., Digard, P., Anttila, V., Baillie, J. K., Walsh, T. S., Hume, D. A., Palotie, A. & 10 othersXue, Y., Colonna, V., Tyler-Smith, C., Dunning, J., Gordon, S. B., Smyth, R. L., Openshaw, P. J., Dougan, G., Brass, A. L. & Kellam, P., 26 Apr 2012, In : Nature. 484, 7395, p. 519-523 4 p.

    Research output: Contribution to journalArticle

  43. Published

    OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection

    Snelgrove, R. J., Cornere, M. M., Edwards, L., Dagg, B., Keeble, J., Rodgers, A., Lyonga, D. E., Stewart, G. R., Young, D. B., Walker, B. & Hussell, T., 15 Mar 2012, In : Journal of INfectious Diseases. 205, 6, p. 975-983 8 p.

    Research output: Contribution to journalArticle

  44. Published

    Macrophage-mediated inflammation and disease: a focus on the lung.

    Gwyer Findlay, E. & Hussell, T., 2012, In : Mediators of Inflammation. 2012

    Research output: Contribution to journalArticle

  45. 2011
  46. Published

    Sedation & immunomodulation

    Sanders, R. D., Hussell, T. & Maze, M., Dec 2011, In : Anesthesiology Clinics. 29, 4, p. 687-706 19 p.

    Research output: Contribution to journalArticle

  47. Published

    IL-17 boosts proinflammatory outcome of antiviral response in human cells

    Ryzhakov, G., Lai, C. C. K., Blazek, K., To, K. W., Hussell, T. & Udalova, I., 15 Nov 2011, In : Journal of Immunology. 187, 10, p. 5357-5362 5 p.

    Research output: Contribution to journalArticle

  48. Published

    Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection

    Goulding, J., Godlee, A., Vekaria, S., Hilty, M., Snelgrove, R. & Hussell, T., 1 Oct 2011, In : Journal of INfectious Diseases. 204, 7, p. 1086-1094 8 p.

    Research output: Contribution to journalArticle

  49. Published

    Airway immune homeostasis and implications for influenza-induced inflammation

    Snelgrove, R. J., Godlee, A. & Hussell, T., Jul 2011, In : Trends in Immunology. 32, 7, p. 328-334 6 p.

    Research output: Contribution to journalArticle

  50. Published

    IRF5 promotes inflammatory macrophage polarization and T H1-TH17 responses

    Krausgruber, T., Blazek, K., Smallie, T., Alzabin, S., Lockstone, H., Sahgal, N., Hussell, T., Feldmann, M. & Udalova, I. A., Mar 2011, In : Nature Immunology. 12, 3, p. 231-238 7 p.

    Research output: Contribution to journalArticle

  51. 2010
  52. Published

    A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation

    Snelgrove, R. J., Jackson, P. L., Hardison, M. T., Noerager, B. D., Kinloch, A., Gaggar, A., Shastry, S., Rowe, S. M., Shim, Y. M., Hussell, T. & Blalock, J. E., 1 Oct 2010, In : Science. 330, 6000, p. 90-94 4 p.

    Research output: Contribution to journalArticle

  53. Published

    Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR

    Drexler, S. K., Wales, J., Andreakos, E., Kong, P., Davis, A., Garlanda, C., Mantovani, A., Hussell, T., Feldmann, M. & Foxwell, B. M. J., Jun 2010, In : Scandinavian Journal of Immunology. 71, 6, p. 393-402 9 p.

    Research output: Contribution to journalArticle

  54. Published

    Structured regulation of inflammation during respiratory viral infection

    Hussell, T. & Goulding, J., May 2010, In : The Lancet Infectious Diseases. 10, 5, p. 360-366 6 p.

    Research output: Contribution to journalArticle

  55. Published

    The chemokine MIP1α/CCL3 determines pathology in primary RSV infection by regulating the balance of t cell populations in the murine lung

    Tregoning, J. S., Pribul, P. K., Pennycook, A. M. J., Hussell, T., Wang, B., Lukacs, N., Schwarze, J., Culley, F. J. & Openshaw, P. J. M., 24 Feb 2010, In : PLoS ONE. 5, 2, e9381.

    Research output: Contribution to journalArticle

  56. Published

    Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage toll-like receptor signaling and cytokine production

    Peirce, M. J., Brook, M., Morrice, N., Snelgrove, R., Begum, S., Lanfrancotti, A., Notley, C., Hussell, T., Cope, A. P. & Wait, R., 2010, In : PLoS ONE. 5, 7, e11465.

    Research output: Contribution to journalArticle

  57. 2009
  58. Published

    Sedation & Immunomodulation

    Sanders, R. D., Hussell, T. & Maze, M., Jul 2009, In : Critical Care Clinics. 25, 3, p. 551-570 19 p.

    Research output: Contribution to journalArticle

  59. Published

    Immune homeostasis in the respiratory tract and its impact on heterologous infection

    Wissinger, E., Goulding, J. & Hussell, T., Jun 2009, In : Seminars in Immunology. 21, 3, p. 147-155 8 p.

    Research output: Contribution to journalArticle

  60. Published

    Bacterial complications during pandemic influenza infection

    Hussell, T., Wissinger, E. & Goulding, J., 2009, In : Future microbiology. 4, 3, p. 269-272 3 p.

    Research output: Contribution to journalArticle

  61. Published

    Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

    Janot, L., Sirard, J. C., Secher, T., Noulin, N., Fick, L., Akira, S., Uematsu, S., Didierlaurent, A., Hussell, T., Ryffel, B. & Erard, F., 2009, In : European journal of immunology. 39, 6, p. 1587-1596 9 p.

    Research output: Contribution to journalArticle

  62. Published

    The innate immune rheostat: Influence on lung inflammatory disease and secondary bacterial pneumonia

    Hussell, T. & Cavanagh, M. M., 2009, In : Biochemical Society Transactions. 37, 4, p. 811-813 2 p.

    Research output: Contribution to journalArticle

  63. 2008
  64. Published

    Is it wise to target the late costimulatory molecule OX40 as a therapeutic target?

    Cavanagh, M. M. & Hussell, T., Oct 2008, In : Archivum Immunologiae et Therapiae Experimentalis. 56, 5, p. 291-297 6 p.

    Research output: Contribution to journalArticle

  65. Published

    Manipulation of acute inflammatory lung disease

    Wissinger, E. L., Saldana, J., Didierlaurent, A. & Hussell, T., Jul 2008, In : Mucosal Immunology. 1, 4, p. 265-278 13 p.

    Research output: Contribution to journalArticle

  66. Published

    An antiinflammatory role for IKKβ through the inhibition of "classical" macrophage activation

    Fong, C. H. Y., Bebien, M., Didierlaurent, A., Nebauer, R., Hussell, T., Broide, D., Karin, M. & Lawrence, T., 9 Jun 2008, In : Journal of Experimental Medicine. 205, 6, p. 1269-1276 7 p.

    Research output: Contribution to journalArticle

  67. Published

    Functional group/guild modelling of inter-specific pathogen interactions: A potential tool for predicting the consequences of co-infection

    Lello, J. & Hussell, T., Jun 2008, In : Parasitology. 135, 7, p. 825-839 14 p.

    Research output: Contribution to journalArticle

  68. Published

    Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization

    Tourdot, S., Mathie, S., Hussell, T., Edwards, L., Wang, H., Openshaw, P. J. M., Schwarze, J. & Lloyd, C. M., Jun 2008, In : Clinical and Experimental Allergy. 38, 6, p. 1016-1024 8 p.

    Research output: Contribution to journalArticle

  69. Published

    Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection

    Didierlaurent, A., Goulding, J., Patel, S., Snelgrove, R., Low, L., Bebien, M., Lawrence, T., Van Rijt, L. S., Lambrecht, B. N., Sirard, J. C. & Hussell, T., 18 Feb 2008, In : Journal of Experimental Medicine. 205, 2, p. 323-329 6 p.

    Research output: Contribution to journalArticle

  70. Published

    A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

    Snelgrove, R. J., Goulding, J., Didierlaurent, A. M., Lyonga, D., Vekaria, S., Edwards, L., Gwyer, E., Sedgwick, J. D., Barclay, A. N. & Hussell, T., 2008, In : Nature Immunology. 9, 9, p. 1074-1083 9 p.

    Research output: Contribution to journalArticle

  71. 2007
  72. Published

    Respiratory infections: Do we ever recover?

    Goulding, J., Snelgrove, R., Saldana, J., Didierlaurent, A., Cavanagh, M., Gwyer, E., Wales, J., Wissinger, E. L. & Hussell, T., Dec 2007, In : American Thoracic Society. Proceedings. 4, 8, p. 618-625 7 p.

    Research output: Contribution to journalArticle

  73. Published

    The impact of successive infections on the lung microenvironment

    Didierlaurent, A., Goulding, J. & Hussell, T., Dec 2007, In : Immunology. 122, 4, p. 457-465 8 p.

    Research output: Contribution to journalArticle

  74. Published

    The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature

    Tritto, E., Muzzi, A., Pesce, I., Monaci, E., Nuti, S., Galli, G., Wack, A., Rappuoli, R., Hussell, T. & De Gregorio, E., 15 Oct 2007, In : Journal of Immunology. 179, 8, p. 5346-5357 11 p.

    Research output: Contribution to journalArticle

  75. Published

    Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection

    Thorpe, C., Edwards, L., Snelgrove, R., Finco, O., Rae, A., Grandi, G., Guilio, R. & Hussell, T., 8 Mar 2007, In : Vaccine. 25, 12, p. 2252-2260 8 p.

    Research output: Contribution to journalArticle

  76. 2006
  77. Published

    A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection

    Humphreys, I. R., Edwards, L., Snelgrove, R. J., Rae, A. J., Coyle, A. J. & Hussell, T., Nov 2006, In : European journal of immunology. 36, 11, p. 2928-2938 10 p.

    Research output: Contribution to journalArticle

  78. Published

    In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection

    Snelgrove, R. J., Edwards, L., Williams, A. E., Rae, A. J. & Hussell, T., 15 Oct 2006, In : Journal of Immunology. 177, 8, p. 5509-5516 7 p.

    Research output: Contribution to journalArticle

  79. Published

    Role of CCL5 (RANTES) in viral lung disease

    Culley, F. J., Pennycook, A. M. J., Tregoning, J. S., Dodd, J. S., Walzl, G., Wells, T. N., Hussell, T. & Openshaw, P. J. M., Aug 2006, In : Journal of virology. 80, 16, p. 8151-8157 6 p.

    Research output: Contribution to journalArticle

  80. Published

    An absence of reactive oxygen species improves the resolution of lung influenza infection

    Snelgrove, R. J., Edwards, L., Rae, A. J. & Hussell, T., Jun 2006, In : European journal of immunology. 36, 6, p. 1364-1373 9 p.

    Research output: Contribution to journalArticle

  81. Published

    Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology

    Culley, F. J., Pennycook, A. M. J., Tregoning, J. S., Hussell, T. & Openshaw, P. J. M., May 2006, In : Journal of virology. 80, 9, p. 4521-4527 6 p.

    Research output: Contribution to journalArticle

  82. Published

    Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine

    Cosgrove, C. A., Castello-Branco, L. R. R., Hussell, T., Sexton, A., Giemza, R., Phillips, R., Williams, A., Griffin, G. E., Dougan, G. & Lewis, D. J. M., Apr 2006, In : Infection and immunity. 74, 4, p. 2449-2452 3 p.

    Research output: Contribution to journalArticle

  83. Published

    Amelioration of influenza-induced pathology in mice by coinfection with Trichinella spiralis

    Furze, R. C., Hussell, T. & Selkirk, M. E., Mar 2006, In : Infection and immunity. 74, 3, p. 1924-1932 8 p.

    Research output: Contribution to journalArticle

  84. Published

    Colonic bacterial infection abrogates eosinophilic pulmonary disease

    Williams, A. E., Edwards, L. & Hussell, T., 15 Jan 2006, In : Journal of INfectious Diseases. 193, 2, p. 223-230 7 p.

    Research output: Contribution to journalArticle

  85. Published

    The therapeutic potential of positive and negative immune cell co-stimulation during inflammation

    Gwyer, E., Snelgrove, R. & Hussell, T., 2006, In : Biochemical Society Transactions. 34, 6, p. 1032-1036 4 p.

    Research output: Contribution to journalArticle

  86. 2005
  87. Published

    An IL-7 fusion protein that shows increased thymopoietic ability

    Henson, S. M., Snelgrove, R., Hussell, T., Wells, D. J. & Aspinall, R., 15 Sep 2005, In : Journal of Immunology. 175, 6, p. 4112-4118 6 p.

    Research output: Contribution to journalArticle

  88. Published

    Protection against tetanus toxin using a plant-based vaccine

    Tregoning, J. S., Clare, S., Bowe, F., Edwards, L., Fairweather, N., Qazi, O., Nixon, P. J., Maliga, P., Dougan, G. & Hussell, T., Apr 2005, In : European journal of immunology. 35, 4, p. 1320-1326 6 p.

    Research output: Contribution to journalArticle

  89. Published

    TGF-β prevents eosinophilic lung disease but impairs pathogen clearance

    Williams, A. E., Humphreys, I. R., Cornere, M., Edwards, L., Rae, A. & Hussell, T., Mar 2005, In : Microbes and Infection. 7, 3, p. 365-374 9 p.

    Research output: Contribution to journalArticle

  90. Published

    Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection

    Matthews, S. P., Tregoning, J. S., Coyle, A. J., Hussell, T. & Openshaw, P. J. M., Feb 2005, In : Journal of virology. 79, 4, p. 2050-2057 7 p.

    Research output: Contribution to journalArticle

  91. 2004
  92. Published

    Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease

    Williams, A. E., Edwards, L., Humphreys, I. R., Snelgrove, R., Rae, A., Rappuoli, R. & Hussell, T., 15 Dec 2004, In : Journal of Immunology. 173, 12, p. 7435-7443 8 p.

    Research output: Contribution to journalArticle

  93. Published

    Recombinant respiratory syncytial virus lacking secreted glycoprotein G is attenuated, non-pathogenic but induces protective immunity

    Maher, C. F., Hussell, T., Blair, E., Ring, C. J. A. & Openshaw, P. J. M., Oct 2004, In : Microbes and Infection. 6, 12, p. 1049-1055 6 p.

    Research output: Contribution to journalArticle

  94. Published

    Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines

    Hale, C., Humphreys, I. R., Hussell, T., Bowe, F., Clare, S., Pickard, D., Preston, A., Del Giudice, G. & Dougan, G., 9 Sep 2004, In : Vaccine. 22, 27-28, p. 3595-3602 7 p.

    Research output: Contribution to journalArticle

  95. Published

    Co-stimulation: Novel methods for preventing viral-induced lung inflammation

    Hussell, T., Snelgrove, R., Humphreys, I. R. & Williams, A. E., 1 Aug 2004, In : Trends in molecular medicine. 10, 8, p. 379-386 7 p.

    Research output: Contribution to journalArticle

  96. Published

    Manipulation of immunity to and pathology of respiratory infections

    Snelgrove, R., Williams, A., Thorpe, C. & Hussell, T., Jun 2004, In : Expert Review of Anti-Infective Therapy. 2, 3, p. 413-426 13 p.

    Research output: Contribution to journalArticle

  97. 2003
  98. Published

    A Critical Role for OX40 in T Cell-mediated Immunopathology during Lung Viral Infection

    Humphreys, I. R., Walz, G., Edwards, L., Rae, A., Hill, S. & Hussell, T., 20 Oct 2003, In : Journal of Experimental Medicine. 198, 8, p. 1237-1242 5 p.

    Research output: Contribution to journalArticle

  99. Published

    OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia

    Humphreys, I. R., Edwards, L., Walzl, G., Rae, A. J., Dougan, G., Hill, S. & Hussell, T., 15 Jun 2003, In : Journal of Immunology. 170, 12, p. 6125-6132 7 p.

    Research output: Contribution to journalArticle

  100. Published

    Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner

    Walzl, G., Humphreys, I. R., Marshall, B. G., Edwards, L., Openshaw, P. J. M., Shaw, R. J. & Hussell, T., 1 Jun 2003, In : Infection and immunity. 71, 6, p. 3384-3391 7 p.

    Research output: Contribution to journalArticle

  101. 2002
  102. Published

    The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

    Brown, J. S., Hussell, T., Gilliland, S. M., Holden, D. W., Paton, J. C., Ehrenstein, M. R., Walport, M. J. & Botto, M., 24 Dec 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 26, p. 16969-16974 5 p.

    Research output: Contribution to journalArticle

  103. Published

    Chronic bacterial infections: Living with unwanted guests

    Young, D., Hussell, T. & Dougan, G., 1 Nov 2002, In : Nature Immunology. 3, 11, p. 1026-1032 6 p.

    Research output: Contribution to journalArticle

  104. 2001
  105. Published

    An improved protocol for measuring cytotoxic T cell activity in anatomic compartments with low cell numbers.

    Ostler, T., Schamel, K., Hussell, T., Openshaw, P., Hausmann, J. & Ehl, S., 1 Nov 2001, In : Journal of immunological methods. 257, 1-2, p. 155-161 6 p.

    Research output: Contribution to journalArticle

  106. Published

    Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology

    Walzl, G., Matthews, S., Kendall, S., Gutierrez-Ramos, J. C., Coyle, A. J., Openshaw, P. J. M. & Hussell, T., 2 Apr 2001, In : Journal of Experimental Medicine. 193, 7, p. 785-792 7 p.

    Research output: Contribution to journalArticle

  107. Published

    Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses

    Simmons, C. P., Hussell, T., Sparer, T., Walzl, G., Openshaw, P. & Dougan, G., 15 Jan 2001, In : Journal of Immunology. 166, 2, p. 1106-1113 7 p.

    Research output: Contribution to journalArticle

  108. Published

    Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology

    Hussell, T., Pennycook, A. & Openshaw, P. J. M., 2001, In : European journal of immunology. 31, 9, p. 2566-2573 7 p.

    Research output: Contribution to journalArticle

  109. Published

    Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus

    Ostler, T., Hussell, T., Surh, C. D., Openshaw, P. & Ehl, S., 2001, In : European journal of immunology. 31, 9, p. 2574-2582 8 p.

    Research output: Contribution to journalArticle

  110. Published

    Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection

    Stewart, G. R., Snewin, V. A., Walzl, G., Hussell, T., Tormay, P., O'Gaora, P., Goyal, M., Betts, J., Brown, I. N. & Young, D. B., 2001, In : Nature Medicine. 7, 6, p. 732-737 5 p.

    Research output: Contribution to journalArticle

  111. 2000
  112. Published

    IL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions

    Hussell, T. & Openshaw, P. J. M., 15 Dec 2000, In : Journal of Immunology. 165, 12, p. 7109-7115 6 p.

    Research output: Contribution to journalArticle

  113. Published

    Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology

    Walzl, G., Tafuro, S., Moss, P., Openshaw, P. J. M. & Hussell, T., 6 Nov 2000, In : Journal of Experimental Medicine. 192, 9, p. 1317-1326 9 p.

    Research output: Contribution to journalArticle

  114. Published

    Flow cytometric measurement of intracellular cytokines.

    Pala, P., Hussell, T. & Openshaw, P. J., 21 Sep 2000, In : Journal of immunological methods. 243, 1-2

    Research output: Contribution to journalArticle

  115. 1999
  116. Published

    Recent developments in the biology of respiratory syncytial virus: Are vaccines and new treatments just round the corner?

    Hussell, T. & Openshaw, P., Aug 1999, In : Current Opinion in Microbiology. 2, 4, p. 410-414 4 p.

    Research output: Contribution to journalArticle

  117. 1998
  118. Published

    Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection

    Hussell, T., Georgiou, A., Sparer, T. E., Matthews, S., Pala, P. & Openshaw, P. J. M., 1 Dec 1998, In : Journal of Immunology. 161, 11, p. 6215-6222 7 p.

    Research output: Contribution to journalArticle

  119. Published

    Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection.

    Hussell, T. & Openshaw, P. J., Nov 1998, In : The Journal of general virology. 79 ( Pt 11)

    Research output: Contribution to journalArticle

  120. Published

    Abundant IFN-gamma production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease.

    Spender, L. C., Hussell, T. & Openshaw, P. J., Jul 1998, In : The Journal of general virology. 79 ( Pt 7)

    Research output: Contribution to journalArticle

  121. Published

    Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia

    Sparer, T. E., Matthews, S., Hussell, T., Rae, A. J., Garcia-Barreno, B., Melero, J. A. & Openshaw, P. J. M., 1 Jun 1998, In : Journal of Experimental Medicine. 187, 11, p. 1921-1926 5 p.

    Research output: Contribution to journalArticle

  122. Published

    The effect of IL-12 treatment on vaccine-enhanced illness during infection with respiratory syncytial virus.

    Openshaw, P. J. & Hussell, T., 1998, In : Developments in biological standardization. 92, p. 179-185 6 p.

    Research output: Contribution to journalArticle

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