Prof Timothy IllidgeBSc PhD FRCP FRCR FRCPath

Professor of Targeted Therapy & Oncology

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Research interests

Radiation Treatment is a highly effective anti-cancer treatment that is delivered to over 50% of all cancer patients and 40% of those cured of their disease. In order to further improve cancer outcomes using RT, an increased understanding of what determines effective RT-induced anti-tumour responses and how best to combine RT with others treatments is required. Our research programme evaluates the contribution of RT-induced immunogenic cell death to the induction of tumour-specific immune responses (Project 1); determines how best to integrate RT with immunomodulatory agents to augment such responses and enhance therapeutic outcome (Project 2); and investigates how combination with RT and immune modulation can be utilised to increase the efficacy and durability of anti-CD20 mAb therapy in B- cell lymphomas (Project 3). The pre-clinical experimental programme runs in parallel with early phase clinical trials to form a cohesive and overlapping programme of work that aims to inform further clinical trial design of RT and immunotherapy combinations using these novel approaches to improve outcome for cancer patients

Methodological knowledge

Tumour immunology

anti-cancer antibodies

radiobiology

Projects

Research and projects

  1. NIHR Biomedical Research Centre: Cancer Precision Medicine Theme.

    Dive, C., Baena Chaparro, E., Blackhall, F., Bruce, I., Bundred, N., Carter, L., Clarke, R., Cook, N., Crosbie, P., Evans, D., Harris, J., Hawkins, R., Hussell, T., Illidge, T., Jayson, G., Jorgensen, C., Kirwan, C., Kostarelos, K., Krebs, M., Lorigan, P., Marais, R., Marshall, K., Metcalf, R., Payne, K., Radford, J., Somervaille, T., Springer, C., Taylor, S., Thistlethwaite, F., Viros Usandizaga, A. & Zelenay, S.

    1/04/1731/03/19

    Project: Research

  2. FASTMAN Centre, Movember Prostate Cancer Centre of Excellence

    Marais, R., Brady, G., Choudhury, A., Clarke, N., Dive, C., Illidge, T., Miller, C. & West, C.

    1/07/1430/06/17

    Project: Research