Prof Stuart Pickering-BrownPhD

Professor of Neurogenetics

View graph of relations

Publications

  1. 2019
  2. Published

    Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

    Alzheimer Disease Genetics Consortium (ADGC), European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), 2019, In : Nature Genetics. 51, 3, p. 414-430 17 p.

    Research output: Contribution to journalArticle

  3. 2018
  4. Published

    A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers

    International FTD-Genomics Consortium (IFGC), 1 Oct 2018, In : Brain. 141, 10, p. 2895-2907

    Research output: Contribution to journalArticle

  5. Published

    Expression of C9orf72-related dipeptides impairs motor function in a vertebrate model

    Swaminathan, A., Bouffard, M., Liao, M., Ryan, S., Callister, J. B., Pickering-Brown, S. M., Armstrong, G. A. B. & Drapeau, P., 15 May 2018, In : Human Molecular Genetics. 27, 10, p. 1754-1762 9 p.

    Research output: Contribution to journalArticle

  6. Published

    Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

    ICALS, Jan 2018, In : The Lancet. Neurology. 17, 1, p. 64-74 11 p.

    Research output: Contribution to journalArticle

  7. Published

    Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

    ITALSGEN Consortium, 2018, In : Neuron. 97, 6, p. 1268-1283.e6

    Research output: Contribution to journalArticle

  8. Published

    Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

    International Frontotemporal Dementia Genomics Consortium, 2018, In : Nature Medicine.

    Research output: Contribution to journalArticle

  9. Published

    Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

    International FTD-Genomics Consortium, 2018, In : PLOS Medicine. 15, 1, e1002487.

    Research output: Contribution to journalArticle

  10. Published

    Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains

    Keogh, M. J., Wei, W., Aryaman, J., Wilson, I., Talbot, K., Turner, M. R., Mckenzie, C., Troakes, C., Attems, J., Smith, C., Al Sarraj, S., Morris, C. M., Ansorge, O., Pickering-brown, S., Jones, N., Ironside, J. W. & Chinnery, P. F., 2018, In : Journal of Neurology, Neurosurgery & Psychiatry. 89, 8, p. 813-816

    Research output: Contribution to journalArticle

  11. Published
  12. Published

    The role of lysosomes and autophagosomes in Frontotemporal Lobar Degeneration

    Bain, H. D., Davidson, Y. S., Robinson, A. C., Ryan, S., Rollinson, S., Richardson, A., Jones, M., Snowden, J. S., Pickering-Brown, S. & Mann, D. M. A., 2018, In : Neuropathology and Applied Neurobiology.

    Research output: Contribution to journalArticle

  13. 2017
  14. Published
  15. Published

    Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

    Wei, W., Keogh, M. J., Wilson, I., Coxhead, J., Ryan, S., Rollinson, S., Griffin, H., Kurzawa-akanbi, M., Santibanez-koref, M., Talbot, K., Turner, M. R., Mckenzie, C., Troakes, C., Attems, J., Smith, C., Al Sarraj, S., Morris, C. M., Ansorge, O., Pickering-brown, S., Ironside, J. W. & 1 others, Chinnery, P. F., 1 Dec 2017, In : Acta Neuropathologica Communications. 5, 1

    Research output: Contribution to journalArticle

  16. Published

    Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration

    Davidson, Y. S., Robinson, A. C., Flood, L., Rollinson, S., Benson, B. C., Asi, Y. T., Richardson, A., Jones, M., Snowden, J. S., Pickering-Brown, S., Lashley, T. & Mann, D. M. A., 30 Jun 2017, In : Acta Neuropathologica Communications. 5, 1, 12 p., 54.

    Research output: Contribution to journalArticle

  17. Published

    Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

    Davidson, Y. S., Flood, L., Robinson, A. C., Nihei, Y., Mori, K., Rollinson, S., Richardson, A., Benson, B. C., Jones, M., Snowden, J. S., Pickering-Brown, S., Haass, C., Lashley, T. & Mann, D. M. A., 21 Apr 2017, In : Acta Neuropathologica Communications. 5, 1, p. 31

    Research output: Contribution to journalArticle

  18. Published

    Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource

    Keogh, M. J., Wei, W., Wilson, I., Coxhead, J., Ryan, S., Rollinson, S., Griffin, H., Kurzawa-Akanbi, M., Santibanez-Koref, M., Talbot, K., Turner, M. R., McKenzie, C. A., Troakes, C., Attems, J., Smith, C., Al Sarraj, S., Morris, C. M., Ansorge, O., Pickering-Brown, S., Ironside, J. W. & 1 others, Chinnery, P. F., 1 Jan 2017, In : Genome research. 27, 1, p. 165-173 9 p.

    Research output: Contribution to journalArticle

  19. Published

    Immunohistochemical detection of C9orf72 protein in Frontotemporal Lobar Degeneration and Motor Neurone Disease: patterns of immunostaining and an evaluation of commercial antibodies

    Davidson, Y., Robinson, A., Rollinson, S., Pickering-Brown, S., Xiao, S., Robertson, J. & Mann, D., 2017, In : Amyotrophic lateral sclerosis and frontotemporal degeneration.

    Research output: Contribution to journalArticle

  20. 2016
  21. Published

    Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size

    Bennion Callister, J., Ryan, S., Sim, J., Rollinson, S. & Pickering-Brown, S., 23 Oct 2016, In : Human Molecular Genetics. 25

    Research output: Contribution to journalArticle

  22. Published

    Identification of biological pathways regulated by PGRN and GRN peptide treatments using transcriptome analysis

    Rollinson, S., Young, K., Bennion-Callister, J. & Pickering-Brown, S., 4 Sep 2016, In : European Journal of Neuroscience. 44, 5, p. 2214-2225 12 p.

    Research output: Contribution to journalArticle

  23. Published

    Left hand dystonia as a recurring feature of a family carrying C9ORF72 mutation

    Luzzi, S., Girelli, F., Fiori, C., Ranaldi, V., Baldinelli, S., Cameriere, V., Silvestrini, M., Provinciali, L., Rollinson, S., Pickering-Brown, S., Mann, D. & Snowden, J. S., Jul 2016, In : Journal of neurology, neurosurgery, and psychiatry. 87, 7, p. 793-5 3 p.

    Research output: Contribution to journalArticle

  24. Published

    Psychosis associated with expansions in the C9orf72 gene: the influence of a 10 base pair gene deletion

    Snowden, J. S., Harris, J., Adams, J., Thompson, J. C., Richardson, A. M., Jones, M. S., Neary, D., Davidson, Y. S., Robinson, A. C., Rollinson, S., Pickering-Brown, S. & Mann, D. M., May 2016, In : Journal of neurology, neurosurgery, and psychiatry. 87, 5, p. 562-563 2 p.

    Research output: Contribution to journalArticle

  25. Published

    Pathological tau deposition in Motor Neurone Disease and Frontotemporal Lobar Degeneration associated with TDP-43 proteinopathy

    Behrouzi, R., Liu, X., Wu, D., Robinson, A., Tanaguchi-Watanabe, S., Rollinson, S., Shi, J., Tian, J., Hamdallah, H. H., Ealing, J., Richardson, A., Jones, M., Pickering-Brown, S., Davidson, Y., Strong, M. J., Hasegawa, M., Snowden, J. & Mann, D., 31 Mar 2016, In : Acta Neuropathologica Communications. 4, 33.

    Research output: Contribution to journalArticle

  26. Published

    Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease

    Schott, J. M., Crutch, S. J., Carrasquillo, M. M., Uphill, J., Shakespeare, T. J., Ryan, N. S., Yong, K. X. X., Lehmann, M., Ertekin-Taner, N., Graff-Radford, N. R., Boeve, B. F., Murray, M. E., Khan, Q. U. A., Petersen, R. C., Dickson, D. W., Knopman, D. S., Rabinovici, G. D., Miller, B. L., Gonzalez, A. S., Gil-Néciga, E. & 24 others, Snowden, J. S., Harris, J., Pickering-Brown, S. M., Louwersheimer, E., van der Flier, W. M., Scheltens, P., Pijnenburg, Y. A., Galasko, D., Sarazin, M., Dubois, B., Magnin, E., Galimberti, D., Scarpini, E., Cappa, S. F., Hodges, J. R., Halliday, G. M., Bartley, L., Carrillo, M. C., Bras, J. T., Hardy, J., Rossor, M. N., Collinge, J., Fox, N. C. & Mead, S., 15 Mar 2016, In : Alzheimer's and Dementia.

    Research output: Contribution to journalArticle

  27. Published

    Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies

    Kun-Rodrigues, C., Ross, O. A., Orme, T., Shepherd, C., Parkkinen, L., Darwent, L., Hernandez, D., Ansorge, O., Clark, L. N., Honig, L. S., Marder, K., Lemstra, A., Scheltens, P., van der Flier, W., Louwersheimer, E., Holstege, H., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H. & 44 others, Barber, I., Braae, A., Brown, K., Morgan, K., Maetzler, W., Berg, D., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Trojanowski, J. Q., Serrano, G. E., Beach, T. G., Clarimon, J., Lleó, A., Morenas-Rodríguez, E., Lesage, S., Galasko, D., Masliah, E., Santana, I., Diez, M., Pastor, P., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Stone, D. J., Pickering-Brown, S., Mann, D., Dickson, D. W., Halliday, G. M., Singleton, A., Guerreiro, R. & Bras, J., 2016, In : Neurobiology of Aging.

    Research output: Contribution to journalArticle

  28. 2015
  29. Published

    Neurodegeneration in Frontotemporal Lobar Degeneration and Motor Neurone Disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.

    Davidson, Y., Robinson, A. C., Liu, X., Wu, D., Troakes, C., Rollinson, S., Masuda-Suzukake, M., Suzuki, G., Nonaka, T., Shi, J., Tian, J., Hamdalla, H., Ealing, J., Richardson, A., Jones, M., Pickering-Brown, S., Snowden, J. S., Hasegawa, M. & Mann, D. M. A., 5 Nov 2015, In : Neuropathology and Applied Neurobiology.

    Research output: Contribution to journalArticle

  30. Published

    Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

    Guerreiro, R., Escott-Price, V., Darwent, L., Parkkinen, L., Ansorge, O., Hernandez, D. G., Nalls, M. A., Clark, L., Honig, L., Marder, K., van der Flier, W., Holstege, H., Louwersheimer, E., Lemstra, A., Scheltens, P., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H., Ortega-Cubero, S. & 27 others, Pastor, P., Ferman, T. J., Graff-Radford, N. R., Ross, O. A., Barber, I., Braae, A., Brown, K., Morgan, K., Maetzler, W., Berg, D., Troakes, C., Al-Sarraj, S., Lashley, T., Compta, Y., Revesz, T., Lees, A., Cairns, N. J., Halliday, G. M., Mann, D., Pickering-Brown, S., Powell, J., Lunnon, K., Lupton, M. K., Dickson, D., Hardy, J., Singleton, A. & Bras, J., 2 Nov 2015, In : Neurobiology of Aging.

    Research output: Contribution to journalArticle

  31. Published

    Is SIGMAR1 a confirmed FTD/MND gene?

    Pickering-Brown, S. & Hardy, J., Nov 2015, In : Brain. 138, Pt 11, p. e393

    Research output: Contribution to journalArticle

  32. Published

    Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations.

    Snowden, J. S., Adams, J., Harris, J., Thompson, J. C., Rollinson, S., Richardson, A., Jones, M., Neary, D., Mann, D. M. & Pickering-Brown, S., 16 Oct 2015, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 16, 7-8, p. 497-505 9 p.

    Research output: Contribution to journalArticle

  33. Published

    p62/SQSTM1 analysis in frontotemporal lobar degeneration.

    Miller, L., Rollinson, S., Pickering-Brown, S., Callister, J. B., Young, K., Harris, J., Gerhard, A., Neary, D., Richardson, A., Snowden, J. & Mann, D. M., 10 Oct 2015, In : Neurobiology of Aging. 36, 3, p. 1603

    Research output: Contribution to journalArticle

  34. Published

    Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

    Cooper-Knock, J., Higginbottom, A., Stopford, M. J., Highley, J. R., Ince, P. G., Wharton, S. B., Pickering-Brown, S., Kirby, J., Hautbergue, G. M. & Shaw, P. J., Jul 2015, In : Acta neuropathologica. 130, 1, p. 63-75 13 p.

    Research output: Contribution to journalArticle

  35. Published

    A novel Alzheimer disease locus located near the gene encoding tau protein.

    Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J-C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L-S., Bis, J. C., Bellenguez, C., Harold, D., Lunetta, K. L., Destefano, A. L., Grenier-Boley, B., Sims, R., Beecham, G. W., Smith, A. V., Chouraki, V., Hamilton-Nelson, K. L., Ikram, M. A. & 406 others, Fievet, N., Denning, N., Martin, E. R., Schmidt, H., Kamatani, Y., Dunstan, M. L., Valladares, O., Laza, A. R., Zelenika, D., Ramirez, A., Foroud, T. M., Choi, S-H., Boland, A., Becker, T., Kukull, W. A., van der Lee, S. J., Pasquier, F., Cruchaga, C., Beekly, D., Fitzpatrick, A. L., Hanon, O., Gill, M., Barber, R., Gudnason, V., Campion, D., Love, S., Bennett, D. A., Amin, N., Berr, C., Tsolaki, M., Buxbaum, J. D., Lopez, O. L., Deramecourt, V., Fox, N. C., Cantwell, L. B., Tárraga, L., Dufouil, C., Hardy, J., Crane, P. K., Eiriksdottir, G., Hannequin, D., Clarke, R., Evans, D., Mosley, T. H., Letenneur, L., Brayne, C., Maier, W., De Jager, P., Emilsson, V., Dartigues, J-F., Hampel, H., Kamboh, M. I., de Bruijn, R. F. A. G., Tzourio, C., Pastor, P., Larson, E. B., Rotter, J. I., O'Donovan, M. C., Montine, T. J., Nalls, M. A., Mead, S., Reiman, E. M., Jonsson, P. V., Holmes, C., St George-Hyslop, P. H., Boada, M., Passmore, P., Wendland, J. R., Schmidt, R., Morgan, K., Winslow, A. R., Powell, J. F., Carasquillo, M., Younkin, S. G., Jakobsdóttir, J., Kauwe, J. S. K., Wilhelmsen, K. C., Rujescu, D., Nöthen, M. M., Hofman, A., Jones, L., Haines, J. L., Psaty, B. M., Van Broeckhoven, C., Holmans, P., Launer, L. J., Mayeux, R., Lathrop, M., Goate, A. M., Escott-Price, V., Seshadri, S., Pericak-Vance, M. A., Amouyel, P., Williams, J., van Duijn, C. M., Schellenberg, G. D., Farrer, L. A., Adams, P. M., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Asthana, S., Atwood, C. S., Baldwin, C. T., Barmada, M. M., Barnes, L. L., Beach, T. G., Becker, J. T., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Cairns, N. J., Cao, C., Carlson, C. S., Carlsson, C. M., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Chui, H. C., Clark, D. G., Corneveaux, J., Cribbs, D. H., Crocco, E. A., Cruchaga, C., De Jager, P. L., DeCarli, C., DeKosky, S. T., Demirci, F. Y., Dick, M., Dickson, D. W., Doody, R. S., Duara, R., Ertekin-Taner, N., Faber, K. M., Fairchild, T. J., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, D. R., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Glass, J. D., Graff-Radford, N. R., Green, R. C., Growdon, J. H., Hakonarson, H., Hamilton, R. L., Hardy, J., Harrell, L. E., Head, E., Honig, L. S., Huebinger, R. M., Huentelman, M. J., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L-W., Karydas, A., Kauwe, J. S., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lin, C-F., Lopez, O. L., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Morris, J. C., Mukherjee, S., Murrell, J. R., Myers, A. J., O'Bryant, S., Olichney, J. M., Pankratz, V. S., Parisi, J. E., Partch, A., Paulson, H. L., Perry, W., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Reisch, J. S., Reitz, C., Ringman, J. M., Roberson, E. D., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Royall, D. R., Sager, M. A., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsattel, J. P., Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Wishnek, S., Woltjer, R. L., Wright, C. B., Wu, C-K., Yu, C-E., Yu, L., Au, R., Wolf, P. A., Beiser, A., Satizabal, C., Uitterlinden, A. G., Rivadeneira, F., Koudstaal, P. J., Longstreth Jr, W. T., Kuller, L. H., Lumley, T., Rice, K., Harris, T. B., Nalls, M., Marksteiner, J. J. M., Dal-Bianco, P., Töglhofer, A. M., Freudenberger, P., Ransmayr, G., Benke, T., Toeglhofer, A. M., Boerwinkle, E., Bressler, J., Fornage, M., Morón, F. J., Hernández, I., Roca, M. R., Mauleón, A., Alegret, M., Ramírez-Lorca, R., González-Perez, A., Alpérovitch, A., Alvarez, V., Barberger-Gateau, P., Bettens, K., Bossù, P., Brice, A., Bullido, M., Caffara, P., Clarimon, J., Combarros, O., Coto, E., Zampo, M. D., Delepine, M., Deniz Naranjo, M. C., Epelbaum, J., Fratiglioni, L., Galimberti, D., Graff, C., Hiltunen, M., Ingelsson, M., Keller, L., Lannfelt, L., Llèo, A., Mancuso, M., Mateo, I., Mecocci, P., Nacmias, B., Panza, F., Pilotto, A., Garcia, F. S., Scarpini, E., Seripa, D., Sleegers, K., Soininen, H., Sorbi, S., Spalletta, G., Wallon, D., Thomas, C., Gerrish, A., Chapman, J., Stretton, A., Morgan, A., Oldham, H., Owen, M. J., Kehoe, P. G., Medway, C., Brown, K., Lord, J., Turton, J., Hooper, N. M., Vardy, E., Warren, J. D., Schott, J. M., Uphill, J., Hollingworth, P., Psy, DC., Ryan, N., Rossor, M., Collinge, J., Ben-Shlomo, Y., Makrina, D., Gkatzima, O., Lupton, M., Koutroumani, M., Avramidou, D., Germanou, A., Jessen, F., Riedel-Heller, S., Dichgans, M., Heun, R., Kölsch, H., Schürmann, B., Herold, C., Lacour, A., Drichel, D., Hoffmann, P., Kornhuber, J., Gu, W., Feulner, T., Mayhaus, M., Pichler, S., Riemenschneider, M., Bussche, H. V. D., Lawlor, B., Lynch, A., Mann, D., Smith, A. D., Warden, D., Wilcock, G., Heuser, I., Wiltfang, J., Frölich, L., Hüll, M., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., McQuillin, A., Gwilliam, R., Deloukas, P., Al-Chalabi, A., Shaw, C. E., Singleton, A. B., Guerreiro, R., Russo, G., Jöckel, K-H., Moebus, S., Klopp, N., Wichmann, H-E., Ma, L., Bisceglio, G., Fisher, E., Warner, N., Pickering-Brown, S., Craig, D., Johnston, J. A., McGuinness, B., Todd, S., Rubinsztein, D. C., Lovestone, S., Bayer, A., Gallacher, J., Proitsi, P. & Ortega-Cubero, S., 17 Mar 2015, In : Molecular psychiatry.

    Research output: Contribution to journalArticle

  36. Published

    A UBQLN2 variant of unknown significance in frontotemporal lobar degeneration.

    Ugwu, F., Rollinson, S., Harris, J., Gerhard, A., Richardson, A., Jones, M., Mann, D., Snowden, J. & Pickering-Brown, S., Jan 2015, In : Neurobiology of Aging. 36, 1

    Research output: Contribution to journalArticle

  37. Published

    TREM2 analysis and increased risk of Alzheimer's disease.

    Finelli, D., Rollinson, S., Harris, J., Jones, M., Richardson, A., Gerhard, A., Snowden, J., Mann, D. & Pickering-Brown, S., Jan 2015, In : Neurobiology of Aging. 36, 1

    Research output: Contribution to journalArticle

  38. Published

    Histone deacetylases (HDACs) in Frontotemporal Lobar Degeneration.

    Whitehouse, A., Doherty, K., Yeh, H. H., Robinson, A. C., Rollinson, S., Pickering-Brown, S., Snowden, J., Thompson, J. C., Davidson, Y. S. & Mann, D. M. A., 2015, In : Neuropathology and Applied Neurobiology. 41, 2, p. 245-57 187 p.

    Research output: Contribution to journalArticle

  39. Published

    Semantic corticobasal dementia: challenging nosology in frontotemporal lobar degeneration

    Luzzi, S., Fabi, K., Cafazzo, V., Fringuelli, F. M., Reverberi, C., Baldinelli, S., Silvestrini, M., Provinciali, L., Ascoli, G., Pickering-Brown, S., Mann, D., Neary, D. & Snowden, J. S., 2015, In : Alzheimer disease and associated disorders. 29, 4, p. 360-3 4 p.

    Research output: Contribution to journalArticle

  40. 2014
  41. Published

    A small deletion in C9orf72 hides a proportion of expansion carriers in FTLD.

    Rollinson, S., Bennion Callister, J., Young, K., Ryan, S. J., Druyeh, R., Rohrer, J. D., Snowden, J., Richardson, A., Jones, M., Harris, J., Davidson, Y., Robinson, A., Ealing, J., Johnson, J. O., Traynor, B., Mead, S., Mann, D. & Pickering-Brown, S. M., 12 Dec 2014, In : Neurobiology of Aging. 36, 3, p. 1601.e1-1601.e5 5 p.

    Research output: Contribution to journalArticle

  42. Published

    Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.

    Bras, J., Guerreiro, R., Darwent, L., Parkkinen, L., Ansorge, O., Escott-Price, V., Hernandez, D. G., Nalls, M. A., Clark, L. N., Honig, L. S., Marder, K., Van Der Flier, W. M., Lemstra, A., Scheltens, P., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H., Ortega-Cubero, S., Pastor, P. & 22 others, Ferman, T. J., Graff-Radford, N. R., Ross, O. A., Barber, I., Braae, A., Brown, K., Morgan, K., Maetzler, W., Berg, D., Troakes, C., Al-Sarraj, S., Lashley, T., Compta, Y., Revesz, T., Lees, A., Cairns, N., Halliday, G. M., Mann, D., Pickering-Brown, S., Dickson, D. W., Singleton, A. & Hardy, J., 1 Dec 2014, In : Human Molecular Genetics. 23, 23

    Research output: Contribution to journalArticle

  43. Published

    Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS.

    Bennion Callister, J. & Pickering-Brown, S. M., Dec 2014, In : Experimental neurology. 262 Pt B

    Research output: Contribution to journalArticle

  44. Published

    Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration.

    Gibbons, L., Rollinson, S., Thompson, J. C., Robinson, A., Davidson, Y. S., Richardson, A., Neary, D., Pickering-Brown, S. M., Snowden, J. S. & Mann, D. M. A., 18 Oct 2014, In : Neurobiology of Aging. 36, 3

    Research output: Contribution to journalArticle

  45. Published

    Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease.

    Sassi, C., Guerreiro, R., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Medway, C., Lord, J., Turton, J., Mann, D., Snowden, J., Neary, D., Harris, J., Bras, J., Powell, J. F., Singleton, A., Hardy, J., Passmore, P. & 18 others, Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Mann, D., Pickering-Brown, S., Brown, K., Lowe, J., Morgan, K., Smith, A. D., Wilcock, G., Warden, D. & Holmes, C., Oct 2014, In : Neurobiology of Aging. 35, 10, p. 2422e13-e16

    Research output: Contribution to journalArticle

  46. Published

    Patterns of microglial cell activation in frontotemporal lobar degeneration

    Lant, S. B., Robinson, A. C., Thompson, J. C., Rollinson, S., Pickering-Brown, S., Snowden, J. S., Davidson, Y. S., Gerhard, A. & Mann, D. M. A., Oct 2014, In : Neuropathology and Applied Neurobiology. 40, 6, p. 686-696 10 p.

    Research output: Contribution to journalArticle

  47. Published

    C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

    Mizielinska, S., Grönke, S., Niccoli, T., Ridler, C. E., Clayton, E. L., Devoy, A., Moens, T., Norona, F. E., Woollacott, I. O. C., Pietrzyk, J., Cleverley, K., Nicoll, A. J., Pickering-Brown, S., Dols, J., Cabecinha, M., Hendrich, O., Fratta, P., Fisher, E. M. C., Partridge, L. & Isaacs, A. M., 5 Sep 2014, In : Science (New York, N.Y.). 345, 6201

    Research output: Contribution to journalArticle

  48. Published

    Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene.

    Baborie, A., Griffiths, T. D., Jaros, E., Perry, R., McKeith, I. G., Burn, D. J., Masuda-Suzukake, M., Hasegawa, M., Rollinson, S., Pickering-Brown, S., Robinson, A. C., Davidson, Y. S. & Mann, D. M. A., 3 Sep 2014, In : Neuropathology and Applied Neurobiology. 41, 5

    Research output: Contribution to journalArticle

  49. Published

    Frontotemporal dementia and its subtypes: a genome-wide association study.

    Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Brooks, W. S., Schofield, P. R., Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Haan, E., Hernández, I., Ruiz, A., Boada, M., Borroni, B., Padovani, A. & 138 others, Cruchaga, C., Cairns, N. J., Benussi, L., Binetti, G., Ghidoni, R., Forloni, G., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Clarimón, J., Lleó, A., Blesa, R., Waldö, M. L., Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G-Y. R., Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Pastor, P., Razquin, C., Ortega-Cubero, S., Alonso, E., Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Mead, S., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., van der Zee, J., Deschamps, W., Van Langenhove, T., Cruts, M., Van Broeckhoven, C., Cappa, S. F., Le Ber, I., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M., Mayhaus, M., Ibach, B., Gasparoni, G., Pichler, S., Gu, W., Rossor, M. N., Fox, N. C., Warren, J. D., Spillantini, M. G., Morris, H. R., Rizzu, P., Heutink, P., Snowden, J. S., Rollinson, S., Richardson, A., Gerhard, A., Bruni, A. C., Maletta, R., Frangipane, F., Cupidi, C., Bernardi, L., Anfossi, M., Gallo, M., Conidi, M. E., Smirne, N., Rademakers, R., Baker, M., Dickson, D. W., Graff-Radford, N. R., Petersen, R. C., Knopman, D., Josephs, K. A., Boeve, B. F., Parisi, J. E., Seeley, W. W., Miller, B. L., Karydas, A. M., Rosen, H., van Swieten, J. C., Dopper, E. G. P., Seelaar, H., Pijnenburg, Y. A. L., Scheltens, P., Logroscino, G., Capozzo, R., Novelli, V., Puca, A. A., Franceschi, M., Postiglione, A., Milan, G., Sorrentino, P., Kristiansen, M., Chiang, H-H., Graff, C., Pasquier, F., Rollin, A., Deramecourt, V., Lebert, F., Kapogiannis, D., Ferrucci, L., Pickering-Brown, S., Singleton, A. B., Hardy, J. & Momeni, P., Jul 2014, In : The Lancet. Neurology. 13, 7, p. 686-699 13 p.

    Research output: Contribution to journalArticle

  50. Published

    Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.

    Davidson, Y. S., Barker, H., Robinson, A. C., Thompson, J. C., Harris, J., Troakes, C., Smith, B., Al-Saraj, S., Shaw, C., Rollinson, S., Masuda-Suzukake, M., Hasegawa, M., Pickering-Brown, S., Snowden, J. S. & Mann, D. M., 20 Jun 2014, In : Acta Neuropathologica Communications. 2, 70, p. 70-70 1 p.

    Research output: Contribution to journalArticle

  51. Published

    No interaction between tau and TDP-43 pathologies in either Frontotemporal Lobar Degeneration or Motor Neurone Disease.

    Robinson, A. C., Thompson, J. C., Weedon, L., Rollinson, S., Pickering-Brown, S., Snowden, J. S., Davidson, Y. S. & Mann, D. M. A., 27 May 2014, In : Neuropathology and Applied Neurobiology. 40, 7, p. 844-854 10 p.

    Research output: Contribution to journalArticle

  52. Published

    Genomewide association study in cervical dystonia demonstrates possible association with sodium leak channel.

    Mok, K. Y., Schneider, S. A., Trabzuni, D., Stamelou, M., Edwards, M., Kasperaviciute, D., Pickering-Brown, S., Silverdale, M., Hardy, J. & Bhatia, K. P., Feb 2014, In : Movement disorders : official journal of the Movement Disorder Society. 29, 2

    Research output: Contribution to journalArticle

  53. Published

    Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.

    Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., Jeng, A. T., Cooper, B., Skorupa, T., Carrell, D., Levitch, D., Hsu, S., Choi, J., Ryten, M., Hardy, J., Trabzuni, D. & 60 others, Weale, M. E., Ramasamy, A., Smith, C., Sassi, C., Bras, J., Gibbs, J. R., Hernandez, D. G., Lupton, M. K., Powell, J., Forabosco, P., Ridge, P. G., Corcoran, C. D., Tschanz, J. T., Norton, M. C., Munger, R. G., Schmutz, C., Leary, M., Demirci, F. Y., Bamne, M. N., Wang, X., Lopez, O. L., Ganguli, M., Medway, C., Turton, J., Lord, J., Braae, A., Barber, I., Brown, K., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Mann, D. M., Pickering-Brown, S., Kalsheker, N., Lowe, J., Morgan, K., David Smith, A., Wilcock, G., Warden, D., Holmes, C., Pastor, P., Lorenzo-Betancor, O., Brkanac, Z., Scott, E., Topol, E., Rogaeva, E., Singleton, A. B., Kamboh, M. I., St George-Hyslop, P., Cairns, N., Morris, J. C., Kauwe, J. S. K. & Goate, A. M., 23 Jan 2014, In : Nature. 505, 7484, p. 550-554 4 p.

    Research output: Contribution to journalArticle

  54. Published

    Pathogenesis/Genetics of frontotemporal lobar degeneration and how it relates to ALS

    Callister, J. B. & Pickering-Brown, S., 2014, In : Experimental Neurobiology. 262, p. 84 - 90 6 p.

    Research output: Contribution to journalArticle

  55. 2013
  56. Published

    A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies.

    Nalls, M. A., Duran, R., Lopez, G., Kurzawa-Akanbi, M., McKeith, I. G., Chinnery, P. F., Morris, C. M., Theuns, J., Crosiers, D., Cras, P., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Mann, D. M. A., Snowden, J., Pickering-Brown, S., Halliwell, N., Davidson, Y., Gibbons, L., Harris, J. & 38 others, Sheerin, U-M., Bras, J., Hardy, J., Clark, L., Marder, K., Honig, L. S., Berg, D., Maetzler, W., Brockmann, K., Gasser, T., Novellino, F., Quattrone, A., Annesi, G., De Marco, E. V., Rogaeva, E., Masellis, M., Black, S. E., Bilbao, J. M., Foroud, T., Ghetti, B., Nichols, W. C., Pankratz, N., Halliday, G., Lesage, S., Klebe, S., Durr, A., Duyckaerts, C., Brice, A., Giasson, B. I., Trojanowski, J. Q., Hurtig, H. I., Tayebi, N., Landazabal, C., Knight, M. A., Keller, M., Singleton, A. B., Wolfsberg, T. G. & Sidransky, E., Jun 2013, In : JAMA Neurology. 70, 6, p. 727-35 691 p.

    Research output: Contribution to journalArticle

  57. Published

    Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72.

    Mann, D. M. A., Rollinson, S., Robinson, A., Bennion Callister, J., Thompson, J. C., Snowden, J. S., Gendron, T., Petrucelli, L., Masuda-Suzukake, M., Hasegawa, M., Davidson, Y. & Pickering-Brown, S., 2013, In : Acta Neuropathologica Communications. 1, 1

    Research output: Contribution to journalArticle

  58. Published

    Frontotemporal dementia with amyotrophic lateral sclerosis: a clinical comparison of patients with and without repeat expansions in C9orf72.

    Snowden, J. S., Harris, J., Richardson, A., Rollinson, S., Thompson, J. C., Neary, D., Mann, D. M. A. & Pickering-Brown, S., 2013, In : Amyotrophic lateral sclerosis & frontotemporal degeneration. 14, 3, p. 172-176 4 p.

    Research output: Contribution to journalArticle

  59. 2012
  60. Published

    Prominent sensorimotor neuropathy due to SACS mutations revealed by whole-exome sequencing

    Pyle, A., Griffin, H., Yu-Wai-Man, P., Duff, J., Eglon, G., Pickering-Brown, S., Santibanez-Korev, M., Horvath, R. & Chinnery, P. F., Oct 2012, In : Archives of Neurology. 69, 10, p. 1351-1354 3 p.

    Research output: Contribution to journalArticle

  61. Published

    Psychosis, C9ORF72 and dementia with Lewy bodies

    Snowden, J. S., Rollinson, S., Lafon, C., Harris, J., Thompson, J., Richardson, A. M., Jones, M., Gerhard, A., Neary, D., Mann, D. M. A. & Pickering-Brown, S., Oct 2012, In : Journal of Neurology, Neurosurgery and Psychiatry. 83, 10, p. 1031-1032 1 p.

    Research output: Contribution to journalArticle

  62. Published

    Analysis of the hexanucleotide repeat in C9ORF72 in Alzheimer's disease

    Rollinson, S., Halliwell, N., Young, K., Callister, J. B., Toulson, G., Gibbons, L., Davidson, Y. S., Robinson, A. C., Gerhard, A., Richardson, A., Neary, D., Snowden, J., Mann, D. M. A. & Pickering-Brown, S. M., Aug 2012, In : Neurobiology of Aging. 33, 8, p. 1846

    Research output: Contribution to journalArticle

  63. Published

    Semantic dementia associated with corticobasal syndrome: A further variant of frontotemporal lobe degeneration?

    Snowden, J., Luzzi, S., Cafazzo, V., Silvestrini, M., Provinciali, L., Pickering-Brown, S., Mann, D. & Snowden, J. S., Jul 2012, In : Journal of Neurology. 259, 7, p. 1478-1480 2 p.

    Research output: Contribution to journalArticle

  64. Published

    Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study

    Majounie, E., Renton, A. E., Mok, K., Dopper, E. G. P., Waite, A., Rollinson, S., Chiò, A., Restagno, G., Nicolaou, N., Simon-Sanchez, J., van Swieten, J. C., Abramzon, Y., Johnson, J. O., Sendtner, M., Pamphlett, R., Orrell, R. W., Mead, S., Sidle, K. C., Houlden, H., Rohrer, J. D. & 40 others, Morrison, K. E., Pall, H., Talbot, K., Ansorge, O., Hernandez, D. G., Arepalli, S., Sabatelli, M., Mora, G., Corbo, M., Giannini, F., Calvo, A., Englund, E., Borghero, G., Floris, G. L., Remes, A. M., Laaksovirta, H., McCluskey, L., Trojanowski, J. Q., Van Deerlin, V. M., Schellenberg, G. D., Nalls, M. A., Drory, V. E., Lu, C. S., Yeh, T. H., Ishiura, H., Takahashi, Y., Tsuji, S., Le Ber, I., Brice, A., Drepper, C., Williams, N., Kirby, J., Shaw, P., Hardy, J., Tienari, P. J., Heutink, P., Morris, H. R., Pickering-Brown, S., Traynor, B. J. & Snowden, J., Apr 2012, In : The Lancet Neurology. 11, 4, p. 323-330 7 p.

    Research output: Contribution to journalArticle

  65. Published

    Analysis of optineurin in frontotemporal lobar degeneration

    Rollinson, S., Bennion, J., Toulson, G., Halliwell, N., Usher, S., Snowden, J., Richardson, A., Neary, D., Mann, D. & Pickering-Brown, S. M., Feb 2012, In : Neurobiology of Aging. 33, 2, p. 425-e2

    Research output: Contribution to journalArticle

  66. Published

    The chromosome 9 ALS and FTD locus is probably derived from a single founder

    Mok, K., Traynor, B. J., Schymick, J., Tienari, P. J., Laaksovirta, H., Peuralinna, T., Myllykangas, L., Chiò, A., Shatunov, A., Boeve, B. F., Boxer, A. L., DeJesus-Hernandez, M., Mackenzie, I. R., Waite, A., Williams, N., Morris, H. R., Simón-Sánchez, J., van Swieten, J. C., Heutink, P., Restagno, G. & 10 others, Mora, G., Morrison, K. E., Shaw, P. J., Rollinson, P. S., Al-Chalabi, A., Rademakers, R., Pickering-Brown, S., Orrell, R. W., Nalls, M. A. & Hardy, J., Jan 2012, In : Neurobiology of Aging. 33, 1, p. 209-e8

    Research output: Contribution to journalArticle

  67. Published

    Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations

    Snowden, J., Snowden, J. S., Rollinson, S., Thompson, J. C., Harris, J. M., Stopford, C. L., Richardson, A. M. T., Jones, M., Gerhard, A., Davidson, Y. S., Robinson, A., Gibbons, L., Hu, Q., DuPlessis, D., Neary, D., Mann, D. M. A. & Pickering-Brown, S. M., 2012, In : Brain. 135, 3, p. 693-708 16 p.

    Research output: Contribution to journalArticle

  68. Published

    Distinct clinical characteristics in patients with frontotemporal dementia and C9ORF72 mutations: a study of demographics, neurology, behaviour, cognition and histopathology

    Snowden, JS., Rollinson, S., Thompson, J., Harris, J., Stopford, C., Richardson, A., Jones, M., Gerhard, A., Davidson, Y., Robinson, A., Gibbons, L., Hu, Q., DuPlessis, D., Neary, D., Mann, D. & Pickering-Brown, S., 2012, In : Brain.

    Research output: Contribution to journalArticle

  69. Published

    Next generation sequencing of CLU, PICALM and CR1: Pitfalls and potential solutions

    Lord, J., Turton, J., Medway, C., Shi, H., Brown, K., Lowe, J., Mann, D., Pickering-Brown, S., Kalsheker, N., Passmore, P. & Morgan, K., 2012, In : International Journal of Molecular Epidemiology and Genetics. 3, 4, p. 262-275 13 p.

    Research output: Contribution to journalArticle

  70. 2011
  71. Published

    TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's Syndrome: Association with age, hippocampal sclerosis and clinical phenotype

    Davidson, Y. S., Raby, S., Foulds, P. G., Robinson, A., Thompson, J. C., Sikkink, S., Yusuf, I., Amin, H., Duplessis, D., Troakes, C., Al-Sarraj, S., Sloan, C., Esiri, M. M., Prasher, V. P., Allsop, D., Neary, D., Pickering-Brown, S. M., Snowden, J. S. & Mann, D. M. A., Dec 2011, In : Acta neuropathologica. 122, 6, p. 703-713 10 p.

    Research output: Contribution to journalArticle

  72. Published

    A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

    Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., Kalimo, H., Paetau, A., Abramzon, Y., Remes, A. M., Kaganovich, A., Scholz, S. W., Duckworth, J., Ding, J., Harmer, D. W., Hernandez, D. G. & 56 others, Johnson, J. O., Mok, K., Ryten, M., Trabzuni, D., Guerreiro, R. J., Orrell, R. W., Neal, J., Murray, A., Pearson, J., Jansen, I. E., Sondervan, D., Seelaar, H., Blake, D., Young, K., Halliwell, N., Callister, J. B., Toulson, G., Richardson, A., Gerhard, A., Snowden, J., Mann, D., Neary, D., Nalls, M. A., Peuralinna, T., Jansson, L., Isoviita, V. M., Kaivorinne, A. L., Hölttä-Vuori, M., Ikonen, E., Sulkava, R., Benatar, M., Wuu, J., Chiò, A., Restagno, G., Borghero, G., Sabatelli, M., Heckerman, D., Rogaeva, E., Zinman, L., Rothstein, J. D., Sendtner, M., Drepper, C., Eichler, E. E., Alkan, C., Abdullaev, Z., Pack, S. D., Dutra, A., Pak, E., Hardy, J., Singleton, A., Williams, N. M., Heutink, P., Pickering-Brown, S., Morris, H. R., Tienari, P. J. & Traynor, B. J., 20 Oct 2011, In : Neuron. 72, 2, p. 257-268 11 p.

    Research output: Contribution to journalArticle

  73. Published

    UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting

    Stefani, F., Zhang, L., Taylor, S., Donovan, J., Rollinson, S., Doyotte, A., Brownhill, K., Bennion, J., Pickering-Brown, S. & Woodman, P., 26 Jul 2011, In : Current Biology. 21, 14, p. 1245-1250 5 p.

    Research output: Contribution to journalArticle

  74. Published

    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Höglinger, G. U., Melhem, N. M., Dickson, D. W., Sleiman, P. M. A., Wang, L. S., Klei, L., Rademakers, R., De Silva, R., Litvan, I., Riley, D. E., Van Swieten, J. C., Heutink, P., Wszolek, Z. K., Uitti, R. J., Vandrovcova, J., Hurtig, H. I., Gross, R. G., Maetzler, W., Goldwurm, S., Tolosa, E. & 116 others, Borroni, B., Pastor, P., Cantwell, L. B., Han, M. R., Dillman, A., Van Der Brug, M. P., Gibbs, J. R., Cookson, M. R., Hernandez, D. G., Singleton, A. B., Farrer, M. J., Yu, C. E., Golbe, L. I., Revesz, T., Hardy, J., Lees, A. J., Devlin, B., Hakonarson, H., Müller, U., Schellenberg, G. D., Albin, R. L., Alonso, E., Antonini, A., Apfelbacher, M., Arnold, S. E., Avila, J., Beach, T. G., Beecher, S., Berg, D., Bird, T. D., Bogdanovic, N., Boon, A. J. W., Bordelon, Y., Brice, A., Budka, H., Canesi, M., Chiu, W. Z., Cilia, R., Colosimo, C., De Deyn, P. P., De Yebenes, J. G., Kaat, L. D., Duara, R., Durr, A., Engelborghs, S., Fabbrini, G., Finch, N. A., Flook, R., Frosch, M. P., Gaig, C., Galasko, D. R., Gasser, T., Gearing, M., Geller, E. T., Ghetti, B., Graff-Radford, N. R., Grossman, M., Hall, D. A., Hazrati, L. N., Höllerhage, M., Jankovic, J., Juncos, J. L., Karydas, A., Kretzschmar, H. A., Leber, I., Lee, V. M., Lieberman, A. P., Lyons, K. E., Mariani, C., Masliah, E., Massey, L. A., McLean, C. A., Meucci, N., Miller, B. L., Mollenhauer, B., Möller, J. C., Morris, H. R., Morris, C., O'Sullivan, S. S., Oertel, W. H., Ottaviani, D., Padovani, A., Pahwa, R., Pezzoli, G., Pickering-Brown, S., Poewe, W., Rabano, A., Rajput, A., Reich, S. G., Respondek, G., Roeber, S., Rohrer, J. D., Ross, O. A., Rossor, M. N., Sacilotto, G., Seeley, W. W., Seppi, K., Silveira-Moriyama, L., Spina, S., Srulijes, K., St. George-Hyslop, P., Stamelou, M., Standaert, D. G., Tesei, S., Tourtellotte, W. W., Trenkwalder, C., Troakes, C., Trojanowski, J. Q., Troncoso, J. C., Van Deerlin, V. M., Vonsattel, J. P. G., Wenning, G. K., White, C. L., Winter, P., Zarow, C. & Zecchinelli, A. L., Jul 2011, In : Nature Genetics. 43, 7, p. 699-705 6 p.

    Research output: Contribution to journalArticle

  75. Published

    The most common type of FTLD-FUS (aFTLD-U) is associated with a distinct clinical form of frontotemporal dementia but is not related to mutations in the FUS gene

    Snowden, J., Snowden, J. S., Hu, Q., Rollinson, S., Halliwell, N., Robinson, A., Davidson, Y. S., Momeni, P., Baborie, A., Griffiths, T. D., Jaros, E., Perry, R. H., Richardson, A., Pickering-Brown, S. M., Neary, D. & Mann, D. M. A., Jul 2011, In : Acta neuropathologica. 122, 1, p. 99-110 11 p.

    Research output: Contribution to journalArticle

  76. Published

    Frontotemporal lobar degeneration genome wide association study replication confirms a risk locus shared with amyotrophic lateral sclerosis

    Rollinson, S., Mead, S., Snowden, J., Richardson, A., Rohrer, J., Halliwell, N., Usher, S., Neary, D., Mann, D., Hardy, J. & Pickering-Brown, S., Apr 2011, In : Neurobiology of Aging. 32, 4, p. 758-e7

    Research output: Contribution to journalArticle

  77. Published

    Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration

    Chen-Plotkin, A. S., Martinez-Lage, M., Sleiman, P. M. A., Hu, W., Greene, R., Wood, E. M., Bing, S., Grossman, M., Schellenberg, G. D., Hatanpaa, K. J., Weiner, M. F., White, C. L., Brooks, W. S., Halliday, G. M., Kril, J. J., Gearing, M., Beach, T. G., Graff-Radford, N. R., Dickson, D. W., Rademakers, R. & 36 others, Boeve, B. F., Pickering-Brown, S. M., Snowden, J., Van Swieten, J. C., Heutink, P., Seelaar, H., Murrell, J. R., Ghetti, B., Spina, S., Grafman, J., Kaye, J. A., Woltjer, R. L., Mesulam, M., Bigio, E., Lladó, A., Miller, B. L., Alzualde, A., Moreno, F., Rohrer, J. D., Mackenzie, I. R. A., Feldman, H. H., Hamilton, R. L., Cruts, M., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Bird, T. D., Cairns, N. J., Goate, A., Frosch, M. P., Riederer, P. F., Bogdanovic, N., Lee, V. M. Y., Trojanowski, J. Q., Van Deerlin, V. M. & Mann, D., Apr 2011, In : Archives of Neurology. 68, 4, p. 488-497 9 p.

    Research output: Contribution to journalArticle

  78. Published

    No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration

    Rollinson, S., Rohrer, J. D., van der Zee, J., Sleegers, K., Mead, S., Engelborghs, S., Collinge, J., De Deyn, P. P., Mann, D. M. A., Van Broeckhoven, C. & Pickering-Brown, S. M., Apr 2011, In : Neurobiology of Aging. 32, 4, p. 754-755 1 p.

    Research output: Contribution to journalArticle

  79. Published

    Pathological correlates of frontotemporal lobar degeneration in the elderly

    Baborie, A., Griffiths, T. D., Jaros, E., McKeith, I. G., Burn, D. J., Richardson, A., Ferrari, R., Moreno, J., Momeni, P., Duplessis, D., Pal, P., Rollinson, S., Pickering-Brown, S., Thompson, J. C., Neary, D., Snowden, J. S., Perry, R. & Mann, D. M. A., Mar 2011, In : Acta neuropathologica. 121, 3, p. 365-371 6 p.

    Research output: Contribution to journalArticle

  80. 2010
  81. Published

    Effect of topographical distribution of alpha-synuclein pathology on TDP-43 accumulation in Lewy body disease.

    Yokota, O., Davidson, Y., Arai, T., Hasegawa, M., Akiyama, H., Ishizu, H., Terada, S., Sikkink, S., Pickering-Brown, S. & Mann, DM., 29 Jul 2010, In : Acta Neuropathol.

    Research output: Contribution to journalArticle

  82. Published

    FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration

    Urwin, H., Josephs, K. A., Rohrer, J. D., MacKenzie, I. R., Neumann, M., Authier, A., Seelaar, H., Van Swieten, J. C., Brown, J. M., Johannsen, P., Nielsen, J. E., Holm, I. E., Dickson, D. W., Rademakers, R., Graff-Radford, N. R., Parisi, J. E., Petersen, R. C., Hatanpaa, K. J., White, C. L., Weiner, M. F. & 27 others, Geser, F., Van Deerlin, V. M., Trojanowski, J. Q., Miller, B. L., Seeley, W. W., Van Der Zee, J., Kumar-Singh, S., Engelborghs, S., De Deyn, P. P., Van Broeckhoven, C., Bigio, E. H., Deng, H. X., Halliday, G. M., Kril, J. J., Munoz, D. G., Mann, D. M., Pickering-Brown, S. M., Doodeman, V., Adamson, G., Ghazi-Noori, S., Fisher, E. M. C., Holton, J. L., Revesz, T., Rossor, M. N., Collinge, J., Mead, S. & Isaacs, A. M., Jul 2010, In : Acta neuropathologica. 120, 1, p. 33-41 8 p.

    Research output: Contribution to journalArticle

  83. Published

    Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy

    Yokota, O., Davidson, Y., Bigio, E. H., Ishizu, H., Terada, S., Arai, T., Hasegawa, M., Akiyama, H., Sikkink, S., Pickering-Brown, S. & Mann, D. M. A., Jul 2010, In : Acta neuropathologica. 120, 1, p. 55-66 11 p.

    Research output: Contribution to journalArticle

  84. Published

    Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

    Van Deerlin, V. M., Sleiman, P. M. A., Martinez-Lage, M., Chen-Plotkin, A., Wang, L. S., Graff-Radford, N. R., Dickson, D. W., Rademakers, R., Boeve, B. F., Grossman, M., Arnold, S. E., Mann, D. M. A., Pickering-Brown, S. M., Seelaar, H., Heutink, P., Van Swieten, J. C., Murrell, J. R., Ghetti, B., Spina, S., Grafman, J. & 80 others, Hodges, J., Spillantini, M. G., Gilman, S., Lieberman, A. P., Kaye, J. A., Woltjer, R. L., Bigio, E. H., Mesulam, M., Al-Sarraj, S., Troakes, C., Rosenberg, R. N., White, C. L., Ferrer, I., Lladó, A., Neumann, M., Kretzschmar, H. A., Hulette, C. M., Welsh-Bohmer, K. A., Miller, B. L., Alzualde, A., De Munain, A. L., McKee, A. C., Gearing, M., Levey, A. I., Lah, J. J., Hardy, J., Rohrer, J. D., Lashley, T., MacKenzie, I. R. A., Feldman, H. H., Hamilton, R. L., Dekosky, S. T., Van Der Zee, J., Kumar-Singh, S., Van Broeckhoven, C., Mayeux, R., Vonsattel, J. P. G., Troncoso, J. C., Kril, J. J., Kwok, J. B. J., Halliday, G. M., Bird, T. D., Ince, P. G., Shaw, P. J., Cairns, N. J., Morris, J. C., McLean, C. A., Decarli, C., Ellis, W. G., Freeman, S. H., Frosch, M. P., Growdon, J. H., Perl, D. P., Sano, M., Bennett, D. A., Schneider, J. A., Beach, T. G., Reiman, E. M., Woodruff, B. K., Cummings, J., Vinters, H. V., Miller, C. A., Chui, H. C., Alafuzoff, I., Hartikainen, P., Seilhean, D., Galasko, D., Masliah, E., Cotman, C. W., Tũón, M. T., Martínez, M. C. C., Munoz, D. G., Carroll, S. L., Marson, D., Riederer, P. F., Bogdanovic, N., Schellenberg, G. D., Hakonarson, H., Trojanowski, J. Q. & Lee, V. M. Y., Mar 2010, In : Nature Genetics. 42, 3, p. 234-239 5 p.

    Research output: Contribution to journalArticle

  85. Published

    FTLD GWAS Replication confirms a risk locus shared with ALS

    Rollinson, S., Mead, S., Snowden, J., Richardson, A., Rohrer, J., Halliwell, N., Usher, S., Neary, D., Mann, D., Hardy, J. & Pickering-Brown, S., 2010, In : Neurobiol Aging.

    Research output: Contribution to journalArticle

  86. Published

    Review: Recent progress in frontotemporal lobar degeneration

    Pickering-Brown, S. M., 2010, In : Neuropathology and Applied Neurobiology. 36, 1, p. 4-16 12 p.

    Research output: Contribution to journalArticle

  87. 2009
  88. Published

    Prominent phenotypic variability associated with mutations in Progranulin

    Kelley, B. J., Haidar, W., Boeve, B. F., Baker, M., Graff-Radford, N. R., Krefft, T., Frank, A. R., Jack, C. R., Shiung, M., Knopman, D. S., Josephs, K. A., Parashos, S. A., Rademakers, R., Hutton, M., Pickering-Brown, S., Adamson, J., Kuntz, K. M., Dickson, D. W., Parisi, J. E., Smith, G. E. & 2 others, Ivnik, R. J. & Petersen, R. C., May 2009, In : Neurobiology of Aging. 30, 5, p. 739-751 12 p.

    Research output: Contribution to journalArticle

  89. Published

    Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration

    Rollinson, S., Rizzu, P., Sikkink, S., Baker, M., Halliwell, N., Snowden, J., Traynor, B. J., Ruano, D., Cairns, N., Rohrer, J. D., Mead, S., Collinge, J., Rossor, M., Akay, E., Guerreiro, R., Rademakers, R., Morrison, K. E., Pastor, P., Alonso, E., Martinez-Lage, P. & 6 others, Graff-Radford, N., Neary, D., Heutink, P., Mann, D. M. A., Van Swieten, J. & Pickering-Brown, S. M., Apr 2009, In : Neurobiology of Aging. 30, 4, p. 656-665 9 p.

    Research output: Contribution to journalArticle

  90. Published

    Recent origin and spread of a common Welsh MAPT splice mutation causing frontotemporal lobar degeneration

    Colombo, R., Tavian, D., Baker, M. C., Richardson, A. M. T., Snowden, J. S., Neary, D., Mann, D. M. A. & Pickering-Brown, S. M., 2009, In : Neurogenetics. 10, 4, p. 313-318 5 p.

    Research output: Contribution to journalArticle

  91. Published

    TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: A degenerative process distinct from normal ageing

    Davidson, Y., Amin, H., Kelley, T., Shi, J., Tian, J., Kumaran, R., Lashley, T., Lees, A. J., DuPlessis, D., Neary, D., Snowden, J., Akiyama, H., Arai, T., Hasegawa, M., Bandopadhyay, R., Sikkink, S., Pickering-Brown, S. & Mann, D. M. A., 2009, In : Acta neuropathologica. 118, 3, p. 359-369 10 p.

    Research output: Contribution to journalArticle

  92. 2008
  93. Published

    TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration

    Foulds, P., McAuley, E., Gibbons, L., Davidson, Y., Pickering-Brown, S. M., Neary, D., Snowden, J. S., Allsop, D. & Mann, D. M. A., Aug 2008, In : Acta neuropathologica. 116, 2, p. 141-146 5 p.

    Research output: Contribution to journalArticle

  94. Published

    Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene

    Rohrer, J. D., Warren, J. D., Omar, R., Mead, S., Beck, J., Revesz, T., Holton, J., Stevens, J. M., Al-Sarraj, S., Pickering-Brown, S. M., Hardy, J., Fox, N. C., Collinge, J., Warrington, E. K. & Rossor, M. N., Apr 2008, In : Archives of Neurology. 65, 4, p. 506-513 7 p.

    Research output: Contribution to journalArticle

  95. Published

    Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: Comparison with patients with MAPT and no known mutations

    Pickering-Brown, S. M., Rollinson, S., Du Plessis, D., Morrison, K. E., Varma, A., Richardson, A. M. T., Neary, D., Snowden, J. S. & Mann, D. M. A., Mar 2008, In : Brain. 131, 3, p. 721-731 10 p.

    Research output: Contribution to journalArticle

  96. Published

    The genetics of frontotemporal dementia

    Pickering-Brown, S. & Hutton, M., 2008, In : Handbook of Clinical Neurology. 89, p. 383-392 9 p.

    Research output: Contribution to journalArticle

  97. 2007
  98. Published

    The genetics of frontotemporal lobar degeneration

    Pickering-Brown, S., Sikkink, S., Rollinson, S. & Pickering-Brown, S. M., Dec 2007, In : Current Opinion in Neurology. 20, 6, p. 693-698 5 p.

    Research output: Contribution to journalArticle

  99. Published

    Familial early-onset dementia with tau intron 10 + 16 mutation with clinical features similar to those of Alzheimer disease

    Doran, M., Du Plessis, D. G., Ghadiali, E. J., Mann, D. M. A., Pickering-Brown, S. & Larner, A. J., Oct 2007, In : Archives of Neurology. 64, 10, p. 1535-1539 4 p.

    Research output: Contribution to journalArticle

  100. Published

    Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C→T (Arg493X) mutation: an international initiative

    Rademakers, R., Baker, M., Gass, J., Adamson, J., Huey, E. D., Momeni, P., Spina, S., Coppola, G., Karydas, A. M., Stewart, H., Johnson, N., Hsiung, G. Y., Kelley, B., Kuntz, K., Steinbart, E., Wood, E. M., Yu, C. E., Josephs, K., Sorenson, E., Womack, K. B. & 30 others, Weintraub, S., Pickering-Brown, S. M., Schofield, P. R., Brooks, W. S., Van Deerlin, V. M., Snowden, J., Clark, C. M., Kertesz, A., Boylan, K., Ghetti, B., Neary, D., Schellenberg, G. D., Beach, T. G., Mesulam, M., Mann, D., Grafman, J., Mackenzie, I. R., Feldman, H., Bird, T., Petersen, R., Knopman, D., Boeve, B., Geschwind, D. H., Miller, B., Wszolek, Z., Lippa, C., Bigio, E. H., Dickson, D., Graff-Radford, N. & Hutton, M., Oct 2007, In : The Lancet Neurology. 6, 10, p. 857-868 11 p.

    Research output: Contribution to journalArticle

  101. Published

    Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43

    Zhang, Y. J., Xu, Y. F., Dickey, C. A., Buratti, E., Baralle, F., Bailey, R., Pickering-Brown, S., Dickson, D. & Petrucelli, L., 26 Sep 2007, In : Journal of Neuroscience. 27, 39, p. 10530-10534 4 p.

    Research output: Contribution to journalArticle

  102. Published

    Progranulin and frontotemporal lobar degeneration

    Pickering-Brown, S. M., Jul 2007, In : Acta neuropathologica. 114, 1, p. 39-47 8 p.

    Research output: Contribution to journalArticle

  103. Published

    The complex aetiology of frontotemporal lobar degeneration

    Pickering-Brown, S. & Pickering-Brown, S. M., Jul 2007, In : Experimental neurology. 206, 1, p. 1-10 9 p.

    Research output: Contribution to journalArticle

  104. Published

    TDP-43 gene analysis in frontotemporal lobar degeneration

    Rollinson, S., Snowden, J. S., Neary, D., Morrison, K. E., Mann, D. M. A. & Pickering-Brown, S. M., 23 May 2007, In : Neuroscience letters. 419, 1, p. 1-4 3 p.

    Research output: Contribution to journalArticle

  105. Published

    Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43

    Davidson, Y., Kelley, T., Mackenzie, I. R. A., Pickering-Brown, S., Du Plessis, D., Neary, D., Snowden, J. S. & Mann, D. M. A., May 2007, In : Acta neuropathologica. 113, 5, p. 521-533 12 p.

    Research output: Contribution to journalArticle

  106. Published

    Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease.

    Davidson, Y., Gibbons, L., Pritchard, A., Hardicre, J., Wren, J., Stopford, C., Julien, C., Thompson, J., Payton, A., Pickering-Brown, S., Pendleton, N., Horan, M. A., Burns, AS., Purandare, N., Lendon, C., Neary, D., Snowden, JS. & Mann, D., 2007, In : Dement Geriatr Cogn Disord. 23( 1)

    Research output: Contribution to journalArticle

  107. 2006
  108. Published

    Sequence analysis of all identified open reading frames on the frontal temporal dementia haplotype on chromosome 3 fails to identify unique coding variants except in CHMP2B

    Pickering-Brown, S., Momeni, P., Bell, J., Duckworth, J., Hutton, M., Mann, D., Brown, S. P. & Hardy, J., 20 Dec 2006, In : Neuroscience letters. 410, 2, p. 77-79 2 p.

    Research output: Contribution to journalArticle

  109. Published

    Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

    Momeni, P., Schymick, J., Jain, S., Cookson, M. R., Cairns, N. J., Greggio, E., Greenway, M. J., Berger, S., Pickering-Brown, S., Chiò, A., Fung, H. C., Holtzman, D. M., Huey, E. D., Wassermann, E. M., Adamson, J., Hutton, M. L., Rogaeva, E., St George-Hyslop, P., Rothstein, J. D., Hardiman, O. & 4 others, Grafman, J., Singleton, A., Hardy, J. & Traynor, B. J., 13 Dec 2006, In : BMC Neurology. 6, 44.

    Research output: Contribution to journalArticle

  110. Published

    Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study

    Boeve, B. F., Baker, M., Dickson, D. W., Parisi, J. E., Giannini, C., Josephs, K. A., Hutton, M., Pickering-Brown, S. M., Rademakers, R., Tang-Wai, D., Jack, C. R., Kantarci, K., Shiung, M. M., Golde, T., Smith, G. E., Geda, Y. E., Knopman, D. S. & Petersen, R. C., Nov 2006, In : Brain : a journal of neurology. 129, Pt 11, p. 3103-14 12 p.

    Research output: Contribution to journalArticle

  111. Published

    Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: Classification and relation to clinical phenotype

    Mackenzie, I. R. A., Baborie, A., Pickering-Brown, S., Plessis, D. D., Jaros, E., Perry, R. H., Neary, D., Snowden, J. S. & Mann, D. M. A., Nov 2006, In : Acta neuropathologica. 112, 5, p. 539-549 10 p.

    Research output: Contribution to journalArticle

  112. Published

    Mutations in progranulin explain atypical phenotypes with variants in MAPT

    Pickering-Brown, S., Pickering-Brown, S. M., Baker, M., Gass, J., Boeve, B. F., Loy, C. T., Brooks, W. S., Mackenzie, I. R. A., Martins, R. N., Kwok, J. B. J., Halliday, G. M., Kril, J., Schofield, P. R., Mann, D. M. A. & Hutton, M., Nov 2006, In : Brain. 129, 11, p. 3124-3126 2 p.

    Research output: Contribution to journalArticle

  113. Published

    The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene

    Mackenzie, I. R. A., Baker, M., Pickering-Brown, S., Hsiung, G-Y. R., Lindholm, C., Dwosh, E., Gass, J., Cannon, A., Rademakers, R., Hutton, M. & Feldman, H. H., Nov 2006, In : Brain : a journal of neurology. 129, Pt 11, p. 3081-90 10 p.

    Research output: Contribution to journalArticle

  114. Published

    Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

    Gass, J., Cannon, A., Mackenzie, I. R., Boeve, B., Baker, M., Adamson, J., Crook, R., Melquist, S., Kuntz, K., Petersen, R., Josephs, K., Pickering-Brown, S. M., Graff-Radford, N., Uitti, R., Dickson, D., Wszolek, Z., Gonzalez, J., Beach, T. G., Bigio, E., Johnson, N. & 10 others, Weintraub, S., Mesulam, M., White, C. L., Woodruff, B., Caselli, R., Hsiung, G-Y., Feldman, H., Knopman, D., Hutton, M. & Rademakers, R., 15 Oct 2006, In : Human Molecular Genetics. 15, 20, p. 2988-3001 14 p.

    Research output: Contribution to journalArticle

  115. Published

    Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

    Pickering-Brown, S., Baker, M., Mackenzie, I. R., Pickering-Brown, S. M., Gass, J., Rademakers, R., Lindholm, C., Snowden, J., Adamson, J., Sadovnick, A. D., Rollinson, S., Cannon, A., Dwosh, E., Neary, D., Melquist, S., Richardson, A., Dickson, D., Berger, Z., Eriksen, J., Robinson, T. & 8 others, Zehr, C., Dickey, C. A., Crook, R., McGowan, E., Mann, D., Boeve, B., Feldman, H. & Hutton, M., 24 Aug 2006, In : Nature. 442, 7105, p. 916-919 3 p.

    Research output: Contribution to journalArticle

  116. Published

    Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease

    Shiarli, A. M., Jennings, R., Shi, J., Bailey, K., Davidson, Y., Tian, J., Bigio, E. H., Ghetti, B., Murrell, J. R., Delisle, M. B., Mirra, S., Crain, B., Zolo, P., Arima, K., Iseki, E., Murayama, S., Kretzschmar, H., Neumann, M., Lippa, C., Halliday, G. & 8 others, MacKenzie, J., Khan, N., Ravid, R., Dickson, D., Wszolek, Z., Iwatsubo, T., Pickering-Brown, S. M. & Mann, D. M. A., Aug 2006, In : Neuropathology and Applied Neurobiology. 32, 4, p. 374-387 13 p.

    Research output: Contribution to journalArticle

  117. Published

    CHMP2B mutations are not a common cause of frontotemporal lobar degeneration

    Cannon, A., Baker, M., Boeve, B., Josephs, K., Knopman, D., Petersen, R., Parisi, J., Dickison, D., Adamson, J., Snowden, J., Neary, D., Mann, D., Hutton, M. & Pickering-Brown, S. M., 1 May 2006, In : Neuroscience letters. 398, 1-2, p. 83-84 1 p.

    Research output: Contribution to journalArticle

  118. Published

    A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17

    Mackenzie, I. R., Baker, M., West, G., Woulfe, J., Qadi, N., Gass, J., Cannon, A., Adamson, J., Feldman, H., Lindholm, C., Melquist, S., Pettman, R., Sadovnick, A. D., Dwosh, E., Whiteheart, S. W., Hutton, M. & Pickering-Brown, S. M., Apr 2006, In : Brain. 129, 4, p. 853-867 14 p.

    Research output: Contribution to journalArticle

  119. Published

    An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies

    Pickering-Brown, S., de Silva, R., Lashley, T., Strand, C., Shiarli, A. M., Shi, J., Tian, J., Bailey, K. L., Davies, P., Bigio, E. H., Arima, K., Iseki, E., Murayama, S., Kretzschmar, H., Neumann, M., Lippa, C., Halliday, G., MacKenzie, J., Ravid, R., Dickson, D. & 7 others, Wszolek, Z., Iwatsubo, T., Pickering-Brown, S. M., Holton, J., Lees, A., Revesz, T. & Mann, D. M. A., Apr 2006, In : Acta neuropathologica. 111, 4, p. 329-340 11 p.

    Research output: Contribution to journalArticle

  120. Published

    Genetic associations between cathepsin D exon 2 C→T polymorphism and Alzheimer's disease, and pathological correlations with genotype

    Davidson, Y., Gibbons, L., Pritchard, A., Hardicre, J., Wren, J., Tian, J., Shi, J., Stopford, C., Julien, C., Thompson, J., Payton, A., Thaker, U., Hayes, A. J., Iwatsubo, T., Pickering-Brown, S. M., Pendleton, N., Horan, M. A., Burns, A., Purandare, N., Lendon, C. L. & 3 others, Neary, D., Snowden, J. S. & Mann, D. M. A., Apr 2006, In : Journal of Neurology, Neurosurgery and Psychiatry. 77, 4, p. 515-517 2 p.

    Research output: Contribution to journalArticle

  121. Published

    The apolipoprotein E ε4 allele selectively increases the risk of frontotemporal lobar degeneration in males

    Srinivasan, R., Davidson, Y., Gibbons, L., Payton, A., Richardson, A. M. T., Varma, A., Julien, C., Stopford, C., Thompson, J., Horan, M. A., Pendleton, N., Pickering-Brown, S. M., Neary, D., Snowden, J. S. & Mann, D. M. A., Feb 2006, In : Journal of Neurology, Neurosurgery and Psychiatry. 77, 2, p. 154-158 4 p.

    Research output: Contribution to journalArticle

  122. Published

    CHMP2B mutations are not a common cause of Fontotemporal Lobar Degeneration

    Cannon, A., Baker, M., Boeve, B., Josephs, K., Knopman, D., Peterson, R., Dickson, D., Adamson, J., Snowden, J., Neary, D., Mann, D., Hutton, M. & Pickering-Brown, S., 2006, In : Neurosci Lett. 398

    Research output: Contribution to journalArticle

  123. Published

    Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).

    Wszolek, Z., Tsuboi, Y., Ghetti, B., Pickering-Brown, S., Baba, Y. & Cheshire, W., 2006, In : Orphanet J Rare Dis. 1

    Research output: Contribution to journalArticle

  124. 2005
  125. Published

    Histopathological changes underlying frontotemporal lobar degeneration with clinicopathological correlation

    Shi, J., Shaw, C. L., Du Plessis, D., Richardson, A. M. T., Bailey, K. L., Julien, C., Stopford, C., Thompson, J., Varma, A., Craufurd, D., Tian, J., Pickering-Brown, S., Neary, D., Snowden, J. S. & Mann, D. M. A., Nov 2005, In : Acta neuropathologica. 110, 5, p. 501-512 11 p.

    Research output: Contribution to journalArticle

  126. Published

    The Effect of tau genotype on clinical features in FTDP-17

    Baba, Y., Tsuboi, Y., Baker, M. C., Uitti, R. J., Hutton, M. L., Dickson, D. W., Farrer, M., Putzke, J. D., Woodruff, B. K., Ghetti, B., Murrell, J. R., Boeve, B. F., Petersen, R. C., Verpillat, P., Brice, A., Delisle, M. B., Rascol, O., Arima, K., Dysken, M. W., Yasuda, M. & 11 others, Kobayashi, T., Sunohara, N., Komure, O., Kuno, S., Sperfeld, A. D., Stoppe, G., Kohlhase, J., Pickering-Brown, S., Neary, D., Bugiani, O. & Wszolek, Z. K., Jun 2005, In : Parkinsonism and Related Disorders. 11, 4, p. 205-208 3 p.

    Research output: Contribution to journalArticle

  127. 2004
  128. Published

    Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene

    Pickering-Brown, S. M., Baker, M., Nonaka, T., Ikeda, K., Sharma, S., Mackenzie, J., Simpson, S. A., Moore, J. W., Snowden, J. S., De Silva, R., Revesz, T., Hasegawa, M., Hutton, M., Mann, D. M. A. & Bailey, K., Jun 2004, In : Brain. 127, 6, p. 1415-1426 11 p.

    Research output: Contribution to journalArticle

  129. Published

    The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein

    Taniguchi, S., McDonagh, A. M., Pickering-Brown, S. M., Umeda, Y., Iwatsubo, T., Hasegawa, M. & Mann, D. M. A., Feb 2004, In : Neuropathology and Applied Neurobiology. 30, 1, p. 1-18 17 p.

    Research output: Contribution to journalArticle

  130. Published

    Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease

    Busby, V., Goossens, S., Nowotny, P., Hamilton, G., Smemo, S., Harold, D., Turic, D., Jehu, L., Myers, A., Womick, M., Woo, D., Compton, D., Doil, L. M., Tacey, K. M., Lau, K. F., Al-Saraj, S., Killick, R., Pickering-Brown, S., Moore, P., Hollingworth, P. & 21 others, Archer, N., Foy, C., Walter, S., Lendon, C., Iwatsubo, T., Morris, J. C., Norton, J., Mann, D., Janssens, B., Hardy, J., O'Donovan, M., Jones, L., Williams, J., Holmans, P., Owen, M. J., Grupe, A., Powell, J., van Hengel, J., Goate, A., Van Roy, F. & Lovestone, S., 2004, In : Neuromolecular medicine. 5, 2, p. 133-146 14 p.

    Research output: Contribution to journalArticle

  131. Published

    The tau gene locus and frontotemporal dementia

    Pickering-Brown, S., 2004, In : Dementia and Geriatric Cognitive Disorders. 17, 4, p. 258-60 3 p.

    Research output: Contribution to journalArticle

  132. 2003
  133. Published

    Tau load is associated with apolipoprotein E genotype and the amount of amyloid beta protein, Abeta40, in sporadic and familial Alzheimer's disease

    Thaker, U., McDonagh, A. M., Iwatsubo, T., Lendon, C. L., Pickering-Brown, S. M. & Mann, D. M. A., Feb 2003, In : Neuropathology and Applied Neurobiology. 29, 1, p. 35-44 10 p.

    Research output: Contribution to journalArticle

  134. 2002
  135. Published

    Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease

    Hayes, A., Thaker, U., Iwatsubo, T., Pickering-Brown, S. M. & Mann, D. M. A., 18 Oct 2002, In : Neuroscience letters. 331, 3, p. 171-4 4 p.

    Research output: Contribution to journalArticle

  136. Published

    A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain

    Green, E. K., Thaker, U., McDonagh, A. M., Iwatsubo, T., Lambert, J-C., Chartier-Harlin, M-C., Harris, J. M., Pickering-Brown, S. M., Lendon, C. L. & Mann, D. M. A., 17 May 2002, In : Neuroscience letters. 324, 2, p. 113-6 4 p.

    Research output: Contribution to journalArticle

  137. Published

    Inherited frontotemporal dementia in 9 British families associated with intronic mutations in the tau gene.

    Pickering-Brown, S. M., Richardson, A. M. T., Snowden, J. S., McDonagh, A. M., Burns, A., Braude, W., Baker, M., Liu, W-K., Yen, S-H., Hardy, J., Hutton, M., Davies, Y., Allsop, D., Craufurd, D., Neary, D. & Mann, D. M. A., Apr 2002, In : Brain. 125, 4, p. 732-51 20 p.

    Research output: Contribution to journalArticle

  138. Published

    Sporadic Pick's disease: A tauopathy characterized by a spectrum of pathological τ isoforms in gray and white matter

    Zhukareva, V., Mann, D., Pickering-Brown, S., Uryu, K., Shuck, T., Shah, K., Grossman, M., Miller, B. L., Hulette, C. M., Feinstein, S. C., Trojanowski, J. Q. & Lee, V. M. Y., 2002, In : Annals of Neurology. 51, 6, p. 730-739 9 p.

    Research output: Contribution to journalArticle

  139. 2001
  140. Published

    Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype

    Houlden, H., Baker, M., Morris, H. R., MacDonald, N., Pickering-Brown, S., Adamson, J., Lees, A. J., Rossor, M. N., Quinn, N. P., Kertesz, A., Khan, M. N., Hardy, J., Lantos, P. L., St George-Hyslop, P., Munoz, D. G., Mann, D., Lang, A. E., Bergeron, C., Bigio, E. H., Litvan, I. & 4 others, Bhatia, K. P., Dickson, D., Wood, N. W. & Hutton, M., 26 Jun 2001, In : Neurology. 56, 12, p. 1702-6 5 p.

    Research output: Contribution to journalArticle

  141. Published

    Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype.

    Mann, D., McDonagh, A., Pickering-Brown, S., Kowa, H. & Iwatsubo, T., 25 May 2001, In : Neurosci Lett. 304( 3)

    Research output: Contribution to journalArticle

  142. Published

    The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease

    Russ, C., Lovestone, S., Baker, M., Pickering-Brown, S. M., Andersen, P. M., Furlong, R., Mann, D. & Powell, J. F., 16 Feb 2001, In : Neuroscience letters. 299, 1-2, p. 156-8 3 p.

    Research output: Contribution to journalArticle

  143. Published

    The status of "Pick's Disease" and other tauopathies within the frontotemporal dementias

    Manna, D. M. & Pickering-Brown, S., 13 Feb 2001, In : Neurobiology of Aging. 22, 1, p. 109-11 3 p.

    Research output: Contribution to journalArticle

  144. Published

    Clinical features of dementia associated with apolipoprotein ε4: Discrimination with a neural network genetic algorithm

    Jefferson, M. F., Burlinson, S., Burns, A., Mann, D., Pickering-Brown, S., Owen, F., Sriwardhana, C., Pendleton, N. & Horan, M. A., Jan 2001, In : International journal of geriatric psychiatry. 16, 1, p. 77-81 5 p.

    Research output: Contribution to journalArticle

  145. 2000
  146. Published

    Pick's disease is associated with mutations in the tau gene

    Pickering-Brown, S., Baker, M., Yen, S. H., Liu, W. K., Hasegawa, M., Cairns, N., Lantos, P. L., Rossor, M., Iwatsubo, T., Davies, Y., Allsop, D., Furlong, R., Owen, F., Hardy, J., Mann, D. & Hutton, M., Dec 2000, In : Annals of Neurology. 48, 6, p. 859-67 9 p.

    Research output: Contribution to journalArticle

  147. Published

    Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology

    Pickering-Brown, S. M., Owen, F., Isaacs, A., Snowden, J., Varma, A., Neary, D., Furlong, R., Daniel, S. E., Cairns, N. J. & Mann, D. M., Jun 2000, In : Experimental neurology. 163, 2, p. 452-6 5 p.

    Research output: Contribution to journalArticle

  148. Published

    Molecular classification of the dementias

    Mann, D. M., McDonagh, A. M., Snowden, J., Neary, D. & Pickering-Brown, S. M., 19 Feb 2000, In : Lancet (London, England). 355, 9204, p. 626

    Research output: Contribution to journalArticle

  149. 1999
  150. Published

    Frequency of tau mutations in three series of non-Alzheimer's degenerative dementia

    Houlden, H., Baker, M., Adamson, J., Grover, A., Waring, S., Dickson, D., Lynch, T., Boeve, B., Petersen, R. C., Pickering-Brown, S., Owen, F., Neary, D., Craufurd, D., Snowden, J., Mann, D. & Hutton, M., Aug 1999, In : Annals of Neurology. 46, 2, p. 243-8 6 p.

    Research output: Contribution to journalArticle

  151. Published

    5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10

    Grover, A., Houlden, H., Baker, M., Adamson, J., Lewis, J., Prihar, G., Pickering-Brown, S., Duff, K. & Hutton, M., 21 May 1999, In : The Journal of biological chemistry. 274, 21, p. 15134-43 10 p.

    Research output: Contribution to journalArticle

  152. Published

    Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

    Houlden, H., Rizzu, P., Stevens, M., de Knijff, P., van Duijn, C. M., van Swieten, J. C., Heutink, P., Perez-Tur, J., Thomas, V., Baker, M., Morris, H., Rossor, M., Jannsen, J. C., Petersen, R. C., Dodd, P., Dark, F., Boeve, B., Dickson, D., Davies, P., Pickering-Brown, S. & 5 others, Mann, D., Adamson, J., Lynch, T., Payami, H. & Hardy, J., 5 Feb 1999, In : Neuroscience letters. 260, 3, p. 193-5 3 p.

    Research output: Contribution to journalArticle

  153. 1998
  154. Published

    Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

    Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., Hackett, J., Adamson, J., Lincoln, S., Dickson, D., Davies, P., Petersen, R. C., Stevens, M., de Graaff, E., Wauters, E., van Baren, J. & 31 others, Hillebrand, M., Joosse, M., Kwon, J. M., Nowotny, P., Che, L. K., Norton, J., Morris, J. C., Reed, L. A., Trojanowski, J., Basun, H., Lannfelt, L., Neystat, M., Fahn, S., Dark, F., Tannenberg, T., Dodd, P. R., Hayward, N., Kwok, J. B., Schofield, P. R., Andreadis, A., Snowden, J., Craufurd, D., Neary, D., Owen, F., Oostra, B. A., Hardy, J., Goate, A., van Swieten, J., Mann, D., Lynch, T. & Heutink, P., 18 Jun 1998, In : Nature. 393, 6686, p. 702-5 4 p.

    Research output: Contribution to journalArticle

  155. Published

    Effect of apolipoprotein E status on clinical features of dementia

    Burlinson, S., Burns, A., Mann, D., Pickering-Brown, S. & Owen, F., Mar 1998, In : International journal of geriatric psychiatry. 13, 3, p. 177-85 9 p.

    Research output: Contribution to journalArticle

  156. 1997
  157. Published

    An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease

    Mann, D. M., Pickering-Brown, S. M., Bayatti, N. N., Wright, A. E., Owen, F., Iwatsubo, T. & Saido, T. C., 24 Jan 1997, In : Neuroscience letters. 222, 1, p. 57-60 4 p.

    Research output: Contribution to journalArticle

  158. Published

    Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele

    Mann, D. M., Iwatsubo, T., Pickering-Brown, S. M., Owen, F., Saido, T. C. & Perry, R. H., 17 Jan 1997, In : Neuroscience letters. 221, 2-3, p. 81-4 4 p.

    Research output: Contribution to journalArticle

  159. 1996
  160. Published

    The relative abundance of dopamine D4 receptor mRNA in post mortem brains of schizophrenics and controls

    Roberts, D. A., Balderson, D., Pickering-Brown, S. M., Deakin, J. F. & Owen, F., May 1996, In : Schizophrenia Research. 20, 1-2, p. 171-4 4 p.

    Research output: Contribution to journalArticle

  161. Published

    Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosis

    Siddons, M. A., Pickering-Brown, S. M., Mann, D. M., Owen, F. & Cooper, P. N., 12 Apr 1996, In : Neuroscience letters. 208, 1, p. 65-8 4 p.

    Research output: Contribution to journalArticle

  162. Published

    ApoE2 allele, Down's syndrome, and dementia

    Royston, M. C., Mann, D., Pickering-Brown, S., Owen, F., Perry, R., Ragbavan, R., Khin-Nu, C., Tyner, S., Day, K., Crook, R., Hardy, J. & Roberts, G. W., 17 Jan 1996, In : Annals of the New York Academy of Sciences. 777, p. 255-9 5 p.

    Research output: Contribution to journalArticle

  163. 1995
  164. Published

    The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype

    Mann, D. M., Pickering-Brown, S. M., Siddons, M. A., Iwatsubo, T., Ihara, Y., Asami-Odaka, A. & Suzuki, N., 18 Aug 1995, In : Neuroscience letters. 196, 1-2, p. 105-8 4 p.

    Research output: Contribution to journalArticle

  165. Published

    Apolipoprotein E allelic frequencies in patients with lobar atrophy

    Pickering-Brown, S. M., Siddons, M., Mann, D. M., Owen, F., Neary, D. & Snowden, J. S., 31 Mar 1995, In : Neuroscience letters. 188, 3, p. 205-7 3 p.

    Research output: Contribution to journalArticle

  166. Published

    Allelic variations in apolipoprotein E and prion protein genotype related to plaque formation and age of onset in sporadic Creutzfeldt-Jakob disease

    Pickering-Brown, S. M., Mann, D. M., Owen, F., Ironside, J. W., de Silva, R., Roberts, D. A., Balderson, D. J. & Cooper, P. N., 3 Mar 1995, In : Neuroscience letters. 187, 2, p. 127-9 3 p.

    Research output: Contribution to journalArticle

  167. 1994
  168. Published

    Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia

    Royston, M. C., Mann, D., Pickering-Brown, S., Owen, F., Perry, R., Raghavan, R., Khin-Nu, C., Tyrer, S., Day, K. & Crook, R., 20 Dec 1994, In : NeuroReport. 5, 18, p. 2583-5 3 p.

    Research output: Contribution to journalArticle

  169. Published

    The abundance of mRNA for dopamine D2 receptor isoforms in brain tissue from controls and schizophrenics

    Roberts, D. A., Balderson, D., Pickering-Brown, S. M., Deakin, J. F. & Owen, F., Aug 1994, In : Molecular Brain Research. 25, 1-2, p. 173-5 3 p.

    Research output: Contribution to journalArticle

  170. Published

    Apolipoprotein E4 and Alzheimer's disease pathology in Lewy body disease and in other beta-amyloid-forming diseases

    Pickering-Brown, S. M., Mann, D. M., Bourke, J. P., Roberts, D. A., Balderson, D., Burns, A., Byrne, J. & Owen, F., 7 May 1994, In : Lancet (London, England). 343, 8906, p. 1155

    Research output: Contribution to journalArticle