Prof Stephen High BA, PhD

Professor of Biochemistry

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Publications

  1. 2020
  2. Accepted/In press

    Ring-Expansion Leads to A More Potent Analogue of Ipomoeassin F

    Zong, G., Hu, Z., Baffour Duah, K., Andrews, L. E., Zhou, J., O'Keefe, S., Whisenhunt, L., Shim, J. S., Du, Y., High, S. & Shi, W. Q., 23 Nov 2020, (Accepted/In press) In : The Journal of organic chemistry.

    Research output: Contribution to journalArticlepeer-review

  3. Accepted/In press

    Eeyarestatin 24 Impairs SecYEG-dependent Protein Trafficking and Inhibits Growth of Clinically Relevant Pathogens

    Steenhuis, M., Koningstein, G. M., Oswald, J., Pick, T., O'Keefe, S., Koch, H-G., Cavalie, A., Whitehead, R., Swanton, E., High, S. & Luirink, J., 1 Aug 2020, (Accepted/In press) In : Molecular Microbiology.

    Research output: Contribution to journalArticlepeer-review

  4. 2019
  5. Published

    Characterising the selectivity of ER α-glucosidase inhibitors

    O'keefe, S., Roebuck, Q. P., Nakagome, I., Hirono, S., Kato, A., Nash, R. & High, S., 2019, In : Glycobiology.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    Eeyarestatin compounds selectively enhance Sec61-mediated Ca2+ leakage from the endoplasmic reticulum

    Gamayun, I., O'Keefe, S., Pick, T., Klein, M-C., Nguyen, D., Mckibbin, C., Piacenti, M., Williams, H. M., Flitsch, S., Whitehead, R., Swanton, E., Helms, V., High, S., Zimmermann, R. & Cavalie, A., 2019, In : Cell Chemical Biology.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

    Zong, G., Hu, Z., O’Keefe, S., Tranter, D., Iannotti, M. J., Baron, L., Hall, B., Corfield, K., Paatero, A., Henderson, M., Roboti, P., Zhou, J., Sun, X., Govindarajan, M., Rohde, J., Blanchard, N., Simmonds, R., Inglese, J., Du, Y., Demangel, C. & 3 others, High, S., Paavilainen, V. O. & Shi, W. Q., 2019, In : Journal of the American Chemical Society.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    The use of tail-anchored protein chimeras to enhance liposomal cargo delivery

    Abdelrehim Abdelkerim, O., Shaltiel, L., Zhang, L., Barenholz, Y., High, S. & Harris, L. K., 2019, In : P L o S One.

    Research output: Contribution to journalArticlepeer-review

  9. 2018
  10. Published

    Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier

    Haßdenteufel, S., Johnson, N., Paton, A. W., Paton, J. C., High, S. & Zimmermann, R., May 2018, In : Cell Reports. 23, 5, p. 1373-1386 14 p.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease: Mycolactone-driven Sec61 blockade and Buruli ulcer

    Demangel, C. & High, S., 2018, In : Biology of the Cell.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control

    Martínez-lumbreras, S., Krysztofinska, E. M., Thapaliya, A., Spilotros, A., Matak-vinkovic, D., Salvadori, E., Roboti, P., Nyathi, Y., Muench, J. H., Roessler, M. M., Svergun, D. I., High, S. & Isaacson, R. L., 2018, In : BMC Biology. 16, 1

    Research output: Contribution to journalArticlepeer-review

  13. 2017
  14. Published

    Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins

    Casson, J., Mckenna, M., Haßdenteufel, S., Aviram, N., Zimmermann, R. & High, S., 2017, In : Journal of Cell Science.

    Research output: Contribution to journalArticlepeer-review

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