Dr Stephen FowlerMD FRCP

Senior Lecturer

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Publications

  1. 2019
  2. Published

    Pseudomonas aeruginosa-derived volatile sulphur compounds promote distal Aspergillus fumigatus growth and a synergistic pathogen-pathogen interaction that increases pathogenicity in co-infection

    Scott, J., Sueiro Olivares, M., Ahmed, W., Heddergott, C., Zhao, C., Thomas, R., Bromley, M., Latgé, J. P., Krappmann, S., Fowler, S., Bignell, E. & Amich Elias, J., 9 Oct 2019, In : Frontiers in Microbiology.

    Research output: Contribution to journalArticle

  3. Published

    Stratification of asthma phenotypes by airway proteomic signatures

    U-BIOPRED Study Group, Jul 2019, In : The Journal of allergy and clinical immunology.

    Research output: Contribution to journalArticle

  4. Published

    Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

    U-BIOPRED Study Group, 27 Jun 2019, In : The European respiratory journal.

    Research output: Contribution to journalArticle

  5. E-pub ahead of print

    Circadian rhythm of exhaled biomarkers in health and asthma

    Wilkinson, M., Maidstone, R., Loudon, A., Blaikley, J., White, I., Singh, D., Ray, D., Goodacre, R., Fowler, S. & Durrington, H., 20 Jun 2019, In : The European respiratory journal.

    Research output: Contribution to journalArticle

  6. Published

    Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma

    the U-BIOPRED study group, 1 Apr 2019, In : Respiratory Medicine. 150, p. 66-73 8 p.

    Research output: Contribution to journalArticle

  7. Published

    Heliox for inducible laryngeal obstruction (vocal cord dysfunction): A systematic literature review

    Slinger, C., Slinger, R., Vyas, A., Haines, J. & Fowler, S. J., Apr 2019, In : Laryngoscope investigative otolaryngology. 4, 2, p. 255-258 4 p.

    Research output: Contribution to journalReview article

  8. Published

    Breath biomarkers in idiopathic pulmonary fibrosis: a systematic review

    Hayton, C., Terrington, D., Chaudhuri, N., Leonard, C. & Fowler, S. J., 11 Jan 2019, In : Respiratory research. 20, 1, p. 7

    Research output: Contribution to journalReview article

  9. Published

    “T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

    U-BIOPRED Study Group, 2019, In : European Respiratory Journal. 53, 1, 1800938.

    Research output: Contribution to journalArticle

  10. Published

    Allergen challenge increases capsaicin evoked cough responses in allergic asthma

    Satia, I., Watson, R., Scime, T., Dockry, R. J., Sen, S., Ford, J. W., Mitchell, P. D., Fowler, S. J., Gauvreau, G. M., O'Byrne, P. M. & Smith, J. A., 2019, In : The Journal of allergy and clinical immunology.

    Research output: Contribution to journalArticle

  11. Published

    Burden of fungal asthma in Africa: A systematic review and meta-analysis

    Kwizera, R., Musaazi, J., Meya, D. B., Worodria, W., Bwanga, F., Kajumbula, H., Fowler, S. J., Kirenga, B. J., Gore, R., Denning, D. W. & Barac, A., 2019, In : PLoS ONE. 14, 5, p. e0216568

    Research output: Contribution to journalArticle

  12. Published

    Contribution of airway eosinophils in airway wall remodeling in asthma: role of MMP-10 and MET

    U-BIOPRED Project Team, 2019, In : Allergy.

    Research output: Contribution to journalArticle

  13. Published

    Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria: a proof-of-concept study

    van Oort, P. M. P., Brinkman, P., Slingers, G., Koppen, G., Maas, A., Roelofs, J. J. T. H., Schnabel, R., Bergmans, D. C., Raes, M., Goodacre, R., Fowler, S. J., Schultz, M. J., Bos, L. D. & BreathDx Consortium, 2019, In : American journal of physiology. Lung cellular and molecular physiology.

    Research output: Contribution to journalArticle

  14. Published

    Exhaled Volatile Organic Compounds as Markers for Medication Use in Asthma

    U-BIOPRED Study Group, 2019, In : The European respiratory journal.

    Research output: Contribution to journalArticle

  15. Published

    IL-17-high asthma with features of a psoriasis immunophenotype

    U-BIOPRED Study Group, 2019, In : The Journal of allergy and clinical immunology.

    Research output: Contribution to journalArticle

  16. Published

    Investigating the Safety of Capsaicin Cough Challenge in Severe Asthma

    Wang, R., Fowler, S., Niven, R., Ryan, D., Holt, K., Mitchell, J., Dockry, R., Al-Sheklly, B., Satia, I. & Smith, J., 2019, In : Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

    Research output: Contribution to journalLetter

  17. Published

    Sex and intimacy in people with severe asthma: A qualitative study

    Holmes, L. J., Yorke, J. A., Dutton, C., Fowler, S. J. & Ryan, D., 2019, In : BMJ Open Respiratory Research. 6, 1, e000382.

    Research output: Contribution to journalArticle

  18. Published

    The role of measuring exhaled breath biomarkers in sarcoidosis: A systematic review

    Terrington, D., Hayton, C., Fowler, S. J. & Fraser, W., 2019, In : Journal of Breath Research.

    Research output: Contribution to journalArticle

  19. Published

    Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials: Bridging Clinical and Patient Perspectives

    Siddiqui, S., Denlinger, L. C., Fowler, S. J., Akuthota, P., Shaw, D. E., Heaney, L. G., Brown, L., Castro, M., Winders, T. A., Kraft, M., Wagers, S., Peters, M. C., Pavord, I. D., Walker, S. & Jarjour, N. N., 2019, In : American Journal of Respiratory and Critical Care Medicine .

    Research output: Contribution to journalArticle

  20. 2018
  21. Published

    Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment

    Durrington, H. J., Gioan-tavernier, G. O., Maidstone, R. J., Krakowiak, K., Loudon, A. S. I., Blaikley, J. F., Fowler, S. J., Singh, D., Simpson, A. & Ray, D. W., 15 Dec 2018, In : American Journal of Respiratory and Critical Care Medicine . 13 p., 30156881.

    Research output: Contribution to journalArticle

  22. Published

    Methodological considerations for large-scale breath analysis studies: lessons from the U-BIOPRED severe asthma project

    the U-BIOPRED study group, 30 Oct 2018, In : Journal of Breath Research. 13, 1

    Research output: Contribution to journalArticle

  23. Published

    Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort

    U-BIOPRED Study Group, 21 Sep 2018, In : PLoS ONE. 13, 9, p. e0203874

    Research output: Contribution to journalArticle

  24. Published

    Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers

    U-BIOPRED Study Group, 17 Sep 2018, In : Metabolomics. 14, 10, p. 123

    Research output: Contribution to journalArticle

  25. Published

    Volatile organic compound signature from co-culture of lung epithelial cell line with Pseudomonas aeruginosa

    Lawal, O., Knobel, H., Weda, H., Bos, L. D., Nijsen, T. M. E., Goodacre, R. & Fowler, S. J., 7 Jul 2018, In : The Analyst. 143, 13, p. 3148-3155 8 p.

    Research output: Contribution to journalArticle

  26. Published

    Clinical presentation, assessment, and management of inducible laryngeal obstruction

    Haines, J., Hull, J. H. & Fowler, S. J., 1 Jun 2018, In : Current Opinion in Otolaryngology and Head and Neck Surgery. 26, 3, p. 174-179 6 p.

    Research output: Contribution to journalArticle

  27. Published

    Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome

    Burg, D., Schofield, J. P. R., Brandsma, J., Staykova, D., Folisi, C., Bansal, A., Nicholas, B., Xian, Y., Rowe, A., Corfield, J., Wilson, S., Ward, J., Lutter, R., Fleming, L., Shaw, D. E., Bakke, P. S., Caruso, M., Dahlen, S-E., Fowler, S. J., Hashimoto, S. & 17 others, Horváth, I., Howarth, P., Krug, N., Montuschi, P., Sanak, M., Sandström, T., Singer, F., Sun, K., Pandis, I., Auffray, C., Sousa, A. R., Adcock, I. M., Chung, K. F., Sterk, P. J., Djukanović, R., Skipp, P. J. & The U-Biopred Study Group, 1 Jun 2018, In : Journal of Proteome Research. 17, 6, p. 2072-2091 20 p.

    Research output: Contribution to journalArticle

  28. Published

    A computational framework for complex disease stratification from multiple large-scale datasets

    U-BIOPRED Study Group, eTRIKS Consortium, Fowler, S. J., Murray, C. S., Vestbo, J. & Woodcock, A., 29 May 2018, In : BMC Systems Biology. 12, 1, 60.

    Research output: Contribution to journalArticle

  29. Published

    Utlilising -omics to investigate the mechanisms underlying circadian rhythm in asthma

    Durrington, H., Ray, D., Singh, S., Maidstone, R., Fowler, S. & Wilkinson, M., 26 May 2018.

    Research output: Contribution to conferenceAbstract

  30. Published

    Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: An exploratory analysis

    U-BIOPRED Study Group & Fowler, S. J., 1 May 2018, In : European Respiratory Journal. 51, 5, 1702173.

    Research output: Contribution to journalArticle

  31. Published

    TD/GC–MS analysis of volatile markers emitted from mono- and co-cultures of Enterobacter cloacae and Pseudomonas aeruginosa in artificial sputum

    Lawal, O., Knobel, H., Weda, H., Nijsen, T. M. E., Goodacre, R., Fowler, S. J., Ahmed, W. M., Artigas, A., Bannard-Smith, J., Bos, L. D. J., Camprubi, M., Coelho, L., Dark, P., Davie, A., Diaz, E., Goma, G., Felton, T., Leopold, J. H., van Oort, P. M. P., Povoa, P. & 13 others, Portsmouth, C., Rattray, N. J. W., Rijnders, G., Schultz, M. J., Steenwelle, R., Sterk, P. J., Valles, J., Verhoeckx, F., Vink, A., White, I. R., Winters, T., Zakharkina, T. & the BreathDx consortium, May 2018, In : Metabolomics. 14, 5, 66.

    Research output: Contribution to journalArticle

  32. Published

    Reclassification of Bronchodilator Reversibility in the U-BIOPRED Adult Asthma Cohort Using z Scores

    U-BIOPRED Study Group, 30 Apr 2018, In : Chest. 153, 4, p. 1070-1072 3 p.

    Research output: Contribution to journalLetter

  33. Published

    Peripheral Interventions for Painful Stump Neuromas of the Lower Limb: A Systematic Review

    Poyntz, S. A., Dalal, M., Hacking, N. & Fowler, S., 1 Mar 2018, In : Clinical Journal of Pain.

    Research output: Contribution to journalArticle

  34. Published

    A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

    Hanratty, C. E., Matthews, J. G., Arron, J. R., Choy, D. F., Pavord, I. D., Bradding, P., Brightling, C. E., Chaudhuri, R., Cowan, D. C., Djukanovic, R., Gallagher, N., Fowler, S. J., Hardman, T. C., Harrison, T., Holweg, C. T., Howarth, P. H., Lordan, J., Mansur, A. H., Menzies-Gow, A., Mosesova, S. & 7 others, Niven, R. M., Robinson, D. S., Shaw, D. E., Walker, S., Woodcock, A., Heaney, L. G. & RASP-UK (Refractory Asthma Stratification Programme) Consortium, 4 Jan 2018, In : Trials. 19, 1, p. 5

    Research output: Contribution to journalArticle

  35. Published

    Headspace volatile organic compounds from bacteria implicated in ventilator-associated pneumonia analysed by TD-GC/MS

    Lawal, O., Muhamadali, H., Ahmed, W., White, I. R., Nijsen, T. M. E., Goodacre, R. & Fowler, S. J., 3 Jan 2018, In : Journal of Breath Research. 12, 2

    Research output: Contribution to journalArticle

  36. Published

    Breath analysis for label-free characterisation of airways disease

    Fowler, S. J., Jan 2018, In : The European respiratory journal. 51, 1

    Research output: Contribution to journalArticle

  37. Published

    Development of an adaptable headspace sampling method for metabolic profiling of the fungal volatome

    Ahmed, W. M., Geranios, P., White, I. R., Bromley, M., Lawal, O., Nijsen, T., Goodacre, R., Read, N. & Fowler, S. J., 2018, In : The Analyst.

    Research output: Contribution to journalArticle

  38. Published

    Exhaled breath testing – A tool for the clinician and researcher

    Davis, M. D., Fowler, S. J. & Montpetit, A. J., 2018, In : Paediatric respiratory reviews.

    Research output: Contribution to journalArticle

  39. Published

    Identification and prospective stability of eNose derived inflammatory phenotypes in severe asthma.

    U-BIOPRED Study Group & Fowler, S., 2018, In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalArticle

  40. Published

    The potential role of exhaled breath analysis in the diagnostic process of pneumonia - a systematic review

    van Oort, P., Povoa, P., Schnabel, R., Dark, P., Artigas, A., Bergmans, D., Felton, T., Coelho, L., Schultz, M. J., Fowler, S. J. & Bos, L., 2018, In : Journal of Breath Research.

    Research output: Contribution to journalArticle

  41. Published

    Treatable Traits in the European U-BIOPRED Adult Asthma Cohorts

    U-BIOPRED Study Group, 2018, In : Allergy.

    Research output: Contribution to journalArticle

  42. Published

    Two pathways, one patient; UK asthma guidelines

    Fowler, S. J., O'Byrne, P. M., Buhl, R. & Shaw, D., 2018, In : Thorax. 73, 9

    Research output: Contribution to journalArticle

  43. 2017
  44. Published

    Exhaled Volatile Organic Compounds of Infection: A Systematic Review

    Ahmed, W. M., Lawal, O., Nijsen, T. M., Goodacre, R. & Fowler, S. J., 13 Oct 2017, In : ACS Infectious Diseases. 3, 10, p. 695-710 16 p.

    Research output: Contribution to journalArticle

  45. Published

    An airway traffic jam: a plastic traffic cone masquerading as bronchial carcinoma

    Denny, N., Maqsood, U., Fowler, S. & Munavvar, M., 21 Sep 2017, In : BMJ Case Reports. 2017

    Research output: Contribution to journalArticle

  46. Published

    Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma

    Hekking, P-P., Loza, M. J., Pavlidis, S., De Meulder, B., Lefaudeux, D., Baribaud, F., Auffray, C., Wagener, A. H., Brinkman, P., Lutter, R., Bansal, A. T., Sousa, A. R., Bates, S. A., Pandis, I., Fleming, L. J., Shaw, D. E., Fowler, S. J., Guo, Y., Meiser, A., Sun, K. & 8 others, Corfield, J., Howarth, P., Bel, E. H., Adcock, I. M., Chung, K. F., Djukanovic, R., Sterk, P. J. & U-BIOPRED Study Group, Sep 2017, In : The European respiratory journal. 50, 3

    Research output: Contribution to journalArticle

  47. Published

    Assessing machine learning algorithms for self-management of asthma

    Kocsis, O., Arvanitis, G., Lalos, A., Moustakas, K., Sont, J. K., Honkoop, P. J., Chung, K. F., Bonini, M., Usmani, O. S., Fowler, S. & Simpson, A., 28 Jul 2017, 2017 E-Health and Bioengineering Conference, EHB 2017. IEEE, p. 571-574 4 p. 7995488

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  48. Published

    U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

    Lefaudeux, D., De Meulder, B., Loza, M. J., Peffer, N., Rowe, A., Baribaud, F., Bansal, A. T., Lutter, R., Sousa, A. R., Corfield, J., Pandis, I., Bakke, P. S., Caruso, M., Chanez, P., Dahlén, S-E., Fleming, L. J., Fowler, S., Horvath, I., Krug, N., Montuschi, P. & 11 others, Sanak, M., Sandstrom, T., Shaw, D. E., Singer, F., Sterk, P. J., Roberts, G., Adcock, I. M., Djukanovic, R., Auffray, C., Chung, K. F. & U-BIOPRED Study Group, Jun 2017, In : Journal of Allergy and Clinical Immunology. 139, 6, p. 1797 1807 p.

    Research output: Contribution to journalArticle

  49. E-pub ahead of print

    Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

    Grabiec, A. M., Denny, N., Doherty, J., Happonen, K. E., Hankinson, J., Connolly, E., Fife, M. E., Fujimori, T., Fujino, N., Goenka, A., Holden, S., Gioan-Tavernier, G., Shah, R., Cook, P., MacDonald, A., Niven, R., Dahlbäck, B., Fowler, S., Simpson, A. & Hussell, T., 12 Apr 2017, In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalLetter

  50. Published

    A European Respiratory Society technical standard: exhaled biomarkers in lung disease

    Horváth, I., Barnes, P. J., Loukides, S., Sterk, P. J., Högman, M., Olin, A-C., Amann, A., Antus, B., Baraldi, E., Bikov, A., Boots, A. W., Bos, L. D., Brinkman, P., Bucca, C., Carpagnano, G. E., Corradi, M., Cristescu, S., de Jongste, J. C., Dinh-Xuan, A-T., Dompeling, E. & 22 others, Fens, N., Fowler, S., Hohlfeld, J. M., Holz, O., Jöbsis, Q., Van De Kant, K., Knobel, H. H., Kostikas, K., Lehtimäki, L., Lundberg, J., Montuschi, P., Van Muylem, A., Pennazza, G., Reinhold, P., Ricciardolo, F. L. M., Rosias, P., Santonico, M., van der Schee, M. P., van Schooten, F-J., Spanevello, A., Tonia, T. & Vink, T. J., Apr 2017, In : The European respiratory journal. 49, 4

    Research output: Contribution to journalArticle

  51. Published

    Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction

    Satia, I., Tsamandouras, N., Holt, K., Badri, H., Woodhead, M., Ogungbenro, K., Felton, T. W., O'Byrne, P. M., Fowler, S. J. & Smith, J. A., Mar 2017, In : The Journal of allergy and clinical immunology. 139, 3, p. 771-779.e10

    Research output: Contribution to journalArticle

  52. Published

    Biomarkers in adult asthma: A systematic review of 8-isoprostane in exhaled breath condensate

    Peel, A. M., Crossman-Barnes, C. J., Tang, J., Fowler, S. J., Davies, G. A., Wilson, A. M. & Loke, Y. K., 10 Feb 2017, In : Journal of Breath Research. 11, 1, 016011.

    Research output: Contribution to journalArticle

  53. Published

    MyAirCoach: the use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; study protocol of an observational study

    Honkoop, P. J., Simpson, A., Bonini, M., Snoeck-Stroband, J. B., Meah, S., Fan Chung, K., Usmani, O. S., Fowler, S. & Sont, J. K., 24 Jan 2017, In : BMJ Open. 7, 1, p. e013935

    Research output: Contribution to journalArticle

  54. Published

    Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial

    Chamberlain Mitchell, S. A. F., Garrod, R., Clark, L., Douiri, A., Parker, S. M., Ellis, J., Fowler, S. J., Ludlow, S., Hull, J. H., Chung, K. F., Lee, K. K., Bellas, H., Pandyan, A. & Birring, S. S., 13 Jan 2017, In : Thorax. 72, 2, p. 129-136 8 p.

    Research output: Contribution to journalArticle

  55. Published

    BreathDx - molecular analysis of exhaled breath as a diagnostic test for ventilator-associated pneumonia: protocol for a European multicentre observational study

    van Oort, P. M. P., Nijsen, T., Weda, H., Knobel, H., Dark, P., Felton, T., Rattray, N. J. W., Lawal, O., Ahmed, W., Portsmouth, C., Sterk, P. J., Schultz, M. J., Zakharkina, T., Artigas, A., Povoa, P., Martin-Loeches, I., Fowler, S. J., Bos, L. D. J. & BreathDx Consortium, 3 Jan 2017, In : BMC Pulmonary Medicine. 17, 1, p. 1

    Research output: Contribution to journalArticle

  56. Published

    Exhaled breath analysis: a review of 'breath-taking' methods for off-line analysis

    Fowler, S., 2017, In : Metabolomics.

    Research output: Contribution to journalArticle

  57. Published

    Pathway discovery using transcriptomic profiles in adult-onset severe asthma

    Hekking, P-P. W., Loza, M. J., Pavlidis, S., De Meulder, B., Lefaudeux, D., Baribaud, F., Auffray, C., Wagener, A. H., Brinkman, P., Lutter, R., Bansal, A. T., Sousa, A. R., Bates, S. A., Pandis, Y., Flemming, L. J., Shaw, D. E., Fowler, S., Meiser, A., Sun, K., Corfield, J. & 6 others, Howarth, P., Bel, E. H., Adcock, I. M., Chung, K. F., Djukanovic, R. & Sterk Peter, J., 2017, In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalArticle

  58. Published

    Perspectives of patients and healthcare professionals on mHealth for asthma selfmanagement

    Simpson, A., Honkoop, P., Kennington, E., Snoeck-Stroband, J. B., Smith, I., East, J., Coleman, C., Caress, A-L., Chung, K. F., Sont, J. K., Usmani, O. S. & Fowler, S., 2017, In : European Respiratory Journal. 49, 5, 1601966.

    Research output: Contribution to journalArticle

  59. Published

    The interaction between bronchoconstriction and cough in asthma

    Satia, I., Badri, H., Woodhead, M., O'Byrne, P. M., Fowler, S. J. & Smith, J. A., 2017, In : Thorax.

    Research output: Contribution to journalArticle

  60. 2016
  61. Published

    Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

    Loza, M. J., Djukanovic, R., Chung, K. F., Horowitz, D., Ma, K., Branigan, P., Barnathan, E. S., Susulic, V. S., Silkoff, P. E., Sterk, P. J., Baribaud, F., Strambu, I., Laviolette, M., Singh, D., FitzGerald, J. M., Lam, S., Kelsen, S., Eich, A., Ludwig-Sengpiel, A., hupp, G. C. & 32 others, Backer, V., Porsbjerg, C., Girodet, P. O., Berger, P., Leigh, R., Kline, J., Dransfield, M., Calhoun, W., Hussaini, A., Khatri, S., Chanez, P., Ian, A., Fleming Louis, J., David, G., Sile, H., Scott, K., Sally, M., Andrea, M., Stelios, P., Christos, R., Kirsty, R., Kai, S., Coen, W., Xian, Y., Nora, A., Ariane, W., Fowler, S., Murray, C., Vestbo, J., Woodcock, A., ADEPT (Airways Disease Endotyping for Personalized Therapeutics) & U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators, 15 Dec 2016, In : Respiratory research. 17, 1, 165.

    Research output: Contribution to journalArticle

  62. Published

    Laryngeal Dysfunction: Assessment and Management for the Clinician

    Hull, J. H., Backer, V., Gibson, P. G. & Fowler, S., 1 Nov 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 9, p. 1062-1072 11 p.

    Research output: Contribution to journalArticle

  63. Published

    A pilot study to investigate the use of serum inhaled corticosteroid concentration as a potential marker of treatment adherence in severe asthma

    George, K. E., Ryan, D. M., Keevil, B., Niven, R. & Fowler, S. J., 11 Oct 2016, In : The Journal of allergy and clinical immunology.

    Research output: Contribution to journalLetter

  64. Published

    Breathomics in the setting of asthma and chronic obstructive pulmonary disease

    Bos, L. D., Sterk, P. J. & Fowler, S. J., Oct 2016, In : The Journal of allergy and clinical immunology. 138, 4, p. 970-976 7 p.

    Research output: Contribution to journalArticle

  65. Published

    Dysfunctional breathing: a review of the literature and proposal for classification

    Boulding, R., Stacey, R., Niven, R. & Fowler, S. J., Sep 2016, In : European Respiratory Review . 25, 141, p. 287-294 8 p.

    Research output: Contribution to journalArticle

  66. Published

    Fungal sensitisation in severe asthma is associated with the identification of Aspergillus fumigatus in sputum

    Farrant, J., Brice, H., Fowler, S. & Niven, R., Sep 2016, In : The Journal of asthma : official journal of the Association for the Care of Asthma. 53, 7, p. 732-735 4 p.

    Research output: Contribution to journalArticle

  67. Published

    Reduction in peripheral blood eosinophil counts after bronchial thermoplasty

    Ryan, D., Fowler, S. & Niven, R., Jul 2016, In : The Journal of allergy and clinical immunology. 138, 1, p. 308-310.e2

    Research output: Contribution to journalArticle

  68. Published

    Objective Cough Frequency, Airway Inflammation, and Disease Control in Asthma

    Marsden, P. A., Satia, I., Ibrahim, B., Woodcock, A., Yates, L., Donnelly, I., Jolly, L., Thomson, N. C., Fowler, S. J. & Smith, J. A., Jun 2016, In : Chest. 149, 6, p. 1460-1466 7 p.

    Research output: Contribution to journalArticle

  69. Published

    Electronic cigarette exposure triggers neutrophil inflammatory responses

    Higham, A., Rattray, N. J. W., Dewhurst, J. A., Trivedi, D. K., Fowler, S. J., Goodacre, R. & Singh, D., 17 May 2016, In : Respiratory research. 17, 1, p. 56 56.

    Research output: Contribution to journalArticle

  70. Published

    A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED

    Kuo, C-H. S., Pavlidis, S., Loza, M., Baribaud, F., Rowe, A., Pandis, I., Hoda, U., Rossios, C., Sousa, A., Wilson, S. J., Howarth, P., Dahlen, B., Dahlen, S-E., Chanez, P., Shaw, D., Krug, N., Sandström, T., De Meulder, B., Lefaudeux, D., Fowler, S. & 9 others, Fleming, L., Corfield, J., Auffray, C., Sterk, P. J., Djukanovic, R., Guo, Y., Adcock, I. M., Chung, K. F. & U-BIOPRED Project Team, 2016, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  71. 2015
  72. Published

    Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

    Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., Corfield, J., Pandis, I., Bansal, A. T., Bel, E. H., Auffray, C., Compton, C. H., Bisgaard, H., Bucchioni, E., Caruso, M., Chanez, P., Dahlén, B., Dahlen, S-E., Dyson, K., Frey, U., Geiser, T. & 35 others, Gerhardsson de Verdier, M., Gibeon, D., Guo, Y-K., Hashimoto, S., Hedlin, G., Jeyasingham, E., Hekking, P-P. W., Higenbottam, T., Horváth, I., Knox, A. J., Krug, N., Erpenbeck, V. J., Larsson, L. X., Lazarinis, N., Matthews, J. G., Middelveld, R., Montuschi, P., Musial, J., Myles, D., Pahus, L., Sandström, T., Seibold, W., Singer, F., Strandberg, K., Vestbo, J., Vissing, N., von Garnier, C., Adcock, I. M., Wagers, S., Rowe, A., Howarth, P., Wagener, A. H., Djukanovic, R., Sterk, P. J. & Chung, K. F., Nov 2015, In : The European respiratory journal. 46, 5, p. 1308-1321 14 p.

    Research output: Contribution to journalArticle

  73. Published

    The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

    Fleming, L., Murray, C., Bansal, A. T., Hashimoto, S., Bisgaard, H., Bush, A., Frey, U., Hedlin, G., Singer, F., van Aalderen, W. M., Vissing, N. H., Zolkipli, Z., Selby, A., Fowler, S., Shaw, D., Chung, K. F., Sousa, A. R., Wagers, S., Corfield, J., Pandis, I. & 4 others, Rowe, A., Formaggio, E., Sterk, P. J. & Roberts, G., Nov 2015, In : The European respiratory journal. 46, 5

    Research output: Contribution to journalArticle

  74. Published

    The VCDQ--a Questionnaire for symptom monitoring in vocal cord dysfunction.

    Fowler, S. J., Thurston, A., Chesworth, B., Cheng, V., Constantinou, P., Vyas, A., Lillie, S. & Haines, J., Sep 2015, In : Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 45, 9

    Research output: Contribution to journalArticle

  75. Published

    Detecting laryngopharyngeal reflux in patients with upper airways symptoms: Symptoms, signs or salivary pepsin?

    Spyridoulias, A., Lillie, S., Vyas, A. & Fowler, S. J., Aug 2015, In : Respiratory Medicine. 109, 8

    Research output: Contribution to journalArticle

  76. Published
  77. Published

    Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.

    Kane, B., Fowler, S. J. & Niven, R., Feb 2015, In : Chronic Respiratory Disease. 12, 1

    Research output: Contribution to journalArticle

  78. Published

    Interventions for bronchiectasis: an overview of Cochrane systematic reviews.

    Welsh, E. J., Evans, D. J., Fowler, S. J. & Spencer, S., 2015, In : The Cochrane database of systematic reviews. 7

    Research output: Contribution to journalArticle

  79. 2014
  80. Published

    High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.

    Fowler, S., Gioan-Tavernier, G. & Niven, R., Oct 2014, In : Journal of Allergy and Clinical Immunology.

    Research output: Contribution to journalArticle

  81. Published
  82. Published

    Inhaled hyperosmolar agents for bronchiectasis.

    Hart, A., Sugumar, K., Milan, S. J., Fowler, S. J. & Crossingham, I., 2014, In : The Cochrane database of systematic reviews. 5

    Research output: Contribution to journalArticle

  83. Published

    Taking your breath away: metabolomics breathes life in to personalized medicine

    Rattray, N., Hamrang, Z., Trivedi, D., Goodacre, R. & Fowler, S., 2014, In : Trends in Biotechnology. 32, 10, p. 538-548 11 p.

    Research output: Contribution to journalArticle

  84. 2013
  85. Published

    Application of 'omics technologies to biomarker discovery in inflammatory lung diseases

    Wheelock, C. E., Goss, V. M., Balgoma, D., Nicholas, B., Brandsma, J., Skipp, P. J., Snowden, S., Burg, D., D'Amico, A., Horvath, I., Chaiboonchoe, A., Ahmed, H., Ballereau, S., Rossios, C., Chung, K. F., Montuschi, P., Fowler, S. J., Adcock, I. M., Postle, A. D., Dahleń, S. E. & 4 others, Rowe, A., Sterk, P. J., Auffray, C. & Djukanović, R., 1 Sep 2013, In : European Respiratory Journal. 42, 3, p. 802-825 23 p.

    Research output: Contribution to journalArticle

  86. Published

    Metabolomic Analysis of Exhaled Breath Condensate by NMR Spectroscopy Discriminates Inflammatory Phenotypes in Asthma

    Ibrahim, B., Marsden, P., Morris, J., Smith, J., Nilsson, M. & Fowler, SJ., 2013, In : Allergy.

    Research output: Contribution to journalArticle

  87. 2012
  88. Published

    Exhaled volatile organic compounds for phenotyping chronic obstructive pulmonary disease: a cross-sectional study

    Basanta, M., Ibrahim, B., Dockry, R., Douce, D., Morris, M., Singh, D., Woodcock, A. & Fowler, S. J., 23 Aug 2012, In : Respiratory research. 13, 72.

    Research output: Contribution to journalArticle

  89. Published

    Methodology validation, intra-subject reproducibility and stability of exhaled volatile organic compounds

    Basanta, M., Ibrahim, B., Douce, D., Morris, M., Woodcock, A. & Fowler, S., Jun 2012, In : Journal of Breath Research. 6, 2, 026002.

    Research output: Contribution to journalArticle

  90. 2011
  91. Published

    Non-invasive phenotyping using exhaled volatile organic compounds in asthma

    Ibrahim, B., Basanta, M., Cadden, P., Singh, D., Douce, D., Woodcock, A., Fowler, S. J. & Singh, S., Sep 2011, In : Thorax. 66, 9, p. 804-809 5 p.

    Research output: Contribution to journalArticle

  92. 2010
  93. Published

    Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers

    Fowler, S., Basanta, M., Jarvis, R. M., Xu, Y., Blackburn, G., Tal-Singer, R., Woodcock, A., Singh, D., Goodacre, R., Paul Thomas, C. L. & Fowler, S. J., 2010, In : Analyst. 135, 2, p. 315-320 5 p.

    Research output: Contribution to journalArticle

  94. 2009
  95. Published

    Long term effects of allergen sensitisation and exposure in adult asthma: A prospective study.

    Fowler, S., Langley, SJ., Truman, N., Simpson, A., Woodcock, A. & Custovic, A., 15 May 2009, In : The World Allergy Organization journal. 2, 5, p. 83-90 8 p.

    Research output: Contribution to journalArticle

  96. 2008
  97. Published

    Medical Masterclass: Module 7: Cardiology and Respiratory Medicine

    Fowler, S., Firth, J. (ed.) & Roberts, P. (ed.), 2008, 2 ed. Royal College of Physicians.

    Research output: Book/ReportAnthology

  98. Published

    Multiple Chapters

    Fowler, S., Firth, J. (ed.) & Roberts, P. (ed.), 2008, Medical Masterclass: Module 7: Cardiology and Respiratory Medicine. 2 ed. Royal College of Physicians

    Research output: Chapter in Book/Report/Conference proceedingChapter

  99. Published

    Respiratory System

    Fowler, S. & Firth, J. (ed.), 2008, Medical Masterclass: Module 1: Scientific Background to Medicine 1. 2 ed. Royal College of Physicians

    Research output: Chapter in Book/Report/Conference proceedingChapter

  100. 2007
  101. Published

    Increasing analytical space in gas chromatography-differential mobility spectrometry with dispersion field amplitude programming

    Basanta, M., Singh, D., Fowler, S., Wilson, I., Dennis, R. & Thomas, C. L. P., 30 Nov 2007, In : Journal of Chromatography A. 1173, 1-2, p. 129-138 9 p.

    Research output: Contribution to journalArticle

  102. 2006
  103. Published

    Nontuberculous mycobacteria in bronchiectasis: Prevalence and patient characteristics

    Fowler, S., Fowler, S. J., French, J., Screaton, N. J., Foweraker, J., Condliffe, A., Haworth, C. S., Exley, A. R. & Bilton, D., Dec 2006, In : European Respiratory Journal. 28, 6, p. 1204-1210 6 p.

    Research output: Contribution to journalArticle

  104. 2003
  105. Published

    RAPID RESPONSES FROM BMJ.COM: Anti-inflammatory end points

    Lipworth, B. J., Fowler, S., Currie, G., Wilson, A. & Holt, S., 4 Oct 2003, In : BMJ (Clinical Research Edition). 327, 7418, p. E73

    Research output: Contribution to journalArticle

  106. Published

    A proof of concept study to evaluate putative benefits of montelukast in moderate persistent asthmatics

    Currie, G. P., Lee, D. K. C., Dempsey, O. J., Fowler, S. J., Cowan, L. M. & Lipworth, B. J., 1 Jun 2003, In : British Journal of Clinical Pharmacology. 55, 6, p. 609-615 6 p.

    Research output: Contribution to journalArticle

  107. Published

    Effects of mediator antagonism on mannitol and adenosine monophosphate challenges

    Currie, G. P., Haggart, K., Lee, D. K. C., Fowler, S. J., Wilson, A. M., Brannan, J. D., Anderson, S. D. & Lipworth, B. J., 1 Jun 2003, In : Clinical and Experimental Allergy. 33, 6, p. 783-788 5 p.

    Research output: Contribution to journalArticle

  108. Published

    Evaluation of surrogate inflammatory markers for optimizing inhaled corticosteroid therapy in a real-life clinical setting

    Fowler, S. J., Syme-Grant, N. J., Carey, F. A. & Lipworth, B. J., Jun 2003, In : Allergology International. 52, 2, p. 71-75 5 p.

    Research output: Contribution to journalArticle

  109. Published

    Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: A meta-analysis

    Currie, G. P., Fowler, S. J. & Lipworth, B. J., 1 Feb 2003, In : Annals of Allergy, Asthma, & Immunology . 90, 2, p. 194-198 4 p.

    Research output: Contribution to journalArticle

  110. Published

    Relationship of skin-prick reactivity to aeroallergens and hyperresponsiveness to challenges with methacholine and adenosine monophosphate

    Fowler, S. J. & Lipworth, B. J., 1 Jan 2003, In : Allergy: European Journal of Allergy and Clinical Immunology. 58, 1, p. 46-52 6 p.

    Research output: Contribution to journalArticle

  111. Published

    Relationship between changes in quality of life and measures of lung function and bronchial hyper-responsiveness during high-dose inhaled corticosteroid treatment in uncontrolled asthma

    Orr, L. C., Fowler, S. J. & Lipworth, B. J., 2003, In : American Journal of Respiratory Medicine. 2, 5, p. 433-438 5 p.

    Research output: Contribution to journalArticle

  112. 2002
  113. Published

    Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma

    Currie, G. P., Fowler, S. J., Wilson, A. M., Sims, E. J., Orr, L. C. & Lipworth, B. J., 1 Oct 2002, In : Thorax. 57, 10, p. 865-868 3 p.

    Research output: Contribution to journalArticle

  114. Published

    5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists

    Fowler, S. J., Hall, I. P., Wilson, A. M., Wheatley, A. P. & Lipworth, B. J., 2002, In : European journal of clinical pharmacology. 58, 3, p. 187-190 3 p.

    Research output: Contribution to journalArticle

  115. Published

    Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma

    Dempsey, O. J., Fowler, S. J., Wilson, A., Kennedy, G. & Lipworth, B. J., 2002, In : Chest. 122, 1, p. 151-159 8 p.

    Research output: Contribution to journalArticle

  116. Published

    Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone

    Fowler, S. J., Currie, G. P. & Lipworth, B. J., 2002, In : Journal of Allergy and Clinical Immunology. 109, 6, p. 929-935 6 p.

    Research output: Contribution to journalArticle

  117. Published

    Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate

    Fowler, S. J., Orr, L. C., Sims, E. J., Wilson, A. M., Currie, G. P., McFarlane, L. & Lipworth, B. J., 2002, In : Chest. 122, 2, p. 618-623 5 p.

    Research output: Contribution to journalArticle

  118. 2001
  119. Published

    Salmeterol and inhaled corticosteroids in patients with persistent asthma.

    Fowler, SJ. & Lipworth, B., 26 Dec 2001, In : JAMA. 286( 24)

    Research output: Contribution to journalArticle

  120. Published

    Montelukast for persistent asthma [3] (multiple letters)

    Lipworth, B. J., Fowler, S., Currie, G., Morice, A. H., Robinson, D., Campbell, D. A., Barnes, P. J., Szczeklik, A., Mastalerz, L., Nizankowska, E. & Sanak, M., 27 Oct 2001, In : Lancet. 358, 9291, p. 1455-1457 3 p.

    Research output: Contribution to journalLetter

  121. Published

    On-demand relief treatment for asthma [3]

    Lipworth, B. J., Currie, G., Fowler, S., Joseph, J., Badrinath, P. & Tattersfield, A. E., 9 Jun 2001, In : Lancet. 357, 9271, p. 1882-1883 2 p.

    Research output: Contribution to journalLetter

  122. Published

    Pharmacokinetics and systemic beta2-adrenoceptor-mediated responses to inhaled salbutamol.

    Fowler, SJ. & Lipworth, B., Apr 2001, In : Br J Clin Pharmacol. 51( 4)

    Research output: Contribution to journalArticle

  123. Published

    Comparative in vivo lung delivery of hydrofluoroalkane-salbutamol formulation via metered-dose inhaler alone, with plastic spacer, or with cardboard tube

    Fowler, S. J., Wilson, A. M., Griffiths, E. A. & Lipworth, B. J., 2001, In : Chest. 119, 4, p. 1018-1020 2 p.

    Research output: Contribution to journalArticle

  124. Published

    Dose-response for adrenal suppression with hydrofluoroalkane formulations of fluticasone propionate and beclomethasone dipropionate

    Fowler, S. J., Orr, L. C., Wilson, A. M., Sims, E. J. & Lipworth, B. J., 2001, In : British Journal of Clinical Pharmacology. 52, 1, p. 93-95 2 p.

    Research output: Contribution to journalArticle

  125. Published

    Evaluation of the importance of head and probe stabilisation in acoustic rhinometry

    Wilson, A. M., Fowler, S. J., Martin, S. W., White, P. S., Gardiner, Q. & Lipworth, B. J., 2001, In : Rhinology. 39, 2, p. 93-97 4 p.

    Research output: Contribution to journalArticle

  126. Published

    Pharmacokinetics and systemic β 2-adrenoceptor-mediated responses to inhaled salbutamol

    Fowler, S. J. & Lipworth, B. J., 2001, In : British Journal of Clinical Pharmacology. 51, 4, p. 359-362 4 p.

    Research output: Contribution to journalArticle

  127. 2000
  128. Published

    Fluticasone propionate bioavailability in asthma [1] (multiple letters)

    Lipworth, B. J., Fowler, S., Wilson, A., Crompton, G. K., Woodcock, A. & Daley-Yates, P. T., 11 Nov 2000, In : Lancet. 356, 9242, p. 1681-1682 2 p.

    Research output: Contribution to journalLetter

  129. Published

    Screening for bronchial hyperresponsiveness using methacholine and adenosine monophosphate. Relationship to asthma severity and beta(2)-receptor genotype.

    Fowler, SJ., Dempsey, O., Sims, E. & Lipworth, B., Oct 2000, In : American Journal of Respiratory and Critical Care Medicine . 162( 4 Pt 1)

    Research output: Contribution to journalArticle

  130. Published

    Regular use of salbutamol in asthma [2]

    Fowler, S. J. & Lipworth, B. J., 2 Sep 2000, In : Lancet. 356, 9232, p. 853 1 p.

    Research output: Contribution to journalLetter

  131. Published

    Screening for bronchial hyperresponsiveness using methacholine and adenosine monophosphate: Relationship to asthma severity and β2-receptor genotype

    Fowler, S. J., Dempsey, O. J., Sims, E. J. & Lipworth, B. J., 2000, In : American Journal of Respiratory and Critical Care Medicine . 162, 4 I, p. 1318-1322 5 p.

    Research output: Contribution to journalArticle

  132. Published

    Therapeutic equivalence of inhaled salbutamol (multiple letters)

    Fowler, S. J. & Lipworth, B. J., 2000, In : Thorax. 55, 4, p. 347-348 2 p.

    Research output: Contribution to journalArticle