Dr Stefan Meyer MD PhD MRCPCH

Clinical Senior Lecturer Paediatric Oncology

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Research interests

Stefan works as a Honorary Consultant Paediatric Oncologist at the Royal Manchester Children’s Hospital, and the Young Oncology Unit/Palatine Treatment Centre at the Chrisite NHS Foundation Frust. He leads the multidisciplinary care for children with Fanconi anaemia, Bloom's syndrome and other Chromosomal Instability Syndromes.

Fanconi anaemia (FA), Blooms syndrome (BS) and other Chromosomal Instability syndromes (CIS) are inherited diseases with congenital and developmental abnormalities and extreme cancer predisposition. These conditions result from defects in fundamental DNA damage response pathways with an important role in development, haematopoiesis and cancer prevention. Our research is focused on malignant transformation associated with CIS, and functional aspects of the these pathways in sporadic cancers. Studying FA-derived AML cell lines we have identified amplification and overexpression of the EVI1 oncogene as a key event  associated with FA-characteristic gains in the chromosomal region 3q26q29 and leukaemic transformation. EVI1 is an oncogenic transcriptional regulator with a critical role in self renewal, with  chromatin remodeling properties, which we are exploring in the context of the FA defect.

Our FA-derived AML cell lines derived from the AML associated with bi-allelic disruption of the FANCD1/BRCA2 gene maintain the FA characteristic cross linker hypersensitivity. We explore the characteristics of the DNA damage response using systems biology approaches in order to identify regulatory events that might be therapeutically accessible.


 

Projects

Research and projects

No current projects are available for public display