Dr Sacha Howell PhD FRCP

Clinical Snr Lecturer: Breast Oncology

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Publications

  1. 2020
  2. Accepted/In press

    High likelihood of actionable pathogenic variant detection in breast cancer genes in women with very early onset breast cancer

    Evans, D. G., Van Veen, E., Byers, H., Evans, S., Burghel, G., Woodward, E., Harkness, E., Eccles, D. M., Greville-Heygate, S., Ellingford, J., Bowers, N. L., Pereira, M., Wallace, A. J., Howell, S., Howell, T., Lalloo, F., Newman, W. & Smith, M. J., 31 Oct 2020, (Accepted/In press) In : Journal of Medical Genetics.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Increased expression of interleukin-1 receptor characterizes anti-estrogen resistant ALDH+ breast cancer stem cells

    Sarmiento Castro, A., Caamaño-Gutiérrez, E., Sims, A. H., Hull, N., James, M., Santiago-Gómez, A., Eyre, R., Clark, C., Brown, M. E., Brooks, M. D., Hayes, D. F., Wicha, M. S., Howell, S., Clarke, R. & M Simoes, B., 11 Aug 2020, In : Stem Cell Reports. 15, 2, p. 307-316 10 p.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

    M Simoes, B., Santiago-Gómez, A., Chiodo, C., Moreira, T., Conole, D., Lovell, S., Alferez-Castro, D., Eyre, R., Spence, K., Sarmiento Castro, A., Kohler, B., Morisset, L., Lanzino, M., Ando, S., Marangoni, E., Sims, A. H., Tate, E., Howell, S. & Clarke, R., 18 Jun 2020, In : Oncogene. 39, 25, p. 4896–4908 13 p.

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Fulvestrant plus Capivasertib (AZD5363) versus placebo after relapse or progression on an aromatase inhibitor in metastatic estrogen receptor positive breast cancer (FAKTION): a multicentre, phase 2, randomised, controlled trial

    Jones, R., Casbard, A., Carucci, M., Cox, C., Butler, R., Alchami, F., Madden, T-A., Bale, C., Bezecny, P., Joffe, J., Moon, S., Twelves, C., Venkitaraman, R., Waters, S., Foxley, A. & Howell, S., 1 Mar 2020, In : The Lancet Oncology.

    Research output: Contribution to journalArticlepeer-review

  6. Published

    CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases (CARBON): Study protocol for a phase IB/IIA randomised controlled trial

    Coleman, R., Brown, J., Rathbone, E., Flanagan, L., Reid, A., Kendall, J., Howell, S., Twelves, C., Palmieri, C., Anand, A., MacPherson, I. & Brown, S., 15 Jan 2020, In : Trials. 21, 1, 89.

    Research output: Contribution to journalArticlepeer-review

  7. Published

    Reply to Comment on "The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial"

    Harvie, M., Pegington, M., Bundred, N., Campbell, A., Belcher, J., Howell, S. & Howell, A., 14 Jan 2020, In : British Journal of Cancer.

    Research output: Contribution to journalArticlepeer-review

  8. Published

    Correction: Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five country cohort study.

    Evans, DGR., Kallionpää, RA., Clementi, M., Trevisson, E., Mautner, VF., Howell, SJ., Lewis, L., Zehou, O., Peltonen, S., Brunello, A., Harkness, EF., Wolkenstein, P. & Peltonen, J., Jan 2020, In : Genetics in medicine : official journal of the American College of Medical Genetics.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Outcome of CT staging prior to neo‐adjuvant chemotherapy in patients with early breast cancer

    Broadbent, R., Ralston, S., Lauder, J. & Howell, S., 2020, In : Breast Journal.

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Risk of contralateral breast cancer in women with and without pathogenic variants in BRCA1, BRCA2 and TP53 genes in women with very early onset (<36 years) breast cancer

    Hyder, Z., Harkness, E., Woodward, E., Bowers, N. L., Perreira, M., Wallace, A. J., Howell, S., Howell, T., Lalloo, F., Newman, W., Smith, M. J. & Evans, D. G., 2020, In : Cancers.

    Research output: Contribution to journalArticlepeer-review

  11. 2019
  12. Published

    Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

    Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In : Nature Communications. 10, 1, p. 5016 15 p.

    Research output: Contribution to journalArticlepeer-review

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