Dr Robert ClarkePhD

Reader (T&R)

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Overview

Director of the Manchester Breast Centre, which comprises 25 basic, translational and clinician scientists active in breast cancer research:

http://www.breastcentre.manchester.ac.uk/

Former President (2012-2014) and Board Member, International Association for Breast Cancer Research

Editorial Board: Breast Cancer Research and Journal of Mammary Gland Biology and Neoplasia

Latest Publications:

Piggott L, Silva A, Robinson T, Santiago-Gómez A, Simões B, Becker M, Andera L, Young P, Morris C, Barret-Lee P, Alchami F, Piva M, Vivanco MdM, Clarke RB, Gee J and Clarkson R. (2018) Acquired resistance of ER-positive breast cancer to endocrine treatment confers an adaptive sensitivity to TRAIL through post-translational downregulation of c-FLIP. Clinical Cancer Research, Jan 23 [Epub ahead of print]

Simões BM, Kohler B, Clarke RB, Stringer J, Novak-Frazer L, Young K, Rautemaa-Richardson R, Zucchini G, Armstrong A, Howell SJ (2018) Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors. Ther Adv Med Oncol. 2018 Apr 2;10:1758835918766189.

Byrne AT, Alférez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A,  Budinská E, Caldas C, Chang DK, Clarke RB, et al. (2017) Interrogating open issues in cancer precision medicine using Patient-Derived Xenograft models. Nature Reviews Cancer, 17(4):254-268.

De Francesco EM, Sims AH, Maggiolini M, Sotgia F, Lisanti M and Clarke RB (2017) GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment. Breast Cancer Research, 19(1):129.

Biography

I did my undergraduate BSc studies in Biology at the University of Sussex and the Université de Grenoble.  Following two and half years as a Research Assistant with Professor Potten at the Paterson Institute for Cancer Research, I studied the control of proliferation in the normal and neoplastic human mammary gland for my PhD at The University of Manchester (1995). Subsequently, I undertook post-doctoral training with Dr Liz Anderson in the Clinical Research Department of The Christie, Manchester, and in 2001, I returned to The University of Manchester as a Group Leader in the Division of Cancer Sciences. I was appointed as a Lecturer and Cancer Research UK Research Fellow from 2001-2006 and as a Senior Lecturer and Breast Cancer Now Research Fellow from 2006-2011.  I am currently a Reader in Breast Biology leading the Breast Cancer Now Research Unit and Director of the Manchester Breast Centre, based at the Manchester Cancer Research Centre.

Qualifications

BSc (Hons), PhD

Memberships of committees and professional bodies

Service on committees

Organising Committee for 7th Annual ‘Targeting Notch in Cancer’ Conference, 20th -22nd June, 2018.

http://www.cancerconferences.org/annual_meetings/information-notch.html

Organising committee for the 11th European Network for Breast Development and Cancer (ENBDC) Workshop, Luzern, Switzerland, May 16th-18th 2019.

http://www.enbdc.org/

Organising committee for the 2nd EurOPDX Workshop on Patient-derived Models of Cancer, Luzern, Switzerland, October 1st-3rd, 2018.

http://europdx.eu/news-events.html

Research Networks and Beacons

Biology, Medicine and Health (BMH) Domains

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