Dr Riina Richardson DDS, PhD, FRCPath

Clinical Senior Lecturer (Hon Cons Stat)

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Research interests

My research group undertakes basic research (genomics, pathogenesis and mechanisms of antimicrobial drug resistance and carcinogenicity of microbial acetaldehyde production), applied laboratory work (models of pathogenesis, molecular diagnostics, antifungal resistance testing, pharmacology of new antimicrobials), and clinical studies (antimicrobial resistance, tissue responses to chronic mucosal infection and acetaldehyde exposure). To date I has published a total of over 120 peer-reviewed articles and books or book chapters in the field of medical microbiology, mucosal immunology, infectious diseases and oral medicine.

My main research focus is on the pathogenesis of chronic mucosal infections. My main contributions to the field include pioneering work on carcinogenicity and mutagenicity of chronic Candidainfections (i), innovative work on the impact of candidal biofilm formation on antifungal resistance and cellular mechanisms responsible for this (with Scottish collaborators) (ii) and pioneering work on antifungal stewardship on intensive care unit resulting in significant (50%) reduction in both antifungal consumption and mortality to candidaemia (iii). I am also a PI for phase 3 clinical trial on a novel antifungal.

My aim is to advance our understanding of the interplay between the opportunistic bacterial and fungal pathogens and the host. My research group undertakes basic research (genomics, pathogenesis and mechanisms of antimicrobial drug resistance and carcinogenicity of microbial acetaldehyde production), applied laboratory work (models of pathogenesis, molecular diagnostics, antifungal resistance testing, pharmacology of new antimicrobials), and clinical studies (tissue response to chronic oral infection and acetaldehyde exposure) with main emphasis is on the pathogenesis of chronic mucosal infections.

Projects

Research and projects