Dr Richard Unwin PhD

Senior Lecturer in Mass Spectrometry/Proteomics

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Research interests

My key research interests lie in the analysis protein expression changes which underpin pathogenesis, particularly in neurodegenerative diseases. The aim of this work is to dissect molecular events which are involved in disease development, even in cases where disease is subclinical, to provide information on key processes which contribute to the development of pathology.

In turn this may involve the development of novel tools for protein analysis primarily involving mass spectrometry, and their application to disease characterisation, including identification of key pathways in disease development and identification and characterisation of novel therapeutic targets.These tools encompass both global proteome profiling (small sample number, many proteins) or targeted analysis (fewer and specific target proteins/peptides, many samples).

We are also part of several collaborations which aim to develop or apply novel data processing tools to improve the quality and utility of proteomics data handling, statistics and outputs.

 

 

Methodological knowledge

Mass Spectrometry
Liquid Chromatography
Protein chemistry
Peptide and protein relative quantification
Assay development and biomarkers
Proteomics
Protein purification and characterisation
Post-Translational Modification analysis
Western Blotting  

Projects

Research and projects

No current projects are available for public display