Lung cancer is the leading cause of cancer mortality in the world and the leading cause of premature death in Manchester. Early detection of lung cancer is critically important to improve survival. My research interests include
1. Early detection of lung cancer: including targeted, community-based, low dose CT screening.
2. The study of lung cancer biomarkers to further understand the biology of early stage disease and develop novel approaches for early detection.
Current studies include:
1. Yorkshire Lung Screening Trial (YLST) (co-chief investigator); funded by Yorkshire Cancer Research (2017-23).
2. YLST Biomarker Sub-Study (chief investigator); funded by Yorkshire Cancer Research (2018-22).
3. The Community Lung Health Study (PI); funded by Cancer Research UK (2017-18).
4. Manchester Early Detection of Lung Disease Pilot (Research lead / database PI); funded by Macmillan Cancer Support and developed in collaboration with the Macmillan Cancer Improvement Partnership (2016-18).
5. Lung Cancer Indicator Detection: LuCID (local PI). Cambridge University and Owlstone.
6. SPUtNIk: Accuracy and cost effectiveness of dynamic contrast enhanced computed tomography in the characterisation of solitary pulmonary nodules. (local PI); University of Southampton.
7. Tumourigenicity of circulating tumour cells in early stage lung cancer to predict disease recurrence (PI), with Prof Dive, CRUK Manchester Institute (2015-19).
8. TRACERx: TRAcking lung Cancer Evolution through treatment (Rx). (2013-22) (Co-investigator; UCL).
Clinical study design and set up (attended ECCO-AACR-EORTC-ESMO Workshop, Jun 2011: "Methods in Clinical Cancer Research" Flims, Switzerland).
Good Clinical Practice trained.
Lung cancer screening.