Prof Peter Clayton BSc, MB ChB, MD(Manchester), MRCP, FRCPCH

Professor of Child Health and Paediatric

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Research interests

  • Normal & disordered growth
  • Pharmacogenomics
  • Growth factor signaling
  • Genetic causes for being born small and pathophysiological mechanisms
  • Congenital Hyperinsulinism - clinical aspects
  • Information needs and Communication in paediatric disorders for Young People

I run a paediatric endocrine research group with both clinical and basic research interests, the broad remit being – Clinical, biochemical and molecular study of growth & development

Our present projects include:

  • Characterising the role of ubiquitination in growth disorders, using the 3M syndrome as a model disorder
  • Genomic and metabolomic approaches to understanding why some children born small fail to show catch-up growth
  • Using pharmacogenomics to predict clinical responses to human growth hormone treatment
  • The Manchester Growth & Vascular Health Study – follow-up of normal infants to assess growth, growth factors and CVS parameters in White European and Pakistani children
  • The Ibadan (Nigeria) Growth & Vascular Health Study
  • Promoting better communication in young people with endocrine disorders
  • The Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) Follow-up study (NIH-funded)


  • Keywords
  • Growth Hormone
  • Insulin-like Growth Factor-1
  • Pharmacogenomics
  • Basic Science
  • Clinical investigation
  • Genetics
  • High-risk groups (eg ethnic minorities)
  • Long-term/chronic illness
  • Childhood obesity

Methodological knowledge

Cohort Studies

Clinical Trials

Laboratory Science

Research in Children & Adolescents




Research and projects

No current projects are available for public display