Dr Pawel Paszek PhD, FHEA

Senior Lecturer

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  1. 2020
  2. Published

    Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling

    Paszek, A., Kardynska, M., Bagnall, J., Smieja, J., Spiller, D., Widlak, P., Kimmel, M., Widlak, W. & Paszek, P., 24 May 2020, In : Cell Communication and Signaling. 18, p. 1-21 77.

    Research output: Contribution to journalArticle

  3. 2019
  4. Published

    Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

    Papoutsopoulou, S., Burkitt, M. D., Bergey, F., England, H., Rachel, H., Schmidt, L., Spiller, D., White, M., Paszek, P., Jackson, D., Martins Dos Santos, V. A. P., Selge, G., Prittchard, M. D., Campbell, B. J., Muller, W. & Probert, C. S., 11 Sep 2019, In : Frontiers in Immunology. 10, p. 2168

    Research output: Contribution to journalArticle

  5. 2018
  6. Published

    Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation

    Bagnall, J., Boddington, C., England, H., Brignall, R., Downton, P., Alsoufi, Z., Boyd, J., Rowe, W., Bennett, A., Walker, C., Adamson, A., Patel, N., O'Cualain, R., Schmidt, L., Spiller, D., Jackson, D., Muller, W., Muldoon, M., White, M. & Paszek, P., 24 Jul 2018, In : Science Signaling. 11, 540, 15 p., eaaf3998.

    Research output: Contribution to journalArticle

  7. Published

    Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level

    Kardyńska, M., Paszek, A., Śmieja, J., Spiller, D., Widłak, W., White, M. R. H., Paszek, P. & Kimmel, M., 2018, In : PLoS computational biology. 14, 4, p. e1006130

    Research output: Contribution to journalArticle

  8. 2017
  9. Published

    Anti-inflammatory effects of infliximab in mice are independent of TNFα neutralization

    Assas, B. M., Levison, S., Little, M., England, H., Battrick, L., Bagnall, J., Mclaughlin, J., Paszek, P., Else, K. & Pennock, J., Feb 2017, In : Clinical and experimental immunology. 187, 2

    Research output: Contribution to journalArticle

  10. Published

    Integration of kinase and calcium signaling at 1 the level of chromatin underlies inducible gene activation in T cells

    Brignall, R., Cauchy, P., Bevington, S. L. B., Gorman, B., Pisco, A. O., Bagnall, J., Boddington, C., Rowe, W., England, H., Rich, K., Schmidt, L., Dyer, N. P., Travis, M., Ott, S., Jackson, D., Cockerill, P. N. & Paszek, P., 2017, In : Journal of Immunology.

    Research output: Contribution to journalArticle

  11. 2016
  12. Published

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Phillips, N., Manning, C., Pettini, T., Biga, V., Marinopoulou, E., Stanley, P., Boyd, J., Bagnall, J., Paszek, P., Spiller, D., White, M., Goodfellow, M., Galla, T., Rattray, M. & Papalopulu, N., 4 Oct 2016, In : eLife. 5, e16118.

    Research output: Contribution to journalArticle

  13. Published

    Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

    Daniels, M. J. D., Rivers-Auty, J., Schilling, T., Spencer, N. G., Watremez, W., Fasolino, V., Booth, S. J., White, C. S., Baldwin, A. G., Freeman, S., Wong, R., Latta, C., Yu, S., Jackson, J., Fischer, N., Koziel, V., Pillot, T., Bagnall, J., Allan, S. M., Paszek, P. & 5 others, Galea, J., Harte, M. K., Eder, C., Lawrence, C. B. & Brough, D., 11 Aug 2016, In : Nature Communications. 7, p. 12504 12504.

    Research output: Contribution to journalArticle

  14. Published

    Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

    Adamson, A., Boddington, C., Downton, P., Rowe, W., Bagnall, J., Lam, C., Maya-Mendoza, A., Schmidt, L., Harper, C. V., Spiller, D., Rand, D. A., Jackson, D., White, M. R. H. & Paszek, P., 6 Jul 2016, In : Nature Communications. 7, 12057.

    Research output: Contribution to journalArticle

  15. Published

    Inflammasome-dependent IL-1β release depends upon membrane permeabilisation.

    Martín-Sánchez, F., Diamond, C., Zeitler, M., Gomez-Sanchez, A., Baroja-Mazo, A., Bagnall, J., Spiller, D., White, M., Daniels, M., Mortellaro, A., Peñalver, M., Paszek, P., Steringer, J. P., Nickel, W., Brough, D. & Pelegrin, P., Jul 2016, In : Cell Death & Differentiation. 23, 7, p. 1219-1231 13 p.

    Research output: Contribution to journalArticle

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