Prof Paul Brenchley PhD
Honorary Professor
Research interests
Since 2009, my group has investigated the autoimmune mechanism causing membranous nephropathy, a rare glomerulopathy associated with heavy proteinuria and the most common cause of nephrotic syndrome in adults.
We have
- developed the first ELISA for quantitating circulating anti-PLA2R antibodies in patients
- linked levels of anti-PLA2R with the HLA DQA1 *05:01 DQB1 *02:01 allotype
- studied the role of anti-PLA2R levels in clinical management of patients over time
- identified the dominant epitope on PLA2R as a 31mer disulphide bonded structure
- identified A2t as a coreceptor for PLA2R on podocytes
- proposed a new structure for PLA2R based on single molecule EM
- developed an ELISA for the minor autoantigen THSD7A
- identified a common epitope structure shared by PLA2R and THSD7A
- contributed to the largest global GWAS in MN which confirms DQA1 and PLA2R as risk genes and identifies NfKB and IRF4 as additional risk genes for MN
- contributed to the first study of recurrent MN in transplants which identifies a donor specific HLA-D risk factor
- identified candidate T cell epitopes in PLA2R
Projects
Research and projects
Manchester Bioelectronics Network
Casson, A., Grieve, B., Ozanyan, K., Blanford, C., Cartmell, S., Li, Y., Ballestrem, C., Reid, A., Turner, M., Wong, L. S., Yeates, S., Trimble, E., Jones, C., Scully, P., Holmes, M., Wimpenny, I., Humphrey, B., Turner, M., Dobson, C., Halsall, M., Jones, S., Echtermeyer, T., Wijekoon, J., Curry, R., Picardo, M., Tracey, K., Persaud, K., Migliorato, M., Treves Brown, B., Ozanyan, K., Wright, P., Majewski, L., Hodgson, A., Dudek, P., Gaydecki, P., Morgan, P., Zhang, H., Keavney, B., Brenchley, P., Fields, R., Khan, U., Casiraghi, C., Blaker, J., Saiani, A., Vijayaraghavan, A., Lu, J., Kell, D., Donald, A., Ozols, M., Derby, B., Sharma, J., Mills, E. C., Mohd Nawi, I., Tandon, B., Read, M., Zhu, Q., Ren, L., Waigh, T., Petersen, R., Beach, C., Brown, T., Thomas, A. & Crowe, I.
1/02/18 → 31/07/18
Project: Research