Prof Paul BishopPhD, FRCOphth

Professor of Ophthalmology & Matrix Biol

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Publications

  1. 2019
  2. Published

    Loss-of-function mutations in the CFH gene affecting alternatively encoded Factor H-like 1 protein cause dominant early-onset macular drusen

    Taylor, R. L., Poulter, J., Downes, S., McKibbin, M., Khan, K. N., Inglehearn, C. F., Webster, A. R., Hardcastle, A. J., Michaelides, M., Bishop, P., Clark, S. & Black, G., 2019, In : Ophthalmology.

    Research output: Contribution to journalArticle

  3. Published

    Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

    Porter, L. F., Saptarshi, N., Fang, Y., Rathi, S., den Hollander, A., de Jong, E., Clark, S., Bishop, P., Olsen, T., Liloglou, T., Chavali, V. & Paraoan, L., 2019, In : Clinical Epigenetics. 11, 6

    Research output: Contribution to journalArticle

  4. 2018
  5. Published

    Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

    CREAM, 23andMe Research Team, UK Biobank Eye and Vision Consortium, Aslam, T. M. & Bishop, P. N., 1 Jun 2018, In : Nature Genetics. 50, 6, p. 834-848 15 p.

    Research output: Contribution to journalArticle

  6. Published

    In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis

    Farrán, A., Valverde-Franco, G., Tío, L., Lussier, B., Fahmi, H., Pelletier, J-P., Bishop, P. N., Monfort, J. & Martel-Pelletier, J., 11 Jan 2018, In : Scientific Reports. 8, 1, p. 457

    Research output: Contribution to journalArticle

  7. 2017
  8. Published

    Bruch's membrane compartmentalises complement regulation in the eye with implications for therapeutic design in age-related macular degeneration.

    Clark, S., Mcharg, S., Tilakaratna, V., Brace, N. & Bishop, P., 19 Dec 2017, In : Frontiers in Immunology.

    Research output: Contribution to journalArticle

  9. Published

    Ultrastructural and histopathologic findings after pars plana vitrectomy with a new hypersonic vitrector system. Qualitative preliminary assessment

    Pastor-Idoate, S., Bonshek, R., Dreher Irion, L., Zambrano, I., Carlin, P., Mironov, A., Bishop, P., McLeod, D. & Stanga, P. E., 11 Apr 2017, In : PLoS ONE. 12, 4, e0173883.

    Research output: Contribution to journalArticle

  10. Published

    Efficacy and safety of glycosidic enzymes for improved gene delivery to the retina following intravitreal injection in mice

    Cehajic-Kapetanovic, J., Milosavljevic, N., Bedford, R., Lucas, R. & Bishop, P., 2017, In : Molecular Therapy - Methods & Clinical Development.

    Research output: Contribution to journalArticle

  11. Published

    The eye as a complement dysregulation hotspot

    Clark, S. & Bishop, P., 2017, In : Seminars in Immunopathology.

    Research output: Contribution to journalArticle

  12. 2016
  13. Published

    Molecular findings from 537 individuals with inherited retinal disease

    Ellingford, J., Barton, S., Bhaskar, S., O'Sullivan, J., Williams, S., Lamb, J., Panda, B., Sergouniotis, P., Gillespie, R., Daiger, S., Hall, G., Gale, T., Lloyd, C., Bishop, P., Ramsden, S. & Black, G., Nov 2016, In : Journal of Medical Genetics. 53, 11, p. 761-767 7 p.

    Research output: Contribution to journalArticle

  14. Published

    Characterisation of the metabolome of ocular tissues and postmortem changes in the rat retina

    Tan, S. Z., Mullard, G., Hollywood, K., Dunn, W. B. & Bishop, P., Aug 2016, In : Experimental eye research. 149, p. 8-15 8 p.

    Research output: Contribution to journalArticle

  15. Published

    Introduction to metabolomics and its applications in ophthalmology

    Tan, S. Z., Begley, P., Mullard, G., Hollywood, K. A. & Bishop, P. N., Jun 2016, In : Eye (London, England). 30, 6, p. 773-783 11 p.

    Research output: Contribution to journalArticle

  16. Published

    Vitrectomy for primary symptomatic vitreous opacities: an evidence-based review

    Ivanova, T., Jalil, A., Antoniou, Y., Bishop, P. N., Vallejo-Garcia, J. L. & Patton, N., May 2016, In : Eye (London, England). 30, 5, p. 645-655 11 p.

    Research output: Contribution to journalArticle

  17. Published

    Whole genome sequencing increases molecular diagnostic yield compared with current diagnostic testing for inherited retinal disease

    Ellingford, J., Barton, S., Bhaskar, S., Williams, S., Sergouniotis, P., O'Sullivan, J., Lamb, J., Perveen, R., Hall, G., Newman, W., Bishop, P., Roberts, S., Leach, R., Tearle, R., Bayliss, S., Ramsden, S., Nemeth, A. H. & Black, G., May 2016, In : Ophthalmology. p. 1143–1150

    Research output: Contribution to journalArticle

  18. Published

    Automated retinal image quality assessment on the UK Biobank dataset for epidemiological studies

    UK Biobank Eye and Vision Consortium, 1 Apr 2016, In : Computers in Biology and Medicine. 71, p. 67-76 10 p.

    Research output: Contribution to journalArticle

  19. Published

    Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation

    Langford-Smith, A., Tilakaratna, V., Lythgoe, P. R., Clark, S., Bishop, P. N. & Day, A. J., Jan 2016, In : P L o S One. 11, 1, 16 p.

    Research output: Contribution to journalArticle

  20. 2015
  21. Published

    Enrichment of Bruch’s membrane from human donor eyes

    McHarg, S., Brace, N., Bishop, P. N. & Clark, S. J., 16 Nov 2015, In : Journal of Visualized Experiments. 105

    Research output: Contribution to journalArticle

  22. Published

    Age-related macular degeneration and the role of the complement system.

    Mcharg, S., Clark, S. J., Day, A. J. & Bishop, P. N., Sep 2015, In : Molecular immunology. 67, 1, p. 43-50 7 p.

    Research output: Contribution to journalArticle

  23. Published

    Restoration of Vision with Ectopic Expression of Human Rod Opsin

    Cehajic-Kapetanovic, J., Eleftheriou, C., Allen, A. E., Milosavljevic, N., Pienaar, A., Bedford, R., Davis, K., Bishop, P. N. & Lucas, R., 17 Aug 2015, In : Current Biology. 25, 16, p. 2111-2122 11 p.

    Research output: Contribution to journalArticle

  24. Published

    Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B.

    Keenan, T. D. L., Toso, M., Pappas, C., Nichols, L., Bishop, P. N. & Hageman, G. S., Jul 2015, In : Investigative ophthalmology & visual science. 56, 8

    Research output: Contribution to journalArticle

  25. Published
  26. Published

    Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

    Church, S. J., Begley, P., Kureishy, N., McHarg, S., Bishop, P. N., Bechtold, D. A., Unwin, R. D. & Cooper, G. J. S., 8 May 2015, In : Biochemical and biophysical research communications. 460, 3, p. 549-554

    Research output: Contribution to journalArticle

  27. Published

    The role of extracellular matrix in retinal vascular development and preretinal neovascularization.

    Bishop, P. N., Apr 2015, In : Experimental eye research. 133

    Research output: Contribution to journalArticle

  28. Published

    Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration.

    Clark, S. J. & Bishop, P. N., 1 Jan 2015, In : Journal of Clinical Medicine. 4, 1, p. 18-31 13 p.

    Research output: Contribution to journalArticle

  29. Published

    Complementing the sugar code: role of GAGs and sialic acid in complement regulation

    Langford-Smith, A., Day, A. J., Bishop, P. N. & Clark, S. J., 2015, In : Frontiers in Immunology. 6, 6, 25.

    Research output: Contribution to journalArticle

  30. Published

    Erratum to: A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications

    Mullard, G., Allwood, J. W., Weber, J., Brown, R. J. M., Begley, P., Hollywood, K. A., Jones, M., Unwin, R., Bishop, P., Cooper, G. & Dunn, W. B., 2015, In : Metabolomics. 11, p. 1081 1 p.

    Research output: Contribution to journalArticle

  31. Published

    Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature.

    MacGillivray, T. J., Cameron, J. R., Zhang, Q., El-Medany, A., Mulholland, C., Sheng, Z., Doubal, F. N., Trucco, E., Aslam, T., Bao, Y., Barman, S., Bishop, P., Blows, P., Bunce, C., Chakravarthy, U., Chan, M., Chianca, A., Cipriani, V., Crabb, D., Cumberland, P. & 53 others, Day, A., Desai, P., Dhillon, B., Dick, A., Foster, P., Gallacher, J., Garway, D. T., Goverdhan, S., Guggenheim, J., Gupta, P., Hammond, C., Hogg, R., Hughes, A., Keane, P., Khaw, P. T., Khawaja, A., Lascaratos, G., Lotery, A., Luthert, P., MacGillivray, T., Mackie, S., Martin, K., McGaughey, M., McGuinness, B., McKay, G., McKibbin, M., Mitry, D., Moore, T., Morgan, J., Muthy, Z., O'Sullivan, E., Owen, C., Patel, P., Peto, T., Rahi, J., Rudnicka, A., Sampedro, C. G., Steel, D., Stratton, I., Strouthdis, N., Sudlow, C., Thaung, C., Thomas, D., Trucco, E., Tufail, A., Vernon, S., Viswanathan, A., Williams, C., Williams, K., Yates, J., Yates, M., Yip, J. & Zhu, H., 2015, In : PLoS ONE. 10, 5

    Research output: Contribution to journalArticle

  32. 2014
  33. Published

    Author's reply: To PMID 24888710

    Dawes, P., Dickinson, C., Emsley, R., Bishop, P., Cruickshanks, K. J., Edmondson-Jones, M., McCormack, A., Fortnum, H., Norman, P., Munro, K. & Moore, D., 23 Dec 2014, In : Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). 35, 1, p. 107-8 2 p.

    Research output: Contribution to journalArticle

  34. Published

    Identification of factor H-like protein 1 as the predominant complement regulator on Bruch’s membrane: implications for age-related macular degeneration

    Clark, S. J., Schmidt, C. Q., White, A. M., Hakobyan, S., Morgan, B. P. & Bishop, P. N., 15 Nov 2014, In : Journal of Immunology. 193, p. 4962-4970 8 p.

    Research output: Contribution to journalArticle

  35. Published

    Age-dependent changes in heparan sulfate in human Bruch's membrane: Implications for age-related macular degeneration

    Keenan, T. D. L., Pickford, C. E., Holley, R. J., Clark, S. J., Lin, W., Dowsey, A. W., Merry, C. L., Day, A. J. & Bishop, P. N., 29 Jul 2014, In : Investigative Ophthalmology and Visual Science. 55, 8, p. 5370-5379 9 p.

    Research output: Contribution to journalArticle

  36. Published

    Characterization of opticin digestion by proteases involved in osteoarthritis development.

    Tío, L., Martel-Pelletier, J., Pelletier, J-P., Bishop, P. N., Roughley, P., Farran, A., Benito, P. & Monfort, J., Mar 2014, In : Joint, bone, spine : revue du rhumatisme. 81, 2, p. 137-141 4 p.

    Research output: Contribution to journalArticle

  37. Published

    Repeatability of visual function measures in age-related macular degeneration

    Aslam, T., Mahmood, S., Balaskas, K., Patton, N., Tanawade, R. G., Tan, S. Z., Roberts, S., Parkes, J. & Bishop, P. N., Feb 2014, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 252, 2, p. 201-206 5 p.

    Research output: Contribution to journalArticle

  38. Published

    The role of complement in age-related macular degeneration: Heparan sulphate, a ZIP code for complement factor H?

    Clark, S., Langford-Smith, A., Keenan, T. D. L., Clark, S., Bishop, P. N. & Day, A. J., 2014, In : Journal of Innate Immunity. 6, 4, p. 407-416 9 p.

    Research output: Contribution to journalArticle

  39. Published

    Vision impairment and dual sensory problems in middle age

    Dawes, P., Dickinson, C., Emsley, R., Bishop, P. N., Cruickshanks, K. J., Edmondson-Jones, M., Mccormack, A., Fortnum, H., Moore, D. R., Norman, P. & Munro, K., 2014, In : Ophthalmic and Physiological Optics. 34, 4, p. 479-488 9 p.

    Research output: Contribution to journalArticle

  40. 2013
  41. Published

    Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration

    Ansari, M., Mckeigue, P. M., Skerka, C., Hayward, C., Rudan, I., Vitart, V., Polasek, O., Armbrecht, A. M., Yates, J. R. W., Vatavuk, Z., Bencic, G., Kolcic, I., Oostra, B. A., Van Duijn, C. M., Campbell, S., Stanton, C. M., Huffman, J., Shu, X., Khan, J. C., Shahid, H. & 11 others, Harding, S. P., Bishop, P. N., Deary Ian J., I. J., Moore, A. T., Dhillon, B., Rudan, P., Zipfel, P. F., Sim, R. B., Hastie, N. D., Campbell, H. & Wright, A. F., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4857-4869 12 p., ddt336.

    Research output: Contribution to journalArticle

  42. Published

    The Royal College of Ophthalmologists Guidelines on AMD: Executive Summary.

    Chakravarthy, U., Williams, M., Amoaku, W., Bailey, C., Bishop, P., Brand, C., Chakravarthy, U., Chong, V., Downes, S., Evans, J., Lotery, A., Rubin, G., Sparrow, J., Talks, J., Williams, M. & Yelf, C., Dec 2013, In : Eye (London, England). 27, 12

    Research output: Contribution to journalArticle

  43. Published

    Iron, zinc, and copper in retinal physiology and disease

    Ugarte, M., Osborne, N. N., Brown, L. A. & Bishop, P. N., Nov 2013, In : Survey of ophthalmology. 58, 6, p. 585-609 24 p.

    Research output: Contribution to journalArticle

  44. Published

    Seven new loci associated with age-related macular degeneration

    Fritsche, L. G., Chen, W., Schu, M., Yaspan, B. L., Yu, Y., Thorleifsson, G., Zack, D. J., Arakawa, S., Cipriani, V., Ripke, S., Igo, R. P., Buitendijk, G. H. S., Sim, X., Weeks, D. E., Guymer, R. H., Merriam, J. E., Francis, P. J., Hannum, G., Agarwal, A., Armbrecht, A. M. & 136 others, Audo, I., Aung, T., Barile, G. R., Benchaboune, M., Bird, A. C., Bishop, P. N., Branham, K. E., Brooks, M., Brucker, A. J., Cade, W. H., Cain, M. S., Campochiaro, P. A., Chan, C. C., Cheng, C. Y., Chew, E. Y., Chin, K. A., Chowers, I., Clayton, D. G., Cojocaru, R., Conley, Y. P., Cornes, B. K., Daly, M. J., Dhillon, B., Edwards, A. O., Evangelou, E., Fagerness, J., Ferreyra, H. A., Friedman, J. S., Geirsdottir, A., George, R. J., Gieger, C., Gupta, N., Hagstrom, S. A., Harding, S. P., Haritoglou, C., Heckenlively, J. R., Holz, F. G., Hughes, G., Ioannidis, J. P. A., Ishibashi, T., Joseph, P., Jun, G., Kamatani, Y., Katsanis, N., N Keilhauer, C., Khan, J. C., Kim, I. K., Kiyohara, Y., Klein, B. E. K., Klein, R., Kovach, J. L., Kozak, I., Lee, C. J., Lee, K. E., Lichtner, P., Lotery, A. J., Meitinger, T., Mitchell, P., Mohand-Saïd, S., Moore, A. T., Morgan, D. J., Morrison, M. A., Myers, C. E., Naj, A. C., Nakamura, Y., Okada, Y., Orlin, A., Ortube, M. C., Othman, M. I., Pappas, C., Park, K. H., Pauer, G. J. T., Peachey, N. S., Poch, O., Priya, R. R., Reynolds, R., Richardson, A. J., Ripp, R., Rudolph, G., Ryu, E., Sahel, J. A., Schaumberg, D. A., Scholl, H. P. N., Schwartz, S. G., Scott, W. K., Shahid, H., Sigurdsson, H., Silvestri, G., Sivakumaran, T. A., Smith, R. T., Sobrin, L., Souied, E. H., Stambolian, D. E., Stefansson, H., Sturgill-Short, G. M., Takahashi, A., Tosakulwong, N., Truitt, B. J., Tsironi, E. E., Uitterlinden, A. G., Van Duijn, C. M., Vijaya, L., Vingerling, J. R., Vithana, E. N., Webster, A. R., Wichmann, H. E., Winkler, T. W., Wong, T. Y., Wright, A. F., Zelenika, D., Zhang, M., Zhao, L., Zhang, K., Klein, M. L., Hageman, G. S., Lathrop, G. M., Stefansson, K., Allikmets, R., Baird, P. N., Gorin, M. B., Wang, J. J., Klaver, C. C. W., Seddon, J. M., Pericak-Vance, M. A., Iyengar, S. K., Yates, J. R. W., Swaroop, A., Weber, B. H. F., Kubo, M., Deangelis, M. M., Léveillard, T., Thorsteinsdottir, U., Haines, J. L., Farrer, L. A., Heid, I. M. & Abecasis, G. R., Apr 2013, In : Nature Genetics. 45, 4, p. 433-439 6 p.

    Research output: Contribution to journalArticle

  45. Published

    Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions

    Clark, S. J., Ridge, L. A., Herbert, A. P., Hakobyan, S., Mulloy, B., Lennon, R., Würzner, R., Morgan, B. P., Uhrín, D., Bishop, P. N. & Day, A. J., 1 Mar 2013, In : Journal of Immunology. 190, 5, p. 2049-2057 8 p.

    Research output: Contribution to journalArticle

  46. Published

    Opticin, a small leucine-rich proteoglycan, is uniquely expressed and translocated to the nucleus of chronic lymphocytic leukemia cells

    Mikaelsson, E., Osterberg, A., Fard, ZT., Mahmoudi, A., Mahmoudian, J., Jeddi-Tahrani, M., Akhondi, M., Shokri, F., Bishop, PN. & Rabbani, H., 2013, In : Experimental Hematology & Oncology. 2, p. 23

    Research output: Contribution to journalArticle

  47. Published

    The proteoglycan glycomatrix: A sugar microenvironment essential for complement regulation

    Clark, S. J., Bishop, P. N. & Day, A. J., 2013, In : Frontiers in Immunology. 4, Article 412.

    Research output: Contribution to journalArticle

  48. 2012
  49. Published

    Concentration of various trace elements in the rat retina and their distribution in different structures

    Ugarte, M., Grime, G. W., Lord, G., Geraki, K., Collingwood, J. F., Finnegan, M. E., Farnfield, H., Merchant, M., Bailey, M. J., Ward, N. I., Foster, P. J., Bishop, P. N., Osborne, N. N., Grime, GW., Collingwood, JF., Finnegan, ME., Bailey, MJ., Foster, PJ. & Bishop, PN., Dec 2012, In : Metallomics. 4, 12, p. 1245-1254 9 p.

    Research output: Contribution to journalArticle

  50. Published

    Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera

    Keenan, T., Keenan, T. D. L., Clark, S. J., Unwin, R. D., Ridge, L. A., Day, A. J. & Bishop, P. N., Nov 2012, In : Investigative Ophthalmology and Visual Science. 53, 12, p. 7528-7538 10 p.

    Research output: Contribution to journalArticle

  51. Published

    Ranibizumab for the management of Sorsby fundus dystrophy

    Balaskas, K., Hovan, M., Mahmood, S. & Bishop, P., Oct 2012, In : Eye. 27, 1, p. 101-102 1 p.

    Research output: Contribution to journalArticle

  52. Published

    Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3

    Cipriani, V., Leung, H. T., Plagnol, V., Bunce, C., Khan, J. C., Shahid, H., Moore, A. T., Harding, S. P., Bishop, P. N., Hayward, C., Campbell, S., Armbrecht, A. M., Dhillon, B., Deary, I. J., Campbell, H., Dunlop, M., Dominiczak, A. F., Mann, S. S., Jenkins, S. A., Webster, A. R. & 13 others, Bird, A. C., Lathrop, M., Zelenika, D., Souied, E. H., Sahel, J. A., Léveillard, T., Cree, A. J., Gibson, J., Ennis, S., Lotery, A. J., Wright, A. F., Clayton, D. G. & Yates, J. R. W., Sep 2012, In : Human Molecular Genetics. 21, 18, p. 4138-4150 12 p., dds225.

    Research output: Contribution to journalArticle

  53. Published

    Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness

    Le Goff, M. M., Sutton, M. J., Slevins, M., Latif, A., Humphries, M. J. & Bishop, P. N., 10 Aug 2012, In : Journal of Biological Chemistry. 287, 33, p. 28027-28036 9 p.

    Research output: Contribution to journalArticle

  54. Published

    Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: One-year findings from the IVAN randomized trial

    Aslam, T., Chakravarthy, U., Harding, S. P., Rogers, C. A., Downes, S. M., Lotery, A. J., Wordsworth, S., Reeves, B. C. & Bishop, P., Jul 2012, In : Ophthalmology. 119, 7, p. 1399-1411 12 p.

    Research output: Contribution to journalArticle

  55. Published

    Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)

    Ugarte, M., Brown, M., Hollywood, K. A., Cooper, G., Bishop, P. & Dunn, W. B., 30 Apr 2012, In : Genome Medicine. 4, 4, 35.

    Research output: Contribution to journalArticle

  56. Published

    Age-related macular degeneration: The importance of family history as a risk factor

    Bishop, P., Shahid, H., Khan, J. C., Cipriani, V., Sepp, T., Matharu, B. K., Bunce, C., Harding, S. P., Clayton, D. G., Moore, A. T. & Yates, J. R. W., Mar 2012, In : British Journal Of Ophthalmology. 96, 3, p. 427-431 4 p.

    Research output: Contribution to journalArticle

  57. Published

    No evidence of association between complement factor i genetic variant rs10033900 and age-related macular degeneration

    Cipriani, V., Matharu, B. K., Khan, J. C., Shahid, H., Hayward, C., Wright, A. F., Armbrecht, A. M., Dhillon, B., Harding, S. P., Bishop, P. N., Bunce, C., Clayton, D. G., Moore, A. T. & Yates, J. R. W., Jan 2012, In : European Journal of Human Genetics. 20, 1, p. 1-2 1 p.

    Research output: Contribution to journalArticle

  58. Published

    The vitreous glycoprotein opticin inhibits preretinal neovascularization

    le Goff, M. M., Lu, H., Ugarte, M., Henry, S., Takanosu, M., Mayne, R. & Bishop, P. N., Jan 2012, In : Investigative Ophthalmology and Visual Science. 53, 1, p. 228-234 6 p.

    Research output: Contribution to journalArticle

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