Prof Paul BishopPhD, FRCOphth

Professor of Ophthalmology & Matrix Biol

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Publications

  1. Published

    A novel peripherin/RDS mutation resulting in a retinal dystrophy with phenotypic variation

    Kalyanasundaram, T. S., Black, G. C., O'Sullivan, J. & Bishop, P. N., Jan 2009, In : Eye. 23, 1, p. 237-239 2 p.

    Research output: Contribution to journalArticle

  2. Published

    Acute visual loss after thioridazine overdose [4]

    Anderton, L. & Bishop, P., 2001, In : The American journal of psychiatry. 158, 5, p. 818

    Research output: Contribution to journalArticle

  3. Published

    Acute visual loss following thioridazine overdose

    Anderton, L. & Bishop, PN., 2001, In : The American journal of psychiatry. 158

    Research output: Contribution to journalArticle

  4. Published

    Adult vitreous structure and postnatal changes

    Le Goff, M. M. & Bishop, P. N., 2008, In : Eye. 22, 10, p. 1214-1222 8 p.

    Research output: Contribution to journalArticle

  5. Published

    Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract Formation

    Langford-Smith, A., Tilakaratna, V., Lythgoe, P. R., Clark, S., Bishop, P. N. & Day, A. J., Jan 2016, In : P L o S One. 11, 1, 16 p.

    Research output: Contribution to journalArticle

  6. Published

    Age-dependent changes in heparan sulfate in human Bruch's membrane: Implications for age-related macular degeneration

    Keenan, T. D. L., Pickford, C. E., Holley, R. J., Clark, S. J., Lin, W., Dowsey, A. W., Merry, C. L., Day, A. J. & Bishop, P. N., 29 Jul 2014, In : Investigative Ophthalmology and Visual Science. 55, 8, p. 5370-5379 9 p.

    Research output: Contribution to journalArticle

  7. Published

    Age-dependent changes in the basal retinovitreous adhesion

    Wang, J., McLeod, D., Henson, D. B. & Bishop, P. N., 1 May 2003, In : Investigative Ophthalmology and Visual Science. 44, 5, p. 1793-1800 7 p.

    Research output: Contribution to journalArticle

  8. Published

    Age-related macular degeneration and the role of the complement system.

    Mcharg, S., Clark, S. J., Day, A. J. & Bishop, P. N., Sep 2015, In : Molecular immunology. 67, 1, p. 43-50 7 p.

    Research output: Contribution to journalArticle

  9. Published

    Age-related macular degeneration: The importance of family history as a risk factor

    Bishop, P., Shahid, H., Khan, J. C., Cipriani, V., Sepp, T., Matharu, B. K., Bunce, C., Harding, S. P., Clayton, D. G., Moore, A. T. & Yates, J. R. W., Mar 2012, In : British Journal Of Ophthalmology. 96, 3, p. 427-431 4 p.

    Research output: Contribution to journalArticle

  10. Published

    An immune dot-blot test for the diagnosis of ocular infection with Chlamydia trachomatis

    Bishop, P. N., Tullo, A. B., Killough, R. & Richmond, S. J., 1991, In : Eye. 5, 3, p. 305-308 3 p.

    Research output: Contribution to journalArticle

  11. Published

    Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B.

    Keenan, T. D. L., Toso, M., Pappas, C., Nichols, L., Bishop, P. N. & Hageman, G. S., Jul 2015, In : Investigative ophthalmology & visual science. 56, 8

    Research output: Contribution to journalArticle

  12. Published

    Author's reply: To PMID 24888710

    Dawes, P., Dickinson, C., Emsley, R., Bishop, P., Cruickshanks, K. J., Edmondson-Jones, M., McCormack, A., Fortnum, H., Norman, P., Munro, K. & Moore, D., 23 Dec 2014, In : Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). 35, 1, p. 107-8 2 p.

    Research output: Contribution to journalArticle

  13. Published

    Automated retinal image quality assessment on the UK Biobank dataset for epidemiological studies

    UK Biobank Eye and Vision Consortium, 1 Apr 2016, In : Computers in Biology and Medicine. 71, p. 67-76 10 p.

    Research output: Contribution to journalArticle

  14. Published

    Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage

    Mcleod, D., Bos, K. J., Holmes, D. F., Kadler, K. E., McLeod, D., Morris, N. P. & Bishop, P. N., 9 Mar 2001, In : Journal of molecular biology. 306, 5, p. 1011-1022 11 p.

    Research output: Contribution to journalArticle

  15. Published

    Bilateral subfoveal choroidal neovascularization in Turner's syndrome: Coincidence or consequence?

    Beatty, S., Black, G., Rhatigan, M. & Bishop, P., Oct 1999, In : Canadian Journal of Ophthalmology. 34, 6, p. 346-348 2 p.

    Research output: Contribution to journalArticle

  16. Published

    Bruch's membrane compartmentalises complement regulation in the eye with implications for therapeutic design in age-related macular degeneration.

    Clark, S., Mcharg, S., Tilakaratna, V., Brace, N. & Bishop, P., 19 Dec 2017, In : Frontiers in Immunology.

    Research output: Contribution to journalArticle

  17. Published

    Characterisation of the metabolome of ocular tissues and postmortem changes in the rat retina

    Tan, S. Z., Mullard, G., Hollywood, K., Dunn, W. B. & Bishop, P., Aug 2016, In : Experimental eye research. 149, p. 8-15 8 p.

    Research output: Contribution to journalArticle

  18. Published

    Characterization of Opticin and Evidence of Stable Dimerization in Solution

    Le Goff, M. M., Hindson, V. J., Jowitt, T. A., Scott, P. G. & Bishop, P. N., 14 Nov 2003, In : Journal of Biological Chemistry. 278, 46, p. 45280-45287 7 p.

    Research output: Contribution to journalArticle

  19. Published

    Characterization of opticin digestion by proteases involved in osteoarthritis development.

    Tío, L., Martel-Pelletier, J., Pelletier, J-P., Bishop, P. N., Roughley, P., Farran, A., Benito, P. & Monfort, J., Mar 2014, In : Joint, bone, spine : revue du rhumatisme. 81, 2, p. 137-141 4 p.

    Research output: Contribution to journalArticle

  20. Published

    Class III SLRP agonists for the reduction of blood vessel formation

    Bishop, P. N., 15 Apr 2008, Patent No. US7358224

    Research output: Patent

  21. Published

    Collagen fibril organisation in mammalian vitreous by freeze etch/rotary shadowing electron microscopy

    Bos, K. J., Holmes, D. F., Meadows, R. S., Kadler, K. E., McLeod, D. & Bishop, P. N., 2001, In : Micron. 32, 3, p. 301-306 5 p.

    Research output: Contribution to journalArticle

  22. Published

    Collagen fibril organization in mammalian vitreous by freeze etching/rotary shadowing electon microscopy

    Bos, KJ., Holmes, DF., Meadows, RS., Kadler, KE., Mcleod, D. & Bishop, PN., 2001, In : Micron. 32

    Research output: Contribution to journalArticle

  23. Published

    Complement factor H and age-related macular degeneration: The role of glycosaminoglycan recognition in disease pathology

    Clark, S. J., Bishop, P. N. & Day, A. J., Oct 2010, In : Biochemical Society Transactions. 38, 5, p. 1342-1348 6 p.

    Research output: Contribution to journalArticle

  24. Published

    Complementing the sugar code: role of GAGs and sialic acid in complement regulation

    Langford-Smith, A., Day, A. J., Bishop, P. N. & Clark, S. J., 2015, In : Frontiers in Immunology. 6, 6, 25.

    Research output: Contribution to journalArticle

  25. Published

    Concentration of various trace elements in the rat retina and their distribution in different structures

    Ugarte, M., Grime, G. W., Lord, G., Geraki, K., Collingwood, J. F., Finnegan, M. E., Farnfield, H., Merchant, M., Bailey, M. J., Ward, N. I., Foster, P. J., Bishop, P. N., Osborne, N. N., Grime, GW., Collingwood, JF., Finnegan, ME., Bailey, MJ., Foster, PJ. & Bishop, PN., Dec 2012, In : Metallomics. 4, 12, p. 1245-1254 9 p.

    Research output: Contribution to journalArticle

  26. Published

    Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans

    Scott, P. G., Dodd, C. M., Bergmann, E. M., Sheehan, J. K. & Bishop, P. N., 12 May 2006, In : Journal of Biological Chemistry. 281, 19, p. 13324-13332 8 p.

    Research output: Contribution to journalArticle

  27. Published

    Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan

    Scott, P. G., McEwan, P. A., Dodd, C. M., Bergmann, E. M., Bishop, P. N. & Bella, J., 2 Nov 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 44, p. 15633-15638 5 p.

    Research output: Contribution to journalArticle

  28. Published

    Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

    Church, S. J., Begley, P., Kureishy, N., McHarg, S., Bishop, P. N., Bechtold, D. A., Unwin, R. D. & Cooper, G. J. S., 8 May 2015, In : Biochemical and biophysical research communications. 460, 3, p. 549-554

    Research output: Contribution to journalArticle

  29. Published

    Development of vitreous and composition of the vitreous gel.

    Bishop, PN., 2003, Pathologie du vitre.: Raport annuel de la societe francaise d’ophtalmologie pour l’annee. Brasseur, G. (ed.). Masson

    Research output: Chapter in Book/Report/Conference proceedingChapter

  30. Published

    Discovery and Functional Analysis of a Retinitis Pigmentosa Gene, C2ORF71

    Nishimura, D. Y., Baye, L. M., Perveen, R., Searby, C. C., Avila-Fernandez, A., Pereiro, I., Ayuso, C., Valverde, D., Bishop, P. N., Manson, F. D. C., Urquhart, J., Stone, E. M., Slusarski, D. C., Black, G. C. M. & Sheffield, V. C., 14 May 2010, In : American Journal of Human Genetics. 86, 5, p. 686-695 9 p.

    Research output: Contribution to journalArticle

  31. Published

    Disorders of the vitreous

    Bishop, PN., 2008, Pathobiology of Ocular Disease: A Dynamic Approach. 3 ed. New York: Marcel Dekker Inc.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  32. Published

    Efficacy and safety of glycosidic enzymes for improved gene delivery to the retina following intravitreal injection in mice

    Cehajic-Kapetanovic, J., Milosavljevic, N., Bedford, R., Lucas, R. & Bishop, P., 2017, In : Molecular Therapy - Methods & Clinical Development.

    Research output: Contribution to journalArticle

  33. Published

    Enrichment of Bruch’s membrane from human donor eyes

    McHarg, S., Brace, N., Bishop, P. N. & Clark, S. J., 16 Nov 2015, In : Journal of Visualized Experiments. 105

    Research output: Contribution to journalArticle

  34. Published

    Erratum to: A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications

    Mullard, G., Allwood, J. W., Weber, J., Brown, R. J. M., Begley, P., Hollywood, K. A., Jones, M., Unwin, R., Bishop, P., Cooper, G. & Dunn, W. B., 2015, In : Metabolomics. 11, p. 1081 1 p.

    Research output: Contribution to journalArticle

  35. Published

    Extraction and characterisation of the intact form of bovine vitreous type IX collagen

    Bishop, P., McLeod, D. & Ayad, S., 29 May 1992, In : Biochemical and Biophysical Research Communications. 185, 1, p. 392-397 5 p.

    Research output: Contribution to journalArticle

  36. Published

    Extraction and characterization of the tissue forms of collagen types II and IX from bovine vitreous

    Bishop, P. N., Crossman, M. V., McLeod, D. & Ayad, S., 1994, In : Biochemical Journal. 299, 2, p. 497-505 8 p.

    Research output: Contribution to journalArticle

  37. Published

    Extraction of the intact form of type IX collagen from mammalian vitreous

    Bishop, P. N., McLeod, D. & Ayad, S., 1991, In : Biochemical Society Transactions. 19, 4, p. 351

    Research output: Contribution to journalArticle

  38. Published

    Fibulin 5 forms a compact dimer in physiological solutions

    Jones, R. P. O., Wang, M. C., Jowitt, T. A., Ridley, C., Mellody, K. T., Howard, M., Wang, T., Bishop, P. N., Lotery, A. J., Kielty, C. M., Baldock, C. & Trump, D., 18 Sep 2009, In : Journal of Biological Chemistry. 284, 38, p. 25938-25943 5 p.

    Research output: Contribution to journalArticle

  39. Published

    Focus on Molecules: Opticin

    Le Goff, M. M. & Bishop, P. N., Sep 2007, In : Experimental eye research. 85, 3, p. 303-304 1 p.

    Research output: Contribution to journalArticle

  40. Published

    Fragmentation of structural components of mammalian vitreous by an endogenous matrix metalloproteinase

    Brown, DJ., Bishop, PN., Hamdi, H. & Kenney, MC., 1996, In : Current Eye Research. 15

    Research output: Contribution to journalArticle

  41. Published

    Fundamentals and Principles of Ophthalmology

    Bishop, PN., Mayne, R., Morris, RE. & McLeod, D., 2001, American Academy and Ophthalmology Basic and Clinical Science Course, Section 2. American Association of Ophthalmologists , p. 348-354

    Research output: Chapter in Book/Report/Conference proceedingChapter

  42. Published

    Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration

    Ansari, M., Mckeigue, P. M., Skerka, C., Hayward, C., Rudan, I., Vitart, V., Polasek, O., Armbrecht, A. M., Yates, J. R. W., Vatavuk, Z., Bencic, G., Kolcic, I., Oostra, B. A., Van Duijn, C. M., Campbell, S., Stanton, C. M., Huffman, J., Shu, X., Khan, J. C., Shahid, H. & 11 others, Harding, S. P., Bishop, P. N., Deary Ian J., I. J., Moore, A. T., Dhillon, B., Rudan, P., Zipfel, P. F., Sim, R. B., Hastie, N. D., Campbell, H. & Wright, A. F., Dec 2013, In : Human Molecular Genetics. 22, 23, p. 4857-4869 12 p., ddt336.

    Research output: Contribution to journalArticle

  43. Published

    Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

    CREAM, 23andMe Research Team, UK Biobank Eye and Vision Consortium, Aslam, T. M. & Bishop, P. N., 1 Jun 2018, In : Nature Genetics. 50, 6, p. 834-848 15 p.

    Research output: Contribution to journalArticle

  44. Published

    Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3

    Cipriani, V., Leung, H. T., Plagnol, V., Bunce, C., Khan, J. C., Shahid, H., Moore, A. T., Harding, S. P., Bishop, P. N., Hayward, C., Campbell, S., Armbrecht, A. M., Dhillon, B., Deary, I. J., Campbell, H., Dunlop, M., Dominiczak, A. F., Mann, S. S., Jenkins, S. A., Webster, A. R. & 13 others, Bird, A. C., Lathrop, M., Zelenika, D., Souied, E. H., Sahel, J. A., Léveillard, T., Cree, A. J., Gibson, J., Ennis, S., Lotery, A. J., Wright, A. F., Clayton, D. G. & Yates, J. R. W., Sep 2012, In : Human Molecular Genetics. 21, 18, p. 4138-4150 12 p., dds225.

    Research output: Contribution to journalArticle

  45. Published

    Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segments

    Bishop, P. N., Boulton, M., McLeod, D. & Stoddart, R. W., 1993, In : Glycobiology. 3, 4, p. 403-412 9 p.

    Research output: Contribution to journalArticle

  46. Published

    Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2

    Cehajic-Kapetanovic, J., le Goff, M. M., Allen, A., Lucas, R. J. & Bishop, P. N., 2011, In : Molecular vision. 17, p. 1771-1783 12 p.

    Research output: Contribution to journalArticle

  47. Published

    Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix

    Mcleod, D., Reardon, A. J., Le Goff, M. L., Briggs, M. D., McLeod, D., Sheehan, J. K., Thornton, D. J. & Bishop, P. N., 21 Jan 2000, In : Journal of Biological Chemistry. 275, 3, p. 2123-2129 6 p.

    Research output: Contribution to journalArticle

  48. Published

    Identification of alternatively spliced variants of type II procollagen in vitreous

    Bishop, P. N., Reardon, A. J., McLeod, D. & Ayad, S., 1994, In : Biochemical and Biophysical Research Communications. 203, 1, p. 289-295 6 p.

    Research output: Contribution to journalArticle

  49. Published

    Identification of factor H-like protein 1 as the predominant complement regulator on Bruch’s membrane: implications for age-related macular degeneration

    Clark, S. J., Schmidt, C. Q., White, A. M., Hakobyan, S., Morgan, B. P. & Bishop, P. N., 15 Nov 2014, In : Journal of Immunology. 193, p. 4962-4970 8 p.

    Research output: Contribution to journalArticle

  50. Published

    Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis

    Monfort, J., Tardif, G., Roughley, P., Reboul, P., Boileau, C., Bishop, P. N., Pelletier, J. P. & Martel-Pelletier, J., Jul 2008, In : Osteoarthritis and Cartilage. 16, 7, p. 749-755 6 p.

    Research output: Contribution to journalArticle

  51. Published

    Immunolocalisation of opticin in the human eye

    Ramesh, S., Bonshek, R. E. & Bishop, P. N., May 2004, In : British Journal Of Ophthalmology. 88, 5, p. 697-702 5 p.

    Research output: Contribution to journalArticle

  52. Published

    Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina

    Clark, S. J., Perveen, R., Hakobyan, S., Morgan, B. P., Sim, R. B., Bishop, P. N. & Day, A. J., 24 Sep 2010, In : Journal of Biological Chemistry. 285, 39, p. 30192-30202 10 p.

    Research output: Contribution to journalArticle

  53. Published

    In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis

    Farrán, A., Valverde-Franco, G., Tío, L., Lussier, B., Fahmi, H., Pelletier, J-P., Bishop, P. N., Monfort, J. & Martel-Pelletier, J., 11 Jan 2018, In : Scientific Reports. 8, 1, p. 457

    Research output: Contribution to journalArticle

  54. Published

    Introduction to metabolomics and its applications in ophthalmology

    Tan, S. Z., Begley, P., Mullard, G., Hollywood, K. A. & Bishop, P. N., Jun 2016, In : Eye (London, England). 30, 6, p. 773-783 11 p.

    Research output: Contribution to journalArticle

  55. Published

    Iron, zinc, and copper in retinal physiology and disease

    Ugarte, M., Osborne, N. N., Brown, L. A. & Bishop, P. N., Nov 2013, In : Survey of ophthalmology. 58, 6, p. 585-609 24 p.

    Research output: Contribution to journalArticle

  56. Published

    Lectin binding sites in normal, scarred, and lattice dystrophy corneas

    Bishop, P. N., Bonshek, R. E., Jones, C. J. P., Ridgway, A. E. A. & Stoddart, R. W., 1991, In : British Journal Of Ophthalmology. 75, 1, p. 22-27 5 p.

    Research output: Contribution to journalArticle

  57. Published

    Light and X-ray scattering show decorin to be a dimer in solution

    Scott, P. G., Grossmann, J. G., Dodd, C. M., Sheehan, J. K. & Bishop, P. N., 16 May 2003, In : Journal of Biological Chemistry. 278, 20, p. 18353-18359 6 p.

    Research output: Contribution to journalArticle

  58. Published

    Localisation of opticin in human proliferative retinal disease

    Pattwell, D. M., Sheridan, C. M., Le Goff, M., Bishop, P. N. & Hiscott, P., Mar 2010, In : Experimental eye research. 90, 3, p. 461-464 3 p.

    Research output: Contribution to journalArticle

  59. Published

    Localization of pN-type IIA procollagen on adult bovine vitreous collagen fibrils

    Reardon, A., Sandell, L., Jones, C. J. P., McLeod, D. & Bishop, P. N., 1 May 2000, In : Matrix Biology. 19, 2, p. 169-173 4 p.

    Research output: Contribution to journalArticle

  60. Published

    Loss-of-function mutations in the CFH gene affecting alternatively encoded Factor H-like 1 protein cause dominant early-onset macular drusen

    Taylor, R. L., Poulter, J., Downes, S., McKibbin, M., Khan, K. N., Inglehearn, C. F., Webster, A. R., Hardcastle, A. J., Michaelides, M., Bishop, P., Clark, S. & Black, G., 2019, In : Ophthalmology.

    Research output: Contribution to journalArticle

  61. Published

    LRRCE: A leucine-rich repeat cysteine capping motif unique to the chordate lineage

    Park, H., Huxley-Jones, J., Boot-Handford, R. P., Bishop, P. N., Attwood, T. K. & Bella, J., 12 Dec 2008, In : BMC Genomics. 9, 599.

    Research output: Contribution to journalArticle

  62. Published

    Mapping the differential distribution of glycosaminoglycans in the adult human retina, choroid, and sclera

    Keenan, T., Clark, S. J., Keenan, T. D. L., Fielder, H. L., Collinson, L. J., Holley, R. J., Merry, C. L. R., van Kuppevelt, T. H., Day, A. J. & Bishop, P. N., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6511-6521 10 p.

    Research output: Contribution to journalArticle

  63. Published

    Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera

    Keenan, T., Keenan, T. D. L., Clark, S. J., Unwin, R. D., Ridge, L. A., Day, A. J. & Bishop, P. N., Nov 2012, In : Investigative Ophthalmology and Visual Science. 53, 12, p. 7528-7538 10 p.

    Research output: Contribution to journalArticle

  64. Published

    Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C Degradation during apoptosis

    Limb, G. A., Matter, K., Murphy, G., Cambrey, A. D., Bishop, P. N., Morris, G. E. & Khaw, P. T., May 2005, In : American journal of pathology. 166, 5, p. 1555-1563 8 p.

    Research output: Contribution to journalArticle

  65. Published

    Matrix metalloproteinases and their natural inhibitors

    Bishop, PN., 2000, In : British Journal Of Ophthalmology. 84

    Research output: Contribution to journalArticle

  66. Published

    Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)

    Ugarte, M., Brown, M., Hollywood, K. A., Cooper, G., Bishop, P. & Dunn, W. B., 30 Apr 2012, In : Genome Medicine. 4, 4, 35.

    Research output: Contribution to journalArticle

  67. Published

    Missense and nonsense mutations in the alternatively-spliced exon 2 of COL2A1 cause the ocular variant of Stickler syndrome

    McAlinden, A., Majava, M., Bishop, P. N., Perveen, R., Black, G. C. M., Pierpont, M. E., Ala-Kokko, L. & Männikkö, M., Jan 2008, In : Human Mutation. 29, 1, p. 83-90 7 p.

    Research output: Contribution to journalArticle

  68. Published

    Molecular composition of the vitreous and aging changes

    Bishop, E. I. C. D. D. S. E. P., Jun 2010, Encyclopaedia of the eye. Elsevier BV

    Research output: Chapter in Book/Report/Conference proceedingChapter

  69. Published

    Molecular findings from 537 individuals with inherited retinal disease

    Ellingford, J., Barton, S., Bhaskar, S., O'Sullivan, J., Williams, S., Lamb, J., Panda, B., Sergouniotis, P., Gillespie, R., Daiger, S., Hall, G., Gale, T., Lloyd, C., Bishop, P., Ramsden, S. & Black, G., Nov 2016, In : Journal of Medical Genetics. 53, 11, p. 761-767 7 p.

    Research output: Contribution to journalArticle

  70. Published

    Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression

    Assheton, D. C., Guerin, E. P., Sheridan, C. M., Bishop, P. N. & Hiscott, P. S., Feb 2007, In : British Journal Of Ophthalmology. 91, 2, p. 230-232 2 p.

    Research output: Contribution to journalArticle

  71. Published

    No evidence of association between complement factor i genetic variant rs10033900 and age-related macular degeneration

    Cipriani, V., Matharu, B. K., Khan, J. C., Shahid, H., Hayward, C., Wright, A. F., Armbrecht, A. M., Dhillon, B., Harding, S. P., Bishop, P. N., Bunce, C., Clayton, D. G., Moore, A. T. & Yates, J. R. W., Jan 2012, In : European Journal of Human Genetics. 20, 1, p. 1-2 1 p.

    Research output: Contribution to journalArticle

  72. Published

    Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia

    Majava, M., Bishop, P. N., Hägg, P., Scott, P. G., Rice, A., Inglehearn, C., Hammond, C. J., Spector, T. D., Ala-Kokko, L. & Männikkö, M., Apr 2007, In : Human Mutation. 28, 4, p. 336-344 8 p.

    Research output: Contribution to journalArticle

  73. Published

    On the calculation of the binding force between decorin and collagen [2]

    Scott, P. G., Bishop, P. N. & Bella, J., 2006, In : Journal of biomechanics. 39, 6, p. 1159-1160 1 p.

    Research output: Contribution to journalArticle

  74. Published

    Opticin binds to heparan and chondroitin sulfate proteoglycans

    Hindson, V. J., Gallagher, J. T., Halfter, W. & Bishop, P. N., Dec 2005, In : Investigative Ophthalmology and Visual Science. 46, 12, p. 4417-4423 6 p.

    Research output: Contribution to journalArticle

  75. Published

    Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness

    Le Goff, M. M., Sutton, M. J., Slevins, M., Latif, A., Humphries, M. J. & Bishop, P. N., 10 Aug 2012, In : Journal of Biological Chemistry. 287, 33, p. 28027-28036 9 p.

    Research output: Contribution to journalArticle

  76. Published

    Opticin nucleic acid administration reduces blood vessel formation

    Bishop, P., 22 Mar 2011, Patent No. US 7910567 B2

    Research output: Patent

  77. Published

    Opticin, a small leucine-rich proteoglycan, is uniquely expressed and translocated to the nucleus of chronic lymphocytic leukemia cells

    Mikaelsson, E., Osterberg, A., Fard, ZT., Mahmoudi, A., Mahmoudian, J., Jeddi-Tahrani, M., Akhondi, M., Shokri, F., Bishop, PN. & Rabbani, H., 2013, In : Experimental Hematology & Oncology. 2, p. 23

    Research output: Contribution to journalArticle

  78. Published
  79. Published

    Photocoagulation of subfoveal choroidal neovascular membranes in age related macular degeneration: The impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland

    Beatty, S., Au Eong, K. G., McLeod, D. & Bishop, P. N., 1999, In : British Journal Of Ophthalmology. 83, 10, p. 1103-1104 1 p.

    Research output: Contribution to journalArticle

  80. Published

    Pyoderma gangrenosum and peripheral ulcerative keratitis

    Bishop, PN. & Tullo, AB., 1998, In : Cornea. 17

    Research output: Contribution to journalArticle

  81. Published

    Ranibizumab for the management of Sorsby fundus dystrophy

    Balaskas, K., Hovan, M., Mahmood, S. & Bishop, P., Oct 2012, In : Eye. 27, 1, p. 101-102 1 p.

    Research output: Contribution to journalArticle

  82. Published

    Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: One-year findings from the IVAN randomized trial

    Aslam, T., Chakravarthy, U., Harding, S. P., Rogers, C. A., Downes, S. M., Lotery, A. J., Wordsworth, S., Reeves, B. C. & Bishop, P., Jul 2012, In : Ophthalmology. 119, 7, p. 1399-1411 12 p.

    Research output: Contribution to journalArticle

  83. Published

    Reappraisal of age-dependent changes in the basal retinovitreal adhesion

    Wang, J., Mcleod, D. & Bishop, PN., 2002, In : Investigative Ophthalmology and Vision Sciences.

    Research output: Contribution to journalArticle

  84. Published

    Regulation of eye size by the retinal basement membrane and vitreous body

    Halfter, W., Winzen, U., Bishop, P. N. & Eller, A., Aug 2006, In : Investigative Ophthalmology and Visual Science. 47, 8, p. 3586-3594 8 p.

    Research output: Contribution to journalArticle

  85. Published

    Repeatability of visual function measures in age-related macular degeneration

    Aslam, T., Mahmood, S., Balaskas, K., Patton, N., Tanawade, R. G., Tan, S. Z., Roberts, S., Parkes, J. & Bishop, P. N., Feb 2014, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 252, 2, p. 201-206 5 p.

    Research output: Contribution to journalArticle

  86. Published

    Restoration of Vision with Ectopic Expression of Human Rod Opsin

    Cehajic-Kapetanovic, J., Eleftheriou, C., Allen, A. E., Milosavljevic, N., Pienaar, A., Bedford, R., Davis, K., Bishop, P. N. & Lucas, R., 17 Aug 2015, In : Current Biology. 25, 16, p. 2111-2122 11 p.

    Research output: Contribution to journalArticle

  87. Published

    Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration.

    Clark, S. J. & Bishop, P. N., 1 Jan 2015, In : Journal of Clinical Medicine. 4, 1, p. 18-31 13 p.

    Research output: Contribution to journalArticle

  88. Published
  89. Published

    Screening assays for binding antagonists of the AMD-associated variant of factor H (H384)

    Bishop, P. N., Day, A. J., Clark, S. J., Simm, R. B., Blom, A. M. & Heinegard, D., Nov 2010, Patent No. US7829301 B2

    Research output: Patent

  90. Published

    Seven new loci associated with age-related macular degeneration

    Fritsche, L. G., Chen, W., Schu, M., Yaspan, B. L., Yu, Y., Thorleifsson, G., Zack, D. J., Arakawa, S., Cipriani, V., Ripke, S., Igo, R. P., Buitendijk, G. H. S., Sim, X., Weeks, D. E., Guymer, R. H., Merriam, J. E., Francis, P. J., Hannum, G., Agarwal, A., Armbrecht, A. M. & 136 others, Audo, I., Aung, T., Barile, G. R., Benchaboune, M., Bird, A. C., Bishop, P. N., Branham, K. E., Brooks, M., Brucker, A. J., Cade, W. H., Cain, M. S., Campochiaro, P. A., Chan, C. C., Cheng, C. Y., Chew, E. Y., Chin, K. A., Chowers, I., Clayton, D. G., Cojocaru, R., Conley, Y. P., Cornes, B. K., Daly, M. J., Dhillon, B., Edwards, A. O., Evangelou, E., Fagerness, J., Ferreyra, H. A., Friedman, J. S., Geirsdottir, A., George, R. J., Gieger, C., Gupta, N., Hagstrom, S. A., Harding, S. P., Haritoglou, C., Heckenlively, J. R., Holz, F. G., Hughes, G., Ioannidis, J. P. A., Ishibashi, T., Joseph, P., Jun, G., Kamatani, Y., Katsanis, N., N Keilhauer, C., Khan, J. C., Kim, I. K., Kiyohara, Y., Klein, B. E. K., Klein, R., Kovach, J. L., Kozak, I., Lee, C. J., Lee, K. E., Lichtner, P., Lotery, A. J., Meitinger, T., Mitchell, P., Mohand-Saïd, S., Moore, A. T., Morgan, D. J., Morrison, M. A., Myers, C. E., Naj, A. C., Nakamura, Y., Okada, Y., Orlin, A., Ortube, M. C., Othman, M. I., Pappas, C., Park, K. H., Pauer, G. J. T., Peachey, N. S., Poch, O., Priya, R. R., Reynolds, R., Richardson, A. J., Ripp, R., Rudolph, G., Ryu, E., Sahel, J. A., Schaumberg, D. A., Scholl, H. P. N., Schwartz, S. G., Scott, W. K., Shahid, H., Sigurdsson, H., Silvestri, G., Sivakumaran, T. A., Smith, R. T., Sobrin, L., Souied, E. H., Stambolian, D. E., Stefansson, H., Sturgill-Short, G. M., Takahashi, A., Tosakulwong, N., Truitt, B. J., Tsironi, E. E., Uitterlinden, A. G., Van Duijn, C. M., Vijaya, L., Vingerling, J. R., Vithana, E. N., Webster, A. R., Wichmann, H. E., Winkler, T. W., Wong, T. Y., Wright, A. F., Zelenika, D., Zhang, M., Zhao, L., Zhang, K., Klein, M. L., Hageman, G. S., Lathrop, G. M., Stefansson, K., Allikmets, R., Baird, P. N., Gorin, M. B., Wang, J. J., Klaver, C. C. W., Seddon, J. M., Pericak-Vance, M. A., Iyengar, S. K., Yates, J. R. W., Swaroop, A., Weber, B. H. F., Kubo, M., Deangelis, M. M., Léveillard, T., Thorsteinsdottir, U., Haines, J. L., Farrer, L. A., Heid, I. M. & Abecasis, G. R., Apr 2013, In : Nature Genetics. 45, 4, p. 433-439 6 p.

    Research output: Contribution to journalArticle

  91. Published

    Solar retinopathy in a patient with bipolar affective disorder [6]

    Devadason, D. S., Mahmood, S., Stanga, P. E. & Bishop, P. N., Feb 2006, In : British Journal Of Ophthalmology. 90, 2, p. 247

    Research output: Contribution to journalArticle

  92. Published

    Species specific membrane anchoring of nyctalopin, a small leucine-rich repeat protein

    O'Connor, E., Eisenhaber, B., Dalley, J., Wang, T., Missen, C., Bulleid, N., Bishop, P. N., Trump, D. & Ridley, C., 1 Jul 2005, In : Human Molecular Genetics. 14, 13, p. 1877-1887 10 p.

    Research output: Contribution to journalArticle

  93. Published

    Structural correlations in the family of small leucine-rich repeat proteins and proteoglycans

    McEwan, P. A., Scott, P. G., Bishop, P. N. & Bella, J., Aug 2006, In : Journal of Structural Biology. 155, 2, p. 294-305 11 p.

    Research output: Contribution to journalArticle

  94. Published

    Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa

    Jones, R. P. O., Ridley, C., Jowitt, T. A., Wang, M. C., Howard, M., Bobola, N., Wang, T., Bishop, P. N., Kielty, C. M., Baldock, C., Lotery, A. J. & Trump, D., May 2010, In : Investigative Ophthalmology and Visual Science. 51, 5, p. 2356-2362 6 p.

    Research output: Contribution to journalArticle

  95. Published

    Structural macromolecules and supramolecular organisation of the vitreous gel

    Bishop, P. N., May 2000, In : Progress in Retinal and Eye Research. 19, 3, p. 323-344 21 p.

    Research output: Contribution to journalArticle

  96. Published

    Structure and location of the mouse opticin gene and ocular expression of opticin, PRELP and vitreous humor collagen genes

    Takanosu, M., Boyd, T., Le, G. M., Henry, S., Zhang, Y., Bishop, PN. & Mayne, R., 2001, In : Invest. Ophthalmol. Vis. Sci. 42

    Research output: Contribution to journalArticle

  97. Published

    Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature.

    MacGillivray, T. J., Cameron, J. R., Zhang, Q., El-Medany, A., Mulholland, C., Sheng, Z., Doubal, F. N., Trucco, E., Aslam, T., Bao, Y., Barman, S., Bishop, P., Blows, P., Bunce, C., Chakravarthy, U., Chan, M., Chianca, A., Cipriani, V., Crabb, D., Cumberland, P. & 53 others, Day, A., Desai, P., Dhillon, B., Dick, A., Foster, P., Gallacher, J., Garway, D. T., Goverdhan, S., Guggenheim, J., Gupta, P., Hammond, C., Hogg, R., Hughes, A., Keane, P., Khaw, P. T., Khawaja, A., Lascaratos, G., Lotery, A., Luthert, P., MacGillivray, T., Mackie, S., Martin, K., McGaughey, M., McGuinness, B., McKay, G., McKibbin, M., Mitry, D., Moore, T., Morgan, J., Muthy, Z., O'Sullivan, E., Owen, C., Patel, P., Peto, T., Rahi, J., Rudnicka, A., Sampedro, C. G., Steel, D., Stratton, I., Strouthdis, N., Sudlow, C., Thaung, C., Thomas, D., Trucco, E., Tufail, A., Vernon, S., Viswanathan, A., Williams, C., Williams, K., Yates, J., Yates, M., Yip, J. & Zhu, H., 2015, In : PLoS ONE. 10, 5

    Research output: Contribution to journalArticle

  98. Published

    Synchronous and metachronous gastric adenocarcinoma: Case report and literature review

    Gnanalingham, K. K. & Bishop, P., 1 Feb 1999, In : Journal of the Royal College of Surgeons of Edinburgh. 44, 1, p. 61-62 2 p.

    Research output: Contribution to journalArticle

  99. Published

    The biochemical structure of mammalian vitreous

    Bishop, P., 1996, In : Eye. 10, 6, p. 664-670 6 p.

    Research output: Contribution to journalArticle

  100. Published

    The eye as a complement dysregulation hotspot

    Clark, S. & Bishop, P., 2017, In : Seminars in Immunopathology.

    Research output: Contribution to journalArticle

  101. Published

    The large chondroitin sulphate proteoglycan versican in mammalian vitreous

    Reardon, A., Heinegård, D., Mcleod, D., Sheehan, J. K. & Bishop, P. N., Oct 1998, In : Matrix Biology. 17, 5, p. 325-333 8 p.

    Research output: Contribution to journalArticle

  102. Published

    The proteoglycan glycomatrix: A sugar microenvironment essential for complement regulation

    Clark, S. J., Bishop, P. N. & Day, A. J., 2013, In : Frontiers in Immunology. 4, Article 412.

    Research output: Contribution to journalArticle

  103. Published

    The role of complement in age-related macular degeneration: Heparan sulphate, a ZIP code for complement factor H?

    Clark, S., Langford-Smith, A., Keenan, T. D. L., Clark, S., Bishop, P. N. & Day, A. J., 2014, In : Journal of Innate Immunity. 6, 4, p. 407-416 9 p.

    Research output: Contribution to journalArticle

  104. Published

    The role of extracellular matrix in retinal vascular development and preretinal neovascularization.

    Bishop, P. N., Apr 2015, In : Experimental eye research. 133

    Research output: Contribution to journalArticle

  105. Published

    The role of the posterior ciliary body in the biosynthesis of vitreous humour

    Bishop, P. N., Takanosu, M., le Goff, M. & Mayne, R., 2002, In : Eye. 16, 4, p. 454-460 6 p.

    Research output: Contribution to journalArticle

  106. Published

    The Royal College of Ophthalmologists Guidelines on AMD: Executive Summary.

    Chakravarthy, U., Williams, M., Amoaku, W., Bailey, C., Bishop, P., Brand, C., Chakravarthy, U., Chong, V., Downes, S., Evans, J., Lotery, A., Rubin, G., Sparrow, J., Talks, J., Williams, M. & Yelf, C., Dec 2013, In : Eye (London, England). 27, 12

    Research output: Contribution to journalArticle

  107. Published

    The vitreous glycoprotein opticin inhibits preretinal neovascularization

    le Goff, M. M., Lu, H., Ugarte, M., Henry, S., Takanosu, M., Mayne, R. & Bishop, P. N., Jan 2012, In : Investigative Ophthalmology and Visual Science. 53, 1, p. 228-234 6 p.

    Research output: Contribution to journalArticle

  108. Published

    Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions

    Clark, S. J., Ridge, L. A., Herbert, A. P., Hakobyan, S., Mulloy, B., Lennon, R., Würzner, R., Morgan, B. P., Uhrín, D., Bishop, P. N. & Day, A. J., 1 Mar 2013, In : Journal of Immunology. 190, 5, p. 2049-2057 8 p.

    Research output: Contribution to journalArticle

  109. Published

    Type VI collagen is present in human and bovine vitreous

    Mcleod, D., Bishop, P., Ayad, S., Reardon, A., McLeod, D., Sheehan, J. & Kielty, C., 1996, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 234, 11, p. 710-713 3 p.

    Research output: Contribution to journalArticle

  110. Published

    Ultrastructural and histopathologic findings after pars plana vitrectomy with a new hypersonic vitrector system. Qualitative preliminary assessment

    Pastor-Idoate, S., Bonshek, R., Dreher Irion, L., Zambrano, I., Carlin, P., Mironov, A., Bishop, P., McLeod, D. & Stanga, P. E., 11 Apr 2017, In : PLoS ONE. 12, 4, e0173883.

    Research output: Contribution to journalArticle

  111. Published
  112. Published

    Vision impairment and dual sensory problems in middle age

    Dawes, P., Dickinson, C., Emsley, R., Bishop, P. N., Cruickshanks, K. J., Edmondson-Jones, M., Mccormack, A., Fortnum, H., Moore, D. R., Norman, P. & Munro, K., 2014, In : Ophthalmic and Physiological Optics. 34, 4, p. 479-488 9 p.

    Research output: Contribution to journalArticle

  113. Published

    Vitrectomy for primary symptomatic vitreous opacities: an evidence-based review

    Ivanova, T., Jalil, A., Antoniou, Y., Bishop, P. N., Vallejo-Garcia, J. L. & Patton, N., May 2016, In : Eye (London, England). 30, 5, p. 645-655 11 p.

    Research output: Contribution to journalArticle

  114. Published

    Vitreous as a substrate for vitreolysis.

    Bishop, P. N., 2009, In : Developments in ophthalmology. 44, p. 7-19 12 p.

    Research output: Contribution to journalArticle

  115. Published

    Vitreous phenotype: Genotype correlation in Stickler syndrome (multiple letters) [1]

    Mcleod, D., McLeod, D., Black, G. C. M., Bishop, P. N. & Parentin, F., 2002, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 240, 1, p. 63-65 2 p.

    Research output: Contribution to journalArticle

  116. Published

    Whole genome sequencing increases molecular diagnostic yield compared with current diagnostic testing for inherited retinal disease

    Ellingford, J., Barton, S., Bhaskar, S., Williams, S., Sergouniotis, P., O'Sullivan, J., Lamb, J., Perveen, R., Hall, G., Newman, W., Bishop, P., Roberts, S., Leach, R., Tearle, R., Bayliss, S., Ramsden, S., Nemeth, A. H. & Black, G., May 2016, In : Ophthalmology. p. 1143–1150

    Research output: Contribution to journalArticle

  117. Published

    Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes

    Porter, L. F., Saptarshi, N., Fang, Y., Rathi, S., den Hollander, A., de Jong, E., Clark, S., Bishop, P., Olsen, T., Liloglou, T., Chavali, V. & Paraoan, L., 2019, In : Clinical Epigenetics. 11, 6

    Research output: Contribution to journalArticle

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