I am a Lecturer in Cardiovascular Computational Biology interested in studying the biological impact of genetic and epigenetic variation on human health using high-throughput sequencing technologies (multi-omics, data-science methods and biomedical imaging data. I have a special interest in translational research in cardiovascular medicine (hypertension, coronary artery disease) and nephrology (chronic kidney disease and renal histology) informed by genomics and transcriptomics.
I have been performing computational experiments for the large-scale analysis of genomics, transcriptomics, and epigenomics data for the last 10 years and have a particular interest in techniques for summarisation, visualisation and communication of high-dimensionality data for identifying causal disease genes.
I am principal investigator on two translational grants, current co-investigator on two British Heart Foundation project grants and one Kidney Research UK grant and I have previously secured, as principal investigator, two grants for enterprise projects.
I have over 20 recent publications, many in high-impact journals including Nature Genetics, the European Heart Journal, Nature Communications, Arteriosclerosis, Thrombosis and Vascular Biology and Journal of the American Society of Nephrology. I am also a recent reviewer for the European Heart Journal, Cardiovascular Research, Journal of Hypertension, Journal of Human Hypertension and Scientific Reports.
I am an active member of the communications committee of the International Society of Hypertension.
I'm always happy to engage on twitter as well @EalesJames