Cell biology of Alzheimer’s disease and ageing
Our overall aim is to understand the molecular and cellular mechanisms that contribute to neurodegeneration so as to identify new approaches for prevention, diagnosis and intervention in dementia.
We use a variety of biochemical, biophysical, molecular biological and cell biological techniques on individual proteins, cells in culture (including stem cell/iPSC-derived cells), animal models and human tissues. Our research receives support from the Medical Research Council, Alzheimer’s Research UK, Alzheimer’s Society, EPSRC and BBSRC.
1. Developing 3D stem cell models to study neurovascular dysfunction in dementia
2. Identifying the receptors for (i) the neuroprotective soluble amyloid precursor protein and (ii) the cognitive-enhancing anti-aging protein klotho
3. Investigating the proteolysis of the low density lipoprotein receptor.