Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Article › Research › Peer-reviewed
  2. Published

    Improved Descriptors for the QSAR Modeling of Peptides and Proteins

    Barley, M., Turner, N. & Goodacre, R., 2018, In : Journal of Chemical Information and Modeling.

    Research output: Contribution to journalArticle

  3. Published

    InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines

    Grogan, G. & Turner, N., 5 Feb 2016, In : Chemistry - A European Journal. 22, 6, p. 1900-1907 8 p.

    Research output: Contribution to journalArticle

  4. Published

    Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source

    Weise, N., Ahmed, S., Parmeggiani, F., Siirola, E., Pushpanath, A., Schell, U. & Turner, N., 24 May 2016, In : Catalysis Science and Technology. 6, 12, p. 4086-4089

    Research output: Contribution to journalArticle

  5. Published

    Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

    Aleku, G. A., Mangas-Sanchez, J., Citoler, J., France, S. P., Montgomery, S. L., Heath, R. S., Thompson, M. P. & Turner, N. J., 7 Feb 2018, In : ChemCatChem. 10, 3, p. 515-519 5 p.

    Research output: Contribution to journalArticle

  6. Published
  7. Published

    Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts

    Westley, C., Xu, Y., Carnell, A. J., Turner, N. & Goodacre, R., 30 Apr 2016, In : Analytical Chemistry. 88, 11, p. 5898-5903 6 p.

    Research output: Contribution to journalArticle

  8. Published

    Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy

    Humphrey, C. E., Turner, N. J., Easson, M. A. M., Flitsch, S. L. & Ulijn, R. V., 19 Nov 2003, In : Journal of the American Chemical Society. 125, 46, p. 13952-13953 1 p.

    Research output: Contribution to journalArticle

  9. Published

    Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

    Herter, S., Medina, F., Wagschal, S., Benhaïm, C., Leipold, F. & Turner, N. J., 2017, In : Bioorganic and Medicinal Chemistry.

    Research output: Contribution to journalArticle

  10. Published

    Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

    Toscani, A., Risi, C., Black, G. W., Brown, N. L., Shaaban, A., Turner, N. J. & Castagnolo, D., 7 Sep 2018, In : ACS Catalysis. 8, 9, p. 8781-8787 6 p.

    Research output: Contribution to journalArticle

  11. Published

    Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

    Turner, N., O'Reilly, E. & Iglesias, C., 2014, In : ChemCatChem. 6, 4, p. 992-995

    Research output: Contribution to journalArticle

  12. Published

    n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones

    Slabu, I., Galman, J., Iglesias, C., Weise, N., Lloyd, R. C. & Turner, N., 2017, In : Catalysis Today.

    Research output: Contribution to journalArticle

  13. Published

    One Pot Cascade Synthesis of Mono- and Di-Substituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA) and Imine Reductase (IRED) Biocatalysts

    France, S., Hussain, S., Hill, A., Hepworth, L., Howard, R. M., Mulholland, K. R., Flitsch, S. & Turner, N., 2 May 2016, In : ACS Catalysis. p. 3753-3759

    Research output: Contribution to journalArticle

  14. Published

    One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone

    Tavanti, M., Parmeggiani, F., Castellanos, J. R. G., Mattevi, A. & Turner, N. J., 2017, In : ChemCatChem. 9, 17, p. 3338-3348 11 p.

    Research output: Contribution to journalArticle

  15. Published

    Oxidation of Alcohols

    Turner, N., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  16. Published

    Phenylalanine Ammonia Lyase Catalyzed Synthesis of Amino Acids by an MIO‐Cofactor Independent Pathway

    Lovelock, S., Lloyd, R. C. & Turner, N., 25 Apr 2014, In : Angewandte Chemie - International Edition. 53, 18, p. 4652-4656

    Research output: Contribution to journalArticle

  17. Published

    Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols

    Toftgaard Pedersen, A., Birmingham, W., Rehn, G., Charnock, S. J., Turner, N. & Woodley, J. M., 2015, In : Organic Process Research and Development. 19, 11, p. 1580-1589

    Research output: Contribution to journalArticle

  18. Published

    Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines

    Slabu, I., Galman, J. L., Weise, N. J., Lloyd, R. C. & Turner, N. J., 2016, In : ChemCatChem. 8, 6, p. 1038-1042 5 p.

    Research output: Contribution to journalArticle

  19. Published

    Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

    Yan, C., Schmidberger, J., Parmeggiani, F., Hussain, S., Turner, N., Flitsch, S. & Barran, P., 2016, In : Analyst.

    Research output: Contribution to journalArticle

  20. Published

    Rapid determination of both the activity and enantioselectivity of ketoreductases

    Truppo, M. D., Escalettes, F. & Turner, N. J., 25 Mar 2008, In : Angewandte Chemie - International Edition. 47, 14, p. 2639-2641 2 p.

    Research output: Contribution to journalArticle

  21. Published

    Real-time monitoring of enzyme-catalysed reactions using deep UV resonance Raman spectroscopy

    Westley, C., Fisk, H., Xu, Y., Hollywood, K., Carnell, A. J., Micklefield, J., Turner, N. & Goodacre, R., 23 May 2017, In : Chemistry: A European Journal. 23, 29, p. 6983-6987 5 p.

    Research output: Contribution to journalArticle

  22. Published

    Real-time screening of biocatalysts in live bacterial colonies

    Yan, C., Parmeggiani, F., Jones, E. A., Claude, E., Hussain, S., Turner, N., Flitsch, S. & Barran, P., 2017, In : Journal of the American Chemical Society. 139, 4, p. 1408-1411 4 p.

    Research output: Contribution to journalArticle

  23. Published

    Recommendations on the implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes

    Barley, M., Turner, N. & Goodacre, R., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  24. Published

    Reductive Amination

    Turner, N., Stella, S. & Chadha, A., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  25. Published

    Regio- and Enantio-selective Chemo-enzymatic C-H-lactonization of Decanoic Acid to (S)-δ-Decalactone.

    Manning, J., Tavanti, M., Porter, J., Kress, N., De Visser, S., Turner, N. & Flitsch, S., 2019, In : Angewandte Chemie.

    Research output: Contribution to journalArticle

  26. Published

    Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous

    O'Reilly, E., Aitken, S. J., Grogan, G., Kelly, P. P., Turner, N. J. & Flitsch, S. L., 3 Apr 2012, In : Beilstein Journal of Organic Chemistry. 8, p. 496-500 4 p.

    Research output: Contribution to journalArticle

  27. Published

    Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification

    Heap, L., Green, A., Brown, D., van Dongen, B. E. & Turner, N., 2014, In : Catalysis Science and Technology. 4, 8, p. 2251-2259 8 p.

    Research output: Contribution to journalArticle

  28. Published

    Selective chemical intervention in the proteome of caenorhabditis elegans

    Husi, H., McAllister, F., Angelopoulos, N., Butler, V. J., Bailey, K. R., Malone, K., MacKay, L., Taylor, P., Page, A. P., Turner, N. J., Barran, P. E. & Walkinshaw, M., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 6060-6070 10 p.

    Research output: Contribution to journalArticle

  29. Published

    Selective Oxidation

    Turner, N. & Kroutil, W., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  30. Published

    Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant

    Mattey, A., Birmingham, W. R., Both, P., Kress, N., Huang, K., Van Munster, J. M., Bulmer, G., Parmeggiani, F., Voglmeir, J., Reyes Martinez, J. E., Turner, N. J. & Flitsch, S. L., 2019, In : ACS Catalysis.

    Research output: Contribution to journalArticle

  31. Published

    Selenzyme: Enzyme selection tool for pathway design

    Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., Kell, D., Breitling, R. & Faulon, J-L., 15 Jun 2018, In : Bioinformatics. 34, 12

    Research output: Contribution to journalArticle

  32. Published

    Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

    Chapman, M. R., Kwan, M. H. T., King, G., Jolley, K. E., Hussain, M., Hussain, S., Salama, I. E., González Nino, C., Thompson, L. A., Bayana, M. E., Clayton, A. D., Nguyen, B. N., Turner, N. J., Kapur, N. & Blacker, A. J., 15 Sep 2017, In : Organic Process Research and Development. 21, 9, p. 1294-1301 8 p.

    Research output: Contribution to journalArticle

  33. Published

    Single-Biocatalyst Synthesis of Enantiopure D-Arylalanines Exploiting an Engineered D-Amino Acid Dehydrogenase

    Parmeggiani, F., Ahmed, S., Thompson, M., Weise, N., Galman, J., Gahloth, D., Leys, D., Turner, N. & Dunstan, M., 13 Oct 2016, In : Advanced synthesis & catalysis.

    Research output: Contribution to journalArticle

  34. Published

    Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer

    Turner, N., de Graaff, C., Oppelaar, B., Péruch, O., Vande Velde, C. M. L., Bechi, B., Ruijter, E. & Orru, R. V. A., May 2016, In : Advanced Synthesis and Catalysis. 358, 10, p. 1555-1560

    Research output: Contribution to journalArticle

  35. Published

    Stereoselective synthesis of N-aryl proline amides by biotransformation- Ugi-Smiles sequence

    Znabet, A., Blanken, S., Janssen, E., De Kanter, F. J. J., Helliwell, M., Turner, N. J., Ruijter, E. & Orru, R. V. A., 7 Feb 2012, In : Organic and Biomolecular Chemistry. 10, 5, p. 941-944 4 p.

    Research output: Contribution to journalArticle

  36. Published

    Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

    Aleku, G. A., Man, H., France, S. P., Leipold, F., Hussain, S., Toca-Gonzalez, L., Marchington, R., Hart, S., Turkenburg, J. P., Grogan, G. & Turner, N. J., 3 Jun 2016, In : ACS Catalysis. 6, 6, p. 3880-3889 10 p.

    Research output: Contribution to journalArticle

  37. Published

    Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline

    Man, H., Wells, E., Hussain, S., Leipold, F., Hart, S., Turkenburg, J. P., Turner, N. & Grogan, G., 2015, In : CHEMBIOCHEM. 16, 7, p. 1052-1059

    Research output: Contribution to journalArticle

  38. Published

    Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

    Gahloth, D., Dunstan, M. S., Quaglia, D., Klumbys, E., Lockhart-Cairns, M. P., Hill, A., Derrington, S. R., Scrutton, N. S., Turner, N. J. & Leys, D., 2017, In : Nature chemical biology. 13, p. 975-981 7 p.

    Research output: Contribution to journalArticle

  39. Published

    Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation

    Turner, N., Mas Roselló, J., Staniland, S. & Clayden, J., Aug 2016, In : Tetrahedron. 72, 34, p. 5172-5177

    Research output: Contribution to journalArticle

  40. Published

    Substrate promiscuity of cytochrome P450 RhF

    O'Reilly, E., Corbett, M., Hussain, S., Kelly, P. P., Richardson, D., Flitsch, S. L. & Turner, N. J., Jun 2013, In : Catalysis Science and Technology. 3, 6, p. 1490-1492 2 p.

    Research output: Contribution to journalArticle

  41. Published

    Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis

    Hartley, C. J., French, N. G., Scoble, J. A., Williams, C. C., Churches, Q. I., Frazer, A. R., Taylor, M. C., Coia, G., Simpson, G., Turner, N. J. & Scott, C., Nov 2017, In : PLoS ONE. 12, 11, e0184183.

    Research output: Contribution to journalArticle

  42. Published

    SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.

    Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G. G-Q., Faulon, J-L., Goble, C., Goodacre, R., Kell, D. B., Feuvre, R. L., Micklefield, J. & 4 othersScrutton, N. S., Shapira, P., Takano, E. & Turner, N. J., 15 Jun 2016, In : Biochemical Society Transactions. 44, 3, p. 675-7

    Research output: Contribution to journalArticle

  43. Published

    SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production

    Feuvre, R. L., Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G. G-Q., Faulon, J-L., Goble, C., Goodacre, R., Kell, D. B., Micklefield, J. & 4 othersScrutton, N. S., Shapira, P., Takano, E. & Turner, N. J., 2016, In : Synthetic and Systems Biotechnology.

    Research output: Contribution to journalArticle

  44. Published

    Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines

    Cosgrove, S. C., Hussain, S., Turner, N. J. & Marsden, S. P., 1 Jun 2018, In : ACS Catalysis. 8, 6, p. 5570-5573 4 p.

    Research output: Contribution to journalArticle

  45. Published

    Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure

    March-Cortijos, A., Snape, T. J. & Turner, N. J., 30 May 2012, In : SYNLETT. 23, 10, p. 1511-1515 5 p., ST-2012-D0041-L.

    Research output: Contribution to journalArticle

  46. Published

    Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

    Costa, B. Z., Galman, J. L., Slabu, I., France, S. P., Marsaioli, A. J. & Turner, N. J., 2018, In : ChemCatChem.

    Research output: Contribution to journalArticle

  47. E-pub ahead of print

    Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles

    Kimber, R., Parmeggiani, F., Joshi, N., Rakowski, A., Haigh, S., Turner, N. & Lloyd, J., 8 Jul 2019, In : Green Chemistry.

    Research output: Contribution to journalArticle

  48. Published

    Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process

    Weise, N., Parmeggiani, F., Ahmed, S., Turner, N. & Lovelock, S., 26 Feb 2015, In : Angewandte Chemie (International Edition). 54, 15

    Research output: Contribution to journalArticle

  49. Published
  50. Published

    Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases

    Parmeggiani, F., Weise, N., Ahmed, S. & Turner, N., 2017, In : Chemical Reviews.

    Research output: Contribution to journalArticle

  51. Published

    Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

    Köhler, V., Wilson, Y. M., Dürrenberger, M., Ghislieri, D., Churakova, E., Quinto, T., Knörr, L., Häussinger, D., Hollmann, F., Turner, N. J. & Ward, T. R., Feb 2013, In : Nature Chemistry. 5, 2, p. 93-99 6 p.

    Research output: Contribution to journalArticle

  52. Published

    Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes

    Knaus, T., Mutti, F., Humphreys, LD., Turner, N. & Scrutton, N., 29 Oct 2015, In : Organic & biomolecular chemistry. 13, 1, p. 223-233 10 p.

    Research output: Contribution to journalArticle

  53. Published

    Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes

    Turner, N., Parmeggiani, F., Ahmed, S. & Weise, N., Nov 2016, In : Tetrahedron. 72, 46, p. 7256-7262

    Research output: Contribution to journalArticle

  54. Published

    The Bacterial Ammonia Lyase EncP: A Tunable Biocatalyst for the Synthesis of Unnatural Amino Acids

    Weise, N., Parmeggiani, F., Ahmed, S. & Turner, N., 2015, In : Journal of the American Chemical Society. 137, 40, p. 12977-12983

    Research output: Contribution to journalArticle

  55. Published

    The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

    McKenna, S. M., Mines, P., Law, P., Kovacs-Schreiner, K., Birmingham, W. R., Turner, N. J., Leimkühler, S. & Carnell, A. J., 2017, In : Green Chemistry. 19, 19, p. 4660-4665 6 p.

    Research output: Contribution to journalArticle

  56. Published

    The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

    Tavanti, M., Porter, J. L., Levy, C. W., Gómez Castellanos, J. R., Flitsch, S. L. & Turner, N. J., 17 May 2018, In : Biochemical and Biophysical Research Communications. 501, 4, p. 846-850 5 p.

    Research output: Contribution to journalArticle

  57. Published

    The enzyme spring: Biocatalysis at its best

    Turner, N. & Wells, A., 2014, In : ChemCatChem. 6, 4, p. 900-901

    Research output: Contribution to journalArticle

  58. Published

    The self‐sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5‐hydroxylation of diclofenac

    Klenk, J. M., Nebel, B., Porter, J., Kulig, J. K., Hussain, S., Richter, S. M., Tavanti, M., Turner, N., Hayes, M. A., Hauer, B. & Flitsch, S., 2017, In : Biotechnology Journal (Print).

    Research output: Contribution to journalArticle

  59. Published

    Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase

    Thompson, M. P. & Turner, N. J., 2017, In : ChemCatChem. 9, 20, p. 3833-3836 4 p.

    Research output: Contribution to journalArticle

  60. Published

    Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

    Scalacci, N., Black, G. W., Mattedi, G., Brown, N. L., Turner, N. J. & Castagnolo, D., 3 Feb 2017, In : ACS Catalysis. 7, 2, p. 1295-1300 6 p.

    Research output: Contribution to journalArticle

  61. Published

    Whole-cell biocatalysts for stereoselective C-H amination reactions

    Both, P., Kelly, P., Mutti, F., Turner, N. & Flitsch, S., 18 Jan 2016, In : Angewandte Chemie (International Edition).

    Research output: Contribution to journalArticle

  62. Published

    Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s

    Weissenborn, M. J., Notonier, S., Lang, S. L., Otte, K. B., Herter, S., Turner, N., Flitsch, S. & Hauer, B., 2016, In : Chemical Communications. 52, 36, p. 6158-6161 4 p.

    Research output: Contribution to journalArticle

  63. Published

    Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

    Weise, N. J., Ahmed, S. T., Parmeggiani, F., Galman, J. L., Dunstan, M. S., Charnock, S. J., Leys, D. & Turner, N. J., 2017, In : Scientific Reports. 7, 1, 13691.

    Research output: Contribution to journalArticle

  64. Editorial › Research › Peer-reviewed
  65. Published

    Sustainable catalysis

    Turner, N. J., 8 Aug 2016, In : Beilstein Journal of Organic Chemistry. 12, p. 1778-1779 2 p.

    Research output: Contribution to journalEditorial

  66. Chapter › Research › Peer-reviewed
  67. Published

    A Reduction of C N to CH-NH Using Enzymes and Microorganisms

    Turner, N., 2014, Comprehensive Organic Synthesis: Second Edition. Knochel, P. & Molander, G. A. (eds.). second ed. Vol. 8. p. 328-338

    Research output: Chapter in Book/Report/Conference proceedingChapter

  68. Published

    Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions

    Humphrey, C., Ahmed, M., Ghanem, A. & Turner, N., 2014, Separation Of Enantiomers : Synthetic Methods. Todd, M. (ed.). p. 123-160

    Research output: Chapter in Book/Report/Conference proceedingChapter

  69. Published

    Oxidation of C-N Bonds

    Turner, N. J., 20 Apr 2012, Enzyme Catalysis in Organic Synthesis. Drauz, K., Gröger, H. & May, O. (eds.). 3 ed. John Wiley & Sons Ltd, p. 1535-1552 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  70. Review article › Research › Peer-reviewed
  71. Published

    Imine reductases (IREDs)

    Mangas-Sanchez, J., France, S. P., Montgomery, S. L., Aleku, G. A., Man, H., Sharma, M., Ramsden, J. I., Grogan, G. & Turner, N. J., 1 Apr 2017, In : Current Opinion in Chemical Biology. 37, p. 19-25 7 p.

    Research output: Contribution to journalReview article

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