Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Published

    A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

    Tavanti, M., Mangas-Sanchez, J., Montgomery, S. L., Thompson, M. P. & Turner, N. J., 14 Dec 2017, In : Organic and Biomolecular Chemistry. 15, 46, p. 9790-9793 4 p.

    Research output: Contribution to journalArticle

  2. Published

    A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

    Hopwood, J., Truppo, M. D., Turner, N. J. & Lloyd, R. C., 14 Jan 2011, In : Chemical Communications. 47, 2, p. 773-775 2 p.

    Research output: Contribution to journalArticle

  3. Published

    A generic platform for the immobilisation of engineered biocatalysts

    Thompson, M. P., Derrington, S. R., Heath, R. S., Porter, J. L., Mangas-Sanchez, J., Devine, P. N., Truppo, M. D. & Turner, N. J., 18 Jan 2019, In : Tetrahedron. 75, 3, p. 327-334 8 p.

    Research output: Contribution to journalArticle

  4. Published

    A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

    Sharma, M., Mangas-Sanchez, J., France, S. P., Aleku, G. A., Montgomery, S. L., Ramsden, J. I., Turner, N. J. & Grogan, G., 7 Dec 2018, In : ACS Catalysis. 8, 12, p. 11534-11541 8 p.

    Research output: Contribution to journalArticle

  5. Published

    A novel hyaluronan-based biomaterial (Hyaff-11®) as a scaffold for endothelial cells in tissue engineered vascular grafts

    Turner, N. J., Kielty, C. M., Walker, M. G., Canfield, A. E. & Turner, N., Dec 2004, In : Biomaterials. 25, 28, p. 5955-5964 9 p.

    Research output: Contribution to journalArticle

  6. Published
  7. Published

    A Reduction of C N to CH-NH Using Enzymes and Microorganisms

    Turner, N., 2014, Comprehensive Organic Synthesis: Second Edition. Knochel, P. & Molander, G. A. (eds.). second ed. Vol. 8. p. 328-338

    Research output: Chapter in Book/Report/Conference proceedingChapter

  8. Published

    A reductive aminase from Aspergillus oryzae

    Aleku, G., France, S., Man, H., Mangas-Sanchez, J., Montgomery, S., Sharma, M., Leipold, F., Hussain, S., Grogan, G. & Turner, N., 2017, In : Nature Chemistry.

    Research output: Contribution to journalArticle

  9. Published

    A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines

    O'Reilly, E., Iglesias, C., Ghislieri, D., Hopwood, J., Galman, J. L., Lloyd, R. C. & Turner, N. J., 24 Feb 2014, In : Angewandte Chemie - International Edition. 53, 9, p. 2447-2450 3 p.

    Research output: Contribution to journalArticle

  10. Published

    A Single Enzyme Oxidative "cascade" via a Dual-Functional Galactose Oxidase

    Birmingham, W. R. & Turner, N. J., 4 May 2018, In : ACS Catalysis. 8, 5, p. 4025-4032 8 p.

    Research output: Contribution to journalArticle

  11. Published

    A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases

    Willies, S., Galman, J., Slabu, I. & Turner, N., 11 Jan 2016, In : Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences.

    Research output: Contribution to journalArticle

  12. Published

    A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

    Bailey, K. R., Ellis, A. J., Reiss, R., Snape, T. J. & Turner, N. J., 2007, In : Chemical Communications. 35, p. 3640-3642 2 p.

    Research output: Contribution to journalArticle

  13. Published

    A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids

    Roff, G. J., Lloyd, R. C. & Turner, N. J., 7 Apr 2004, In : Journal of the American Chemical Society. 126, 13, p. 4098-4099 1 p.

    Research output: Contribution to journalArticle

  14. Published

    Absolute quantification of uric acid in human urine using surface enhanced Raman scattering with the standard addition method

    Westley, C., Xu, Y., Thilaganathan, B., Carnell, A. J., Turner, N. & Goodacre, R., 21 Feb 2017, In : Analytical Chemistry. 89, 4, p. 2472–2477 6 p.

    Research output: Contribution to journalArticle

  15. Published

    Achieving optimal SERS through enhanced experimental design

    Turner, N., Fisk, H., Westley, C. & Goodacre, R., 16 Dec 2016, In : Journal of Raman Spectroscopy. 47, 1, p. 59-66

    Research output: Contribution to journalArticle

  16. Published

    Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

    Flitsch, S., Kelly, P., Eichler, A., Herter, S., Kranz, D. C. & Turner, N., Sep 2015, In : Beilstein Journal of Organic Chemistry. 11, p. 1713-1720

    Research output: Contribution to journalArticle

  17. Published

    Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides

    Wood, A., Weise, N., Frampton, J. D., Dunstan, M., Hollas, M., Derrington, S., Lloyd, R. C., Quaglia, D., Parmeggiani, F., Leys, D., Turner, N. & Flitsch, S., 13 Nov 2017, In : Angewandte Chemie. 56, 46, p. 14498-14501 4 p.

    Research output: Contribution to journalArticle

  18. Published

    Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids

    Turner, N. J., Apr 2011, In : Current Opinion in Chemical Biology. 15, 2, p. 234-240 6 p.

    Research output: Contribution to journalArticle

  19. Published

    An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

    Hussain, S., Leipold, F., Man, H., Wells, E., France, S. P., Mulholland, K. R., Grogan, G. & Turner, N., 21 Jan 2015, In : ChemCatChem (Online).

    Research output: Contribution to journalArticle

  20. Published

    An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

    Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P., Goodacre, R. & 9 others, Turner, N., Goble, C., Guoqiang Chen, G., Kell, D., Micklefield, J., Breitling, R., Takano, E., Faulon, J-L. & Scrutton, N., 2018, In : Communications Biology. 1, 66.

    Research output: Contribution to journalArticle

  21. Published

    An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols

    Heath, R. S., Birmingham, W. R., Thompson, M. P., Taglieber, A., Daviet, L. & Turner, N. J., 10 Dec 2018, In : CHEMBIOCHEM.

    Research output: Contribution to journalArticle

  22. Published

    Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions

    Humphrey, C., Ahmed, M., Ghanem, A. & Turner, N., 2014, Separation Of Enantiomers : Synthetic Methods. Todd, M. (ed.). p. 123-160

    Research output: Chapter in Book/Report/Conference proceedingChapter

  23. Published
  24. Published

    Artificial concurrent catalytic processes involving enzymes

    Turner, N. & Köhler, V., 2015, In : Chemical Communications. 51, 3, p. 450-464

    Research output: Contribution to journalArticle

  25. Published

    Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

    de Graaff, C., Bensch, L., Boersma, S. J., Cioc, R. C., Van Lint, M. J., Janssen, E., Turner, N., Orru, R. V. A. & Ruijter, E., 2015, In : Angewandte Chemie - International Edition. 54, 47, p. 14133-14136

    Research output: Contribution to journalArticle

  26. Published

    Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity

    Lovelock, S. & Turner, N., 2014, In : Bioorganic and Medicinal Chemistry. 22, 20, p. 5555-5557

    Research output: Contribution to journalArticle

  27. Published

    Biocatalysis

    Turner, N. J., Aug 2012, In : Catalysis Science and Technology. 2, 8, p. 1523

    Research output: Contribution to journalArticle

  28. Published

    Biocatalysis - A gateway to industrial biotechnology

    Fessner, W. D., Turner, N. J. & Wang, M. X., Sep 2011, In : Advanced synthesis & catalysis. 353, 13, p. 2189-2190 1 p.

    Research output: Contribution to journalArticle

  29. Published

    Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

    Hugentobler, K. G., Sharif, H., Rasparini, M., Heath, R. S. & Turner, N. J., 2016, In : Organic and Biomolecular Chemistry. 14, 34, p. 8064-8067 4 p.

    Research output: Contribution to journalArticle

  30. Published

    Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines

    Ghislieri, D. & Turner, N., 2014, In : Topics in Catalysis. 57, 5, p. 284-300

    Research output: Contribution to journalArticle

  31. Published

    Biocatalytic conversion of cyclic ketones bearing α-quaternary stereocenters to lactones in an enantioselective radical approach to medium-sized carbocycles

    Morrill, C., Jensen, C., Just-Baringo, X., Grogan, G., Turner, N. & Procter, D., 26 Mar 2018, In : Angewandte Chemie - International Edition. 57, 14, p. 3692-3696 4 p.

    Research output: Contribution to journalArticle

  32. Published

    Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases

    Yuan, B., Page, A., Worrall, C. P., Escalettes, F., Willies, S. C., McDouall, J. J. W., Turner, N. J. & Clayden, J., 17 Sep 2010, In : Angewandte Chemie - International Edition. 49, 39, p. 7010-7013 3 p.

    Research output: Contribution to journalArticle

  33. Published

    Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts

    Staniland, S., Adams, R., Mcdouall, J., Maffucci, I., Contini, A., Grainger, D., Turner, N. & Clayden, J., 26 Aug 2016, In : Angewandte Chemie. 55, 36, p. 10755-10759 5 p.

    Research output: Contribution to journalArticle

  34. Published

    Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

    Ramsden, J. I., Heath, R. S., Derrington, S. R., Montgomery, S. L., Mangas-Sanchez, J., Mulholland, K. R. & Turner, N. J., 23 Jan 2019, In : Journal of the American Chemical Society.

    Research output: Contribution to journalArticle

  35. Published

    Biocatalytic retrosynthesis: Redesigning synthetic routes to high-value chemicals

    Turner, N. & Green, A., 14 Sep 2016, In : Perspectives in Science.

    Research output: Contribution to journalArticle

  36. Published

    Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

    France, S. P., Aleku, G. A., Sharma, M., Mangas-Sanchez, J., Howard, R. M., Steflik, J., Kumar, R., Adams, R. W., Slabu, I., Crook, R., Grogan, G., Wallace, T. W. & Turner, N. J., 2017, In : Angewandte Chemie - International Edition. 56, 49, p. 15589-15593 5 p.

    Research output: Contribution to journalArticle

  37. Published

    Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

    Galman, J., Slabu, I., Weise, N., Iglesias, C., Parmeggiani, F., Lloyd, R. C. & Turner, N., 2017, In : Green Chemistry.

    Research output: Contribution to journalArticle

  38. Published

    Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering

    Klumbys, E., Zebec, Z., Weise, N., Turner, N. & Scrutton, N., 2018, In : Green Chemistry.

    Research output: Contribution to journalArticle

  39. Published

    Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

    Galman, J. L., Slabu, I., Parmeggiani, F. & Turner, N. J., 2018, In : Chemical Communications. 54, 80, p. 11316-11319 4 p.

    Research output: Contribution to journalArticle

  40. Published

    Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry

    Kimber, R., Lewis, E. A., Parmeggiani, F., Smith, K., Bagshaw, H., Starborg, T., Joshi, N., Figueroa, A. I., Van der Laan, G., Cibin, G., Gianolio, D., Haigh, S., Pattrick, R. A. D., Turner, N. & Lloyd, J., 2018, In : Small.

    Research output: Contribution to journalArticle

  41. Published

    Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities

    Kalim Akhtara, M., Turner, N. J. & Jones, P. R., 2 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 87-92 5 p.

    Research output: Contribution to journalArticle

  42. Published

    Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form

    Turner, N., Wells, A., Wong, J. W., Michels, P. C., Fandrick, K., Finch, G. L., Goswami, A., Lee, H., Mix, S., Moody, T., Pang, L., Entwistle, D. A., Sato, R. K. & Watson, T. J., 9 Feb 2016, In : Organic Process Research & Development. 20, 3, p. 3298-3306

    Research output: Contribution to journalArticle

  43. Published

    Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

    Bechi, B., Herter, S., McKenna, S., Riley, C., Leimkühler, S., Turner, N. J. & Carnell, A. J., 18 Aug 2014, In : Green Chemistry. 16, p. 4524-4529 5 p., C4GC01321B.

    Research output: Contribution to journalArticle

  44. Published

    Characterisation of CYP102A25 from B. marmarensis and CYP102A26 from P. halophilus: P450 homologues of BM3 with preference towards hydroxylation of medium chain fatty acids

    Porter, J., Manning, J., Sabatini, S., Tavanti, M., Turner, N. & Flitsch, S., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  45. Published

    Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum

    Turner, N., Özgün, G., Karagüler, N. G. & Turunen, O., 2015, In : Journal of Molecular Catalysis B: Enzymatic. 122, p. 212-217

    Research output: Contribution to journalArticle

  46. Published

    Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase

    Zajkoska, P., Cárdenas-Fernández, M., Lye, G. J., Rosenberg, M., Turner, N. J. & Rebroš, M., 1 Jul 2017, In : Journal of Chemical Technology and Biotechnology. 92, 7, p. 1558-1565 8 p.

    Research output: Contribution to journalArticle

  47. Published
  48. Published

    Chemo-enzymatic synthesis of pyrazines and pyrroles

    Turner, N. J., Green, A. & Xu, J., 2018, In : Angewandte Chemie International Edition.

    Research output: Contribution to journalArticle

  49. Published

    Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

    Zawodny, W., Montgomery, S. L., Marshall, J. R., Finnigan, J. D., Turner, N. J. & Clayden, J., 26 Dec 2018, In : Journal of the American Chemical Society. 140, 51, p. 17872-17877 6 p.

    Research output: Contribution to journalArticle

  50. Published

    Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope

    Robin, A., Köhler, V., Jones, A., Ali, A., Kelly, P. P., O'Reilly, E., Turner, N. J. & Flitsch, S. L., 2 Nov 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 1494-1498 4 p., 7.

    Research output: Contribution to journalArticle

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