Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. 2002
  2. Published

    Deracemization of α-methylbenzylamine using an enzyme obtained by in vitro evolution

    Alexeeva, M., Enright, A., Dawson, M. J., Mahmoudian, M. & Turner, N. J., 2 Sep 2002, In : Angewandte Chemie - International Edition. 41, 17, p. 3177-3180 3 p.

    Research output: Contribution to journalArticle

  3. 2003
  4. Published

    Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity

    Carr, R., Alexeeva, M., Enright, A., Eve, T. S. C., Dawson, M. J. & Turner, N. J., 13 Oct 2003, In : Angewandte Chemie - International Edition. 42, 39, p. 4807-4810 3 p.

    Research output: Contribution to journalArticle

  5. Published

    Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy

    Humphrey, C. E., Turner, N. J., Easson, M. A. M., Flitsch, S. L. & Ulijn, R. V., 19 Nov 2003, In : Journal of the American Chemical Society. 125, 46, p. 13952-13953 1 p.

    Research output: Contribution to journalArticle

  6. 2004
  7. Published

    A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids

    Roff, G. J., Lloyd, R. C. & Turner, N. J., 7 Apr 2004, In : Journal of the American Chemical Society. 126, 13, p. 4098-4099 1 p.

    Research output: Contribution to journalArticle

  8. Published

    A novel hyaluronan-based biomaterial (Hyaff-11®) as a scaffold for endothelial cells in tissue engineered vascular grafts

    Turner, N. J., Kielty, C. M., Walker, M. G., Canfield, A. E. & Turner, N., Dec 2004, In : Biomaterials. 25, 28, p. 5955-5964 9 p.

    Research output: Contribution to journalArticle

  9. 2007
  10. Published

    A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

    Bailey, K. R., Ellis, A. J., Reiss, R., Snape, T. J. & Turner, N. J., 2007, In : Chemical Communications. 35, p. 3640-3642 2 p.

    Research output: Contribution to journalArticle

  11. 2008
  12. Published

    Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger

    Atkin, K. E., Reiss, R., Turner, N. J., Brzozowski, A. M. & Grogan, G., 2008, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 64, 3, p. 182-185 3 p.

    Research output: Contribution to journalArticle

  13. Published

    Rapid determination of both the activity and enantioselectivity of ketoreductases

    Truppo, M. D., Escalettes, F. & Turner, N. J., 25 Mar 2008, In : Angewandte Chemie - International Edition. 47, 14, p. 2639-2641 2 p.

    Research output: Contribution to journalArticle

  14. Published

    Directed evolution of galactose oxidase: Generation of enantioselective secondary alcohol oxidases

    Escalettes, F. & Turner, N. J., 14 Apr 2008, In : ChemBioChem: a European journal of chemical biology . 9, 6, p. 857-860 3 p.

    Research output: Contribution to journalArticle

  15. Published

    Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis

    Nowicki, M. W., Tulloch, L. B., Worralll, L., McNae, I. W., Hannaert, V., Michels, P. A. M., Fothergill-Gilmore, L. A., Walkinshaw, M. D. & Turner, N. J., 1 May 2008, In : Bioorganic and Medicinal Chemistry. 16, 9, p. 5050-5061 11 p.

    Research output: Contribution to journalArticle

  16. 2009
  17. Published

    Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme

    Robin, A., Roberts, G. A., Kisch, J., Sabbadin, F., Grogan, G., Bruce, N., Turner, N. J. & Flitsch, S. L., 2009, In : Chemical Communications. 18, p. 2478-2480 2 p.

    Research output: Contribution to journalArticle

  18. 2010
  19. Published

    Deracemisation methods

    Turner, N. J., Apr 2010, In : Current Opinion in Chemical Biology. 14, 2, p. 115-121 6 p.

    Research output: Contribution to journalArticle

  20. Published

    Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases

    Yuan, B., Page, A., Worrall, C. P., Escalettes, F., Willies, S. C., McDouall, J. J. W., Turner, N. J. & Clayden, J., 17 Sep 2010, In : Angewandte Chemie - International Edition. 49, 39, p. 7010-7013 3 p.

    Research output: Contribution to journalArticle

  21. Published

    Selective chemical intervention in the proteome of caenorhabditis elegans

    Husi, H., McAllister, F., Angelopoulos, N., Butler, V. J., Bailey, K. R., Malone, K., MacKay, L., Taylor, P., Page, A. P., Turner, N. J., Barran, P. E. & Walkinshaw, M., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 6060-6070 10 p.

    Research output: Contribution to journalArticle

  22. 2011
  23. Published

    A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

    Hopwood, J., Truppo, M. D., Turner, N. J. & Lloyd, R. C., 14 Jan 2011, In : Chemical Communications. 47, 2, p. 773-775 2 p.

    Research output: Contribution to journalArticle

  24. Published

    Cytochromes P450 as useful biocatalysts: Addressing the limitations

    O'Reilly, E., Köhler, V., Flitsch, S. L. & Turner, N. J., 7 Mar 2011, In : Chemical Communications. 47, 9, p. 2490-2501 11 p.

    Research output: Contribution to journalArticle

  25. Published

    Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans

    Dunsmore, C. J., Malone, K. J., Bailey, K. R., Wear, M. A., Florance, H., Shirran, S., Barran, P. E., Page, A. P., Walkinshaw, M. D. & Turner, N. J., 21 Mar 2011, In : ChemBioChem: a European journal of chemical biology . 12, 5, p. 802-810 8 p.

    Research output: Contribution to journalArticle

  26. Published

    Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids

    Turner, N. J., Apr 2011, In : Current Opinion in Chemical Biology. 15, 2, p. 234-240 6 p.

    Research output: Contribution to journalArticle

  27. Published

    High throughput screens yield small molecule inhibitors of leishmania CRK3:CYC6 cyclin-dependent kinase

    Walker, R. G., Thomson, G., Malone, K., Nowicki, M. W., Brown, E., Blake, D. G., Turner, N. J., Walkinshaw, M. D., Grant, K. M. & Mottram, J. C., Apr 2011, In : PL o S Neglected Tropical Diseases. 5, 4, e1033.

    Research output: Contribution to journalArticle

  28. Published

    Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution

    Rannes, J. B., Ioannou, A., Willies, S. C., Grogan, G., Behrens, C., Flitsch, S. L. & Turner, N. J., 8 Jun 2011, In : Journal of the American Chemical Society. 133, 22, p. 8436-8439 3 p.

    Research output: Contribution to journalArticle

  29. Published

    Enantioselective Oxidation of C-O and C-N bonds using oxidases

    Turner, N. J., 13 Jul 2011, In : Chemical Reviews. 111, 7, p. 4073-4087 14 p.

    Research output: Contribution to journalArticle

  30. Published

    Biocatalysis - A gateway to industrial biotechnology

    Fessner, W. D., Turner, N. J. & Wang, M. X., Sep 2011, In : Advanced synthesis & catalysis. 353, 13, p. 2189-2190 1 p.

    Research output: Contribution to journalArticle

  31. Published

    Enzyme-catalyzed enantioselective hydrolysis of dihydrouracils as a route to enantiomerically pure Β-amino acids

    Oneill, M., Hauer, B., Schneider, N. & Turner, N. J., 2 Sep 2011, In : ACS Catalysis. 1, 9, p. 1014-1016 2 p.

    Research output: Contribution to journalArticle

  32. Published

    Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase

    Ioannou, A., Cini, E., Timofte, R. S., Flitsch, S. L., Turner, N. J. & Linclau, B., 28 Oct 2011, In : Chemical Communications. 47, 40, p. 11228-11230 2 p.

    Research output: Contribution to journalArticle

  33. Published

    Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope

    Robin, A., Köhler, V., Jones, A., Ali, A., Kelly, P. P., O'Reilly, E., Turner, N. J. & Flitsch, S. L., 2 Nov 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 1494-1498 4 p., 7.

    Research output: Contribution to journalArticle

  34. Published

    Engineering a biometallic whole cell catalyst for enantioselective deracemization reactions

    Foulkes, J. M., Malone, K. J., Coker, V. S., Turner, N. J. & Lloyd, J. R., 4 Nov 2011, In : ACS Catalysis. 1, 11, p. 1589-1594 5 p.

    Research output: Contribution to journalArticle

  35. 2012
  36. Published

    Stereoselective synthesis of N-aryl proline amides by biotransformation- Ugi-Smiles sequence

    Znabet, A., Blanken, S., Janssen, E., De Kanter, F. J. J., Helliwell, M., Turner, N. J., Ruijter, E. & Orru, R. V. A., 7 Feb 2012, In : Organic and Biomolecular Chemistry. 10, 5, p. 941-944 4 p.

    Research output: Contribution to journalArticle

  37. Published

    Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous

    O'Reilly, E., Aitken, S. J., Grogan, G., Kelly, P. P., Turner, N. J. & Flitsch, S. L., 3 Apr 2012, In : Beilstein Journal of Organic Chemistry. 8, p. 496-500 4 p.

    Research output: Contribution to journalArticle

  38. Published

    Oxidation of C-N Bonds

    Turner, N. J., 20 Apr 2012, Enzyme Catalysis in Organic Synthesis. Drauz, K., Gröger, H. & May, O. (eds.). 3 ed. John Wiley & Sons Ltd, p. 1535-1552 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  39. Published

    Oxidation of Alcohols

    Turner, N., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  40. Published

    Reductive Amination

    Turner, N., Stella, S. & Chadha, A., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  41. Published

    Selective Oxidation

    Turner, N. & Kroutil, W., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  42. Published

    Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure

    March-Cortijos, A., Snape, T. J. & Turner, N. J., 30 May 2012, In : SYNLETT. 23, 10, p. 1511-1515 5 p., ST-2012-D0041-L.

    Research output: Contribution to journalArticle

  43. Published

    Biocatalysis

    Turner, N. J., Aug 2012, In : Catalysis Science and Technology. 2, 8, p. 1523

    Research output: Contribution to journalArticle

  44. Published

    Directed evolution of the enzyme monoamine oxidase (mao-n): Highly efficient chemo-enzymatic deracemisation of the alkaloid (±)-crispinea

    Rowles, I., Malone, K. J., Etchells, L. L., Willies, S. C. & Turner, N. J., Sep 2012, In : ChemCatChem. 4, 9, p. 1259-1261 2 p.

    Research output: Contribution to journalArticle

  45. Published

    Development of a high-throughput screening method for racemase activity and its application to the identification of alanine racemase variants with activity towards l-arginine

    Willies, S. C., White, J. L. & Turner, N. J., 16 Sep 2012, In : Tetrahedron. 68, 37, p. 7564-7567 3 p.

    Research output: Contribution to journalArticle

  46. 2013
  47. Published

    Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities

    Kalim Akhtara, M., Turner, N. J. & Jones, P. R., 2 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 87-92 5 p.

    Research output: Contribution to journalArticle

  48. Published

    Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

    Köhler, V., Wilson, Y. M., Dürrenberger, M., Ghislieri, D., Churakova, E., Quinto, T., Knörr, L., Häussinger, D., Hollmann, F., Turner, N. J. & Ward, T. R., Feb 2013, In : Nature Chemistry. 5, 2, p. 93-99 6 p.

    Research output: Contribution to journalArticle

  49. Published

    Substrate promiscuity of cytochrome P450 RhF

    O'Reilly, E., Corbett, M., Hussain, S., Kelly, P. P., Richardson, D., Flitsch, S. L. & Turner, N. J., Jun 2013, In : Catalysis Science and Technology. 3, 6, p. 1490-1492 2 p.

    Research output: Contribution to journalArticle

  50. Published

    Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products

    Ghislieri, D., Green, A., Pontini, M., Willies, S. C., Rowles, I., Frank, A., Grogan, G. & Turner, N. J., 24 Jul 2013, In : Journal of the American Chemical Society. 135, 29, p. 10863-9 7 p.

    Research output: Contribution to journalArticle

  51. 2014
  52. Published

    A Reduction of C N to CH-NH Using Enzymes and Microorganisms

    Turner, N., 2014, Comprehensive Organic Synthesis: Second Edition. Knochel, P. & Molander, G. A. (eds.). second ed. Vol. 8. p. 328-338

    Research output: Chapter in Book/Report/Conference proceedingChapter

  53. Published

    Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions

    Humphrey, C., Ahmed, M., Ghanem, A. & Turner, N., 2014, Separation Of Enantiomers : Synthetic Methods. Todd, M. (ed.). p. 123-160

    Research output: Chapter in Book/Report/Conference proceedingChapter

  54. Published

    Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity

    Lovelock, S. & Turner, N., 2014, In : Bioorganic and Medicinal Chemistry. 22, 20, p. 5555-5557

    Research output: Contribution to journalArticle

  55. Published

    Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines

    Ghislieri, D. & Turner, N., 2014, In : Topics in Catalysis. 57, 5, p. 284-300

    Research output: Contribution to journalArticle

  56. Published

    Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants

    Schrittwieser, J., Groenendaal, B., Willies, S. C., Ghislieri, D., Rowles, I., Resch, V., Sattler, J. H., Fischereder, E-M., Grischek, B., Lienhart, W-D., Turner, N. & Kroutil, W., 2014, In : Catalysis Science and Technology. 4, 10, p. 3657-3664

    Research output: Contribution to journalArticle

  57. Published

    Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion

    Schrittwieser, J., Groenendaal, B., Resch, V., Ghislieri, D., Wallner, S., Fischereder, E-M., Fuchs, E., Grischek, B., Sattler, J. H., Macheroux, P., Turner, N. & Kroutil, W., 2014, In : Angewandte Chemie - International Edition. 53, 14, p. 3731-3734

    Research output: Contribution to journalArticle

  58. Published

    Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity

    Heath, R., Pontini, M., Turner, N. & Bechi, B., 2014, In : ChemCatChem. 6, 4, p. 996-1002

    Research output: Contribution to journalArticle

  59. Published

    Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers

    Staniland, S., Yuan, B., Giménez-Agulló, N., Marcelli, T., Willies, S. C., Grainger, D. M., Turner, N. J. & Clayden, J., 2014, In : Chemistry: A European Journal. 20, 41, p. 13084-13088

    Research output: Contribution to journalArticle

  60. Published

    Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

    Scheller, P. N., Fademrecht, S., Hofelzer, S., Pleiss, J., Leipold, F., Turner, N., Nestl, B. & Hauer, B., 2014, In : CHEMBIOCHEM. 15, 15, p. 2201-2204

    Research output: Contribution to journalArticle

  61. Published

    Foreword

    Turner, N., Whittall, J. & Ward, T. R., 2014, In : Topics in Catalysis. 57, 5, p. 283

    Research output: Contribution to journalArticle

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