Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. 2017
  2. Published
  3. Published

    A reductive aminase from Aspergillus oryzae

    Aleku, G., France, S., Man, H., Mangas-Sanchez, J., Montgomery, S., Sharma, M., Leipold, F., Hussain, S., Grogan, G. & Turner, N., 2017, In : Nature Chemistry.

    Research output: Contribution to journalArticle

  4. Published
  5. Published

    Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

    France, S. P., Aleku, G. A., Sharma, M., Mangas-Sanchez, J., Howard, R. M., Steflik, J., Kumar, R., Adams, R. W., Slabu, I., Crook, R., Grogan, G., Wallace, T. W. & Turner, N. J., 2017, In : Angewandte Chemie - International Edition. 56, 49, p. 15589-15593 5 p.

    Research output: Contribution to journalArticle

  6. Published

    Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

    Galman, J., Slabu, I., Weise, N., Iglesias, C., Parmeggiani, F., Lloyd, R. C. & Turner, N., 2017, In : Green Chemistry.

    Research output: Contribution to journalArticle

  7. Published

    Characterisation of CYP102A25 from B. marmarensis and CYP102A26 from P. halophilus: P450 homologues of BM3 with preference towards hydroxylation of medium chain fatty acids

    Porter, J., Manning, J., Sabatini, S., Tavanti, M., Turner, N. & Flitsch, S., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  8. Published

    Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris

    Markošová, K., Camattari, A., Rosenberg, M., Glieder, A., Turner, N. J. & Rebroš, M., 2017, In : Biotechnology Letters. p. 1-7 7 p.

    Research output: Contribution to journalArticle

  9. Published

    Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

    Flitsch, S., France, S., Hepworth, L. & Turner, N., 2017, In : ACS Catalysis. p. 710-724 14 p.

    Research output: Contribution to journalArticle

  10. Published

    De Novo Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines.

    Hepworth, L., France, S., Hussain, S., Both, P., Turner, N. & Flitsch, S., 2017, In : ACS Catalysis.

    Research output: Contribution to journalArticle

  11. Published

    Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors

    Weissenborn, M. J., Debecker, D. P., Golten, S., Linclau, B., Turner, N. & Flitsch, S., 2017, In : Protein and Peptide Letters. 24, 8, p. 742-746 5 p.

    Research output: Contribution to journalArticle

  12. Published
  13. Published

    Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

    Herter, S., Medina, F., Wagschal, S., Benhaïm, C., Leipold, F. & Turner, N. J., 2017, In : Bioorganic and Medicinal Chemistry.

    Research output: Contribution to journalArticle

  14. Published

    n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones

    Slabu, I., Galman, J., Iglesias, C., Weise, N., Lloyd, R. C. & Turner, N., 2017, In : Catalysis Today.

    Research output: Contribution to journalArticle

  15. Published

    One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone

    Tavanti, M., Parmeggiani, F., Castellanos, J. R. G., Mattevi, A. & Turner, N. J., 2017, In : ChemCatChem. 9, 17, p. 3338-3348 11 p.

    Research output: Contribution to journalArticle

  16. Published

    Real-time screening of biocatalysts in live bacterial colonies

    Yan, C., Parmeggiani, F., Jones, E. A., Claude, E., Hussain, S., Turner, N., Flitsch, S. & Barran, P., 2017, In : Journal of the American Chemical Society. 139, 4, p. 1408-1411 4 p.

    Research output: Contribution to journalArticle

  17. Published

    Recommendations on the implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes

    Barley, M., Turner, N. & Goodacre, R., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  18. Published

    Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

    Gahloth, D., Dunstan, M. S., Quaglia, D., Klumbys, E., Lockhart-Cairns, M. P., Hill, A., Derrington, S. R., Scrutton, N. S., Turner, N. J. & Leys, D., 2017, In : Nature chemical biology. 13, p. 975-981 7 p.

    Research output: Contribution to journalArticle

  19. Published

    Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases

    Parmeggiani, F., Weise, N., Ahmed, S. & Turner, N., 2017, In : Chemical Reviews.

    Research output: Contribution to journalArticle

  20. Published

    The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

    McKenna, S. M., Mines, P., Law, P., Kovacs-Schreiner, K., Birmingham, W. R., Turner, N. J., Leimkühler, S. & Carnell, A. J., 2017, In : Green Chemistry. 19, 19, p. 4660-4665 6 p.

    Research output: Contribution to journalArticle

  21. Published

    The self‐sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5‐hydroxylation of diclofenac

    Klenk, J. M., Nebel, B., Porter, J., Kulig, J. K., Hussain, S., Richter, S. M., Tavanti, M., Turner, N., Hayes, M. A., Hauer, B. & Flitsch, S., 2017, In : Biotechnology Journal (Print).

    Research output: Contribution to journalArticle

  22. Published

    Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase

    Thompson, M. P. & Turner, N. J., 2017, In : ChemCatChem. 9, 20, p. 3833-3836 4 p.

    Research output: Contribution to journalArticle

  23. Published

    Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

    Weise, N. J., Ahmed, S. T., Parmeggiani, F., Galman, J. L., Dunstan, M. S., Charnock, S. J., Leys, D. & Turner, N. J., 2017, In : Scientific Reports. 7, 1, 13691.

    Research output: Contribution to journalArticle

  24. Published

    Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

    Scalacci, N., Black, G. W., Mattedi, G., Brown, N. L., Turner, N. J. & Castagnolo, D., 3 Feb 2017, In : ACS Catalysis. 7, 2, p. 1295-1300 6 p.

    Research output: Contribution to journalArticle

  25. Published

    Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

    Hugentobler, K. G., Rasparini, M., Thompson, L. A., Jolley, K. E., Blacker, A. J. & Turner, N. J., 17 Feb 2017, In : Organic Process Research and Development. 21, 2, p. 195-199 5 p.

    Research output: Contribution to journalArticle

  26. Published

    Absolute quantification of uric acid in human urine using surface enhanced Raman scattering with the standard addition method

    Westley, C., Xu, Y., Thilaganathan, B., Carnell, A. J., Turner, N. & Goodacre, R., 21 Feb 2017, In : Analytical Chemistry. 89, 4, p. 2472–2477 6 p.

    Research output: Contribution to journalArticle

  27. Published

    Imine reductases (IREDs)

    Mangas-Sanchez, J., France, S. P., Montgomery, S. L., Aleku, G. A., Man, H., Sharma, M., Ramsden, J. I., Grogan, G. & Turner, N. J., 1 Apr 2017, In : Current Opinion in Chemical Biology. 37, p. 19-25 7 p.

    Research output: Contribution to journalReview article

  28. Published

    Real-time monitoring of enzyme-catalysed reactions using deep UV resonance Raman spectroscopy

    Westley, C., Fisk, H., Xu, Y., Hollywood, K., Carnell, A. J., Micklefield, J., Turner, N. & Goodacre, R., 23 May 2017, In : Chemistry: A European Journal. 23, 29, p. 6983-6987 5 p.

    Research output: Contribution to journalArticle

  29. Published

    Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase

    Zajkoska, P., Cárdenas-Fernández, M., Lye, G. J., Rosenberg, M., Turner, N. J. & Rebroš, M., 1 Jul 2017, In : Journal of Chemical Technology and Biotechnology. 92, 7, p. 1558-1565 8 p.

    Research output: Contribution to journalArticle

  30. Published

    Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing

    Montgomery, S. L., Mangas-Sanchez, J., Thompson, M. P., Aleku, G. A., Dominguez, B. & Turner, N. J., 16 Aug 2017, In : Angewandte Chemie (International ed. in English). 56, 35, p. 10491-10494 4 p.

    Research output: Contribution to journalArticle

  31. Published

    Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

    Chapman, M. R., Kwan, M. H. T., King, G., Jolley, K. E., Hussain, M., Hussain, S., Salama, I. E., González Nino, C., Thompson, L. A., Bayana, M. E., Clayton, A. D., Nguyen, B. N., Turner, N. J., Kapur, N. & Blacker, A. J., 15 Sep 2017, In : Organic Process Research and Development. 21, 9, p. 1294-1301 8 p.

    Research output: Contribution to journalArticle

  32. Published

    Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

    France, S., Weise, N., Mangas-Sanchez, J., Montgomery, S., Howard, R. M. & Turner, N., 21 Sep 2017, In : ChemCatChem.

    Research output: Contribution to journalArticle

  33. Published

    Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis

    Hartley, C. J., French, N. G., Scoble, J. A., Williams, C. C., Churches, Q. I., Frazer, A. R., Taylor, M. C., Coia, G., Simpson, G., Turner, N. J. & Scott, C., Nov 2017, In : PLoS ONE. 12, 11, e0184183.

    Research output: Contribution to journalArticle

  34. Published

    Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides

    Wood, A., Weise, N., Frampton, J. D., Dunstan, M., Hollas, M., Derrington, S., Lloyd, R. C., Quaglia, D., Parmeggiani, F., Leys, D., Turner, N. & Flitsch, S., 13 Nov 2017, In : Angewandte Chemie. 56, 46, p. 14498-14501 4 p.

    Research output: Contribution to journalArticle

  35. Published

    From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy

    Fisk, H., Xu, Y., Westley, C., Turner, N., Micklefield, J. & Goodacre, R., 21 Nov 2017, In : Analytical Chemistry. 89, 22, p. 12527-12532 5 p.

    Research output: Contribution to journalArticle

  36. Published

    Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

    Slabu, I., Galman, J. L., Lloyd, R. C. & Turner, N. J., 1 Dec 2017, In : ACS Catalysis. 7, 12, p. 8263-8284 22 p.

    Research output: Contribution to journalArticle

  37. Published

    Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades

    Walton, C. J. W., Parmeggiani, F., Barber, J. E. B., McCann, J. L., Turner, N. J. & Chica, R. A., 5 Dec 2017, In : ChemCatChem. 10, 2, p. 470-474 5 p.

    Research output: Contribution to journalArticle

  38. Published

    A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

    Tavanti, M., Mangas-Sanchez, J., Montgomery, S. L., Thompson, M. P. & Turner, N. J., 14 Dec 2017, In : Organic and Biomolecular Chemistry. 15, 46, p. 9790-9793 4 p.

    Research output: Contribution to journalArticle

  39. 2018
  40. Published

    An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

    Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P., Goodacre, R. & 9 othersTurner, N., Goble, C., Guoqiang Chen, G., Kell, D., Micklefield, J., Breitling, R., Takano, E., Faulon, J-L. & Scrutton, N., 2018, In : Communications Biology. 1, 66.

    Research output: Contribution to journalArticle

  41. Published

    Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering

    Klumbys, E., Zebec, Z., Weise, N., Turner, N. & Scrutton, N., 2018, In : Green Chemistry.

    Research output: Contribution to journalArticle

  42. Published

    Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

    Galman, J. L., Slabu, I., Parmeggiani, F. & Turner, N. J., 2018, In : Chemical Communications. 54, 80, p. 11316-11319 4 p.

    Research output: Contribution to journalArticle

  43. Published

    Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry

    Kimber, R., Lewis, E. A., Parmeggiani, F., Smith, K., Bagshaw, H., Starborg, T., Joshi, N., Figueroa, A. I., Van der Laan, G., Cibin, G., Gianolio, D., Haigh, S., Pattrick, R. A. D., Turner, N. & Lloyd, J., 2018, In : Small.

    Research output: Contribution to journalArticle

  44. Published

    Chemo-enzymatic synthesis of pyrazines and pyrroles

    Turner, N. J., Green, A. & Xu, J., 2018, In : Angewandte Chemie International Edition.

    Research output: Contribution to journalArticle

  45. Published

    Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope

    Porter, J., Sabatini, S., Manning, J., Tavanti, M., Galman, J., Turner, N. & Flitsch, S., 2018, In : Enzyme and Microbial Technology.

    Research output: Contribution to journalArticle

  46. Published

    Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii

    Çakar, M. M., Mangas-Sanchez, J., Birmingham, W. R., Turner, N. J. & Binay, B., 2018, In : Preparative Biochemistry and Biotechnology. 48, 4, p. 327-334 8 p.

    Research output: Contribution to journalArticle

  47. Published

    Improved Descriptors for the QSAR Modeling of Peptides and Proteins

    Barley, M., Turner, N. & Goodacre, R., 2018, In : Journal of Chemical Information and Modeling.

    Research output: Contribution to journalArticle

  48. Published

    Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

    Costa, B. Z., Galman, J. L., Slabu, I., France, S. P., Marsaioli, A. J. & Turner, N. J., 2018, In : ChemCatChem.

    Research output: Contribution to journalArticle

  49. Accepted/In press

    Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications

    Cosgrove, S. C., Brzezniak, A., France, S. P., Ramsden, J. I., Mangas-Sanchez, J., Montgomery, S. L., Heath, R. S. & Turner, N. J., 1 Jan 2018, (Accepted/In press) In : Methods in Enzymology.

    Research output: Contribution to journalArticle

  50. Published

    Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis

    Weise, N., Parmeggiani, F., Ahmed, S. & Turner, N., 25 Jan 2018, In : Topics in Catalysis.

    Research output: Contribution to journalArticle

  51. Published

    Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

    Aleku, G. A., Mangas-Sanchez, J., Citoler, J., France, S. P., Montgomery, S. L., Heath, R. S., Thompson, M. P. & Turner, N. J., 7 Feb 2018, In : ChemCatChem. 10, 3, p. 515-519 5 p.

    Research output: Contribution to journalArticle

  52. Published

    Biocatalytic conversion of cyclic ketones bearing α-quaternary stereocenters to lactones in an enantioselective radical approach to medium-sized carbocycles

    Morrill, C., Jensen, C., Just-Baringo, X., Grogan, G., Turner, N. & Procter, D., 26 Mar 2018, In : Angewandte Chemie - International Edition. 57, 14, p. 3692-3696 4 p.

    Research output: Contribution to journalArticle

  53. Published

    A Single Enzyme Oxidative "cascade" via a Dual-Functional Galactose Oxidase

    Birmingham, W. R. & Turner, N. J., 4 May 2018, In : ACS Catalysis. 8, 5, p. 4025-4032 8 p.

    Research output: Contribution to journalArticle

  54. Published

    The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

    Tavanti, M., Porter, J. L., Levy, C. W., Gómez Castellanos, J. R., Flitsch, S. L. & Turner, N. J., 17 May 2018, In : Biochemical and Biophysical Research Communications. 501, 4, p. 846-850 5 p.

    Research output: Contribution to journalArticle

  55. Published

    Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines

    Cosgrove, S. C., Hussain, S., Turner, N. J. & Marsden, S. P., 1 Jun 2018, In : ACS Catalysis. 8, 6, p. 5570-5573 4 p.

    Research output: Contribution to journalArticle

  56. Published

    Selenzyme: Enzyme selection tool for pathway design

    Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., Kell, D., Breitling, R. & Faulon, J-L., 15 Jun 2018, In : Bioinformatics. 34, 12

    Research output: Contribution to journalArticle

  57. Published

    Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen

    Chapman, M. R., Cosgrove, S. C., Turner, N. J., Kapur, N. & Blacker, A. J., 13 Aug 2018, In : Angewandte Chemie - International Edition. 57, 33, p. 10535-10539 5 p.

    Research output: Contribution to journalArticle

  58. Published

    Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

    Toscani, A., Risi, C., Black, G. W., Brown, N. L., Shaaban, A., Turner, N. J. & Castagnolo, D., 7 Sep 2018, In : ACS Catalysis. 8, 9, p. 8781-8787 6 p.

    Research output: Contribution to journalArticle

  59. Published

    Concurrent Biocatalytic Oxidation and C–C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines

    Odachowski, M., Greaney, M. F. & Turner, N. J., 2 Nov 2018, In : ACS Catalysis. 8, 11, p. 10032-10035

    Research output: Contribution to journalArticle

  60. Published

    A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

    Sharma, M., Mangas-Sanchez, J., France, S. P., Aleku, G. A., Montgomery, S. L., Ramsden, J. I., Turner, N. J. & Grogan, G., 7 Dec 2018, In : ACS Catalysis. 8, 12, p. 11534-11541 8 p.

    Research output: Contribution to journalArticle

  61. Published

    An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols

    Heath, R. S., Birmingham, W. R., Thompson, M. P., Taglieber, A., Daviet, L. & Turner, N. J., 10 Dec 2018, In : CHEMBIOCHEM.

    Research output: Contribution to journalArticle

  62. Published

    Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

    Zawodny, W., Montgomery, S. L., Marshall, J. R., Finnigan, J. D., Turner, N. J. & Clayden, J., 26 Dec 2018, In : Journal of the American Chemical Society. 140, 51, p. 17872-17877 6 p.

    Research output: Contribution to journalArticle

  63. 2019
  64. Published

    Regio- and Enantio-selective Chemo-enzymatic C-H-lactonization of Decanoic Acid to (S)-δ-Decalactone.

    Manning, J., Tavanti, M., Porter, J., Kress, N., De Visser, S., Turner, N. & Flitsch, S., 2019, In : Angewandte Chemie.

    Research output: Contribution to journalArticle

  65. Published

    A generic platform for the immobilisation of engineered biocatalysts

    Thompson, M. P., Derrington, S. R., Heath, R. S., Porter, J. L., Mangas-Sanchez, J., Devine, P. N., Truppo, M. D. & Turner, N. J., 18 Jan 2019, In : Tetrahedron. 75, 3, p. 327-334 8 p.

    Research output: Contribution to journalArticle

  66. Published

    Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

    Ramsden, J. I., Heath, R. S., Derrington, S. R., Montgomery, S. L., Mangas-Sanchez, J., Mulholland, K. R. & Turner, N. J., 23 Jan 2019, In : Journal of the American Chemical Society.

    Research output: Contribution to journalArticle

  67. Published

    Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

    Megarity, C. F., Siritanaratkul, B., Heath, R. S., Wan, L., Morello, G., FitzPatrick, S. R., Booth, R. L., Sills, A. J., Robertson, A. W., Warner, J. H., Turner, N. J. & Armstrong, F. A., 14 Feb 2019, In : Angewandte Chemie - International Edition.

    Research output: Contribution to journalArticle

  68. Published

    GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

    Currin, A., Kwok, J., Sadler, J. C., Bell, E. L., Swainston, N., Ababi, M., Day, P., Turner, N. J. & Kell, D. B., 21 Jun 2019, In : ACS Synthetic Biology. 8, 6, p. 1371-1378

    Research output: Contribution to journalArticle

  69. E-pub ahead of print

    Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable nanoparticles

    Kimber, R., Parmeggiani, F., Joshi, N., Rakowski, A., Haigh, S., Turner, N. & Lloyd, J., 8 Jul 2019, In : Green Chemistry.

    Research output: Contribution to journalArticle

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