Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Published

    Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans

    Dunsmore, C. J., Malone, K. J., Bailey, K. R., Wear, M. A., Florance, H., Shirran, S., Barran, P. E., Page, A. P., Walkinshaw, M. D. & Turner, N. J., 21 Mar 2011, In : ChemBioChem: a European journal of chemical biology . 12, 5, p. 802-810 8 p.

    Research output: Contribution to journalArticle

  2. Published

    Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

    de Graaff, C., Bensch, L., Boersma, S. J., Cioc, R. C., Van Lint, M. J., Janssen, E., Turner, N., Orru, R. V. A. & Ruijter, E., 2015, In : Angewandte Chemie - International Edition. 54, 47, p. 14133-14136

    Research output: Contribution to journalArticle

  3. Published

    GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

    Currin, A., Kwok, J., Sadler, J. C., Bell, E. L., Swainston, N., Ababi, M., Day, P., Turner, N. J. & Kell, D. B., 21 Jun 2019, In : ACS Synthetic Biology. 8, 6, p. 1371-1378

    Research output: Contribution to journalArticle

  4. Published

    Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

    Costa, B. Z., Galman, J. L., Slabu, I., France, S. P., Marsaioli, A. J. & Turner, N. J., 2018, In : ChemCatChem.

    Research output: Contribution to journalArticle

  5. Accepted/In press

    Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications

    Cosgrove, S. C., Brzezniak, A., France, S. P., Ramsden, J. I., Mangas-Sanchez, J., Montgomery, S. L., Heath, R. S. & Turner, N. J., 1 Jan 2018, (Accepted/In press) In : Methods in Enzymology.

    Research output: Contribution to journalArticle

  6. Published

    Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines

    Cosgrove, S. C., Hussain, S., Turner, N. J. & Marsden, S. P., 1 Jun 2018, In : ACS Catalysis. 8, 6, p. 5570-5573 4 p.

    Research output: Contribution to journalArticle

  7. Published

    Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen

    Chapman, M. R., Cosgrove, S. C., Turner, N. J., Kapur, N. & Blacker, A. J., 13 Aug 2018, In : Angewandte Chemie - International Edition. 57, 33, p. 10535-10539 5 p.

    Research output: Contribution to journalArticle

  8. Published

    Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

    Chapman, M. R., Kwan, M. H. T., King, G., Jolley, K. E., Hussain, M., Hussain, S., Salama, I. E., González Nino, C., Thompson, L. A., Bayana, M. E., Clayton, A. D., Nguyen, B. N., Turner, N. J., Kapur, N. & Blacker, A. J., 15 Sep 2017, In : Organic Process Research and Development. 21, 9, p. 1294-1301 8 p.

    Research output: Contribution to journalArticle

  9. Published

    Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity

    Carr, R., Alexeeva, M., Enright, A., Eve, T. S. C., Dawson, M. J. & Turner, N. J., 13 Oct 2003, In : Angewandte Chemie - International Edition. 42, 39, p. 4807-4810 3 p.

    Research output: Contribution to journalArticle

  10. Published

    SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.

    Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G. G-Q., Faulon, J-L., Goble, C., Goodacre, R., Kell, D. B., Feuvre, R. L., Micklefield, J. & 4 others, Scrutton, N. S., Shapira, P., Takano, E. & Turner, N. J., 15 Jun 2016, In : Biochemical Society Transactions. 44, 3, p. 675-7

    Research output: Contribution to journalArticle

  11. Published

    Selenzyme: Enzyme selection tool for pathway design

    Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., Kell, D., Breitling, R. & Faulon, J-L., 15 Jun 2018, In : Bioinformatics. 34, 12

    Research output: Contribution to journalArticle

  12. Published

    An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

    Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P., Goodacre, R. & 9 others, Turner, N., Goble, C., Guoqiang Chen, G., Kell, D., Micklefield, J., Breitling, R., Takano, E., Faulon, J-L. & Scrutton, N., 2018, In : Communications Biology. 1, 66.

    Research output: Contribution to journalArticle

  13. Published

    Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii

    Çakar, M. M., Mangas-Sanchez, J., Birmingham, W. R., Turner, N. J. & Binay, B., 2018, In : Preparative Biochemistry and Biotechnology. 48, 4, p. 327-334 8 p.

    Research output: Contribution to journalArticle

  14. Published

    Whole-cell biocatalysts for stereoselective C-H amination reactions

    Both, P., Kelly, P., Mutti, F., Turner, N. & Flitsch, S., 18 Jan 2016, In : Angewandte Chemie (International Edition).

    Research output: Contribution to journalArticle

  15. Published

    A Single Enzyme Oxidative "cascade" via a Dual-Functional Galactose Oxidase

    Birmingham, W. R. & Turner, N. J., 4 May 2018, In : ACS Catalysis. 8, 5, p. 4025-4032 8 p.

    Research output: Contribution to journalArticle

  16. Published

    Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

    Bechi, B., Herter, S., McKenna, S., Riley, C., Leimkühler, S., Turner, N. J. & Carnell, A. J., 18 Aug 2014, In : Green Chemistry. 16, p. 4524-4529 5 p., C4GC01321B.

    Research output: Contribution to journalArticle

  17. Published

    Recommendations on the implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes

    Barley, M., Turner, N. & Goodacre, R., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  18. Published

    Improved Descriptors for the QSAR Modeling of Peptides and Proteins

    Barley, M., Turner, N. & Goodacre, R., 2018, In : Journal of Chemical Information and Modeling.

    Research output: Contribution to journalArticle

  19. Published

    A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

    Bailey, K. R., Ellis, A. J., Reiss, R., Snape, T. J. & Turner, N. J., 2007, In : Chemical Communications. 35, p. 3640-3642 2 p.

    Research output: Contribution to journalArticle

  20. Published

    Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger

    Atkin, K. E., Reiss, R., Turner, N. J., Brzozowski, A. M. & Grogan, G., 2008, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 64, 3, p. 182-185 3 p.

    Research output: Contribution to journalArticle

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