Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Published

    Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis

    Hartley, C. J., French, N. G., Scoble, J. A., Williams, C. C., Churches, Q. I., Frazer, A. R., Taylor, M. C., Coia, G., Simpson, G., Turner, N. J. & Scott, C., Nov 2017, In : PLoS ONE. 12, 11, e0184183.

    Research output: Contribution to journalArticle

  2. Published

    InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines

    Grogan, G. & Turner, N., 5 Feb 2016, In : Chemistry - A European Journal. 22, 6, p. 1900-1907 8 p.

    Research output: Contribution to journalArticle

  3. Published

    Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor Which Displaces Equilibria and Enables High-Throughput Screening

    Green, A., Turner, N. & O'Reilly, E., 19 Aug 2014, In : Angewandte Chemie (International Edition). 53, 40, p. 10714-10717

    Research output: Contribution to journalArticle

  4. Published

    Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products

    Ghislieri, D., Green, A., Pontini, M., Willies, S. C., Rowles, I., Frank, A., Grogan, G. & Turner, N. J., 24 Jul 2013, In : Journal of the American Chemical Society. 135, 29, p. 10863-9 7 p.

    Research output: Contribution to journalArticle

  5. Published

    Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines

    Ghislieri, D. & Turner, N., 2014, In : Topics in Catalysis. 57, 5, p. 284-300

    Research output: Contribution to journalArticle

  6. Published

    Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

    Galman, J., Slabu, I., Weise, N., Iglesias, C., Parmeggiani, F., Lloyd, R. C. & Turner, N., 2017, In : Green Chemistry.

    Research output: Contribution to journalArticle

  7. Published

    Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

    Galman, J. L., Slabu, I., Parmeggiani, F. & Turner, N. J., 2018, In : Chemical Communications. 54, 80, p. 11316-11319 4 p.

    Research output: Contribution to journalArticle

  8. Published

    Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

    Gahloth, D., Dunstan, M. S., Quaglia, D., Klumbys, E., Lockhart-Cairns, M. P., Hill, A., Derrington, S. R., Scrutton, N. S., Turner, N. J. & Leys, D., 2017, In : Nature chemical biology. 13, p. 975-981 7 p.

    Research output: Contribution to journalArticle

  9. Published

    One Pot Cascade Synthesis of Mono- and Di-Substituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA) and Imine Reductase (IRED) Biocatalysts

    France, S., Hussain, S., Hill, A., Hepworth, L., Howard, R. M., Mulholland, K. R., Flitsch, S. & Turner, N., 2 May 2016, In : ACS Catalysis. p. 3753-3759

    Research output: Contribution to journalArticle

  10. Published

    Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

    France, S., Weise, N., Mangas-Sanchez, J., Montgomery, S., Howard, R. M. & Turner, N., 21 Sep 2017, In : ChemCatChem.

    Research output: Contribution to journalArticle

  11. Published

    Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

    France, S. P., Aleku, G. A., Sharma, M., Mangas-Sanchez, J., Howard, R. M., Steflik, J., Kumar, R., Adams, R. W., Slabu, I., Crook, R., Grogan, G., Wallace, T. W. & Turner, N. J., 2017, In : Angewandte Chemie - International Edition. 56, 49, p. 15589-15593 5 p.

    Research output: Contribution to journalArticle

  12. Published

    Engineering a biometallic whole cell catalyst for enantioselective deracemization reactions

    Foulkes, J. M., Malone, K. J., Coker, V. S., Turner, N. J. & Lloyd, J. R., 4 Nov 2011, In : ACS Catalysis. 1, 11, p. 1589-1594 5 p.

    Research output: Contribution to journalArticle

  13. Published

    Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

    Flitsch, S., Kelly, P., Eichler, A., Herter, S., Kranz, D. C. & Turner, N., Sep 2015, In : Beilstein Journal of Organic Chemistry. 11, p. 1713-1720

    Research output: Contribution to journalArticle

  14. Published

    Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

    Flitsch, S., France, S., Hepworth, L. & Turner, N., 2017, In : ACS Catalysis. p. 710-724 14 p.

    Research output: Contribution to journalArticle

  15. Published

    From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy

    Fisk, H., Xu, Y., Westley, C., Turner, N., Micklefield, J. & Goodacre, R., 21 Nov 2017, In : Analytical Chemistry. 89, 22, p. 12527-12532 5 p.

    Research output: Contribution to journalArticle

  16. Published

    SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production

    Feuvre, R. L., Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G. G-Q., Faulon, J-L., Goble, C., Goodacre, R., Kell, D. B., Micklefield, J. & 4 others, Scrutton, N. S., Shapira, P., Takano, E. & Turner, N. J., 2016, In : Synthetic and Systems Biotechnology.

    Research output: Contribution to journalArticle

  17. Published

    Biocatalysis - A gateway to industrial biotechnology

    Fessner, W. D., Turner, N. J. & Wang, M. X., Sep 2011, In : Advanced synthesis & catalysis. 353, 13, p. 2189-2190 1 p.

    Research output: Contribution to journalArticle

  18. Published

    Engineering biocatalysts for synthesis including cascade processes

    Faber, K., Fessner, W. D. & Turner, N., 2015, In : Advanced Synthesis and Catalysis. 357, 8, p. 1565-1566

    Research output: Contribution to journalArticle

  19. Published

    Directed evolution of galactose oxidase: Generation of enantioselective secondary alcohol oxidases

    Escalettes, F. & Turner, N. J., 14 Apr 2008, In : ChemBioChem: a European journal of chemical biology . 9, 6, p. 857-860 3 p.

    Research output: Contribution to journalArticle

  20. Published

    Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling

    Eichler, A., Gricman, Ł., Herter, S., Kelly, P., Turner, N., Pleiss, J. & Flitsch, S., 2 Mar 2016, In : CHEMBIOCHEM. 17, 5, p. 426-432 7 p.

    Research output: Contribution to journalArticle

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