Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Published

    Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

    Köhler, V., Wilson, Y. M., Dürrenberger, M., Ghislieri, D., Churakova, E., Quinto, T., Knörr, L., Häussinger, D., Hollmann, F., Turner, N. J. & Ward, T. R., Feb 2013, In : Nature Chemistry. 5, 2, p. 93-99 6 p.

    Research output: Contribution to journalArticle

  2. Published

    Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes

    Knaus, T., Mutti, F., Humphreys, LD., Turner, N. & Scrutton, N., 29 Oct 2015, In : Organic & biomolecular chemistry. 13, 1, p. 223-233 10 p.

    Research output: Contribution to journalArticle

  3. Published

    Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering

    Klumbys, E., Zebec, Z., Weise, N., Turner, N. & Scrutton, N., 2018, In : Green Chemistry.

    Research output: Contribution to journalArticle

  4. Published

    The self‐sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5‐hydroxylation of diclofenac

    Klenk, J. M., Nebel, B., Porter, J., Kulig, J. K., Hussain, S., Richter, S. M., Tavanti, M., Turner, N., Hayes, M. A., Hauer, B. & Flitsch, S., 2017, In : Biotechnology Journal (Print).

    Research output: Contribution to journalArticle

  5. Published

    Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry

    Kimber, R., Lewis, E. A., Parmeggiani, F., Smith, K., Bagshaw, H., Starborg, T., Joshi, N., Figueroa, A. I., Van der Laan, G., Cibin, G., Gianolio, D., Haigh, S., Pattrick, R. A. D., Turner, N. & Lloyd, J., 2018, In : Small.

    Research output: Contribution to journalArticle

  6. E-pub ahead of print

    Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles

    Kimber, R., Parmeggiani, F., Joshi, N., Rakowski, A., Haigh, S., Turner, N. & Lloyd, J., 8 Jul 2019, In : Green Chemistry.

    Research output: Contribution to journalArticle

  7. Published

    Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities

    Kalim Akhtara, M., Turner, N. J. & Jones, P. R., 2 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 87-92 5 p.

    Research output: Contribution to journalArticle

  8. Published

    Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase

    Ioannou, A., Cini, E., Timofte, R. S., Flitsch, S. L., Turner, N. J. & Linclau, B., 28 Oct 2011, In : Chemical Communications. 47, 40, p. 11228-11230 2 p.

    Research output: Contribution to journalArticle

  9. Published

    An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

    Hussain, S., Leipold, F., Man, H., Wells, E., France, S. P., Mulholland, K. R., Grogan, G. & Turner, N., 21 Jan 2015, In : ChemCatChem (Online).

    Research output: Contribution to journalArticle

  10. Published

    Selective chemical intervention in the proteome of caenorhabditis elegans

    Husi, H., McAllister, F., Angelopoulos, N., Butler, V. J., Bailey, K. R., Malone, K., MacKay, L., Taylor, P., Page, A. P., Turner, N. J., Barran, P. E. & Walkinshaw, M., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 6060-6070 10 p.

    Research output: Contribution to journalArticle

  11. Published

    Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy

    Humphrey, C. E., Turner, N. J., Easson, M. A. M., Flitsch, S. L. & Ulijn, R. V., 19 Nov 2003, In : Journal of the American Chemical Society. 125, 46, p. 13952-13953 1 p.

    Research output: Contribution to journalArticle

  12. Published

    Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions

    Humphrey, C., Ahmed, M., Ghanem, A. & Turner, N., 2014, Separation Of Enantiomers : Synthetic Methods. Todd, M. (ed.). p. 123-160

    Research output: Chapter in Book/Report/Conference proceedingChapter

  13. Published

    Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

    Hugentobler, K. G., Sharif, H., Rasparini, M., Heath, R. S. & Turner, N. J., 2016, In : Organic and Biomolecular Chemistry. 14, 34, p. 8064-8067 4 p.

    Research output: Contribution to journalArticle

  14. Published

    Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

    Hugentobler, K. G., Rasparini, M., Thompson, L. A., Jolley, K. E., Blacker, A. J. & Turner, N. J., 17 Feb 2017, In : Organic Process Research and Development. 21, 2, p. 195-199 5 p.

    Research output: Contribution to journalArticle

  15. Published

    A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

    Hopwood, J., Truppo, M. D., Turner, N. J. & Lloyd, R. C., 14 Jan 2011, In : Chemical Communications. 47, 2, p. 773-775 2 p.

    Research output: Contribution to journalArticle

  16. Published

    Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

    Herter, S., Medina, F., Wagschal, S., Benhaïm, C., Leipold, F. & Turner, N. J., 2017, In : Bioorganic and Medicinal Chemistry.

    Research output: Contribution to journalArticle

  17. Published

    De Novo Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines.

    Hepworth, L., France, S., Hussain, S., Both, P., Turner, N. & Flitsch, S., 2017, In : ACS Catalysis.

    Research output: Contribution to journalArticle

  18. Published

    Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles

    Heath, R. S., Pontini, M., Hussain, S. & Turner, N. J., 7 Jan 2016, In : ChemCatChem. 8, 1, p. 117-120 4 p.

    Research output: Contribution to journalArticle

  19. Published

    Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity

    Heath, R., Pontini, M., Turner, N. & Bechi, B., 2014, In : ChemCatChem. 6, 4, p. 996-1002

    Research output: Contribution to journalArticle

  20. Published

    An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols

    Heath, R. S., Birmingham, W. R., Thompson, M. P., Taglieber, A., Daviet, L. & Turner, N. J., 10 Dec 2018, In : CHEMBIOCHEM.

    Research output: Contribution to journalArticle