Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Published

    n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones

    Slabu, I., Galman, J., Iglesias, C., Weise, N., Lloyd, R. C. & Turner, N., 2017, In : Catalysis Today.

    Research output: Contribution to journalArticle

  2. Published

    Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

    Slabu, I., Galman, J. L., Lloyd, R. C. & Turner, N. J., 1 Dec 2017, In : ACS Catalysis. 7, 12, p. 8263-8284 22 p.

    Research output: Contribution to journalArticle

  3. Published

    A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

    Sharma, M., Mangas-Sanchez, J., France, S. P., Aleku, G. A., Montgomery, S. L., Ramsden, J. I., Turner, N. J. & Grogan, G., 7 Dec 2018, In : ACS Catalysis. 8, 12, p. 11534-11541 8 p.

    Research output: Contribution to journalArticle

  4. Published

    Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants

    Schrittwieser, J., Groenendaal, B., Willies, S. C., Ghislieri, D., Rowles, I., Resch, V., Sattler, J. H., Fischereder, E-M., Grischek, B., Lienhart, W-D., Turner, N. & Kroutil, W., 2014, In : Catalysis Science and Technology. 4, 10, p. 3657-3664

    Research output: Contribution to journalArticle

  5. Published

    Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion

    Schrittwieser, J., Groenendaal, B., Resch, V., Ghislieri, D., Wallner, S., Fischereder, E-M., Fuchs, E., Grischek, B., Sattler, J. H., Macheroux, P., Turner, N. & Kroutil, W., 2014, In : Angewandte Chemie - International Edition. 53, 14, p. 3731-3734

    Research output: Contribution to journalArticle

  6. Published

    Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

    Scheller, P. N., Fademrecht, S., Hofelzer, S., Pleiss, J., Leipold, F., Turner, N., Nestl, B. & Hauer, B., 2014, In : CHEMBIOCHEM. 15, 15, p. 2201-2204

    Research output: Contribution to journalArticle

  7. Published

    Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

    Scalacci, N., Black, G. W., Mattedi, G., Brown, N. L., Turner, N. J. & Castagnolo, D., 3 Feb 2017, In : ACS Catalysis. 7, 2, p. 1295-1300 6 p.

    Research output: Contribution to journalArticle

  8. Published

    Directed evolution of the enzyme monoamine oxidase (mao-n): Highly efficient chemo-enzymatic deracemisation of the alkaloid (±)-crispinea

    Rowles, I., Malone, K. J., Etchells, L. L., Willies, S. C. & Turner, N. J., Sep 2012, In : ChemCatChem. 4, 9, p. 1259-1261 2 p.

    Research output: Contribution to journalArticle

  9. Published

    Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids

    Rowles, I., Groenendaal, B., Binay, B., Malone, K. J., Willies, S. C. & Turner, N. J., 17 Nov 2016, In : Tetrahedron. 72, 46, p. 7343-7347 5 p.

    Research output: Contribution to journalArticle

  10. Published

    A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids

    Roff, G. J., Lloyd, R. C. & Turner, N. J., 7 Apr 2004, In : Journal of the American Chemical Society. 126, 13, p. 4098-4099 1 p.

    Research output: Contribution to journalArticle

  11. Published

    Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme

    Robin, A., Roberts, G. A., Kisch, J., Sabbadin, F., Grogan, G., Bruce, N., Turner, N. J. & Flitsch, S. L., 2009, In : Chemical Communications. 18, p. 2478-2480 2 p.

    Research output: Contribution to journalArticle

  12. Published

    Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope

    Robin, A., Köhler, V., Jones, A., Ali, A., Kelly, P. P., O'Reilly, E., Turner, N. J. & Flitsch, S. L., 2 Nov 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 1494-1498 4 p., 7.

    Research output: Contribution to journalArticle

  13. Published

    Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution

    Rannes, J. B., Ioannou, A., Willies, S. C., Grogan, G., Behrens, C., Flitsch, S. L. & Turner, N. J., 8 Jun 2011, In : Journal of the American Chemical Society. 133, 22, p. 8436-8439 3 p.

    Research output: Contribution to journalArticle

  14. Published

    Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

    Ramsden, J. I., Heath, R. S., Derrington, S. R., Montgomery, S. L., Mangas-Sanchez, J., Mulholland, K. R. & Turner, N. J., 23 Jan 2019, In : Journal of the American Chemical Society.

    Research output: Contribution to journalArticle

  15. Published

    Characterisation of CYP102A25 from B. marmarensis and CYP102A26 from P. halophilus: P450 homologues of BM3 with preference towards hydroxylation of medium chain fatty acids

    Porter, J., Manning, J., Sabatini, S., Tavanti, M., Turner, N. & Flitsch, S., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  16. Published

    Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope

    Porter, J., Sabatini, S., Manning, J., Tavanti, M., Galman, J., Turner, N. & Flitsch, S., 2018, In : Enzyme and Microbial Technology.

    Research output: Contribution to journalArticle

  17. Published

    Single-Biocatalyst Synthesis of Enantiopure D-Arylalanines Exploiting an Engineered D-Amino Acid Dehydrogenase

    Parmeggiani, F., Ahmed, S., Thompson, M., Weise, N., Galman, J., Gahloth, D., Leys, D., Turner, N. & Dunstan, M., 13 Oct 2016, In : Advanced synthesis & catalysis.

    Research output: Contribution to journalArticle

  18. Published

    Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases

    Parmeggiani, F., Weise, N., Ahmed, S. & Turner, N., 2017, In : Chemical Reviews.

    Research output: Contribution to journalArticle

  19. Published

    A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines

    O'Reilly, E., Iglesias, C., Ghislieri, D., Hopwood, J., Galman, J. L., Lloyd, R. C. & Turner, N. J., 24 Feb 2014, In : Angewandte Chemie - International Edition. 53, 9, p. 2447-2450 3 p.

    Research output: Contribution to journalArticle

  20. Published

    Substrate promiscuity of cytochrome P450 RhF

    O'Reilly, E., Corbett, M., Hussain, S., Kelly, P. P., Richardson, D., Flitsch, S. L. & Turner, N. J., Jun 2013, In : Catalysis Science and Technology. 3, 6, p. 1490-1492 2 p.

    Research output: Contribution to journalArticle