Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Published

    Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids

    Rowles, I., Groenendaal, B., Binay, B., Malone, K. J., Willies, S. C. & Turner, N. J., 17 Nov 2016, In : Tetrahedron. 72, 46, p. 7343-7347 5 p.

    Research output: Contribution to journalArticle

  2. Published

    Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

    Scalacci, N., Black, G. W., Mattedi, G., Brown, N. L., Turner, N. J. & Castagnolo, D., 3 Feb 2017, In : ACS Catalysis. 7, 2, p. 1295-1300 6 p.

    Research output: Contribution to journalArticle

  3. Published

    Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

    Scheller, P. N., Fademrecht, S., Hofelzer, S., Pleiss, J., Leipold, F., Turner, N., Nestl, B. & Hauer, B., 2014, In : CHEMBIOCHEM. 15, 15, p. 2201-2204

    Research output: Contribution to journalArticle

  4. Published

    Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants

    Schrittwieser, J., Groenendaal, B., Willies, S. C., Ghislieri, D., Rowles, I., Resch, V., Sattler, J. H., Fischereder, E-M., Grischek, B., Lienhart, W-D., Turner, N. & Kroutil, W., 2014, In : Catalysis Science and Technology. 4, 10, p. 3657-3664

    Research output: Contribution to journalArticle

  5. Published

    Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion

    Schrittwieser, J., Groenendaal, B., Resch, V., Ghislieri, D., Wallner, S., Fischereder, E-M., Fuchs, E., Grischek, B., Sattler, J. H., Macheroux, P., Turner, N. & Kroutil, W., 2014, In : Angewandte Chemie - International Edition. 53, 14, p. 3731-3734

    Research output: Contribution to journalArticle

  6. Published

    A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

    Sharma, M., Mangas-Sanchez, J., France, S. P., Aleku, G. A., Montgomery, S. L., Ramsden, J. I., Turner, N. J. & Grogan, G., 7 Dec 2018, In : ACS Catalysis. 8, 12, p. 11534-11541 8 p.

    Research output: Contribution to journalArticle

  7. Published

    Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines

    Slabu, I., Galman, J. L., Weise, N. J., Lloyd, R. C. & Turner, N. J., 2016, In : ChemCatChem. 8, 6, p. 1038-1042 5 p.

    Research output: Contribution to journalArticle

  8. Published

    n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones

    Slabu, I., Galman, J., Iglesias, C., Weise, N., Lloyd, R. C. & Turner, N., 2017, In : Catalysis Today.

    Research output: Contribution to journalArticle

  9. Published

    Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

    Slabu, I., Galman, J. L., Lloyd, R. C. & Turner, N. J., 1 Dec 2017, In : ACS Catalysis. 7, 12, p. 8263-8284 22 p.

    Research output: Contribution to journalArticle

  10. Published

    Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers

    Staniland, S., Yuan, B., Giménez-Agulló, N., Marcelli, T., Willies, S. C., Grainger, D. M., Turner, N. J. & Clayden, J., 2014, In : Chemistry: A European Journal. 20, 41, p. 13084-13088

    Research output: Contribution to journalArticle

  11. Published

    Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts

    Staniland, S., Adams, R., Mcdouall, J., Maffucci, I., Contini, A., Grainger, D., Turner, N. & Clayden, J., 26 Aug 2016, In : Angewandte Chemie. 55, 36, p. 10755-10759 5 p.

    Research output: Contribution to journalArticle

  12. Published
  13. Published

    One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone

    Tavanti, M., Parmeggiani, F., Castellanos, J. R. G., Mattevi, A. & Turner, N. J., 2017, In : ChemCatChem. 9, 17, p. 3338-3348 11 p.

    Research output: Contribution to journalArticle

  14. Published

    A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

    Tavanti, M., Mangas-Sanchez, J., Montgomery, S. L., Thompson, M. P. & Turner, N. J., 14 Dec 2017, In : Organic and Biomolecular Chemistry. 15, 46, p. 9790-9793 4 p.

    Research output: Contribution to journalArticle

  15. Published

    The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

    Tavanti, M., Porter, J. L., Levy, C. W., Gómez Castellanos, J. R., Flitsch, S. L. & Turner, N. J., 17 May 2018, In : Biochemical and Biophysical Research Communications. 501, 4, p. 846-850 5 p.

    Research output: Contribution to journalArticle

  16. Published

    Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase

    Thompson, M. P. & Turner, N. J., 2017, In : ChemCatChem. 9, 20, p. 3833-3836 4 p.

    Research output: Contribution to journalArticle

  17. Published

    A generic platform for the immobilisation of engineered biocatalysts

    Thompson, M. P., Derrington, S. R., Heath, R. S., Porter, J. L., Mangas-Sanchez, J., Devine, P. N., Truppo, M. D. & Turner, N. J., 18 Jan 2019, In : Tetrahedron. 75, 3, p. 327-334 8 p.

    Research output: Contribution to journalArticle

  18. Published

    Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols

    Toftgaard Pedersen, A., Birmingham, W., Rehn, G., Charnock, S. J., Turner, N. & Woodley, J. M., 2015, In : Organic Process Research and Development. 19, 11, p. 1580-1589

    Research output: Contribution to journalArticle

  19. Published

    Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

    Toscani, A., Risi, C., Black, G. W., Brown, N. L., Shaaban, A., Turner, N. J. & Castagnolo, D., 7 Sep 2018, In : ACS Catalysis. 8, 9, p. 8781-8787 6 p.

    Research output: Contribution to journalArticle

  20. Published

    Rapid determination of both the activity and enantioselectivity of ketoreductases

    Truppo, M. D., Escalettes, F. & Turner, N. J., 25 Mar 2008, In : Angewandte Chemie - International Edition. 47, 14, p. 2639-2641 2 p.

    Research output: Contribution to journalArticle

  21. Published

    A novel hyaluronan-based biomaterial (Hyaff-11®) as a scaffold for endothelial cells in tissue engineered vascular grafts

    Turner, N. J., Kielty, C. M., Walker, M. G., Canfield, A. E. & Turner, N., Dec 2004, In : Biomaterials. 25, 28, p. 5955-5964 9 p.

    Research output: Contribution to journalArticle

  22. Published

    Biocatalysis

    Turner, N. J., Aug 2012, In : Catalysis Science and Technology. 2, 8, p. 1523

    Research output: Contribution to journalArticle

  23. Published

    Achieving optimal SERS through enhanced experimental design

    Turner, N., Fisk, H., Westley, C. & Goodacre, R., 16 Dec 2016, In : Journal of Raman Spectroscopy. 47, 1, p. 59-66

    Research output: Contribution to journalArticle

  24. Published

    Selective Oxidation

    Turner, N. & Kroutil, W., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  25. Published

    Deracemisation methods

    Turner, N. J., Apr 2010, In : Current Opinion in Chemical Biology. 14, 2, p. 115-121 6 p.

    Research output: Contribution to journalArticle

  26. Published

    Oxidation of Alcohols

    Turner, N., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  27. Published

    Reductive Amination

    Turner, N., Stella, S. & Chadha, A., 13 May 2012, In : Practical Methods for Biocatalysis and Biotransformations 2.

    Research output: Contribution to journalArticle

  28. Published

    Enantioselective Oxidation of C-O and C-N bonds using oxidases

    Turner, N. J., 13 Jul 2011, In : Chemical Reviews. 111, 7, p. 4073-4087 14 p.

    Research output: Contribution to journalArticle

  29. Published

    Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids

    Turner, N. J., Apr 2011, In : Current Opinion in Chemical Biology. 15, 2, p. 234-240 6 p.

    Research output: Contribution to journalArticle

  30. Published

    Oxidation of C-N Bonds

    Turner, N. J., 20 Apr 2012, Enzyme Catalysis in Organic Synthesis. Drauz, K., Gröger, H. & May, O. (eds.). 3 ed. John Wiley & Sons Ltd, p. 1535-1552 17 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  31. Published

    Biocatalytic retrosynthesis: Redesigning synthetic routes to high-value chemicals

    Turner, N. & Green, A., 14 Sep 2016, In : Perspectives in Science.

    Research output: Contribution to journalArticle

  32. Published

    Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form

    Turner, N., Wells, A., Wong, J. W., Michels, P. C., Fandrick, K., Finch, G. L., Goswami, A., Lee, H., Mix, S., Moody, T., Pang, L., Entwistle, D. A., Sato, R. K. & Watson, T. J., 9 Feb 2016, In : Organic Process Research & Development. 20, 3, p. 3298-3306

    Research output: Contribution to journalArticle

  33. Published

    Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes

    Turner, N., Parmeggiani, F., Ahmed, S. & Weise, N., Nov 2016, In : Tetrahedron. 72, 46, p. 7256-7262

    Research output: Contribution to journalArticle

  34. Published

    Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation

    Turner, N., Mas Roselló, J., Staniland, S. & Clayden, J., Aug 2016, In : Tetrahedron. 72, 34, p. 5172-5177

    Research output: Contribution to journalArticle

  35. Published

    Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer

    Turner, N., de Graaff, C., Oppelaar, B., Péruch, O., Vande Velde, C. M. L., Bechi, B., Ruijter, E. & Orru, R. V. A., May 2016, In : Advanced Synthesis and Catalysis. 358, 10, p. 1555-1560

    Research output: Contribution to journalArticle

  36. Published

    Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum

    Turner, N., Özgün, G., Karagüler, N. G. & Turunen, O., 2015, In : Journal of Molecular Catalysis B: Enzymatic. 122, p. 212-217

    Research output: Contribution to journalArticle

  37. Published

    Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis

    Turner, N., Herter, S., McKenna, S. M., Frazer, A., Leimkühler, S. & Carnell, A. J., 2015, In : ChemCatChem. 7, 15, p. 2313-2317

    Research output: Contribution to journalArticle

  38. Published

    Artificial concurrent catalytic processes involving enzymes

    Turner, N. & Köhler, V., 2015, In : Chemical Communications. 51, 3, p. 450-464

    Research output: Contribution to journalArticle

  39. Published

    Foreword

    Turner, N., Whittall, J. & Ward, T. R., 2014, In : Topics in Catalysis. 57, 5, p. 283

    Research output: Contribution to journalArticle

  40. Published

    A Reduction of C N to CH-NH Using Enzymes and Microorganisms

    Turner, N., 2014, Comprehensive Organic Synthesis: Second Edition. Knochel, P. & Molander, G. A. (eds.). second ed. Vol. 8. p. 328-338

    Research output: Chapter in Book/Report/Conference proceedingChapter

  41. Published

    The enzyme spring: Biocatalysis at its best

    Turner, N. & Wells, A., 2014, In : ChemCatChem. 6, 4, p. 900-901

    Research output: Contribution to journalArticle

  42. Published

    Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

    Turner, N., O'Reilly, E. & Iglesias, C., 2014, In : ChemCatChem. 6, 4, p. 992-995

    Research output: Contribution to journalArticle

  43. Published

    Sustainable catalysis

    Turner, N. J., 8 Aug 2016, In : Beilstein Journal of Organic Chemistry. 12, p. 1778-1779 2 p.

    Research output: Contribution to journalEditorial

  44. Published

    Chemo-enzymatic synthesis of pyrazines and pyrroles

    Turner, N. J., Green, A. & Xu, J., 2018, In : Angewandte Chemie International Edition.

    Research output: Contribution to journalArticle

  45. Published

    High throughput screens yield small molecule inhibitors of leishmania CRK3:CYC6 cyclin-dependent kinase

    Walker, R. G., Thomson, G., Malone, K., Nowicki, M. W., Brown, E., Blake, D. G., Turner, N. J., Walkinshaw, M. D., Grant, K. M. & Mottram, J. C., Apr 2011, In : PL o S Neglected Tropical Diseases. 5, 4, e1033.

    Research output: Contribution to journalArticle

  46. Published

    Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades

    Walton, C. J. W., Parmeggiani, F., Barber, J. E. B., McCann, J. L., Turner, N. J. & Chica, R. A., 5 Dec 2017, In : ChemCatChem. 10, 2, p. 470-474 5 p.

    Research output: Contribution to journalArticle

  47. Published

    Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process

    Weise, N., Parmeggiani, F., Ahmed, S., Turner, N. & Lovelock, S., 26 Feb 2015, In : Angewandte Chemie (International Edition). 54, 15

    Research output: Contribution to journalArticle

  48. Published

    Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source

    Weise, N., Ahmed, S., Parmeggiani, F., Siirola, E., Pushpanath, A., Schell, U. & Turner, N., 24 May 2016, In : Catalysis Science and Technology. 6, 12, p. 4086-4089

    Research output: Contribution to journalArticle

  49. Published

    The Bacterial Ammonia Lyase EncP: A Tunable Biocatalyst for the Synthesis of Unnatural Amino Acids

    Weise, N., Parmeggiani, F., Ahmed, S. & Turner, N., 2015, In : Journal of the American Chemical Society. 137, 40, p. 12977-12983

    Research output: Contribution to journalArticle

  50. Published
  51. Published

    Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

    Weise, N. J., Ahmed, S. T., Parmeggiani, F., Galman, J. L., Dunstan, M. S., Charnock, S. J., Leys, D. & Turner, N. J., 2017, In : Scientific Reports. 7, 1, 13691.

    Research output: Contribution to journalArticle

  52. Published

    Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis

    Weise, N., Parmeggiani, F., Ahmed, S. & Turner, N., 25 Jan 2018, In : Topics in Catalysis.

    Research output: Contribution to journalArticle

  53. Published

    Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s

    Weissenborn, M. J., Notonier, S., Lang, S. L., Otte, K. B., Herter, S., Turner, N., Flitsch, S. & Hauer, B., 2016, In : Chemical Communications. 52, 36, p. 6158-6161 4 p.

    Research output: Contribution to journalArticle

  54. Published

    Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors

    Weissenborn, M. J., Debecker, D. P., Golten, S., Linclau, B., Turner, N. & Flitsch, S., 2017, In : Protein and Peptide Letters. 24, 8, p. 742-746 5 p.

    Research output: Contribution to journalArticle

  55. Published

    Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts

    Westley, C., Xu, Y., Carnell, A. J., Turner, N. & Goodacre, R., 30 Apr 2016, In : Analytical Chemistry. 88, 11, p. 5898-5903 6 p.

    Research output: Contribution to journalArticle

  56. Published

    Absolute quantification of uric acid in human urine using surface enhanced Raman scattering with the standard addition method

    Westley, C., Xu, Y., Thilaganathan, B., Carnell, A. J., Turner, N. & Goodacre, R., 21 Feb 2017, In : Analytical Chemistry. 89, 4, p. 2472–2477 6 p.

    Research output: Contribution to journalArticle

  57. Published

    Real-time monitoring of enzyme-catalysed reactions using deep UV resonance Raman spectroscopy

    Westley, C., Fisk, H., Xu, Y., Hollywood, K., Carnell, A. J., Micklefield, J., Turner, N. & Goodacre, R., 23 May 2017, In : Chemistry: A European Journal. 23, 29, p. 6983-6987 5 p.

    Research output: Contribution to journalArticle

  58. Published

    Development of a high-throughput screening method for racemase activity and its application to the identification of alanine racemase variants with activity towards l-arginine

    Willies, S. C., White, J. L. & Turner, N. J., 16 Sep 2012, In : Tetrahedron. 68, 37, p. 7564-7567 3 p.

    Research output: Contribution to journalArticle

  59. Published

    A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases

    Willies, S., Galman, J., Slabu, I. & Turner, N., 11 Jan 2016, In : Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences.

    Research output: Contribution to journalArticle

  60. Published

    Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides

    Wood, A., Weise, N., Frampton, J. D., Dunstan, M., Hollas, M., Derrington, S., Lloyd, R. C., Quaglia, D., Parmeggiani, F., Leys, D., Turner, N. & Flitsch, S., 13 Nov 2017, In : Angewandte Chemie. 56, 46, p. 14498-14501 4 p.

    Research output: Contribution to journalArticle

  61. Published

    Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

    Yan, C., Schmidberger, J., Parmeggiani, F., Hussain, S., Turner, N., Flitsch, S. & Barran, P., 2016, In : Analyst.

    Research output: Contribution to journalArticle

  62. Published

    Real-time screening of biocatalysts in live bacterial colonies

    Yan, C., Parmeggiani, F., Jones, E. A., Claude, E., Hussain, S., Turner, N., Flitsch, S. & Barran, P., 2017, In : Journal of the American Chemical Society. 139, 4, p. 1408-1411 4 p.

    Research output: Contribution to journalArticle

  63. Published

    Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases

    Yuan, B., Page, A., Worrall, C. P., Escalettes, F., Willies, S. C., McDouall, J. J. W., Turner, N. J. & Clayden, J., 17 Sep 2010, In : Angewandte Chemie - International Edition. 49, 39, p. 7010-7013 3 p.

    Research output: Contribution to journalArticle

  64. Published

    Immobilised whole-cell recombinant monoamine oxidase biocatalysis

    Zajkoska, P., Rosenberg, M., Heath, R., Malone, K., Stloukal, R., Turner, N. & Rebros, M., 2014, In : Applied microbiology and biotechnology. 99, 3, p. 1229-1236

    Research output: Contribution to journalArticle

  65. Published

    Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase

    Zajkoska, P., Cárdenas-Fernández, M., Lye, G. J., Rosenberg, M., Turner, N. J. & Rebroš, M., 1 Jul 2017, In : Journal of Chemical Technology and Biotechnology. 92, 7, p. 1558-1565 8 p.

    Research output: Contribution to journalArticle

  66. Published

    Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

    Zawodny, W., Montgomery, S. L., Marshall, J. R., Finnigan, J. D., Turner, N. J. & Clayden, J., 26 Dec 2018, In : Journal of the American Chemical Society. 140, 51, p. 17872-17877 6 p.

    Research output: Contribution to journalArticle

  67. Published

    Stereoselective synthesis of N-aryl proline amides by biotransformation- Ugi-Smiles sequence

    Znabet, A., Blanken, S., Janssen, E., De Kanter, F. J. J., Helliwell, M., Turner, N. J., Ruijter, E. & Orru, R. V. A., 7 Feb 2012, In : Organic and Biomolecular Chemistry. 10, 5, p. 941-944 4 p.

    Research output: Contribution to journalArticle

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