Prof Nicholas Turner

Professor of Chemical Biology

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Publications

  1. Published
  2. Published
  3. Published
  4. Published

    A reductive aminase from Aspergillus oryzae

    Aleku, G., France, S., Man, H., Mangas-Sanchez, J., Montgomery, S., Sharma, M., Leipold, F., Hussain, S., Grogan, G. & Turner, N., 2017, In : Nature Chemistry.

    Research output: Contribution to journalArticle

  5. Published

    Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

    Aleku, G. A., Man, H., France, S. P., Leipold, F., Hussain, S., Toca-Gonzalez, L., Marchington, R., Hart, S., Turkenburg, J. P., Grogan, G. & Turner, N. J., 3 Jun 2016, In : ACS Catalysis. 6, 6, p. 3880-3889 10 p.

    Research output: Contribution to journalArticle

  6. Published

    Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

    Aleku, G. A., Mangas-Sanchez, J., Citoler, J., France, S. P., Montgomery, S. L., Heath, R. S., Thompson, M. P. & Turner, N. J., 7 Feb 2018, In : ChemCatChem. 10, 3, p. 515-519 5 p.

    Research output: Contribution to journalArticle

  7. Published

    Deracemization of α-methylbenzylamine using an enzyme obtained by in vitro evolution

    Alexeeva, M., Enright, A., Dawson, M. J., Mahmoudian, M. & Turner, N. J., 2 Sep 2002, In : Angewandte Chemie - International Edition. 41, 17, p. 3177-3180 3 p.

    Research output: Contribution to journalArticle

  8. Published

    Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger

    Atkin, K. E., Reiss, R., Turner, N. J., Brzozowski, A. M. & Grogan, G., 2008, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 64, 3, p. 182-185 3 p.

    Research output: Contribution to journalArticle

  9. Published

    A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A

    Bailey, K. R., Ellis, A. J., Reiss, R., Snape, T. J. & Turner, N. J., 2007, In : Chemical Communications. 35, p. 3640-3642 2 p.

    Research output: Contribution to journalArticle

  10. Published

    Recommendations on the implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes

    Barley, M., Turner, N. & Goodacre, R., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  11. Published

    Improved Descriptors for the QSAR Modeling of Peptides and Proteins

    Barley, M., Turner, N. & Goodacre, R., 2018, In : Journal of Chemical Information and Modeling.

    Research output: Contribution to journalArticle

  12. Published

    Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

    Bechi, B., Herter, S., McKenna, S., Riley, C., Leimkühler, S., Turner, N. J. & Carnell, A. J., 18 Aug 2014, In : Green Chemistry. 16, p. 4524-4529 5 p., C4GC01321B.

    Research output: Contribution to journalArticle

  13. Published

    A Single Enzyme Oxidative "cascade" via a Dual-Functional Galactose Oxidase

    Birmingham, W. R. & Turner, N. J., 4 May 2018, In : ACS Catalysis. 8, 5, p. 4025-4032 8 p.

    Research output: Contribution to journalArticle

  14. Published

    Whole-cell biocatalysts for stereoselective C-H amination reactions

    Both, P., Kelly, P., Mutti, F., Turner, N. & Flitsch, S., 18 Jan 2016, In : Angewandte Chemie (International Edition).

    Research output: Contribution to journalArticle

  15. Published

    Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii

    Çakar, M. M., Mangas-Sanchez, J., Birmingham, W. R., Turner, N. J. & Binay, B., 2018, In : Preparative Biochemistry and Biotechnology. 48, 4, p. 327-334 8 p.

    Research output: Contribution to journalArticle

  16. Published

    SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.

    Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G. G-Q., Faulon, J-L., Goble, C., Goodacre, R., Kell, D. B., Feuvre, R. L., Micklefield, J. & 4 othersScrutton, N. S., Shapira, P., Takano, E. & Turner, N. J., 15 Jun 2016, In : Biochemical Society Transactions. 44, 3, p. 675-7

    Research output: Contribution to journalArticle

  17. Published

    Selenzyme: Enzyme selection tool for pathway design

    Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., Kell, D., Breitling, R. & Faulon, J-L., 15 Jun 2018, In : Bioinformatics. 34, 12

    Research output: Contribution to journalArticle

  18. Published

    An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

    Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P., Goodacre, R. & 9 othersTurner, N., Goble, C., Guoqiang Chen, G., Kell, D., Micklefield, J., Breitling, R., Takano, E., Faulon, J-L. & Scrutton, N., 2018, In : Communications Biology. 1, 66.

    Research output: Contribution to journalArticle

  19. Published

    Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity

    Carr, R., Alexeeva, M., Enright, A., Eve, T. S. C., Dawson, M. J. & Turner, N. J., 13 Oct 2003, In : Angewandte Chemie - International Edition. 42, 39, p. 4807-4810 3 p.

    Research output: Contribution to journalArticle

  20. Published

    Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen

    Chapman, M. R., Cosgrove, S. C., Turner, N. J., Kapur, N. & Blacker, A. J., 13 Aug 2018, In : Angewandte Chemie - International Edition. 57, 33, p. 10535-10539 5 p.

    Research output: Contribution to journalArticle

  21. Published

    Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

    Chapman, M. R., Kwan, M. H. T., King, G., Jolley, K. E., Hussain, M., Hussain, S., Salama, I. E., González Nino, C., Thompson, L. A., Bayana, M. E., Clayton, A. D., Nguyen, B. N., Turner, N. J., Kapur, N. & Blacker, A. J., 15 Sep 2017, In : Organic Process Research and Development. 21, 9, p. 1294-1301 8 p.

    Research output: Contribution to journalArticle

  22. Accepted/In press

    Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications

    Cosgrove, S. C., Brzezniak, A., France, S. P., Ramsden, J. I., Mangas-Sanchez, J., Montgomery, S. L., Heath, R. S. & Turner, N. J., 1 Jan 2018, (Accepted/In press) In : Methods in Enzymology.

    Research output: Contribution to journalArticle

  23. Published

    Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines

    Cosgrove, S. C., Hussain, S., Turner, N. J. & Marsden, S. P., 1 Jun 2018, In : ACS Catalysis. 8, 6, p. 5570-5573 4 p.

    Research output: Contribution to journalArticle

  24. Published

    Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

    Costa, B. Z., Galman, J. L., Slabu, I., France, S. P., Marsaioli, A. J. & Turner, N. J., 2018, In : ChemCatChem.

    Research output: Contribution to journalArticle

  25. Published

    Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

    de Graaff, C., Bensch, L., Boersma, S. J., Cioc, R. C., Van Lint, M. J., Janssen, E., Turner, N., Orru, R. V. A. & Ruijter, E., 2015, In : Angewandte Chemie - International Edition. 54, 47, p. 14133-14136

    Research output: Contribution to journalArticle

  26. Published

    Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans

    Dunsmore, C. J., Malone, K. J., Bailey, K. R., Wear, M. A., Florance, H., Shirran, S., Barran, P. E., Page, A. P., Walkinshaw, M. D. & Turner, N. J., 21 Mar 2011, In : ChemBioChem: a European journal of chemical biology . 12, 5, p. 802-810 8 p.

    Research output: Contribution to journalArticle

  27. Published

    Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling

    Eichler, A., Gricman, Ł., Herter, S., Kelly, P., Turner, N., Pleiss, J. & Flitsch, S., 2 Mar 2016, In : CHEMBIOCHEM. 17, 5, p. 426-432 7 p.

    Research output: Contribution to journalArticle

  28. Published

    Directed evolution of galactose oxidase: Generation of enantioselective secondary alcohol oxidases

    Escalettes, F. & Turner, N. J., 14 Apr 2008, In : ChemBioChem: a European journal of chemical biology . 9, 6, p. 857-860 3 p.

    Research output: Contribution to journalArticle

  29. Published

    Engineering biocatalysts for synthesis including cascade processes

    Faber, K., Fessner, W. D. & Turner, N., 2015, In : Advanced Synthesis and Catalysis. 357, 8, p. 1565-1566

    Research output: Contribution to journalArticle

  30. Published

    Biocatalysis - A gateway to industrial biotechnology

    Fessner, W. D., Turner, N. J. & Wang, M. X., Sep 2011, In : Advanced synthesis & catalysis. 353, 13, p. 2189-2190 1 p.

    Research output: Contribution to journalArticle

  31. Published

    SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production

    Feuvre, R. L., Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G. G-Q., Faulon, J-L., Goble, C., Goodacre, R., Kell, D. B., Micklefield, J. & 4 othersScrutton, N. S., Shapira, P., Takano, E. & Turner, N. J., 2016, In : Synthetic and Systems Biotechnology.

    Research output: Contribution to journalArticle

  32. Published

    From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy

    Fisk, H., Xu, Y., Westley, C., Turner, N., Micklefield, J. & Goodacre, R., 21 Nov 2017, In : Analytical Chemistry. 89, 22, p. 12527-12532 5 p.

    Research output: Contribution to journalArticle

  33. Published

    Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

    Flitsch, S., Kelly, P., Eichler, A., Herter, S., Kranz, D. C. & Turner, N., Sep 2015, In : Beilstein Journal of Organic Chemistry. 11, p. 1713-1720

    Research output: Contribution to journalArticle

  34. Published

    Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

    Flitsch, S., France, S., Hepworth, L. & Turner, N., 2017, In : ACS Catalysis. p. 710-724 14 p.

    Research output: Contribution to journalArticle

  35. Published

    Engineering a biometallic whole cell catalyst for enantioselective deracemization reactions

    Foulkes, J. M., Malone, K. J., Coker, V. S., Turner, N. J. & Lloyd, J. R., 4 Nov 2011, In : ACS Catalysis. 1, 11, p. 1589-1594 5 p.

    Research output: Contribution to journalArticle

  36. Published

    One Pot Cascade Synthesis of Mono- and Di-Substituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA) and Imine Reductase (IRED) Biocatalysts

    France, S., Hussain, S., Hill, A., Hepworth, L., Howard, R. M., Mulholland, K. R., Flitsch, S. & Turner, N., 2 May 2016, In : ACS Catalysis. p. 3753-3759

    Research output: Contribution to journalArticle

  37. Published

    Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

    France, S., Weise, N., Mangas-Sanchez, J., Montgomery, S., Howard, R. M. & Turner, N., 21 Sep 2017, In : ChemCatChem.

    Research output: Contribution to journalArticle

  38. Published

    Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

    France, S. P., Aleku, G. A., Sharma, M., Mangas-Sanchez, J., Howard, R. M., Steflik, J., Kumar, R., Adams, R. W., Slabu, I., Crook, R., Grogan, G., Wallace, T. W. & Turner, N. J., 2017, In : Angewandte Chemie - International Edition. 56, 49, p. 15589-15593 5 p.

    Research output: Contribution to journalArticle

  39. Published

    Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

    Gahloth, D., Dunstan, M. S., Quaglia, D., Klumbys, E., Lockhart-Cairns, M. P., Hill, A., Derrington, S. R., Scrutton, N. S., Turner, N. J. & Leys, D., 2017, In : Nature chemical biology. 13, p. 975-981 7 p.

    Research output: Contribution to journalArticle

  40. Published

    Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

    Galman, J., Slabu, I., Weise, N., Iglesias, C., Parmeggiani, F., Lloyd, R. C. & Turner, N., 2017, In : Green Chemistry.

    Research output: Contribution to journalArticle

  41. Published

    Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

    Galman, J. L., Slabu, I., Parmeggiani, F. & Turner, N. J., 2018, In : Chemical Communications. 54, 80, p. 11316-11319 4 p.

    Research output: Contribution to journalArticle

  42. Published

    Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products

    Ghislieri, D., Green, A., Pontini, M., Willies, S. C., Rowles, I., Frank, A., Grogan, G. & Turner, N. J., 24 Jul 2013, In : Journal of the American Chemical Society. 135, 29, p. 10863-9 7 p.

    Research output: Contribution to journalArticle

  43. Published

    Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines

    Ghislieri, D. & Turner, N., 2014, In : Topics in Catalysis. 57, 5, p. 284-300

    Research output: Contribution to journalArticle

  44. Published

    Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor Which Displaces Equilibria and Enables High-Throughput Screening

    Green, A., Turner, N. & O'Reilly, E., 19 Aug 2014, In : Angewandte Chemie (International Edition). 53, 40, p. 10714-10717

    Research output: Contribution to journalArticle

  45. Published

    InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines

    Grogan, G. & Turner, N., 5 Feb 2016, In : Chemistry - A European Journal. 22, 6, p. 1900-1907 8 p.

    Research output: Contribution to journalArticle

  46. Published

    Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis

    Hartley, C. J., French, N. G., Scoble, J. A., Williams, C. C., Churches, Q. I., Frazer, A. R., Taylor, M. C., Coia, G., Simpson, G., Turner, N. J. & Scott, C., Nov 2017, In : PLoS ONE. 12, 11, e0184183.

    Research output: Contribution to journalArticle

  47. Published

    Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification

    Heap, L., Green, A., Brown, D., van Dongen, B. E. & Turner, N., 2014, In : Catalysis Science and Technology. 4, 8, p. 2251-2259 8 p.

    Research output: Contribution to journalArticle

  48. Published

    Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles

    Heath, R. S., Pontini, M., Hussain, S. & Turner, N. J., 7 Jan 2016, In : ChemCatChem. 8, 1, p. 117-120 4 p.

    Research output: Contribution to journalArticle

  49. Published

    Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity

    Heath, R., Pontini, M., Turner, N. & Bechi, B., 2014, In : ChemCatChem. 6, 4, p. 996-1002

    Research output: Contribution to journalArticle

  50. Published

    An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols

    Heath, R. S., Birmingham, W. R., Thompson, M. P., Taglieber, A., Daviet, L. & Turner, N. J., 10 Dec 2018, In : CHEMBIOCHEM.

    Research output: Contribution to journalArticle

  51. Published

    De Novo Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines.

    Hepworth, L., France, S., Hussain, S., Both, P., Turner, N. & Flitsch, S., 2017, In : ACS Catalysis.

    Research output: Contribution to journalArticle

  52. Published

    Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

    Herter, S., Medina, F., Wagschal, S., Benhaïm, C., Leipold, F. & Turner, N. J., 2017, In : Bioorganic and Medicinal Chemistry.

    Research output: Contribution to journalArticle

  53. Published

    A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

    Hopwood, J., Truppo, M. D., Turner, N. J. & Lloyd, R. C., 14 Jan 2011, In : Chemical Communications. 47, 2, p. 773-775 2 p.

    Research output: Contribution to journalArticle

  54. Published

    Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

    Hugentobler, K. G., Sharif, H., Rasparini, M., Heath, R. S. & Turner, N. J., 2016, In : Organic and Biomolecular Chemistry. 14, 34, p. 8064-8067 4 p.

    Research output: Contribution to journalArticle

  55. Published

    Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

    Hugentobler, K. G., Rasparini, M., Thompson, L. A., Jolley, K. E., Blacker, A. J. & Turner, N. J., 17 Feb 2017, In : Organic Process Research and Development. 21, 2, p. 195-199 5 p.

    Research output: Contribution to journalArticle

  56. Published

    Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy

    Humphrey, C. E., Turner, N. J., Easson, M. A. M., Flitsch, S. L. & Ulijn, R. V., 19 Nov 2003, In : Journal of the American Chemical Society. 125, 46, p. 13952-13953 1 p.

    Research output: Contribution to journalArticle

  57. Published

    Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions

    Humphrey, C., Ahmed, M., Ghanem, A. & Turner, N., 2014, Separation Of Enantiomers : Synthetic Methods. Todd, M. (ed.). p. 123-160

    Research output: Chapter in Book/Report/Conference proceedingChapter

  58. Published

    Selective chemical intervention in the proteome of caenorhabditis elegans

    Husi, H., McAllister, F., Angelopoulos, N., Butler, V. J., Bailey, K. R., Malone, K., MacKay, L., Taylor, P., Page, A. P., Turner, N. J., Barran, P. E. & Walkinshaw, M., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 6060-6070 10 p.

    Research output: Contribution to journalArticle

  59. Published

    An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines

    Hussain, S., Leipold, F., Man, H., Wells, E., France, S. P., Mulholland, K. R., Grogan, G. & Turner, N., 21 Jan 2015, In : ChemCatChem (Online).

    Research output: Contribution to journalArticle

  60. Published

    Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase

    Ioannou, A., Cini, E., Timofte, R. S., Flitsch, S. L., Turner, N. J. & Linclau, B., 28 Oct 2011, In : Chemical Communications. 47, 40, p. 11228-11230 2 p.

    Research output: Contribution to journalArticle

  61. Published

    Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities

    Kalim Akhtara, M., Turner, N. J. & Jones, P. R., 2 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 87-92 5 p.

    Research output: Contribution to journalArticle

  62. Published

    Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry

    Kimber, R., Lewis, E. A., Parmeggiani, F., Smith, K., Bagshaw, H., Starborg, T., Joshi, N., Figueroa, A. I., Van der Laan, G., Cibin, G., Gianolio, D., Haigh, S., Pattrick, R. A. D., Turner, N. & Lloyd, J., 2018, In : Small.

    Research output: Contribution to journalArticle

  63. Accepted/In press

    Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable nanoparticles

    Kimber, R., Parmeggiani, F., Joshi, N., Rakowski, A., Haigh, S., Turner, N. & Lloyd, J., 22 May 2019, (Accepted/In press) In : Green Chemistry.

    Research output: Contribution to journalArticle

  64. Published

    The self‐sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5‐hydroxylation of diclofenac

    Klenk, J. M., Nebel, B., Porter, J., Kulig, J. K., Hussain, S., Richter, S. M., Tavanti, M., Turner, N., Hayes, M. A., Hauer, B. & Flitsch, S., 2017, In : Biotechnology Journal (Print).

    Research output: Contribution to journalArticle

  65. Published

    Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering

    Klumbys, E., Zebec, Z., Weise, N., Turner, N. & Scrutton, N., 2018, In : Green Chemistry.

    Research output: Contribution to journalArticle

  66. Published

    Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes

    Knaus, T., Mutti, F., Humphreys, LD., Turner, N. & Scrutton, N., 29 Oct 2015, In : Organic & biomolecular chemistry. 13, 1, p. 223-233 10 p.

    Research output: Contribution to journalArticle

  67. Published

    Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

    Köhler, V., Wilson, Y. M., Dürrenberger, M., Ghislieri, D., Churakova, E., Quinto, T., Knörr, L., Häussinger, D., Hollmann, F., Turner, N. J. & Ward, T. R., Feb 2013, In : Nature Chemistry. 5, 2, p. 93-99 6 p.

    Research output: Contribution to journalArticle

  68. Published

    Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity

    Lovelock, S. & Turner, N., 2014, In : Bioorganic and Medicinal Chemistry. 22, 20, p. 5555-5557

    Research output: Contribution to journalArticle

  69. Published

    Phenylalanine Ammonia Lyase Catalyzed Synthesis of Amino Acids by an MIO‐Cofactor Independent Pathway

    Lovelock, S., Lloyd, R. C. & Turner, N., 25 Apr 2014, In : Angewandte Chemie - International Edition. 53, 18, p. 4652-4656

    Research output: Contribution to journalArticle

  70. Published

    Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline

    Man, H., Wells, E., Hussain, S., Leipold, F., Hart, S., Turkenburg, J. P., Turner, N. & Grogan, G., 2015, In : CHEMBIOCHEM. 16, 7, p. 1052-1059

    Research output: Contribution to journalArticle

  71. Published

    Imine reductases (IREDs)

    Mangas-Sanchez, J., France, S. P., Montgomery, S. L., Aleku, G. A., Man, H., Sharma, M., Ramsden, J. I., Grogan, G. & Turner, N. J., 1 Apr 2017, In : Current Opinion in Chemical Biology. 37, p. 19-25 7 p.

    Research output: Contribution to journalReview article

  72. Published

    Regio- and Enantio-selective Chemo-enzymatic C-H-lactonization of Decanoic Acid to (S)-δ-Decalactone.

    Manning, J., Tavanti, M., Porter, J., Kress, N., De Visser, S., Turner, N. & Flitsch, S., 2019, In : Angewandte Chemie.

    Research output: Contribution to journalArticle

  73. Published

    Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure

    March-Cortijos, A., Snape, T. J. & Turner, N. J., 30 May 2012, In : SYNLETT. 23, 10, p. 1511-1515 5 p., ST-2012-D0041-L.

    Research output: Contribution to journalArticle

  74. Published

    Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels

    Markošová, K., Dolejš, I., Stloukal, R., Rios-Solis, L., Rosenberg, M., Micheletti, M., Lye, G. J., Turner, N. & Rebroš, M., 1 Jul 2016, In : Journal of Molecular Catalysis - B Enzymatic. 129, p. 69-74 6 p.

    Research output: Contribution to journalArticle

  75. Published

    Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris

    Markošová, K., Camattari, A., Rosenberg, M., Glieder, A., Turner, N. J. & Rebroš, M., 2017, In : Biotechnology Letters. p. 1-7 7 p.

    Research output: Contribution to journalArticle

  76. Published

    Enzyme cascade reactions: Synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

    McKenna, S., Leimkühler, S., Herter, S., Turner, N. & Carnell, A. J., 2015, In : Green Chemistry. 17, 6, p. 3271-3275

    Research output: Contribution to journalArticle

  77. Published

    The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

    McKenna, S. M., Mines, P., Law, P., Kovacs-Schreiner, K., Birmingham, W. R., Turner, N. J., Leimkühler, S. & Carnell, A. J., 2017, In : Green Chemistry. 19, 19, p. 4660-4665 6 p.

    Research output: Contribution to journalArticle

  78. Published

    Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

    Megarity, C. F., Siritanaratkul, B., Heath, R. S., Wan, L., Morello, G., FitzPatrick, S. R., Booth, R. L., Sills, A. J., Robertson, A. W., Warner, J. H., Turner, N. J. & Armstrong, F. A., 14 Feb 2019, In : Angewandte Chemie - International Edition.

    Research output: Contribution to journalArticle

  79. Published

    Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing

    Montgomery, S. L., Mangas-Sanchez, J., Thompson, M. P., Aleku, G. A., Dominguez, B. & Turner, N. J., 16 Aug 2017, In : Angewandte Chemie (International ed. in English). 56, 35, p. 10491-10494 4 p.

    Research output: Contribution to journalArticle

  80. Published

    Biocatalytic conversion of cyclic ketones bearing α-quaternary stereocenters to lactones in an enantioselective radical approach to medium-sized carbocycles

    Morrill, C., Jensen, C., Just-Baringo, X., Grogan, G., Turner, N. & Procter, D., 26 Mar 2018, In : Angewandte Chemie - International Edition. 57, 14, p. 3692-3696 4 p.

    Research output: Contribution to journalArticle

  81. Published

    Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.

    Mutti, FG., Knaus, T., Scrutton, NS., Breuer, M. & Turner, N., 2015, In : Science. 349, p. 1525-1529 4 p.

    Research output: Contribution to journalArticle

  82. Published

    Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis

    Nowicki, M. W., Tulloch, L. B., Worralll, L., McNae, I. W., Hannaert, V., Michels, P. A. M., Fothergill-Gilmore, L. A., Walkinshaw, M. D. & Turner, N. J., 1 May 2008, In : Bioorganic and Medicinal Chemistry. 16, 9, p. 5050-5061 11 p.

    Research output: Contribution to journalArticle

  83. Published

    Concurrent Biocatalytic Oxidation and C–C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines

    Odachowski, M., Greaney, M. F. & Turner, N. J., 2 Nov 2018, In : ACS Catalysis. 8, 11, p. 10032-10035

    Research output: Contribution to journalArticle

  84. Published

    Enzyme-catalyzed enantioselective hydrolysis of dihydrouracils as a route to enantiomerically pure Β-amino acids

    Oneill, M., Hauer, B., Schneider, N. & Turner, N. J., 2 Sep 2011, In : ACS Catalysis. 1, 9, p. 1014-1016 2 p.

    Research output: Contribution to journalArticle

  85. Published

    A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines

    O'Reilly, E., Iglesias, C., Ghislieri, D., Hopwood, J., Galman, J. L., Lloyd, R. C. & Turner, N. J., 24 Feb 2014, In : Angewandte Chemie - International Edition. 53, 9, p. 2447-2450 3 p.

    Research output: Contribution to journalArticle

  86. Published

    Substrate promiscuity of cytochrome P450 RhF

    O'Reilly, E., Corbett, M., Hussain, S., Kelly, P. P., Richardson, D., Flitsch, S. L. & Turner, N. J., Jun 2013, In : Catalysis Science and Technology. 3, 6, p. 1490-1492 2 p.

    Research output: Contribution to journalArticle

  87. Published

    Cytochromes P450 as useful biocatalysts: Addressing the limitations

    O'Reilly, E., Köhler, V., Flitsch, S. L. & Turner, N. J., 7 Mar 2011, In : Chemical Communications. 47, 9, p. 2490-2501 11 p.

    Research output: Contribution to journalArticle

  88. Published

    Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous

    O'Reilly, E., Aitken, S. J., Grogan, G., Kelly, P. P., Turner, N. J. & Flitsch, S. L., 3 Apr 2012, In : Beilstein Journal of Organic Chemistry. 8, p. 496-500 4 p.

    Research output: Contribution to journalArticle

  89. Published

    Single-Biocatalyst Synthesis of Enantiopure D-Arylalanines Exploiting an Engineered D-Amino Acid Dehydrogenase

    Parmeggiani, F., Ahmed, S., Thompson, M., Weise, N., Galman, J., Gahloth, D., Leys, D., Turner, N. & Dunstan, M., 13 Oct 2016, In : Advanced synthesis & catalysis.

    Research output: Contribution to journalArticle

  90. Published

    Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases

    Parmeggiani, F., Weise, N., Ahmed, S. & Turner, N., 2017, In : Chemical Reviews.

    Research output: Contribution to journalArticle

  91. Published

    Characterisation of CYP102A25 from B. marmarensis and CYP102A26 from P. halophilus: P450 homologues of BM3 with preference towards hydroxylation of medium chain fatty acids

    Porter, J., Manning, J., Sabatini, S., Tavanti, M., Turner, N. & Flitsch, S., 2017, In : ChemBioChem: a European journal of chemical biology .

    Research output: Contribution to journalArticle

  92. Published

    Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope

    Porter, J., Sabatini, S., Manning, J., Tavanti, M., Galman, J., Turner, N. & Flitsch, S., 2018, In : Enzyme and Microbial Technology.

    Research output: Contribution to journalArticle

  93. Published

    Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

    Ramsden, J. I., Heath, R. S., Derrington, S. R., Montgomery, S. L., Mangas-Sanchez, J., Mulholland, K. R. & Turner, N. J., 23 Jan 2019, In : Journal of the American Chemical Society.

    Research output: Contribution to journalArticle

  94. Published

    Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution

    Rannes, J. B., Ioannou, A., Willies, S. C., Grogan, G., Behrens, C., Flitsch, S. L. & Turner, N. J., 8 Jun 2011, In : Journal of the American Chemical Society. 133, 22, p. 8436-8439 3 p.

    Research output: Contribution to journalArticle

  95. Published

    Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme

    Robin, A., Roberts, G. A., Kisch, J., Sabbadin, F., Grogan, G., Bruce, N., Turner, N. J. & Flitsch, S. L., 2009, In : Chemical Communications. 18, p. 2478-2480 2 p.

    Research output: Contribution to journalArticle

  96. Published

    Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope

    Robin, A., Köhler, V., Jones, A., Ali, A., Kelly, P. P., O'Reilly, E., Turner, N. J. & Flitsch, S. L., 2 Nov 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 1494-1498 4 p., 7.

    Research output: Contribution to journalArticle

  97. Published

    A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids

    Roff, G. J., Lloyd, R. C. & Turner, N. J., 7 Apr 2004, In : Journal of the American Chemical Society. 126, 13, p. 4098-4099 1 p.

    Research output: Contribution to journalArticle

  98. Published

    Directed evolution of the enzyme monoamine oxidase (mao-n): Highly efficient chemo-enzymatic deracemisation of the alkaloid (±)-crispinea

    Rowles, I., Malone, K. J., Etchells, L. L., Willies, S. C. & Turner, N. J., Sep 2012, In : ChemCatChem. 4, 9, p. 1259-1261 2 p.

    Research output: Contribution to journalArticle

  99. Published

    Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids

    Rowles, I., Groenendaal, B., Binay, B., Malone, K. J., Willies, S. C. & Turner, N. J., 17 Nov 2016, In : Tetrahedron. 72, 46, p. 7343-7347 5 p.

    Research output: Contribution to journalArticle

  100. Published

    Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

    Scalacci, N., Black, G. W., Mattedi, G., Brown, N. L., Turner, N. J. & Castagnolo, D., 3 Feb 2017, In : ACS Catalysis. 7, 2, p. 1295-1300 6 p.

    Research output: Contribution to journalArticle

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