Dr Michael Harte

Senior Lecturer

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Research interests

I am an active neuropharmacology researcher with over 20 years of experience in my field, specialising in neuropsychitric (e.g. schizophrenia) and neurodegenerative (e.g. Alzheimer's disease), with a strong focus on the characterisation of behavioural, pathological and neurochemical deficits in animal models of cognitive dysfunction.

My main research interests are focused around:

  • Utilising preclinical models (genetic/pharmacological/non-pharmacological) to investigate the neural circuitry and neurochemistry involved in the aetiology and treatment of neuropsychiatric and neurodegenerative disorders.
  • Assessing the effects of novel treatments on behavioural and patholgical deficits in preclinical models. 
  • Investigating the pathological correlates and discrepancies between human post-mortem work and preclinical models of disease.

 

I have extensive experience in a large number of techniques and have established a fully equipped laboratory that includes provision for:

  • Behavioural studies focussing manily on cognitive function.
  • mRNA, Wes and Immunohistochemical analysis of human & rodent post-mortem tissue (e.g. staining of tissue for specific synaptic, neuronal and inflammatory populations followed by microscopic analysis using a state of the art image analysis systems)
  • In vivo microdialysis
  • HPLC (experienced in ex vivo analysis of brain and microdialysis samples for catecholamines, amino acids and N-acetylaspartate)

Projects

Research and projects

No current projects are available for public display