I am an active neuropharmacology researcher with over 20 years of experience in my field, specialising in neuropsychitric (e.g. schizophrenia) and neurodegenerative (e.g. Alzheimer's disease), with a strong focus on the characterisation of behavioural, pathological and neurochemical deficits in animal models of cognitive dysfunction.
My main research interests are focused around:
- Utilising preclinical models (genetic/pharmacological/non-pharmacological) to investigate the neural circuitry and neurochemistry involved in the aetiology and treatment of neuropsychiatric and neurodegenerative disorders.
- Assessing the effects of novel treatments on behavioural and patholgical deficits in preclinical models.
- Investigating the pathological correlates and discrepancies between human post-mortem work and preclinical models of disease.
I have extensive experience in a large number of techniques and have established a fully equipped laboratory that includes provision for:
- Behavioural studies focussing manily on cognitive function.
- mRNA, Wes and Immunohistochemical analysis of human & rodent post-mortem tissue (e.g. staining of tissue for specific synaptic, neuronal and inflammatory populations followed by microscopic analysis using a state of the art image analysis systems)
- In vivo microdialysis
- HPLC (experienced in ex vivo analysis of brain and microdialysis samples for catecholamines, amino acids and N-acetylaspartate)