Mr Michael Haley

Exhausted CD4+ T cells during malaria exhibit reduced mTORc1 activity correlated with loss of T-bet expression.

Villegas-Mendez, A., Khandelwal, G., McGowan, L. M., Dookie, R., Haley, M., George, C., Sims, D., Lord, G., Sinclair, L. V., Jenner, R. G. & Couper, K., 21 Jul 2020, (Accepted/In press) In: Journal of Immunology.

Research output: Contribution to journal › Article › peer-review

Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice

Haley, M. J., White, C. S., Roberts, D., O’Toole, K., Cunningham, C. J., Rivers-Auty, J., O’Boyle, C., Lane, C., Heaney, O., Allan, S. M. & Lawrence, C. B., 21 Dec 2019, In: Translational stroke research.

Research output: Contribution to journal › Article › peer-review

Selective Liposomal Transport through Blood Brain Barrier Disruption in Ischemic Stroke Reveals Two Distinct Therapeutic Opportunities

Al-Ahmady, Z., Jasim, D., Wong, R., Haley, M., Coutts, G., Schiessl, I., Allan, S. & Kostarelos, K., 6 Nov 2019, In: ACS Nano. 13, 11, p. 12470–12486

Research output: Contribution to journal › Article › peer-review

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome

Lemarchand, E., Barrington, J., Chenery, A., Haley, M., Coutts, G., Allen, J. E., Allan, S. M. & Brough, D., 1 May 2019, In: Stroke. 50, 5, p. 1232-1239 8 p.

Research output: Contribution to journal › Article › peer-review

Comparison of CD8+ T cell accumulation in the brain during human and murine cerebral malaria

Barrera, V., Haley, M., Strangward, P., Attree, E., Kamiza, S., Seydel, K., Taylor, T., Milner, D., Craig, A. & Couper, K., 2019, In: Frontiers in Immunology.

Research output: Contribution to journal › Article › peer-review

Extent of ischemic brain injury following thrombotic stroke is independent of the NLRP3 inflammasome

Lemarchand, E., Barrington, J., Chenery, A., Haley, M., Coutts, G., Allen, J., Allan, S. & Brough, D., 2019, In: Stroke.

Research output: Contribution to journal › Article › peer-review

Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice

O'Boyle, C., Haley, M. J., Lemarchand, E., Smith, C. J., Allan, S. M., Konkel, J. E. & Lawrence, C. B., 2019, In: International Journal of Stroke. p. 1747493019834191

Research output: Contribution to journal › Article › peer-review

Targeting the IL-33-NLRP3 axis improves therapy for experimental cerebral malaria

Strangward, P., Haley, M., Garcia Albornoz, M., Barrington, J., Shaw, T., Dookie, R., Zeef, L., Murtuza Baker, S., Winter, E., Tzeng, T-C., Golenbock, D., Cruickshank, S., Allan, S., Craig, A., Liew, F., Brough, D. & Couper, K., 28 Jun 2018, In: Proceedings of the National Academy of Sciences. 115, 28, p. 7404-7409 6 p.

Research output: Contribution to journal › Article › peer-review

Development of a characterised tool kit for the interrogation of NLRP3 inflammasomedependent responses

Redondo Castro, E., Faust, D., Fox, S., Baldwin, A., Osborne, S., Haley, M., Karran, E., Nuthall, H., Atkinson, P. J., Dawson, L. A., Routledge, C., Allan, S., Freeman, S., Brownlees, J. & Brough, D., 2018, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Microglial priming as trained immunity in the brain

Haley, M., Brough, D., Quintin, J. & Allan, S., 2018, In: Neuroscience.

Research output: Contribution to journal › Article › peer-review

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Percie du Sert, N., Alfieri, A., Allan, S. M., Carswell, H. V., Deuchar, G. A., Farr, T. D., Flecknell, P., Gallagher, L., Gibson, C. L., Haley, M. J., Macleod, M. R., McColl, B. W., McCabe, C., Morancho, A., Moon, L. D., O'Neill, M. J., Pérez de Puig, I., Planas, A., Ragan, C. I., Rosell, A. & 10 others, Roy, L. A., Ryder, K. O., Simats, A., Sena, E. S., Sutherland, B. A., Tricklebank, M. D., Trueman, R. C., Whitfield, L., Wong, R. & Macrae, I. M., 1 Nov 2017, In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 37, 11, p. 3488-3517 30 p.

Research output: Contribution to journal › Review article › peer-review

A quantitative brain map of experimental cerebral malaria pathology

Strangward, P., Haley, M. J., Shaw, T. N., Schwartz, J-M., Greig, R., Mironov, A., de Souza, J. B., Cruickshank, S. M., Craig, A. G., Milner, D. A., Allan, S. M. & Couper, K. N., 8 Mar 2017, In: PL o S Pathogens. 13, 3, p. e1006267

Research output: Contribution to journal › Article › peer-review

The blood-brain barrier after stroke: structural studies and the role of transcytotic vesicles

Haley, M. J. & Lawrence, C. B., 1 Feb 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 2, p. 456-470 15 p.

Research output: Contribution to journal › Article › peer-review

Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome

Haley, M., Krishnan, S., Burrows, D., de Hogg, L., Thakrar, J., Schiessl, I., Allan, S. & Lawrence, C. B., 2017, In: Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journal › Article › peer-review

Adipose tissue, metabolic and inflammatory responses to stroke are altered in obese mice

Haley, M., Mullard, G., Hollywood, K., Cooper, G. JS., Dunn, W. B. & Lawrence, C. B., 2017, In: DMM Disease Models and Mechanisms.

Research output: Contribution to journal › Article › peer-review

Systemic Inflammation Affects Reperfusion Following Transient Cerebral Ischaemia

Burrows, F., Haley, M., Scott, E., Coutts, G., Lawrence, C., Allan, S. & Schiessl, I., Mar 2016, In: Experimental neurology. 277, p. 252-60 9 p.

Research output: Contribution to journal › Article › peer-review

Obesity and stroke: Can we translate from rodents to patients?

Haley, M. & Lawrence, C., 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 12

Research output: Contribution to journal › Article › peer-review

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke

Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., Mccoll, B. & Lawrence, C., 4 Aug 2015, In: Journal of Neuroinflammation. 12, 140, p. 1-12 11 p.

Research output: Contribution to journal › Article › peer-review

Pharmacological validation of a telemetric model for the measurement of bronchoconstriction in conscious rats

Ewart, L. C., Haley, M., Bickerton, S., Bright, J., Elliott, K., McCarthy, A., Williams, L., Ricketts, S-A., Holland, T. & Valentin, J-P., 12 Mar 2010, In: Journal of Pharmacological and Toxicological Methods. 61, 2, p. 219-29 11 p.

Research output: Contribution to journal › Article › peer-review