Our research makes use of four key methodologies: neuropsychology, computational models (models that can mimic neural organisation in their construction but also produce target behaviours), transcranial magnetic stimulation (TMS), structural and functional neuroimaging, and cortical grid-electrode studies. The various research projects can be summarised under three themes:
(1) Semantic memory : various interlinked projects explore the nature and neural underpinnings of semantic memory or conceptual knowledge, including category-specific disorders. This uses data from semantic dementia, herpes simplex virus encephalitis (HSVE), aphasia after CVA and temporal lobe resection for epilepsy for the neuropsychological investigations and is complemented by TMS, fMRI and MR tractography studies.
(2) Language : there are several ongoing projects exploring different aspects of language production and comprehension, and their neural bases. For neuropsychology, these include a direct comparison of fluent and non-fluent varieties of progressive and non-progressive aphasia; acquired dyslexias and dysgraphias; verb morphology deficits; and verbal short-term memory deficits. We also conduct parallel studies in neurological intact studies utilising experimental psycholingistics, TMS, computational modelling and fMRI studies.
(3) Recovery, rehabilitation and neuroplasticity : As well as concentrating on the nature of chronic and progressive cognitive and language deficits, the third theme is devoted to the study of the neural and cognitive principles that guide recovery and rehabilitation. This includes active rehabilitation programmes, longitudinal neuropsychological assessment of recovery, computational models of neuroplasticity and parallel functional imaging studies of patients.
See the MRC CBU website for more details on my research.