Metabolic predictors of cardiometabolic disease: his work largely focuses on understanding mechanisms of disease using data from UK Biobank, the Clinical Practice Research Datalink (CPRD), the European Male Ageing Study (EMAS), islet and pancreas transplant registries and locally generated data.
Sleep/chronotype: he leads a group exploring causal relationships between sleep/chronotype and cardiometabolic and chronic inflammatory diseases using UK Biobank data. He is a member of the UK Biobank Sleep working group (focussing on the use of actigraphy data). He is co-I on a University-funded grant supporting studies in biological timing.
Vascular stiffness: he leads a group exploring the pathogenesis of vascular stiffness using UK Biobank data. He is co-lead of a UK Biobank Cardiometabolic Peripheral Arterial Disease (PAD) working group. These studies links to the Molecules and Pathways in Cardiovascular Disease (MAP-CVD) Study that he leads.
UK Biobank Cardiometabolic Consortium: He is a member of CHD, Diabetes and Obesity working groups and is co-lead for the PAD working group
Cardiovascular disease in diabetes: he leads several projects investigating the links between diabetes and cardiovascular disease and in a particular the impact of medical therapies on cardiovascular risk. These projects use data from CPRD and the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial.
Frailty: he co-leads a project focusing on the endocrine predictors of frailty using data from the European Male Ageing Study (EMAS) and an MRC-funded project in collaboration with a team at Manchester Metropolitan University.
Identification and Management of Psoriasis Associated Co-morbidity (IMPACT) study: he is a co-investigator in this NIHR-funded 5-year Programme of work and leads study focusing on arterial stiffness.
Manchester Centre for Biological Timing: he was a co-applicant on a University-funded grant supporting studies in biological timing and now serves on the steering committee. His focus is on the relevance of circadian rhythms to metabolic disease/diabetes.
Islet cell and pancreas transplantation: he leads and co-leads several projects focusing on the role of insulin therapy in transplantation and the cardiovascular and microvascular benefits of transplantation.